All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Kurt A Jellinge. Pathobiological Subtypes of Alzheimer Disease. Dementia and geriatric cognitive disorders. vol 49. issue 4. 2021-05-21. PMID:33429401. in addition to the 4 major subtypes based on the distribution of tau pathology and brain atrophy (typical, limbic predominant, hippocampal sparing, and minimal atrophy [ma]), several other clinical variants showing distinct regional patterns of tau burden have been identified: nonamnestic, corticobasal syndromal, primary progressive aphasia, posterior cortical atrophy, behavioral/dysexecutive, and mild dementia variants. 2021-05-21 2023-08-13 Not clear
Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. 2021-05-18 2023-08-13 mouse
Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zhen. Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649817. immunohistochemical analysis revealed that rg1 decreased the expression of amyloid β, tau phosphorylated at serine 404 and pro-apoptotic factor bax, while increasing the expression of bcl-2 in the hippocampus and cortex. 2021-05-17 2023-08-13 Not clear
Ari Loren Mendell, Samantha D Creighton, Hayley A Wilson, Kristen H Jardine, Lauren Isaacs, Boyer D Winters, Neil J MacLusk. Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice. Neuroscience. vol 429. 2021-05-14. PMID:31954826. inhibition of 5α reductase impairs cognitive performance, alters dendritic morphology and increases tau phosphorylation in the hippocampus of male 3xtg-ad mice. 2021-05-14 2023-08-13 mouse
D Monteiro-Fernandes, N Sousa, O F X Almeida, I Sotiropoulo. Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain. Neuroscience. vol 454. 2021-05-14. PMID:32512138. we here report that both, long-term gc deprivation (by adrenalectomy) and exogenous gc administration with natural or synthetic glucocorticoid receptor ligands (corticosterone and dexamethasone, respectively) induce tau hyperphosphorylation in the hippocampus and frontocortical regions at epitopes associated with disruption of cytoskeletal and synaptic function. 2021-05-14 2023-08-13 rat
Wen Yang, Yue Liu, Qing-Qing Xu, Yan-Fang Xian, Zhi-Xiu Li. Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3 Oxidative medicine and cellular longevity. vol 2020. 2021-05-14. PMID:32963694. sulforaphene ameliorates neuroinflammation and hyperphosphorylated tau protein via regulating the pi3k/akt/gsk-3 alzheimer's disease (ad) is the most common form of dementia characterized by progressive loss of cognitive functions due to neuronal death mainly in the hippocampal and cortical brain. 2021-05-14 2023-08-13 Not clear
Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J Czuczwa. Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671097. participation of amyloid and tau protein in post-ischemic neurodegeneration of the hippocampus of a nature identical to alzheimer's disease. 2021-05-12 2023-08-13 Not clear
Ryszard Pluta, Liang Ouyang, Sławomir Januszewski, Yang Li, Stanisław J Czuczwa. Participation of Amyloid and Tau Protein in Post-Ischemic Neurodegeneration of the Hippocampus of a Nature Identical to Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 5. 2021-05-12. PMID:33671097. recent evidence suggests that amyloid and tau protein are of vital importance in post-ischemic death of ca1 pyramidal neurons of the hippocampus. 2021-05-12 2023-08-13 Not clear
Connor M Wander, Jui-Heng Tseng, Sheng Song, Heba A Al Housseiny, Dalton S Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B Meeker, David J Irwin, Todd J Cohe. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. vol 23. issue 7. 2021-05-11. PMID:32585593. the accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging. 2021-05-11 2023-08-13 mouse
Cheng Xu, Jing Guo, Li Li, Xin Wang, Qiuzhi Zhou, Dongsheng Sun, Shujuan Zhang, Shihong Li, Jinwang Ye, Yanchao Liu, Enjie Liu, Peng Zeng, Xiaochuan Wang, Ying Yang, Jian-Zhi Wan. Co-Expression of Three Wild-Type 3R-Tau Isoforms Induces Memory Deficit via Oxidation-Related DNA Damage and Cell Death: A Promising Model for Tauopathies. Journal of Alzheimer's disease : JAD. vol 73. issue 3. 2021-05-10. PMID:31884489. here, we co-expressed three isoforms of human wild-type 3r-tau in adult mouse hippocampal to mimic the pathologic tau accumulating observed in pid patients. 2021-05-10 2023-08-13 mouse
