All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. alzheimer's disease is characterized by the presence of amyloid-β and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. 2021-03-01 2023-08-13 Not clear
Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. tdp-43, tau and amyloid-β have all been linked to hippocampal atrophy. 2021-03-01 2023-08-13 Not clear
Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. tdp-43 and tau have also been linked to hippocampal atrophy in cases of primary age-related tauopathy, a pathological entity with features that strongly overlap with those of alzheimer's disease. 2021-03-01 2023-08-13 Not clear
Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. 2021-03-01 2023-08-13 Not clear
Laetitia Degiorgis, Meltem Karatas, Marion Sourty, Emilie Faivre, Julien Lamy, Vincent Noblet, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Luc Buée, David Blum, Anne-Laurence Boutillier, Jean-Paul Armspach, Frédéric Blanc, Laura-Adela Harsa. Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33184651. disrupted ventral hip-amg functional pathway and altered dynamic functional connectivity were consistent with high pathological tau deposition and astrogliosis in both hippocampus and amygdala, and significant microglial reactivity in amygdalar nuclei. 2021-03-01 2023-08-13 mouse
Chongyang Chen, Pan Liu, Jing Wang, Haitao Yu, Zaijun Zhang, Jianjun Liu, Xiao Chen, Feiqi Zhu, Xifei Yan. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Frontiers in cell and developmental biology. vol 8. 2021-02-27. PMID:33634105. in this study, we investigated the potential therapeutic effects of dauricine (dau), a benzyl tetrahydroisoquinoline alkaloid, on ad, and found that dau administration significantly improved cognitive impairments in 3xtg-ad mice by decreasing aβ plaques and hyperphosphorylated tau and increasing the hippocampal atp level. 2021-02-27 2023-08-13 mouse
Sara Becker, Oliver Granert, Maarten Timmers, Andrea Pilotto, Luc Van Nueten, Benjamin Roeben, Giacomo Salvadore, Wendy R Galpern, Johannes Streffer, Klaus Scheffler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfon. Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia. Neurology. vol 96. issue 6. 2021-02-23. PMID:33219138. to examine whether hippocampal volume loss is primarily associated with cognitive status or pathologic β-amyloid 1-42 (aβ42) levels, this study compared hippocampal subfield volumes between patients with parkinson disease (pd) with mild cognitive impairment (pd-mci) and without cognitive impairment (pd-cn) and between patients with low and high aβ42 levels, in addition exploring the relationship among hippocampal subfield volumes, csf biomarkers (aβ42, phosphorylated and total tau), neuropsychological tests, and activities of daily living. 2021-02-23 2023-08-13 Not clear
Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. coenzyme q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein e and phosphorylated tau protein in mouse hippocampal neurons. 2021-02-16 2023-08-13 mouse
Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. the present study aimed to reveal the role of apoe in the pathogenesis of tau protein hyperphosphorylation and neuroinflammation enhancement caused by sevoflurane anesthesia, as well as the protective mechanism of coq10 in an anesthetic sevoflurane treatment model of primary mouse hippocampal neurons. 2021-02-16 2023-08-13 mouse
Man Yang, Naqi Lian, Yang Yu, Yaoqi Wang, Keliang Xie, Yonghao Y. Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377738. coq10 improved energy replenishment and inhibited oxidative stress, which may lead to a decrease in apoe and phosphorylated tau protein expression, thus mitigating the sevoflurane‑induced neuroinflammation in mouse hippocampal neurons. 2021-02-16 2023-08-13 mouse
