All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. the effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in alzheimer's diseases. 2021-11-01 2023-08-13 Not clear
Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. the present study aims to investigate layer-specific magnetic susceptibility in the hippocampus of ad patients using high-resolution ex-vivo mri, and elucidate its relationship with beta amyloid (aβ) and tau protein histology. 2021-11-01 2023-08-13 Not clear
Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. we manually segmented each sample into seven layers, including four layers in the cornu ammonis1 (ca1) and three layers in the dentate gyrus (dg), and then evaluated ad-related alterations of susceptibility and t2* values and their correlations with aβ and tau in each hippocampal layer. 2021-11-01 2023-08-13 Not clear
D G Coughlin, R Ittyerah, C Peterson, J S Phillips, S Miller, K Rascovsky, D Weintraub, A D Siderowf, J E Duda, H I Hurtig, D A Wolk, C T McMillan, P A Yushkevich, M Grossman, E B Lee, J Q Trojanowski, D J Irwi. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32892355. here we use digital histological methods to test the association between hippocampal syn pathology and the distribution of tau and amyloid-beta (aβ) pathology in lbd and contrast with ad subjects. 2021-10-28 2023-08-13 human
Bin Wu, Haiqing Cai, Shen Tang, Yilu Xu, Qianqian Shi, Lancheng Wei, Ling Meng, Ning Zhang, Xinhang Wang, Deqiang Xiao, Yunfeng Zou, Xiaobo Yang, Xiyi Li, Cailing L. Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32959271. we show that mn-induced neurotoxicity is characterized by pp2ac demethylation accompanied by abnormally decreased lcmt-1 and increased pme-1, which are associated with tau hyperphosphorylation and spatial learning and memory deficits, and that the poor availability of sam in the hippocampus is likely to determine the loss of pp2ac methylation. 2021-10-28 2023-08-13 rat
Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chan. WWOX and Its Binding Proteins in Neurodegeneration. Cells. vol 10. issue 7. 2021-10-28. PMID:34359949. gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. 2021-10-28 2023-08-13 mouse
Meijuan Zhu, Yanhua Zhao, Yongjun Zheng, Diansan Su, Xiangrui Wan. Relative Higher Hematocrit Attenuates the Cerebral Excitatory Amino Acid Elevation Induced by Deep Hypothermic Circulatory Arrest in Rats. Therapeutic hypothermia and temperature management. vol 3. issue 3. 2021-10-21. PMID:24066268. high-performance liquid chromatography was used to determine the concentration of glutamate (glu), aspartate (asp), glycine (gly), gamma-aminobutyric acid (gaba), and taurine (tau) in the cerebral cortex, hippocampus, and thalamus. 2021-10-21 2023-08-12 rat
Vivek Kumar Sharma, Thakur Gurjeet Singh, Shareen Singh, Nikhil Garg, Sonia Dhima. Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34386919. the well-characterized pathological features of ad, including extracellular plaques of amyloid-beta, intracellular hyperphosphorylated tangles of tau protein (nfts), inflammation, mitochondrial dysfunction, oxidative stress, and excitotoxic cell death, also instigate an abnormal apoptotic cascade in susceptible brain regions (cerebral cortex, hippocampus). 2021-10-21 2023-08-13 Not clear
Troy T Rohn, Polina Kokoulin. Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease. International journal of physiology, pathophysiology and pharmacology. vol 1. issue 1. 2021-10-20. PMID:20411029. co-localization of tdpccp with phf-1, a general marker for pick bodies, as well as with an antibody to caspase-cleaved tau (tauc3) was evident within the hippocampus. 2021-10-20 2023-08-12 Not clear
Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica. vol 142. issue 1. 2021-10-19. PMID:33895869. our data reveal that apoe4 boosts tau neurotoxicity via vmat2 inhibition, reduces hippocampal volume, and induces cognitive dysfunction in an aep- and tau n368-dependent manner, while conversely apoe3 binds tau and protects it from cleavage. 2021-10-19 2023-08-13 human
