| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blu. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiology of disease. vol 125. 2019-12-16. PMID:30665005. |
using electrophysiological and biochemical evaluations, we surprisingly observed that, at a time when tau pathology and cognitive deficits are overt and obvious, the hippocampus of thy-tau22 mice exhibits enhanced response to insulin. |
2019-12-16 |
2023-08-13 |
mouse |
| Sheng-Jun Fan, Fang-I Huang, Jing-Ping Liou, Chia-Ron Yan. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model. Cell death & disease. vol 9. issue 6. 2019-12-10. PMID:29844403. |
the primary pathological features of ad include senile plaques (sps) and intracellular neurofibrillary tangles (nfts), comprising aggregated amyloid β (aβ) and hyperphosphorylated tau protein, respectively, in the hippocampus of ad patients. |
2019-12-10 |
2023-08-13 |
Not clear |
| Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qi. The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats. Biochemical and biophysical research communications. vol 510. issue 1. 2019-11-29. PMID:30660367. |
gv promoted tau phosphorylation and inhibited the akt/gsk3β pathway in the hippocampus. |
2019-11-29 |
2023-08-13 |
rat |
| Junpeng Yang, Zhigang Zhao, Huijuan Yuan, Xiangxiang Ma, Yakun Li, Huimeng Wang, Xiaojun Ma, Guijun Qi. The mechanisms of glycemic variability accelerate diabetic central neuropathy and diabetic peripheral neuropathy in diabetic rats. Biochemical and biophysical research communications. vol 510. issue 1. 2019-11-29. PMID:30660367. |
in conclusion, the present study highlighted that gv might induce diabetic central neuropathy through the hyperphosphorylation of tau in the hippocampus by inhibiting the akt/gsk3β pathway and that it may cause dpn through oxidative stress and inflammatory responses by activating the nf-κb pathway. |
2019-11-29 |
2023-08-13 |
rat |
| Veronika Hanko, Alexandra C Apple, Kathryn I Alpert, Kristen N Warren, Julie A Schneider, Konstantinos Arfanakis, David A Bennett, Lei Wan. In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies. Neurobiology of aging. vol 74. 2019-11-26. PMID:30453234. |
in vivo hippocampal subfield shape related to tdp-43, amyloid beta, and tau pathologies. |
2019-11-26 |
2023-08-13 |
human |
| Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M Y Lee, John Q Trojanowski, Carlo Ballatore, Amos B Smith, Kurt R Brunde. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications. vol 4. issue 1. 2019-11-20. PMID:27687527. |
moreover, epothilone d enhanced cognitive performance and decreased hippocampal neuron loss, with evidence of reduced tau pathology. |
2019-11-20 |
2023-08-13 |
mouse |
| Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M Y Lee, John Q Trojanowski, Carlo Ballatore, Amos B Smith, Kurt R Brunde. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications. vol 4. issue 1. 2019-11-20. PMID:27687527. |
importantly, as previously observed with epothilone d, the dictyostatin-treated ps19 mice displayed improved mt density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated ps19 mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. |
we confirmed that grk5 translocates from the cellular membrane to the cytosol in the hippocampus of alzheimer's disease mice and that grk5 deficiency promotes tau hyperphosphorylation, a hallmark of alzheimer's disease pathology. |
2019-11-20 |
2023-08-13 |
mouse |
| S Tomaszewski, S Gauthier, A Wimo, P Rosa-Net. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer's Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. The journal of prevention of Alzheimer's disease. vol 3. issue 3. 2019-11-20. PMID:29205255. |
patients with alzheimer's disease (ad) are known to have characteristic pathology, including senile plaques with amyloid beta-protein aggregates and neurofibrillary tangles with assembled tau proteins, which start in the hippocampus and spread to neighboring areas. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Erratum to: Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2019-11-20. PMID:29429142. |
erratum to: forskolin induces hyperphosphorylation of tau accompanied by cell cycle reactivation in primary hippocampal neurons. |
2019-11-20 |
2023-08-13 |
Not clear |
| Stanislav Sutovsky, Tomas Smolek, Peter Turcani, Robert Petrovic, Petra Brandoburova, Santosh Jadhav, Petr Novak, Johannes Attems, Norbert Zilk. Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 6. 2019-11-12. PMID:29404783. |
in the neocortex, tau pathology, especially neuropil threads, was more abundant in the frontal and occipital cortex and in the hippocampus. |
2019-11-12 |
2023-08-13 |
human |
| Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. |
glycosaminoglycans from alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. |
2019-11-04 |
2023-08-13 |
Not clear |
| Minh Bao Huynh, Mohand Ouidir Ouidja, Sandrine Chantepie, Gilles Carpentier, Auriane Maïza, Ganlin Zhang, Joao Vilares, Rita Raisman-Vozari, Dulce Papy-Garci. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau. PloS one. vol 14. issue 1. 2019-11-04. PMID:30608949. |
here, we show that total sulfated gags from hippocampus of alzheimer's disease have altered capacities to bind and potentiate the activities of growth factors including fgf-2, vegf, and bdnf while their capacity to bind to tau is remarkable increased. |
2019-11-04 |
2023-08-13 |
Not clear |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. |
chronic noise exposure led to progressive overproduction of aβ and increased the hyperphosphorylation of tau at ser396, thr205, and thr231 sites in the hippocampus and the prefrontal cortex (pfc) in young samp8 mice, similar to that observed in aging samp8 mice. |
2019-10-31 |
2023-08-13 |
mouse |
| Donghong Su, Wenlong Li, Xiaojun She, Xuewei Chen, Qingfeng Zhai, Bo Cui, Rui Wan. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to Wnt signaling in the PFC and hippocampus. Scientific reports. vol 8. issue 1. 2019-10-31. PMID:30279527. |
these findings demonstrate that chronic noise stress exacerbated ad-like neuropathology, possibly by disrupting wnt signaling and triggering aberrant tau hyperphosphorylation and aβ in the pfc and hippocampus. |
2019-10-31 |
2023-08-13 |
mouse |
| Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30238463. |
in another experiment, acutely following reboxetine injections, tau phosphorylation was quantified in the frontal cortex, striatum, and hippocampus of the mice. |
2019-10-28 |
2023-08-13 |
mouse |
| H-B Zheng, Y-T Fu, G Wang, L-H Sun, Y-Y Fan, T-W Yan. Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. European review for medical and pharmacological sciences. vol 22. issue 11. 2019-10-22. PMID:29917212. |
hyperphosphorylation of protein tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. |
2019-10-22 |
2023-08-13 |
rat |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. |
tau accumulation in clinically normal older adults is associated with hippocampal hyperactivity. |
2019-10-16 |
2023-08-13 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. |
the relationship between hippocampal hyperactivity and early ad molecular pathology (amyloid-β and tau accumulation) before clinical symptoms remains to be elucidated. |
2019-10-16 |
2023-08-13 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. |
in this subset, we found that inferior temporal tau accumulation was associated with increased fmri activity in the hippocampus, but showed no clear association with amyloid. |
2019-10-16 |
2023-08-13 |
human |