| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Singh S Ankul, Lakshmi Chandran, Singh Anuragh, Ilango Kaliappan, Rapuru Rushendran, Chitra Vellapandia. A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer's disease-like animal model. Frontiers in pharmacology. vol 14. 2023-11-09. PMID:37942488. |
the treated mice also had more hyperphosphorylated tau protein in their cortical and hippocampus neurons. |
2023-11-09 |
2023-11-20 |
mouse |
| Olivia Lu, Taimur Kouser, Irina A Skylar-Scot. Alzheimer's disease and epilepsy: shared neuropathology guides current and future treatment strategies. Frontiers in neurology. vol 14. 2023-11-08. PMID:37936917. |
this bi-directional relationship may be due to underlying shared pathophysiologic hallmarks, including decreased cerebrospinal fluid amyloid beta 42 (aβ42), increased hyperphosphorylated tau protein, and hippocampal hyperexcitability. |
2023-11-08 |
2023-11-20 |
Not clear |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
linear mixed models examined the relationship between apoe profiles and brain changes (i.e., regional wmhs, ventricle size, hippocampal and entorhinal cortex volume, amyloid level, and phosphorylated tau measures), while controlling for age, sex, education, and diagnostic status at baseline and over time. |
2023-11-07 |
2023-11-20 |
human |
| Sophie Nader, Esma Karlovich, Etty P Cortes, Ricardo Insausti, Gregory Meloni, Michelle Jacobs, John F Crary, Susan Morgell. Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection. Journal of neurovirology. 2023-11-05. PMID:37926797. |
the accumulation of hyperphosphorylated tau (p-tau) in hippocampus is a common degenerative change, with specific patterns of hippocampal subfield vulnerability observed in different disease contexts. |
2023-11-05 |
2023-11-08 |
human |
| Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A Fernandez, Perle Roche, Emma L Bunting, Ella K Lacey, Sara E Hamplova, Monlan Yuan, Michael S Wolfe, David A Bennett, Eunjung A Lee, Bruce A Yankne. A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-11-03. PMID:37919281. |
conversely, viral-mediated overexpression of rest in the hippocampus suppresses aβ and tau pathology. |
2023-11-03 |
2023-11-08 |
mouse |
| Brian N Lee, Junwen Wang, Molly A Hall, Dokyoon Kim, Shana D Stites, Li She. Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease. Neurobiology of aging. vol 133. 2023-11-01. PMID:37913627. |
multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (av45), and csf (p-tau, tau) biomarkers were differentially associated with cognitive and functional outcomes. |
2023-11-01 |
2023-11-08 |
human |
| Lanxia Meng, Congcong Liu, Miao Liu, Jiehui Chen, Chaoyang Liu, Zhaohui Zhang, Guiqin Chen, Zhentao Zhan. The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy. Cell reports. vol 42. issue 11. 2023-10-28. PMID:37897723. |
when injected into the hippocampus of tau p301s transgenic mice, the ure2p-seeded tau fibrils show enhanced seeding activity compared with pure tau fibrils. |
2023-10-28 |
2023-11-08 |
mouse |
| Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. |
sarkosyl-insoluble-proteomic analyses of the ckd mouse hippocampus revealed an accumulation of insoluble mapt (microtubule-associated protein tau) and rna-binding proteins such as small nuclear ribonucleoprotein u1 subunit 70 (snrnp70). |
2023-10-27 |
2023-11-08 |
mouse |
| Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min L. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-24. PMID:37867176. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the brain. |
2023-10-24 |
2023-11-08 |
mouse |
| Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikez. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta neuropathologica communications. vol 11. issue 1. 2023-10-20. PMID:37853497. |
antisense oligonucleotide-based targeting of tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in ps19 tauopathy mice. |
2023-10-20 |
2023-11-08 |
mouse |
| Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikez. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta neuropathologica communications. vol 11. issue 1. 2023-10-20. PMID:37853497. |