Xingyu Zhang, Li Zou, Lanxia Meng, Min Xiong, Lina Pan, Guiqin Chen, Yongfa Zheng, Jing Xiong, Zhihao Wang, Duc M Duong, Zhaohui Zhang, Xuebing Cao, Tao Wang, Li Tang, Keqiang Ye, Zhentao Zhan. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. eLife. vol 10. 2021-10-18. PMID:34018922. overexpression of amphiphysin i (1-278) in the hippocampus of tau p301s mice induces synaptic dysfunction, tau hyperphosphorylation, and cognitive deficits. 2021-10-18 2023-08-13 mouse
Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. in addition, tau hyperphosphorylation and aβ expression increase in the cortex and hippocampus of the brain. 2021-10-18 2023-08-13 rat
Kurt A Jellinge. Neuropathological assessment of the Alzheimer spectrum. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 9. 2021-10-15. PMID:32740684. ad is a mixed proteinopathy (amyloid and tau), frequently associated with other age-related co-pathologies, such as cerebrovascular lesions, lewy and tdp-43 pathologies, hippocampal sclerosis, or argyrophilic grain disease. 2021-10-15 2023-08-13 Not clear
M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. concomitantly, it inhibited the hippocampal activity of akt and increased the activity of glycogen synthase kinase 3β and tau protein phosphorylation. 2021-10-12 2023-08-13 rat
M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. in conclusion, ag replacement therapy after sg in rats protects them against memory deficits and hippocampal damage by suppressing tau protein phosphorylation, mediated by activating pi3k/aktinduced inhibition of glycogen synthase kinase 3β. 2021-10-12 2023-08-13 rat
Paula Duarte-Guterman, Arianne Y Albert, Cindy K Barha, Liisa A M Galea, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory. Psychoneuroendocrinology. vol 129. 2021-10-11. PMID:33962245. using the adni database (n = 630 females, n = 830 males), we analyzed the effect of sex, apoe genotype (non-carriers or carriers of apoeε4 alleles), and diagnosis (cognitively normal (cn), early amci (emci), late amci (lmci), probable ad) on cognition (memory and executive function), hippocampal volume, and ad biomarkers (csf levels of amyloid beta, tau, and ptau). 2021-10-11 2023-08-13 Not clear
Jing Cai, Junyong Ruan, Xi Shao, Yuanjun Ding, Kangning Xie, Chi Tang, Zedong Yan, Erping Luo, Da Jin. Oxygen Enrichment Mitigates High-Altitude Hypoxia-Induced Hippocampal Neurodegeneration and Memory Dysfunction Associated with Attenuated Tau Phosphorylation. High altitude medicine & biology. vol 22. issue 3. 2021-10-11. PMID:34348049. oxygen enrichment mitigates high-altitude hypoxia-induced hippocampal neurodegeneration and memory dysfunction associated with attenuated tau phosphorylation. 2021-10-11 2023-08-13 Not clear
Jing Cai, Junyong Ruan, Xi Shao, Yuanjun Ding, Kangning Xie, Chi Tang, Zedong Yan, Erping Luo, Da Jin. Oxygen Enrichment Mitigates High-Altitude Hypoxia-Induced Hippocampal Neurodegeneration and Memory Dysfunction Associated with Attenuated Tau Phosphorylation. High altitude medicine & biology. vol 22. issue 3. 2021-10-11. PMID:34348049. oxygen enrichment mitigates high-altitude hypoxia-induced hippocampal neurodegeneration and memory dysfunction associated with attenuated tau phosphorylation. 2021-10-11 2023-08-13 Not clear
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caillé, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34588422. distinct amyloid and tau pet signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. 2021-10-11 2023-08-13 Not clear
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caillé, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34588422. we aimed to investigate the amyloid and tau pet imaging signatures of patients with amnestic syndrome of the hippocampal type (asht) and study their clinical and imaging progression according to their initial pet imaging status. 2021-10-11 2023-08-13 Not clear