Samuel T Peters, Allyssa Fahrenkopf, Jessica M Choquette, Scott C Vermilyea, Michael K Lee, Keith Vosse. Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein. Frontiers in neurology. vol 11. 2021-02-13. PMID:32636798. recent work revealed that mice expressing human α-syn with the alanine-53-threonine (a53t) mutation have a similar phenotype to the human condition, exhibiting long-term potentiation deficits, learning and memory deficits, and inhibitory hippocampal remodeling, all of which were reversed by genetic ablation of microtubule-associated protein tau. 2021-02-13 2023-08-13 mouse
So Yamamoto, Tomoko Kayama, Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Masahito Yamada, Keiko Abe, Shoko Kobayash. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. NPJ science of food. vol 5. issue 1. 2021-02-12. PMID:33514742. additionally, ra intake suppressed hippocampal inflammation and led to the downregulation of the jnk signaling pathway that induces tau phosphorylation. 2021-02-12 2023-08-13 mouse
Che Wang, Zhengxu Cai, Wei Wang, Min Wei, Xinhong Si, Yuting Shang, Zhaofei Yang, Tianbai Li, Huishu Guo, Song L. Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model. The Journal of nutritional biochemistry. vol 75. 2021-02-10. PMID:31710934. expressions of glycogen synthase kinase-3β (gsk-3β) and its upstream or downstream molecules including phosphatidylinositol 3-kinase (pi3k),protein kinase b (akt), protein kinase c (pkc), nf-e2-related factor 2, nuclear factor-κb and microtubule-associated protein tau in hippocampus were determined by western blotting, immunohistochemical or immunofluorescent staining. 2021-02-10 2023-08-13 mouse
Che Wang, Zhengxu Cai, Wei Wang, Min Wei, Xinhong Si, Yuting Shang, Zhaofei Yang, Tianbai Li, Huishu Guo, Song L. Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model. The Journal of nutritional biochemistry. vol 75. 2021-02-10. PMID:31710934. our data revealed that chronic d-gal exposure in mice led to cognitive impairment in mwm, along with cholinergic malfunction, extensive oxidative stress and neuroinflammation, as well as hyperphosphorylation of tau protein in hippocampus. 2021-02-10 2023-08-13 mouse
Marangelie Criado-Marrero, Jonathan J Sabbagh, Margaret R Jones, Dale Chaput, Chad A Dickey, Laura J Blai. Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice. Cells. vol 9. issue 1. 2021-02-08. PMID:31947657. hippocampal neurogenesis is enhanced in adult tau deficient mice. 2021-02-08 2023-08-13 mouse
Rui Shi, Chang-Bo Zheng, Hongyan Wang, Qiang Rao, Tingyan Du, Chunyun Bai, Chuang Xiao, Zelan Dai, Changhong Zhang, Chen Chen, Xian Li, Menghua Tian, Xianlun Yu, Baixi Ji, Zhiying Weng, Weimin Yan. Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. vol 105. issue 7-8. 2021-02-05. PMID:31752010. mechanistically, in 2-vo rats, treatment with gas (90 mg/kg/day) suppressed aβ plaque deposition by decreasing the hippocampus levels of phosphorylated tau. 2021-02-05 2023-08-13 rat
Nicholas J Braun, Katherine R Yao, Patrick W Alford, Dezhi Lia. Mechanical injuries of neurons induce tau mislocalization to dendritic spines and tau-dependent synaptic dysfunction. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139536. the mechanical energy associated with high-strain rate deformation alone can induce tau mislocalization to dendritic spines and synaptic deficits in cultured rat hippocampal neurons. 2021-01-25 2023-08-13 rat
Amanda K Engstrom, Alicia C Walker, Rohitha A Moudgal, Dexter A Myrick, Stephanie M Kyle, Yu Bai, M Jordan Rowley, David J Kat. The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139560. previously, our laboratory implicated the histone demethylase lsd1 in tau-induced neurodegeneration by showing that lsd1 localizes to pathological tau aggregates in alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. 2021-01-25 2023-08-13 mouse
Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. 2021-01-22 2023-08-13 rat
Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. onset of hippocampal network aberration and memory deficits in p301s tau mice are associated with an early gene signature. 2021-01-19 2023-08-13 mouse