| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanning Li, Runtao Ding, Xinghua Ren, Gehua Wen, Zhibin Dong, Hui Yao, Yaqing Tan, Hao Yu, Xiaolong Wang, Xiaoni Zhan, Jun Yao, Yan Lu, Guohua Zhang, Xu W. Long-term ketamine administration causes Tau protein phosphorylation and Tau protein-dependent AMPA receptor reduction in the hippocampus of mice. Toxicology letters. vol 315. 2019-09-23. PMID:31470060. |
most importantly, long-term ketamine administration decreased ampa receptor levels in the hippocampal cell membrane in a tau protein-dependent manner. |
2019-09-23 |
2023-08-13 |
mouse |
| John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29916037. |
the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. |
2019-09-17 |
2023-08-13 |
human |
| Mireille Moussaed, Sylvaine Huc-Brandt, Nicolas Cubedo, Michele Silhol, Samy Murat, Marie-Christine Lebart, Gabor Kovacs, Jean-Michel Verdier, Francoise Trousse, Mireille Rossel, Anne Marcilha. Regenerating islet-derived 1α (REG-1α) protein increases tau phosphorylation in cell and animal models of tauopathies. Neurobiology of disease. vol 119. 2019-09-17. PMID:30092268. |
first, reg-1α and phosphorylated tau expression were assessed in tissue sections from the hippocampus, representing neurofibrillary tangles (nfts), from patients with ad, and from basal ganglia, representing subcortical nfts, from patients with progressive supranuclear palsy (psp). |
2019-09-17 |
2023-08-13 |
human |
| Olga Pletnikova, Yusuke Kageyama, Gay Rudow, Katherine D LaClair, Marilyn Albert, Barbara J Crain, Jing Tian, David Fowler, Juan C Troncos. The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype. Neurobiology of aging. vol 71. 2019-09-11. PMID:30099348. |
tau lesions were present in the hippocampus and entorhinal cortex in 7% of subjects aged <40 years and increased steadily with age reaching near 70% in the 60- to 65-year age group. |
2019-09-11 |
2023-08-13 |
human |
| M K Schultz, R Gentzel, M Usenovic, C Gretzula, C Ware, S Parmentier-Batteur, J B Schachter, H A Zariwal. Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice. Neurobiology of disease. vol 118. 2019-09-09. PMID:30049665. |
we translated this approach to an in vivo model and used aav to express htau and the excitatory dreadd in the ventral hippocampus of wild type mice, p301l htau-expressing mice, or tau knockout mice. |
2019-09-09 |
2023-08-13 |
mouse |
| Céline Laurencé, Narimane Zeghbib, Michael Rivard, Sonia Lehri-Boufala, Isabelle Lachaise, Caroline Barau, Philippe Le Corvoisier, Thierry Martens, Laure Garrigue-Antar, Christophe Mori. A new human pyridinium metabolite of furosemide, inhibitor of mitochondrial complex I, is a candidate inducer of neurodegeneration. Biochemical pharmacology. vol 160. 2019-09-09. PMID:30537467. |
moreover, in mice, pof induced neurodegenerative diseases hallmarks like phospho-serine129 alpha-synuclein, tyrosine hydroxylase decrease in striatum, tau accumulation in hippocampus. |
2019-09-09 |
2023-08-13 |
mouse |
| Heidi Martini-Stoica, Allysa L Cole, Daniel B Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A Bader, Virginia M Y Lee, John Q Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zhen. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine. vol 215. issue 9. 2019-09-04. PMID:30108137. |
in vivo, induced tfeb expression in astrocytes reduces pathology in the hippocampus of ps19 tauopathy mice, as well as prominently attenuates tau spreading from the ipsilateral to the contralateral hippocampus in a mouse model of tau spreading. |
2019-09-04 |
2023-08-13 |
mouse |
| Mariane C Vicente, Maria C Almeida, Kênia C Bícego, Daniel C Carrettiero, Luciane H Gargaglion. Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30124447. |
in addition, we performed western blot analyses for phosphorylated tau, total tau, and amyloid-β (aβ) peptide in the locus coeruleus (lc), retrotrapezoid nucleus, medullary raphe, pre-bötzinger/bötzinger complex, and hippocampus, and evaluated memory and learning acquisition using the barnes maze. |
2019-08-26 |
2023-08-13 |
rat |
| Michele M Comerota, Batbayar Tumurbaatar, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30120733. |
we found that a 4-week exposure to nir light (90 s/day/5 days a week) significantly reduced levels of endogenous total and oligomeric tau in both synaptosomes and total protein extracts from the hippocampus and cortex of htau mice and improved deteriorating memory function. |
2019-08-20 |
2023-08-13 |
mouse |
| Michele M Comerota, Batbayar Tumurbaatar, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies. Molecular neurobiology. vol 56. issue 5. 2019-08-20. PMID:30120733. |
on the other hand, ex vivo binding of tau oligomers in isolated synaptosomes as well as tau oligomer-induced depression of long-term potentiation (ltp) in hippocampal slices from nir light-treated wt mice were unaffected. |
