| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lon S Schneider, Ronald G Thomas, Suzanne Hendrix, Robert A Rissman, James B Brewer, David P Salmon, Tilman Oltersdorf, Tomohiro Okuda, Howard H Feldma. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA neurology. vol 76. issue 11. 2021-05-03. PMID:31282954. |
edonerpic maleate (t-817ma) protects against aβ40-induced neurotoxic effects and memory deficits, promotes neurite outgrowth, and preserves hippocampal synapses and spatial memory in tau transgenic mice. |
2021-05-03 |
2023-08-13 |
mouse |
| Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. |
our results indicated that maternal exposure to vpa induces: (1) decrease the level of α/β-tubulin along with tau accumulation in the hippocampus and cerebral cortex; (2) excessive tau phosphorylation and activation of tau-kinases: cdk5, erk1/2, and p70s6k in the cerebral cortex; (3) up-regulation of mtor kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. |
2021-04-30 |
2023-08-13 |
rat |
| Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. |
we treated tbi and sham operated mice with dha, and investigated the effects of dha on jnk and tau phosphorylation, hippocampal long term potentiation (ltp), learning and memory, and motor function by western blot analysis, electrophysiology recording and behavioral assessments including morris water maze test, beam-balance test, beam-walk test and rotarod test. |
2021-04-28 |
2023-08-13 |
mouse |
| Wei Zhu, Li Zhao, Tuo Li, Hao Xu, Yuexia Ding, Guangqiang Cu. Docosahexaenoic acid ameliorates traumatic brain injury involving JNK-mediated Tau phosphorylation signaling. Neuroscience research. vol 157. 2021-04-28. PMID:31348997. |
dha suppressed tbi induced jnk and tau hyperphosphorylation, rescued tbi mediated hippocampal ltp deficits and hippocampus dependent learning and memory dysfunction, and improved motor function. |
2021-04-28 |
2023-08-13 |
mouse |
| Eero Vuoksimaa, Linda K McEvoy, Dominic Holland, Carol E Franz, William S Kreme. Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease. Brain imaging and behavior. vol 14. issue 3. 2021-04-27. PMID:30511118. |
cn, avlt+, and avlt- groups differed significantly on baseline brain (hippocampus, entorhinal cortex) and cerebrospinal fluid (amyloid, tau, p-tau) biomarkers, with the avlt- group being most abnormal. |
2021-04-27 |
2023-08-13 |
human |
| Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2021-04-27. PMID:31978364. |
interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing gabaergic transmission. |
2021-04-27 |
2023-08-13 |
mouse |
| Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2021-04-27. PMID:31978364. |
phospho-tau accumulation and adult hippocampal neurogenesis (ahn) impairment both contribute importantly to the cognitive decline in alzheimer's disease (ad), but whether and how tau dysregulates ahn in ad remain poorly understood. |
2021-04-27 |
2023-08-13 |
mouse |
| Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixo. Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease. Cell reports. vol 33. issue 8. 2021-04-26. PMID:33238112. |
modest neuron-specific transgenic rab5 expression inducing hyperactivation of rab5 comparable to that in ad brain reproduces ad-related rab5-endosomal enlargement and mistrafficking, hippocampal synaptic plasticity deficits via accelerated ampar endocytosis and dendritic spine loss, and tau hyperphosphorylation via activated glycogen synthase kinase-3β. |
2021-04-26 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
strikingly, the inoculation of alzheimer's disease or prodromal alzheimer's disease extracellular vesicles containing only 300 pg of tau into the outer molecular layer of the dentate gyrus of 18-month-old c57bl/6 mice resulted in the accumulation of abnormally phosphorylated tau throughout the hippocampus by 4.5 months, whereas inoculation of an equal amount of tau from control extracellular vesicles, isolated tau oligomers, or fibrils from the same alzheimer's disease donor showed little tau pathology. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
