| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Dirk Keene, Angela M Wilson, Mitchell D Kilgore, Lauren T Bruner, Nadia O Postupna, Martin Darva. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-05-18. PMID:30573871. |
consistent with the neuropathologic assessment, luminex assay detected high amounts of amyloid beta in the frontal cortex and striatum, and high amounts of hyperphosphorylated tau in the frontal cortex and hippocampus, of cases with high ad neuropathologic change. |
2020-05-18 |
2023-08-13 |
human |
| Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. |
we show for the first time that treatment of adult (7-8 month-old) male c57bl/6 mice with cisplatin results in reduced cognitive function and a marked increase in the number of large endogenous tau clusters in the hippocampus when assessed 4 months later. |
2020-05-13 |
2023-08-13 |
mouse |
| Angie C A Chiang, Xiaojiao Huo, Annemieke Kavelaars, Cobi J Heijne. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain, behavior, and immunity. vol 79. 2020-05-13. PMID:30953771. |
in contrast, we detected only few small tau clusters in the hippocampus of age-matched 11-12 month-old control mice. |
2020-05-13 |
2023-08-13 |
mouse |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
the focus of this study was to determine whether aβ plaques and phosphorylated tau aggregates occur in the hippocampus as a consequence of lipopolysaccharide administration, and whether behavioral abnormalities related to the hippocampus, particularly the dentate gyrus, can be demonstrated. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
seven days post injection, aβ plaques and phosphorylated tau in the hippocampus were quantified following immunostaining. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide treatment results in the deposition of beta amyloid plaques and intracellular phosphorylated tau in the hippocampus, including the dorsal dentate gyrus. |
2020-05-12 |
2023-08-13 |
rat |
| Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morto. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. GeroScience. vol 41. issue 4. 2020-05-12. PMID:31473912. |
lipopolysaccharide administration results in hippocampal deposition of amyloid-beta plaques and intracellular phosphorylated tau and results in specific behavioral deficits attributable to the dorsal dentate gyrus. |
2020-05-12 |
2023-08-13 |
rat |
| Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. |
the activity of both tau and gsk3β in the hippocampus was increased in aged grk5-knockout mice, which is consistent with what occurs in app/ps1 transgenic mice. |
2020-05-04 |
2023-08-13 |
mouse |
| Minori Iwata, Shoji Watanabe, Ayaka Yamane, Tomohiro Miyasaka, Hiroaki Misono. Regulatory mechanisms for the axonal localization of tau protein in neurons. Molecular biology of the cell. vol 30. issue 19. 2020-05-01. PMID:31364926. |
in this study, we found that the axonal localization of tau in cultured rat hippocampal neurons mainly occur during early neuronal development. |
2020-05-01 |
2023-08-13 |
human |
| Susanne Wegmann, Rachel E Bennett, Louis Delorme, Ashley B Robbins, Miwei Hu, Danny McKenzie, Molly J Kirk, Julia Schiantarelli, Nahel Tunio, Ana C Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T Hyma. Experimental evidence for the age dependence of tau protein spread in the brain. Science advances. vol 5. issue 6. 2020-04-30. PMID:31249873. |
old animals showed more tau spreading in the hippocampus and adjacent cortical areas and accumulated more misfolded tau in ec neurons. |
2020-04-30 |
2023-08-13 |
mouse |
| Alan King Lun Liu, Tsz Wing Chau, Ernest Junwei Lim, Idil Ahmed, Raymond Chuen-Chung Chang, Michail E Kalaitzakis, Manuel B Graeber, Steve M Gentleman, Ronald K B Pearc. Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31023342. |
hippocampal sections from 67 pd, 34 pd with mild cognitive impairment and 96 pdd cases were immunostained for tau and alpha-synuclein, and the respective pathology burden was assessed semi-quantitatively. |
2020-04-21 |
2023-08-13 |
Not clear |
| Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U Monsch, Michel Goedert, Markus Tolnay, David T Winkle. Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31064413. |
csf obtained from ad or mci patients increased hippocampal tau hyperphosphorylation and tau tangle formation in these mice at 4 months post-seeding. |
2020-04-21 |
2023-08-13 |
mouse |
| Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U Monsch, Michel Goedert, Markus Tolnay, David T Winkle. Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice. Acta neuropathologica communications. vol 7. issue 1. 2020-04-21. PMID:31064413. |
tau pathology was also accentuated in the contralateral hippocampus, and in anterior and posterior directions, indicative of spreading.we provide first evidence for in vivo prion-like properties of ad patients' csf, accelerating tau pathology in susceptible tau transgenic mice. |
2020-04-21 |
2023-08-13 |
mouse |
| Yun Zhang, Jing Yang, Wei Jiang, Rong Li, Min Zhu, Feng Xiong, Cui Son. Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers. Pediatric neurology. vol 92. 2020-04-20. PMID:30612744. |
in a case-control study, we quantitatively evaluated whole brain and hippocampal volumes of ds children and analyzed the correlation of hippocampal volumes with blood levels of aβ, tau and va. |
2020-04-20 |
2023-08-13 |
Not clear |
| Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2020-04-20. PMID:32142666. |
interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing gabaergic transmission. |
2020-04-20 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Margarita Lobo, Adela Pelayo, Jimena García, María Teresa Frejo, Javier Del Pin. Primary hippocampal estrogenic dysfunction induces synaptic proteins alteration and neuronal cell death after single and repeated paraquat exposure. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 136. 2020-04-13. PMID:31715309. |
we researched whether pq induces synaptic protein disruption, tau and amyloid beta protein formation, oxidative stress generation, and hippocampal neuronal cell loss through anti-estrogen action in primary hippocampal neurons, after day and two weeks pq treatment, as a probable mechanism of such learning and memory impairment. |
2020-04-13 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2020-04-10. PMID:32002968. |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2020-04-10 |
2023-08-13 |
Not clear |
| Carine Bossenmeyer-Pourié, A David Smith, Sylvain Lehmann, Vincent Deramecourt, Bernard Sablonnière, Jean-Michel Camadro, Grégory Pourié, Racha Kerek, Deborah Helle, Remy Umoret, Rosa-Maria Guéant-Rodriguez, Valérie Rigau, Audrey Gabelle, Jeffrey M Sequeira, Edward V Quadros, Jean-Luc Daval, Jean-Louis Guéan. N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia. The Journal of pathology. vol 248. issue 3. 2020-04-08. PMID:30734924. |
compared with controls, n-homocysteinylated tau and map1 were increased and accumulated in protein aggregates and tangles in the cortex, hippocampus and cerebellum of patients and animals. |
2020-04-08 |
2023-08-13 |
mouse |
| Ercan Babür, Burak Tan, Marwa Yousef, Sümeyra Cinbaş, Cem Süer, Nurcan Dursu. Deficiency but Not Supplementation of Selenium Impairs the Hippocampal Long-Term Potentiation and Hippocampus-Dependent Learning. Biological trace element research. vol 192. issue 2. 2020-04-07. PMID:30796616. |
phosphorylated and total tau levels were measured in whole hippocampus by western blot. |
2020-04-07 |
2023-08-13 |
rat |