All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Passainte S Hassaan, Abeer E Dief, Teshreen M Zeitoun, Azza M Baraka, Robert M J Deacon, Amany Elshorbag. Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life. PloS one. vol 14. issue 8. 2020-03-09. PMID:31412065. accumulation of hyperphosphorylated tau protein was assessed in cortical and hippocampal neurons by immunohistochemistry, and in cerebral cortical homogenates. 2020-03-09 2023-08-13 mouse
Passainte S Hassaan, Abeer E Dief, Teshreen M Zeitoun, Azza M Baraka, Robert M J Deacon, Amany Elshorbag. Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life. PloS one. vol 14. issue 8. 2020-03-09. PMID:31412065. intracellular hyperphosphorylated tau immunostaining was observed diffusely in the cortex and hippocampus, together with cortical atrophic neurons, extensive vacuolation and dysmorphic neuropil suggestive of spongiform neurodegeneration. 2020-03-09 2023-08-13 mouse
Kathleen M McAvoy, Hameetha Rajamohamed Sait, Galina Marsh, Michael Peterson, Taylor L Reynolds, Jake Gagnon, Sarah Geisler, Prescott Leach, Chris Roberts, Ellen Cahir-McFarland, Richard M Ransohoff, Andrea Crott. Cell-autonomous and non-cell autonomous effects of neuronal BIN1 loss in vivo. PloS one. vol 14. issue 8. 2020-03-03. PMID:31408457. to address the relationship between reduction of bin1 and neuronal cell loss in the context of tau pathology, we knocked-down endogenous murine bin1 via stereotaxic injection of aav-bin1 shrna in the hippocampus of mice expressing tau p301s (ps19). 2020-03-03 2023-08-13 mouse
E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). 2020-03-02 2023-08-13 mouse
Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D Ye, Yang Y. Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 67. issue 1. 2020-03-02. PMID:30475772. in the hippocampus and cortex of icv-stz mice, a marked increase was observed in tau phosphorylation at ser199, thr205, and ser396 compared with icv-saline control mice. 2020-03-02 2023-08-13 mouse
Yi-Chun Chen, Ya-Jen Chiu, Chih-Hsin Lin, Wen-Chuin Hsu, Jia-Lu Wu, Chen-Hsiang Huang, Chia-Wei Lin, Ching-Fa Yao, Hei-Jen Huang, Yen-Shi Lo, Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Hsiu Mei Hsieh-L. Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement. Journal of Alzheimer's disease : JAD. vol 67. issue 2. 2020-03-02. PMID:30689566. nc009-1 further rescued the downregulated apoe and trka and reduced aβ and tau levels in hippocampus and cortex, and ameliorated cognitive deficits in streptozocin-induced hyperglycemic 3×tg-ad mice. 2020-03-02 2023-08-13 mouse
Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. frontotemporal dementia mutant tau promotes aberrant fyn nanoclustering in hippocampal dendritic spines. 2020-02-24 2023-08-13 mouse
Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunie. Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines. eLife. vol 8. 2020-02-24. PMID:31237563. as nanoclustering is essential for efficient signaling, we used single-molecule tracking to characterize the nanoscale distribution of fyn in mouse hippocampal neurons, and manipulated the expression of tau to test whether it controls fyn nanoscale organization. 2020-02-24 2023-08-13 mouse
Sandra Aurora Niño, Adriana Morales-Martínez, Erika Chi-Ahumada, Leticia Carrizales, Roberto Salgado-Delgado, Francisca Pérez-Severiano, Sofía Díaz-Cintra, María E Jiménez-Capdeville, Sergio Zarazú. Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer's Disease Model. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30141907. higher immunopositivity to amyloid isoforms and to phosphorylated tau was observed in frontal cortex and hippocampus of exposed animals. 2020-02-18 2023-08-13 mouse
Chen-Zhuo Feng, Lin Cao, Dan Luo, Ling-Sha Ju, Jian-Jun Yang, Xin-Yi Xu, Yue-Ping Y. Dendrobium polysaccharides attenuate cognitive impairment in senescence-accelerated mouse prone 8 mice via modulation of microglial activation. Brain research. vol 1704. 2020-02-11. PMID:30253123. the accumulation of hippocampal aβ42 and phosphated tau proteins in samp8 mice was also reduced. 2020-02-11 2023-08-13 mouse
Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. tau deposition is associated with functional isolation of the hippocampus in aging. 2020-02-11 2023-08-13 Not clear
Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. we show that age and tau pathology are related to higher hippocampal reho. 2020-02-11 2023-08-13 Not clear
Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. functional disconnection between the hippocampus and other components of the mtl memory system, particularly an anterior-temporal network specialized for object memory, is also associated with higher hippocampal reho and greater tau burden in anterior-temporal regions. 2020-02-11 2023-08-13 Not clear
Theresa M Harrison, Anne Maass, Jenna N Adams, Richard Du, Suzanne L Baker, William J Jagus. Tau deposition is associated with functional isolation of the hippocampus in aging. Nature communications. vol 10. issue 1. 2020-02-11. PMID:31653847. these findings suggest that tau pathology plays a role in disconnecting the hippocampus from specific mtl memory systems leading to increased local coherence and memory decline. 2020-02-11 2023-08-13 Not clear
Yuexia Ding, Airong Kang, Qiling Tang, Ying Zha. Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432127. further experiments demonstrated that apoe4 and aβ1‑40 co‑aggregation decreased the expression levels of chat mrna, and the phosphorylation levels of tau gsk3β protein in the hippocampus, whereas inhibition of hdac6 activity resulted in increased expression of chat mrna, tau protein and gsk3β phosphorylation. 2020-02-04 2023-08-13 rat
Wen-Dan Yang, Wan-Qing Guo, Chang-Hui Qian, Qian Xu, Xue-Hua Zheng, Wei-Guo Don. [Effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated Tau protein in SAMP8 mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 1. 2020-01-29. PMID:31930902. [effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated tau protein in samp8 mice]. 2020-01-29 2023-08-13 mouse
Wen-Dan Yang, Wan-Qing Guo, Chang-Hui Qian, Qian Xu, Xue-Hua Zheng, Wei-Guo Don. [Effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated Tau protein in SAMP8 mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 1. 2020-01-29. PMID:31930902. to explore the effect of early intervention electroacupuncture (ea) at "baihui" (gv 20), "dazhui" (gv 14) and "shenshu" (bl 23) on the learning-memory ability and the expression of phosphorylated tau protein in the hippocampus of samp8 mice, so as to provide reference for the intervening period of ea for alzheimer's disease (ad). 2020-01-29 2023-08-13 mouse
Qing-Guo Ren, Wei-Gang Gong, Hong Zhou, Hao Shu, Yan-Juan Wang, Zhi-Jun Zhan. Spatial Training Ameliorates Long-Term Alzheimer's Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 2. 2020-01-09. PMID:30560481. immediately after training, we found that spatial training significantly improved cognitive performance; reduced tau neuropathology; increased the expression level of synaptophysin, psd93, and psd95 in the hippocampus; and increased the number of dendritic spines in pr5 mice. 2020-01-09 2023-08-13 mouse
Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. 2020-01-09 2023-08-13 mouse
Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. to assess the interference of tau pathology, a common key-lesion in these diseases, with adult hippocampal neurogenesis we analyzed adult neurogenesis in the hippocampal dentate gyrus in wild-type mice, tg30 mice expressing a ftdp-17 mutant tau and the same tg30 mice deficient for mouse tau (tg30/tauko). 2020-01-09 2023-08-13 mouse