| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
male mice hippocampal expression of tau was significantly decreased during the cocaine-associated memory formation. |
2021-11-22 |
2023-08-13 |
mouse |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
genetic overexpression of four microtubule-binding repeats tau (4r tau) in the mice hippocampus disrupted cocaine memory by suppressing ahn. |
2021-11-22 |
2023-08-13 |
mouse |
| Hongchun Li, Wei Xu, Denian Wang, Liang Wang, Qiyao Fang, Xuemei Wan, Jiamei Zhang, Yiming Hu, Huifang Li, Jie Zhang, Zhen Yang, Chunqi Liu, Xiaocong Liu, Yonghai Wang, Bin Liu, Zhengtao Hu, Ying Zhao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Ce. 4R Tau Modulates Cocaine-Associated Memory through Adult Dorsal Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 31. 2021-11-22. PMID:34099513. |
furthermore, 4r tau directly interacted with phosphoinositide 3-kinase (pi3k)-p85 and impaired its nuclear translocation and pi3k-akt signaling, processes required for hippocampal neuron proliferation. |
2021-11-22 |
2023-08-13 |
mouse |
| Alireza Moein Alsadat, Farnaz Nikbakht, Hadiseh Hossein Nia, Fereshteh Golab, Yasaman Khadem, Mahmoud Barati, Somayeh Vazifekha. GSK-3β as a target for apigenin-induced neuroprotection against Aβ 25-35 in a rat model of Alzheimer's disease. Neuropeptides. vol 90. 2021-11-22. PMID:34597878. |
immunohistochemistry and western blot analysis showed that apigenin significantly reduced the hyperphosphorylation of tau levels in the hippocampus. |
2021-11-22 |
2023-08-13 |
rat |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
the data indicate that an episode of cerebral ischemia activates the damage and death of neurons in the hippocampus in a tau protein-dependent manner, thus determining a novel and important mechanism for the survival and/or death of neuronal cells following ischemia. |
2021-11-19 |
2023-08-13 |
Not clear |
| Fabiola Paciello, Marco Rinaudo, Valentina Longo, Sara Cocco, Giulia Conforto, Anna Pisani, Maria Vittoria Podda, Anna Rita Fetoni, Gaetano Paludetti, Claudio Grass. Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease. eLife. vol 10. 2021-11-19. PMID:34699347. |
this was associated with earlier hippocampal dysfunction, increased tau phosphorylation, neuroinflammation, and redox imbalance, along with anticipated memory deficits compared to the expected time-course of the neurodegenerative phenotype. |
2021-11-19 |
2023-08-13 |
mouse |
| Lauren V C Miller, Aamir S Mukadam, Claire S Durrant, Marina J Vaysburd, Taxiarchis Katsinelos, Benjamin J Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C James, Michael P Coleman, William A McEwa. Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33712082. |
we used organotypic hippocampal slice cultures from p301s tau transgenic mice in order to precisely control the concentration of extracellular tau assemblies in neural tissue. |
2021-11-18 |
2023-08-13 |
mouse |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
our study shows that in a mouse model of tauopathy spread, the propagation of tau pathology from the ec to the hippocampus is associated with tbm-related atrophy, but atrophy in the dentate gyrus and subiculum precedes overt cell loss. |
2021-11-17 |
2023-08-13 |
mouse |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33627790. |
pathologically phosphorylated tau at s396/404 (phf-1) is accumulated inside of hippocampal synaptic mitochondria of aged wild-type mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33627790. |
here, we demonstrated that phosphorylated tau at ser 396/404 sites, epitope known as phf-1, is increased in the hippocampus of aged mice at the same time that oxidative damage and mitochondrial dysfunction are observed. |
2021-11-15 |
2023-08-13 |
mouse |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33627790. |
most importantly, we showed that tau phf-1 is located in hippocampal mitochondria and accumulates in the mitochondria of old mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Angie K Torres, Claudia Jara, Margrethe A Olesen, Cheril Tapia-Roja. Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33627790. |
these results demonstrated the presence of phosphorylated tau at phf-1 commonly related to tauopathy, inside the mitochondria from the hippocampus of healthy aged mice for the first time. |
2021-11-15 |
2023-08-13 |
mouse |
| Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-13. PMID:34607969. |
we evaluated interactions of wild-type or mutant tau with specific pp1 isoforms (α, β, and γ) to examine how the interaction contributes to this toxic effect using primary rat hippocampal neurons from both sexes. |
2021-11-13 |
2023-08-13 |
rat |
| Paula Moyano, Javier Sanjuna, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, María Victoria Naval, Javier Del Pin. Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption. Chemical research in toxicology. vol 34. issue 5. 2021-11-12. PMID:33156613. |
paraquat treatment compromises the clearance of β-amyloid and tau proteins and induces primary hippocampal neuronal cell death through hsp70, p20s, and tfeb disruption. |
2021-11-12 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuna, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, María Victoria Naval, Javier Del Pin. Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption. Chemical research in toxicology. vol 34. issue 5. 2021-11-12. PMID:33156613. |
single and repeated pq treatment increased aβ and tau protein levels, through hsp70 and tfeb downregulation and proteasome 20s inhibition, producing cell death in primary hippocampal neurons associated with cognitive decline. |
2021-11-12 |
2023-08-13 |
Not clear |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. |
thus, we set out to help clarify the normal localization of tau in the adult cns of middle-aged rats and rhesus macaque using the hippocampus as a representative brain structure. |
2021-11-12 |
2023-08-13 |
rat |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. |
the physiological concentration of tau in the rat hippocampus was 6.6 μm and in white matter was 3.6 μm as determined by quantitative sandwich elisas. |
2021-11-12 |
2023-08-13 |
rat |
| Min Xiong, Li Zou, Lanxia Meng, Xingyu Zhang, Ye Tian, Guoxin Zhang, Jiaolong Yang, Guiqin Chen, Jing Xiong, Keqiang Ye, Zhentao Zhan. A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease. Progress in neurobiology. vol 203. 2021-11-11. PMID:33992672. |
expression of the γ-adducin (1-357) fragment in the hippocampus of tau p301s transgenic mice resulted in significant ad-like pathology and cognitive deficits. |
2021-11-11 |
2023-08-13 |
mouse |
| Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology. vol 203. 2021-11-11. PMID:34004220. |
in an ad mouse model that manifests both aβ and tau pathologies, genetic downregulation of plexin-a4 in the hippocampus reduced tau pathology and ameliorated spatial memory impairment. |
2021-11-11 |
2023-08-13 |
mouse |