| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuexia Ding, Airong Kang, Qiling Tang, Ying Zha. Inhibition of HDAC6 expression decreases brain injury induced by APOE4 and Aβ co‑aggregation in rats. Molecular medicine reports. vol 20. issue 4. 2020-02-04. PMID:31432127. |
further experiments demonstrated that apoe4 and aβ1‑40 co‑aggregation decreased the expression levels of chat mrna, and the phosphorylation levels of tau gsk3β protein in the hippocampus, whereas inhibition of hdac6 activity resulted in increased expression of chat mrna, tau protein and gsk3β phosphorylation. |
2020-02-04 |
2023-08-13 |
rat |
| Wen-Dan Yang, Wan-Qing Guo, Chang-Hui Qian, Qian Xu, Xue-Hua Zheng, Wei-Guo Don. [Effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated Tau protein in SAMP8 mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 1. 2020-01-29. PMID:31930902. |
[effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated tau protein in samp8 mice]. |
2020-01-29 |
2023-08-13 |
mouse |
| Wen-Dan Yang, Wan-Qing Guo, Chang-Hui Qian, Qian Xu, Xue-Hua Zheng, Wei-Guo Don. [Effect of early intervention of electroacupuncture on learning-memory ability and level of hippocampal phosphorylated Tau protein in SAMP8 mice]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 1. 2020-01-29. PMID:31930902. |
to explore the effect of early intervention electroacupuncture (ea) at "baihui" (gv 20), "dazhui" (gv 14) and "shenshu" (bl 23) on the learning-memory ability and the expression of phosphorylated tau protein in the hippocampus of samp8 mice, so as to provide reference for the intervening period of ea for alzheimer's disease (ad). |
2020-01-29 |
2023-08-13 |
mouse |
| Qing-Guo Ren, Wei-Gang Gong, Hong Zhou, Hao Shu, Yan-Juan Wang, Zhi-Jun Zhan. Spatial Training Ameliorates Long-Term Alzheimer's Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 2. 2020-01-09. PMID:30560481. |
immediately after training, we found that spatial training significantly improved cognitive performance; reduced tau neuropathology; increased the expression level of synaptophysin, psd93, and psd95 in the hippocampus; and increased the number of dendritic spines in pr5 mice. |
2020-01-09 |
2023-08-13 |
mouse |
| Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. |
genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. |
2020-01-09 |
2023-08-13 |
mouse |
| Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. |
to assess the interference of tau pathology, a common key-lesion in these diseases, with adult hippocampal neurogenesis we analyzed adult neurogenesis in the hippocampal dentate gyrus in wild-type mice, tg30 mice expressing a ftdp-17 mutant tau and the same tg30 mice deficient for mouse tau (tg30/tauko). |
2020-01-09 |
2023-08-13 |
mouse |
| Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. |
these results demonstrate an impairment of adult hippocampal neurogenesis in a ftdp-17 mutant tau mice resulting from a decrease of proliferation affecting the pool of neuronal precursors. |
2020-01-09 |
2023-08-13 |
mouse |
| Sarah Houben, Karelle Leroy, Kunie Ando, Zehra Yilmaz, Cyprien Widomski, Luc Buée, Jean-Pierre Brio. Genetic ablation of tau in postnatal neurons rescues decreased adult hippocampal neurogenesis in a tauopathy model. Neurobiology of disease. vol 127. 2020-01-09. PMID:30818066. |
these observations suggest that development of tau pathology in granule cells of the dentate gyrus is responsible for reduction of adult hippocampal neurogenesis also in human tauopathies by impairing proliferation of neuronal precursors, and that reduction of tau expression might be an approach to rescue this impairment. |
2020-01-09 |
2023-08-13 |
mouse |
| Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T Corbett, Graham Fraser, Michael S Perkinton, Dominic M Walsh, Andrew Billinton, Michael J Rowa. Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo. Neurobiology of disease. vol 127. 2020-01-09. PMID:30910746. |
the present study examined the ability of different assemblies of full-length human tau to affect ltd in the dorsal hippocampus of the anaesthetized rat. |
2020-01-09 |
2023-08-13 |
human |
| Huanxian Chang, Tingting Di, Ya Wang, Xianying Zeng, Guoxi Li, Qi Wan, Wenfeng Yu, Ling Che. Seipin deletion in mice enhances phosphorylation and aggregation of tau protein through reduced neuronal PPARγ and insulin resistance. Neurobiology of disease. vol 127. 2020-01-09. PMID:30910747. |
this study aimed to investigate the influence of systemic seipin knockout (seipin-sko), neuronal seipin knockout (seipin-nko) or adipose seipin knockout (seipin-ako) in hippocampal tau phosphorylation and aggregation. |
2020-01-09 |
2023-08-13 |
mouse |
| Jiqu Xu, Hui Gao, Li Zhang, Shuang Rong, Wei Yang, Congcong Ma, Meng Chen, Qingde Huang, Qianchun Deng, Fenghong Huan. Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. Journal of pineal research. vol 67. issue 2. 2020-01-09. PMID:31050371. |
melatonin also prevented hfd-induced increases in beta-amyloid (aβ) accumulation and tau phosphorylation in the hippocampus. |
2020-01-09 |
2023-08-13 |
rat |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
differential accumulation of tau phosphorylated at residues thr231, ser262 and thr205 in hippocampal interneurons and its modulation by tau mutations (vlw) and amyloid-β peptide. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
our recent data showed a differential accumulation of tau protein phosphorylated at residue thr231 (pthr231) in distinct hippocampal neurons in vlw mice-a model that overexpresses mutated human tau. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
here we demonstrate that, in vlw mice, the accumulation of human p-tau in pyramidal cells induces the phosphorylation of murine tau at residue thr231 in hippocampal interneurons. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
in addition, we show that pser262 and pthr205 tau are present specifically in the soma of some hippocampal interneurons in control mice. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
analysis of j20 mice-a model that accumulates aβ-and of vlw animals showed that the density of hippocampal interneurons accumulating pthr205 tau is lower in vlw mice than in controls. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
in contrast, the density of interneurons accumulating pthr205 tau in j20 mice was increased compared to controls in hippocampal regions with a higher aβ plaque load, thereby suggesting that pthr205 tau is induced by aβ. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
no significant differences were found between the density of hippocampal interneurons positive for pser262 tau in vlw or j20 mice compared to control animals. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
we also show that pser262 and pthr205 tau are present in the soma of some hippocampal interneurons containing parvalbumin, calbindin or calretinin in control, vlw, and j20 mice. |
2019-12-16 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
taken together, these data point to a specific role of pser262 and pthr205 tau in the soma of hippocampal interneurons in control and pathological conditions. |
2019-12-16 |
2023-08-13 |
mouse |