tau tubulin kinase-1 (ttbk1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in alzheimer's disease (ad). |
2023-10-20 |
2023-11-08 |
mouse |
| Kurt A Jellinge. The Spectrum of Cognitive Dysfunction in Amyotrophic Lateral Sclerosis: An Update. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834094. |
morphological substrates are frontotemporal and hippocampal atrophy with synaptic loss, associated with tdp-43 and other co-pathologies, including tau deposition. |
2023-10-14 |
2023-10-15 |
Not clear |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha. International review of neurobiology. vol 172. 2023-10-13. PMID:37833015. |
after 48 h of spinal cord injury elevation of amyloid beta peptide, phosphorylated tau (p-tau) and tumor necrosis factor-alpha (tnf-α) was seen in t9 and t12 segments of spinal cord in cerebral cortex, hippocampus and brain stem regions associated with microglial activation as seen by upregulation of iba1 and cd86. |
2023-10-13 |
2023-10-15 |
Not clear |
| Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. |
leptin prevents aberrant targeting of tau to hippocampal synapses via pi 3 kinase driven inhibition of gsk3β. |
2023-10-12 |
2023-10-15 |
Not clear |
| Kirsty Hamilton, Kate Morrow, Ermione Markantoni, Jenni Harve. Leptin prevents aberrant targeting of tau to hippocampal synapses via PI 3 kinase driven inhibition of GSK3β. Journal of neurochemistry. 2023-10-12. PMID:37822142. |
amyloid-β (aβ) and hyper-phosphorylated tau are key hallmarks of alzheimer's disease (ad), with an accumulation of both proteins linked to hippocampal synaptic dysfunction. |
2023-10-12 |
2023-10-15 |
Not clear |
| Timna Hitrec, Fabio Squarcio, Emiliana Piscitiello, Matteo Cerri, Davide Martelli, Alessandra Occhinegro, Ludovico Taddei, Domenico Tupone, Roberto Amici, Marco Lupp. Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2023-10-09. PMID:37812305. |
the effects of sd were studied by assessing: (i) deep brain temperature (tb); (ii) immunofluorescent staining for at8 (phosphorylated tau) and tau-1 (non-phosphorylated tau), assessed in 19 brain structures; (iii) different phosphorylated forms of tau and the main cellular factors involved in tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. |
2023-10-09 |
2023-10-15 |
rat |
| Hongli Li, Bo-Lin Xiang, Xiao Li, Cong Li, Yu Li, Ying Miao, Guo-Lan Ma, Yu-Hua Ma, Jia-Qi Chen, Qing-Yu Zhang, Long-Bao Lv, Ping Zheng, Rui Bi, Yong-Gang Ya. Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew. Molecular neurobiology. 2023-10-09. PMID:37814108. |
moreover, the aged tree shrews exhibited several age-related phenotypes that are associated with ad, including increased levels of amyloid-β (aβ) accumulation and phosphorylated tau protein, synaptic and neuronal loss, and reactive gliosis in the cortex and the hippocampal tissues. |
2023-10-09 |
2023-10-15 |
Not clear |
| María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. |
to investigate the mechanism behind mitochondrial dysfunction caused by this tau form, we used transient transfection and pharmacological approaches in immortalized cortical neurons and mouse primary hippocampal neurons. |
2023-09-29 |
2023-10-07 |
mouse |
| María José Pérez, Rodrigo Ibarra-García-Padilla, Maoping Tang, George A Porter, Gail V W Johnson, Rodrigo A Quintanill. Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore. Biochimica et biophysica acta. Molecular basis of disease. 2023-09-29. PMID:37774936. |
moreover, the impairment of mitochondrial length and bioenergetics induced by caspase-3-cleaved tau were prevented in hippocampal neurons obtained from cypd knock-out mice. |
2023-09-29 |
2023-10-07 |
mouse |
| Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallar. Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment. Cells. vol 12. issue 18. 2023-09-28. PMID:37759477. |
transcriptomic analysis in the hippocampus and retina of tg2576 ad mice reveals defective mitochondrial oxidative phosphorylation and recovery by tau 12a12mab treatment. |
2023-09-28 |
2023-10-07 |
mouse |