All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. the present results indicate that hippocampal il-1β, il-6, and phosphorylated tau proteins may be involved in the neurotoxic mechanism of chronic alcohol exposure by mediating synaptic dysfunction. 2021-09-20 2023-08-13 mouse
Akinori Futamura, Sotaro Hieda, Yukiko Mori, Azusa Sugimoto, Hideyo Kasai, Takeshi Kuroda, Satoshi Yano, Kensaku Kasuga, Hidetomo Murakami, Takeshi Ikeuchi, Kenjiro On. Cingulate Island Sign in Single Photon Emission Computed Tomography: Clinical Biomarker Correlations in Lewy Body Disease and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 79. issue 3. 2021-09-17. PMID:33361600. our results showed cis was not related to csf biomarkers in lbd and high csf tau levels were related to clinical disease severity and hippocampal atrophy. 2021-09-17 2023-08-13 Not clear
Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459641. new biomolecular findings reveal the interplay of cbh in increasing tau phosphorylation (p-tau) in the hippocampus and cortex of ad mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mtor), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of ad. 2021-09-15 2023-08-13 mouse
Lei Huang, Yang Zhang, Yongwei Wang, Yajia La. Relationship Between Chronic Noise Exposure, Cognitive Impairment, and Degenerative Dementia: Update on the Experimental and Epidemiological Evidence and Prospects for Further Research. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459723. experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-β deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. 2021-09-15 2023-08-13 Not clear
Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. intraneuronal hippocampal tau hyperphosphorylation at s202/t205, s422, and t231, and tau conformational change were absent in both ctc and cto brains. 2021-09-14 2023-08-13 mouse
Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. a slight accumulation of tau phosphorylated at s396/404 and s202 was observed in cornu ammonis 1 (ca1) hippocampal neuron soma of ctc compared to cto brains. 2021-09-14 2023-08-13 mouse
Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease. vol 36. issue 7. 2021-09-14. PMID:34269982. during in vitro experiment, high-fat diet mice showed cognitive dysfunction, significant hyperphosphorylation of tau protein and neuronal pyroptosis in hippocampus compared with the sham mice. 2021-09-14 2023-08-13 mouse
Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease. vol 36. issue 7. 2021-09-14. PMID:34269982. inhibition of the signaling pathway using axl1717 or znpp ix re-deteriorated cognitive function, tau pathology and neuronal pyroptosis in hippocampus. 2021-09-14 2023-08-13 mouse
Mohamed A Salem, Barbara Budzyńska, Joanna Kowalczyk, Nesrine S El Sayed, Suzan M Mansou. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. Toxicology and applied pharmacology. vol 429. 2021-09-14. PMID:34428446. administration of tad or bg at doses of 20 and 25 mg/kg, respectively, for 21 consecutive days attenuated stz-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the morris water maze and object recognition tests paralleled by reduction in aβ expression by 79 and 89% and tau hyperphosphorylation by 60 and 61%, respectively. 2021-09-14 2023-08-13 mouse
Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. 2021-09-14 2023-08-13 mouse
Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. we investigated if alleviation of hippocampal ir by the antidiabetic agent metformin could reduce tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. 2021-09-14 2023-08-13 mouse
Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. the effects of prolonged (6 h) isoflurane anesthesia on hippocampal ir, hippocampal tau hyperphosphorylation, and hippocampus-dependent cognitive function were evaluated in wild type (wt) adult mice and the high-fat diet plus streptozotocin (hfd/stz) mouse model of t2dm. 2021-09-14 2023-08-13 mouse
Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. isoflurane also induced hippocampal tau hyperphosphorylation and metformin reversed this effect. 2021-09-14 2023-08-13 mouse
Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. our findings show hippocampal ir and tau hyperphosphorylation contribute to acute isoflurane-induced cognitive dysfunction. 2021-09-14 2023-08-13 mouse
Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33660768. the known inhibitory effect of rivastigmine on cognition and acetylcholinesterase activity was observed in both cortex and hippocampus and further its effect on tau level, amyloid aggregation, biochemical alterations, endoplasmic reticulum (er) stress, calcium homeostasis, proteasome activity and apoptosis was estimated. 2021-09-13 2023-08-13 rat
Lauren E McCollum, Sandhitsu R Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X Xie, Laura E M Wisse, Paul A Yushkevich, David A Wol. Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34119903. β-amyloid and tau status were determined by csf assays, while neurodegeneration status was based on hippocampal volume on mri. 2021-09-13 2023-08-13 human
David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology. vol 80. issue 8. 2021-09-13. PMID:34388235. others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and creutzfeldt-jakob disease. 2021-09-13 2023-08-13 Not clear
Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardso. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 5. 2021-09-09. PMID:33860327. asymmetry of hippocampal tau pathology in primary age-related tauopathy and alzheimer disease. 2021-09-09 2023-08-13 Not clear
Xin Wang, En-Jie Liu, Qian Liu, Shi-Hong Li, Ting Li, Qiu-Zhi Zhou, Yan-Chao Liu, Huaqiu Zhang, Jian-Zhi Wan. Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32804150. tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice. 2021-09-08 2023-08-13 mouse
Israa M Abd El-Fatah, Heba M A Abdelrazek, Sherehan M Ibrahim, Dalaal M Abdallah, Hanan S El-Abha. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories. Neurochemistry international. vol 148. 2021-09-08. PMID:34052296. mechanistically, dmf suppressed the hippocampal contents of ad-surrogate markers; viz., apolipoprotein (apo)-e1, bace1, aβ42, and hyperphosphorylated tau. 2021-09-08 2023-08-13 rat