All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theuni. Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies. Molecular therapy. Methods & clinical development. vol 31. 2023-12-11. PMID:38074413. subsequently, we show their capacity to interfere with either mouse or mutant human tau aggregation in two different primary mouse neuron models and organotypic hippocampal slice cultures. 2023-12-11 2023-12-17 mouse
Justin Torok, Pedro D Maia, Chaitali Anand, Ashish Ra. Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076913. hippocampal glutamatergic neurons as a whole were strongly positively associated with regional tau deposition, suggesting vulnerability, while cortical glutamatergic and gabaergic neurons were negatively associated. 2023-12-11 2023-12-17 mouse
Etienne Aumont, Aurélie Bussy, Marc-André Bedard, Gleb Bezgin, Joseph Therriault, Melissa Savard, Jaime Fernandez Arias, Viviane Sziklas, Paolo Vitali, Nina Margherita Poltronetti, Vanessa Pallen, Emilie Thomas, Serge Gauthier, Eliane Kobayashi, Nesrine Rahmouni, Jenna Stevenson, Cecile Tissot, Mallar M Chakravarty, Pedro Rosa-Net. Hippocampal subfield associations with memory depend on stimulus modality and retrieval mode. Brain communications. vol 5. issue 6. 2023-11-30. PMID:38035364. amyloid-β and hippocampal tau positivity were assessed using [ 2023-11-30 2023-12-10 human
Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. effect of sleep deprivation by mmp-wm on rat neurological function and tau protein in hippocampus. 2023-11-28 2023-11-29 human
Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. this study aims to explore the effect of sleep deprivation by modified multiple platform-water maze (mmp-wm) on rat neurological function and tau protein in the hippocampus, as well as the intervention effect of remimazolam. 2023-11-28 2023-11-29 human
Hong Cheng, Lu Gan, Yan Wang, Lin Li, Yongle L. Effect of sleep deprivation by MMP-WM on rat neurological function and Tau protein in hippocampus. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015534. after that, the rats were executed, the hippocampus was isolated for nissl staining, and the protein expression of phosphorylated tau (p-tau) in the ca1 region of the hippocampus was measured by immunohistochemistry. 2023-11-28 2023-11-29 human
Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. moreover, the effects of tau on mitochondrial function and oxidative stress biomarkers as plausible mechanisms of its action in the whole brain and hippocampus have been evaluated. 2023-11-26 2023-11-28 mouse
Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. tau measurement in the brain and hippocampus revealed higher levels of this amino acid. 2023-11-26 2023-11-28 mouse
Mohammad Mehdi Ommati, Heresh Rezaei, Retana-Márquez Socorro, Weishun Tian, Jing Zhao, Ayeh Rouhani, Samira Sabouri, Fatemeh Ghaderi, Amir Mohammad Niknahad, Asma Najibi, Sahra Mazloomi, Moslem Safipour, Zahra Honarpishefard, Hong-Wei Wang, Hossein Niknahad, Reza Heidar. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life sciences. 2023-11-26. PMID:38008208. tau and atp levels were also significantly higher in the mitochondria isolated from the whole brain and hippocampus. 2023-11-26 2023-11-28 mouse
Hansol Lee, Jessie Fanglu Fu, Kyla Gaudet, Annie G Bryant, Julie C Price, Rachel E Bennett, Keith A Johnson, Bradley T Hyman, Trey Hedden, David H Salat, Yi-Fen Yen, Susie Y Huan. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023-11-24. PMID:38000018. aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and alzheimer's disease. 2023-11-24 2023-11-28 mouse
Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J O'Neill, Florian Wegner, Stefan Barghorn, Günter U Höglinger, Roland G Hey. Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain. Acta neuropathologica communications. vol 11. issue 1. 2023-11-15. PMID:37964332. the specificity of our tau saa for ad brain was further supported by analysis of matched hippocampus and cerebellum samples. 2023-11-15 2023-11-20 human
Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J O'Neill, Florian Wegner, Stefan Barghorn, Günter U Höglinger, Roland G Hey. Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain. Acta neuropathologica communications. vol 11. issue 1. 2023-11-15. PMID:37964332. while seeding was detected in hippocampus from braak stages i-ii, no seeding was present in ad cerebellum that is devoid of tau inclusions. 2023-11-15 2023-11-20 human
Claire J Ciampa, Thomas M Morin, Alice Murphy, Renaud La Joie, Susan M Landau, Anne S Berr. DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology. Neurobiology of aging. vol 133. 2023-11-10. PMID:37948982. we tested for effects of dat1 and bdnf polymorphisms on cross-sectional and longitudinal β-amyloid (aβ) and tau pathology (measured with positron emission tomography (pet)), hippocampal volume, and cognition. 2023-11-10 2023-11-20 Not clear
Shanley F Longfield, Mahdie Mollazade, Tristan P Wallis, Rachel S Gormal, Merja Joensuu, Jesse R Wark, Ashley J van Waardenberg, Christopher Small, Mark E Graham, Frédéric A Meunier, Ramón Martínez-Mármo. Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature communications. vol 14. issue 1. 2023-11-10. PMID:37949856. here, we performed a large-scale activity-dependent phosphoproteome analysis of hippocampal neurons in vitro and identified tau as a highly phosphorylated and disordered candidate protein. 2023-11-10 2023-11-20 Not clear
Singh S Ankul, Lakshmi Chandran, Singh Anuragh, Ilango Kaliappan, Rapuru Rushendran, Chitra Vellapandia. A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model. Frontiers in pharmacology. vol 14. 2023-11-09. PMID:37942488. the treated mice also had more hyperphosphorylated tau protein in their cortical and hippocampus neurons. 2023-11-09 2023-11-20 mouse
Olivia Lu, Taimur Kouser, Irina A Skylar-Scot. Alzheimer's disease and epilepsy: shared neuropathology guides current and future treatment strategies. Frontiers in neurology. vol 14. 2023-11-08. PMID:37936917. this bi-directional relationship may be due to underlying shared pathophysiologic hallmarks, including decreased cerebrospinal fluid amyloid beta 42 (aβ42), increased hyperphosphorylated tau protein, and hippocampal hyperexcitability. 2023-11-08 2023-11-20 Not clear
Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. linear mixed models examined the relationship between apoe profiles and brain changes (i.e., regional wmhs, ventricle size, hippocampal and entorhinal cortex volume, amyloid level, and phosphorylated tau measures), while controlling for age, sex, education, and diagnostic status at baseline and over time. 2023-11-07 2023-11-20 human
Sophie Nader, Esma Karlovich, Etty P Cortes, Ricardo Insausti, Gregory Meloni, Michelle Jacobs, John F Crary, Susan Morgell. Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection. Journal of neurovirology. 2023-11-05. PMID:37926797. the accumulation of hyperphosphorylated tau (p-tau) in hippocampus is a common degenerative change, with specific patterns of hippocampal subfield vulnerability observed in different disease contexts. 2023-11-05 2023-11-08 human
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A Fernandez, Perle Roche, Emma L Bunting, Ella K Lacey, Sara E Hamplova, Monlan Yuan, Michael S Wolfe, David A Bennett, Eunjung A Lee, Bruce A Yankne. A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-11-03. PMID:37919281. conversely, viral-mediated overexpression of rest in the hippocampus suppresses aβ and tau pathology. 2023-11-03 2023-11-08 mouse
Brian N Lee, Junwen Wang, Molly A Hall, Dokyoon Kim, Shana D Stites, Li She. Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease. Neurobiology of aging. vol 133. 2023-11-01. PMID:37913627. multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (av45), and csf (p-tau, tau) biomarkers were differentially associated with cognitive and functional outcomes. 2023-11-01 2023-11-08 human