2019-08-20 |
2023-08-13 |
mouse |
| Zizhen Si, Xidi Wang, Zhujun Zhang, Jinxin Wang, Jihong Li, Jing Li, Ling Li, Yuanxin Li, Yahui Peng, Chongran Sun, Yang Hui, Xu Ga. Heme Oxygenase 1 Induces Tau Oligomer Formation and Synapse Aberrations in Hippocampal Neurons. Journal of Alzheimer's disease : JAD. vol 65. issue 2. 2019-08-19. PMID:30040734. |
heme oxygenase 1 induces tau oligomer formation and synapse aberrations in hippocampal neurons. |
2019-08-19 |
2023-08-13 |
mouse |
| Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, John C Morris, Jason J Hassensta. Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30068637. |
influence of tau pet, amyloid pet, and hippocampal volume on cognition in alzheimer disease. |
2019-08-19 |
2023-08-13 |
Not clear |
| Meng-Shan Tan, Ping Wang, Fang-Chen Ma, Jie-Qiong Li, Chen-Chen Tan, Jin-Tai Yu, Lan Ta. Common Variant in PLD3 Influencing Cerebrospinal Fluid Total Tau Levels and Hippocampal Volumes in Mild Cognitive Impairment Patients from the ADNI Cohort. Journal of Alzheimer's disease : JAD. vol 65. issue 3. 2019-08-19. PMID:30103332. |
common variant in pld3 influencing cerebrospinal fluid total tau levels and hippocampal volumes in mild cognitive impairment patients from the adni cohort. |
2019-08-19 |
2023-08-13 |
Not clear |
| Shengnuo Fan, Yuqiu Zheng, Xuan Liu, Wenli Fang, Xiaoyu Chen, Wang Liao, Xiuna Jing, Ming Lei, Enxiang Tao, Qiulan Ma, Xingmei Zhang, Rui Guo, Jun Li. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease. Drug delivery. vol 25. issue 1. 2019-08-14. PMID:30107760. |
the ex vivo assays including bielschowsky silver staining, immunostaining, and western blotting demonstrated that plga-peg-b6/cur could reduce hippocampal β-amyloid formation and deposit and tau hyperphosphorylation. |
2019-08-14 |
2023-08-13 |
mouse |
| Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. |
the overall microglial response and tau phosphorylation were also measured in the sn, surrounding the midbrain gray matter structures and the hippocampal white matter.resultsthe isoflurane-treated uco group had fewer tyrosine hydroxylase-expressing neurons in the sn at 8 h after the insult than the propofol-treated uco or sham-operated groups (p<0.05). |
2019-08-12 |
2023-08-13 |
Not clear |
| Lindsay R Clark, Sara E Berman, Derek Norton, Rebecca L Koscik, Erin Jonaitis, Kaj Blennow, Barbara B Bendlin, Sanjay Asthana, Sterling C Johnson, Henrik Zetterberg, Cynthia M Carlsso. Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid. Neurology. vol 90. issue 15. 2019-08-07. PMID:29523644. |
compare cognitive and hippocampal volume trajectories in asymptomatic middle-aged and older adults with positive csf markers of β-amyloid (aβ) or tau to adults without an alzheimer disease (ad)-associated biomarker profile. |
2019-08-07 |
2023-08-13 |
Not clear |
| Dawling A Dionisio-Santos, John A Olschowka, M Kerry O'Banio. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease. Journal of neuroinflammation. vol 16. issue 1. 2019-08-05. PMID:30953557. |
in rodent models, increased neuroinflammation promoted by overexpression of proinflammatory cytokines can cause an increase in hyperphosphorylated tau and a decrease in hippocampal function. |
2019-08-05 |
2023-08-13 |
Not clear |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30604097. |
using high-performance liquid chromatographic and mass spectrometric assays, the present study systematically determined the tissue concentrations of l-arginine and its nine downstream metabolites in the frontal cortex, hippocampus, parahippocampal region, striatum, thalamus, and cerebellum in male ps19 mice-bearing human tau p301s mutation at 4, 8, and 12-14 months of age. |
2019-07-24 |
2023-08-13 |
mouse |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
in this study, an experimental model of type 2 diabetes mellitus (t2dm) was established by injecting sprague dawley (sd) rats with streptozocin (stz), so as to compare the learning and memory ability, hippocampal neurons pathological changes, beta amyloid protein (a beta) content, degree of tau protein phosphorylation, blood glucose and insulin level. |
2019-07-23 |
2023-08-13 |
human |
| Zhi-Tao Hou, Yu-Sheng Han, Yi-Tian Liu, Yu Xing, Meng Wang, Jing Che. [Effects of Sagacious Confucius' Pillow Elixir on cognitive function in type 2 diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593246. |
the results showed that the sagacious confucius' pillow elixir could improve the learning and memory ability of stz injected rats, reduce the level of a beta content both in hippocampus and serum, effectively reduce tau protein phosphorylation degree, and also significantly alleviate hippocampal pathological injury, blood glucose, insulin and other basic indicators. |
2019-07-23 |
2023-08-13 |
human |