| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marangelie Criado-Marrero, Jonathan J Sabbagh, Margaret R Jones, Dale Chaput, Chad A Dickey, Laura J Blai. Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice. Cells. vol 9. issue 1. 2021-02-08. PMID:31947657. |
hippocampal neurogenesis is enhanced in adult tau deficient mice. |
2021-02-08 |
2023-08-13 |
mouse |
| Rui Shi, Chang-Bo Zheng, Hongyan Wang, Qiang Rao, Tingyan Du, Chunyun Bai, Chuang Xiao, Zelan Dai, Changhong Zhang, Chen Chen, Xian Li, Menghua Tian, Xianlun Yu, Baixi Ji, Zhiying Weng, Weimin Yan. Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. vol 105. issue 7-8. 2021-02-05. PMID:31752010. |
mechanistically, in 2-vo rats, treatment with gas (90 mg/kg/day) suppressed aβ plaque deposition by decreasing the hippocampus levels of phosphorylated tau. |
2021-02-05 |
2023-08-13 |
rat |
| Nicholas J Braun, Katherine R Yao, Patrick W Alford, Dezhi Lia. Mechanical injuries of neurons induce tau mislocalization to dendritic spines and tau-dependent synaptic dysfunction. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139536. |
the mechanical energy associated with high-strain rate deformation alone can induce tau mislocalization to dendritic spines and synaptic deficits in cultured rat hippocampal neurons. |
2021-01-25 |
2023-08-13 |
rat |
| Amanda K Engstrom, Alicia C Walker, Rohitha A Moudgal, Dexter A Myrick, Stephanie M Kyle, Yu Bai, M Jordan Rowley, David J Kat. The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139560. |
previously, our laboratory implicated the histone demethylase lsd1 in tau-induced neurodegeneration by showing that lsd1 localizes to pathological tau aggregates in alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. |
2021-01-25 |
2023-08-13 |
mouse |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. |
2021-01-22 |
2023-08-13 |
rat |
| Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. |
onset of hippocampal network aberration and memory deficits in p301s tau mice are associated with an early gene signature. |
2021-01-19 |
2023-08-13 |
mouse |
| Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. |
here, we characterized the effects of transgenic p301s mutant human tau expression on neuronal network function in the murine hippocampus. |
2021-01-19 |
2023-08-13 |
mouse |
| Tomohiro Imamura, Yuki T Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-Ichi Kir. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model. Neurobiology of disease. vol 137. 2021-01-15. PMID:31927145. |
immunostaining showed the accumulation of toxic aβ42 conformers and hyper-phosphorylated tau protein (p-tau), which was more prominent in the cortical and hippocampal neurons of stz-treated mice compared with hfud-fed and control mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L Croteau, Marie-Christine Galas, Vilhelm A Boh. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32131898. |
hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and dna repair in a mouse model of tauopathy. |
2021-01-15 |
2023-08-13 |
mouse |
| Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L Croteau, Marie-Christine Galas, Vilhelm A Boh. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32131898. |
here, we show that hippocampal neurons in six-month-old transgenic mouse model of tauopathy, thy-tau22, are enriched with oligomeric tau, contain elongated mitochondria, and display cellular stress, but no overt cytotoxicity compared to the control mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Lennart Müller-Thomsen, Diba Borgmann, Kerstin Morcinek, Sophia Schröder, Brigitte Dengler, Natasha Moser, Felix Neumaier, Toni Schneider, Hannsjörg Schröder, Stefan Huggenberge. Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. Neurobiology of aging. vol 93. 2021-01-15. PMID:32278495. |
consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Lennart Müller-Thomsen, Diba Borgmann, Kerstin Morcinek, Sophia Schröder, Brigitte Dengler, Natasha Moser, Felix Neumaier, Toni Schneider, Hannsjörg Schröder, Stefan Huggenberge. Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. Neurobiology of aging. vol 93. 2021-01-15. PMID:32278495. |
especially, the somatodendritic mislocalization of hyperphosphorylated tau seems to affect the neuronal network of the hippocampus. |
2021-01-15 |
2023-08-13 |
mouse |
| Lennart Müller-Thomsen, Diba Borgmann, Kerstin Morcinek, Sophia Schröder, Brigitte Dengler, Natasha Moser, Felix Neumaier, Toni Schneider, Hannsjörg Schröder, Stefan Huggenberge. Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. Neurobiology of aging. vol 93. 2021-01-15. PMID:32278495. |
to show the consequences of aggregation of hyperphosphorylated tau within hippocampal neurons of aged mice, the ca1 pyramidal cells were analyzed morphologically and electrophysiologically. |
2021-01-15 |
2023-08-13 |
mouse |
| Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Anne Brækhus, Oskar Hansson, Kaj Blennow, Henrik Zetterberg, Øystein Sørensen, Kristine Beate Walhovd, Torgeir Bruun Wyller, Anders Martin Fjel. Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults. Neurobiology of aging. vol 93. 2021-01-15. PMID:32438258. |
biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults. |
2021-01-15 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Maria Victoria Zelaya, Meritxell Aguiló García, Margarita Carmona, Irene López-González, Pol Andrés-Benito, Laia Lidón, Rosalina Gavín, Paula Garcia-Esparcia, José Antonio Del Ri. Relevance of host tau in tau seeding and spreading in tauopathies. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31397930. |
tau seeding occurred in the ipsilateral hippocampus and corpus callosum and spread to the septal nuclei, periventricular hypothalamus and contralateral corpus callosum, respectively. |
2021-01-13 |
2023-08-13 |
mouse |
| Jinwang Ye, Yaling Yin, Huanhuan Liu, Lin Fang, Xiaoqing Tao, Linyu Wei, Yue Zuo, Ying Yin, Dan Ke, Jian-Zhi Wan. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31668016. |
here, we report that overexpressing full-length wild-type human tau (htau) in mouse hippocampus induces learning and memory deficits with remarkably reduced levels of multiple synapse- and memory-associated proteins. |
2021-01-13 |
2023-08-13 |
mouse |
| Utcharaporn Kamsrijai, Prapimpun Wongchitrat, Chutikorn Nopparat, Jutamaad Satayavivad, Piyarat Govitrapon. Melatonin attenuates streptozotocin-induced Alzheimer-like features in hyperglycemic rats. Neurochemistry international. vol 132. 2021-01-07. PMID:31726088. |
we found that melatonin was effective in protecting against memory impairment and decreased formation of aβ42 peptide and phosphorylated tau in the hippocampus of stz-treated rats. |
2021-01-07 |
2023-08-13 |
rat |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
the aim of the present study was to examine the association of cerebrospinal fluid levels (csf) hemopexin and hemoglobin subunits (α and β) to alzheimer's pathological proteins (amyloid and tau), hippocampal volume and metabolism, and cognitive performance. |
2021-01-06 |
2023-08-13 |
human |
| Bin Peng, Qiang Yang, Rachna B Joshi, Yuancai Liu, Mohammed Akbar, Byoung-Joon Song, Shuanhu Zhou, Xin Wan. Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 7. 2021-01-05. PMID:32230811. |
epidemiological studies have reported a reduction in the prevalence of alzheimer's disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of aβ and tau phosphorylation. |
2021-01-05 |
2023-08-13 |
Not clear |
| Zhourui Wu, Zhi-Hao Wang, Xia Liu, Zhentao Zhang, Xiaohuan Gu, Shan Ping Yu, C Dirk Keene, Liming Cheng, Keqiang Y. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. Progress in neurobiology. vol 185. 2020-12-30. PMID:31778772. |
remarkably, viral expression of aep-resistant tau n368a in the hippocampus of 3xtg mice also ameliorates the pathological and cognitive consequences of tbi. |
2020-12-30 |
2023-08-13 |
mouse |