Michael G Friedrich, Amanda Skora, Sarah E Hancock, Todd W Mitchell, Paul L Else, Roger J W Truscot. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International journal of molecular sciences. vol 22. issue 7. 2021-05-10. PMID:33805376. antibodies to the c-terminal and n-terminal regions of tau were employed to examine tau cleavage in five human brain regions: the entorhinal cortex, prefrontal cortex, motor cortex, hippocampus, and cerebellum. 2021-05-10 2023-08-13 human
Graciela Muniz Terrera, John E Harrison, Craig W Ritchie, Karen Ritchi. Cognitive Functions as Predictors of Alzheimer's Disease Biomarker Status in the European Prevention of Alzheimer's Dementia Cohort. Journal of Alzheimer's disease : JAD. vol 74. issue 4. 2021-05-07. PMID:32144988. these preliminary findings suggest that profiles of cognitive performance may be specific to a given biomarker, with a primarily hippocampal task being associated with higher levels of tau and a frontal executive task being associated with higher levels of aβ. 2021-05-07 2023-08-13 human
Marangelie Criado-Marrero, Niat T Gebru, Lauren A Gould, Danielle M Blazier, Yamile Vidal-Aguiar, Taylor M Smith, Salma S Abdelmaboud, Lindsey B Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A Dickey, Laura J Blai. FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. NPJ aging and mechanisms of disease. vol 7. issue 1. 2021-05-07. PMID:33941782. to test this, tau transgenic (rtg4510) and wild-type mice received bilateral hippocampal injections of virus overexpressing fkbp52 or gfp control. 2021-05-07 2023-08-13 mouse
Michael Ohene-Nyako, Sara R Nass, Yun K Hahn, Pamela E Knapp, Kurt F Hause. Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice. Neuroscience letters. vol 741. 2021-05-04. PMID:33202259. the pathological phospho-isotypes of tau (pser396, pser404, pthr205, pser202, and pthr181) and the tau kinases gsk3β and cdk5/p35 were explored in the striatum, hippocampus, and prefrontal cortex of inducible male and female hiv-1 tat-transgenic mice, with some receiving escalating doses of morphine for 2 weeks. 2021-05-04 2023-08-13 mouse
Lon S Schneider, Ronald G Thomas, Suzanne Hendrix, Robert A Rissman, James B Brewer, David P Salmon, Tilman Oltersdorf, Tomohiro Okuda, Howard H Feldma. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA neurology. vol 76. issue 11. 2021-05-03. PMID:31282954. edonerpic maleate (t-817ma) protects against aβ40-induced neurotoxic effects and memory deficits, promotes neurite outgrowth, and preserves hippocampal synapses and spatial memory in tau transgenic mice. 2021-05-03 2023-08-13 mouse
Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. our results indicated that maternal exposure to vpa induces: (1) decrease the level of α/β-tubulin along with tau accumulation in the hippocampus and cerebral cortex; (2) excessive tau phosphorylation and activation of tau-kinases: cdk5, erk1/2, and p70s6k in the cerebral cortex; (3) up-regulation of mtor kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. 2021-04-30 2023-08-13 rat
Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. we treated tbi and sham operated mice with dha, and investigated the effects of dha on jnk and tau phosphorylation, hippocampal long term potentiation (ltp), learning and memory, and motor function by western blot analysis, electrophysiology recording and behavioral assessments including morris water maze test, beam-balance test, beam-walk test and rotarod test. 2021-04-28 2023-08-13 mouse
Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. dha suppressed tbi induced jnk and tau hyperphosphorylation, rescued tbi mediated hippocampal ltp deficits and hippocampus dependent learning and memory dysfunction, and improved motor function. 2021-04-28 2023-08-13 mouse
Eero Vuoksimaa, Linda K McEvoy, Dominic Holland, Carol E Franz, William S Kreme. Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease. Brain imaging and behavior. vol 14. issue 3. 2021-04-27. PMID:30511118. cn, avlt+, and avlt- groups differed significantly on baseline brain (hippocampus, entorhinal cortex) and cerebrospinal fluid (amyloid, tau, p-tau) biomarkers, with the avlt- group being most abnormal. 2021-04-27 2023-08-13 human
Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2021-04-27. PMID:31978364. interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing gabaergic transmission. 2021-04-27 2023-08-13 mouse