furthermore, alzheimer's disease extracellular vesicles induced misfolding of endogenous tau in both oligomeric and sarkosyl-insoluble forms in the hippocampal region. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
our study posits a novel mechanism for the spread of tau in hippocampal gabaergic interneurons via brain-derived extracellular vesicles and their subsequent neuronal dysfunction. |
2021-04-20 |
2023-08-13 |
mouse |
| Md Sahab Uddin, Anna Stachowiak, Abdullah Al Mamun, Nikolay T Tzvetkov, Shinya Takeda, Atanas G Atanasov, Leandro B Bergantin, Mohamed M Abdel-Daim, Adrian M Stankiewic. Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. Frontiers in aging neuroscience. vol 10. 2021-04-09. PMID:29441009. |
it is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (aβ), and neurofibrillary tangles (nfts), composed of tau protein, in the hippocampus and cortex of afflicted humans. |
2021-04-09 |
2023-08-13 |
Not clear |
| Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z Peter Wang, Yuyun L. BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease. Cell death discovery. vol 7. issue 1. 2021-04-02. PMID:33723239. |
moreover, their hippocampal tissues exhibited high expression levels of ad-related proteins, including app, aβ, psen-1, tau, p-tau (thr181), and p-tau (thr231). |
2021-04-02 |
2023-08-13 |
mouse |
| Julie Pilliod, Alexandre Desjardins, Camille Pernègre, Hélène Jamann, Catherine Larochelle, Edward A Fon, Nicole Lecler. Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. The Journal of biological chemistry. vol 295. issue 51. 2021-04-01. PMID:33454017. |
increased tau secretion by vamp8 was also observed in murine hippocampal slices. |
2021-04-01 |
2023-08-13 |
Not clear |
| Ali H Abu Almaaty, Rehab M Mosaad, Mohamed K Hassan, Elham H A Ali, Ghada A Mahmoud, Hassan Ahmed, Nahla Anber, Saad Alkahtani, Mohamed M Abdel-Daim, Lotfi Aleya, Seddik Hamma. Urtica dioica extracts abolish scopolamine-induced neuropathies in rats. Environmental science and pollution research international. vol 28. issue 14. 2021-03-31. PMID:33405105. |
furthermore, cortical tau and hippocampal hsp70 were modulated by ud extracts particularly nr compared to the scop group. |
2021-03-31 |
2023-08-13 |
rat |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
insulin resistance or dysfunction of insulin signaling is a universal feature of t2d, the main culprit for altered glucose metabolism and its interdependence on cell death pathways, forming the basis of linking t2d with ad as it may exacerbate aβ accumulation, tau hyperphosphorylation and devastates glucose transportation, energy metabolism, hippocampal framework and promulgate inflammatory pathways. |
2021-03-29 |
2023-08-13 |
Not clear |
| Amira M Abo-Youssef, Waleed A Khallaf, Mahmoud M Khattab, Basim A S Messih. The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32450287. |
furthermore, it improved cognitive impairment and suppressed hippocampal amyloidogenic markers including amyloid-beta level, phosphorylated tau protein and beta site amyloid precursor protein cleaving enzyme 1 expression, while elevated levels of insulin degrading enzyme and recovered permeability of blood brain barrier (bbb). |
2021-03-29 |
2023-08-13 |
rat |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
to address this question, ccl2 was delivered via recombinant adeno-associated virus serotype 9 into both cortex and hippocampus of a mouse model with tau pathology (rtg4510). |
2021-03-29 |
2023-08-13 |
mouse |
| Matthew R Barron, Jane Gartlon, Lee A Dawson, Peter J Atkinson, Marie-Christine Pardo. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in immunology. vol 11. 2021-03-25. PMID:32194553. |
increasing tau 4r tau levels exacerbates hippocampal tau hyperphosphorylation in the htau model of tauopathy but also tau dephosphorylation following acute systemic inflammation. |
2021-03-25 |
2023-08-13 |
mouse |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |