| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa R Zanier, Ilaria Bertani, Eliana Sammali, Francesca Pischiutta, Maria Antonietta Chiaravalloti, Gloria Vegliante, Antonio Masone, Alessandro Corbelli, Douglas H Smith, David K Menon, Nino Stocchetti, Fabio Fiordaliso, Maria-Grazia De Simoni, William Stewart, Roberto Chies. Induction of a transmissible tau pathology by traumatic brain injury. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30084913. |
brain homogenates from these mice, when inoculated into the hippocampus and overlying cerebral cortex of naïve mice, induced widespread tau pathology, synaptic loss, and persistent memory deficits. |
2019-07-17 |
2023-08-13 |
mouse |
| Ilse Eidhof, Jonathan Baets, Erik-Jan Kamsteeg, Tine Deconinck, Lisa van Ninhuijs, Jean-Jacques Martin, Rebecca Schüle, Stephan Züchner, Peter De Jonghe, Annette Schenck, Bart P van de Warrenbur. GDAP2 mutations implicate susceptibility to cellular stress in a new form of cerebellar ataxia. Brain : a journal of neurology. vol 141. issue 9. 2019-07-17. PMID:30084953. |
neuropathological examination showed degenerative changes in the cerebellum, olive inferior, thalamus, substantia nigra, and pyramidal tracts, as well as tau pathology in the hippocampus and amygdala. |
2019-07-17 |
2023-08-13 |
drosophila_melanogaster |
| Kristen M Craven, William R Kochen, Carlos M Hernandez, Jane M Flin. Zinc Exacerbates Tau Pathology in a Tau Mouse Model. Journal of Alzheimer's disease : JAD. vol 64. issue 2. 2019-07-15. PMID:29914030. |
zinc supplementation in tau mice also increased tangle numbers in the hippocampus while decreasing free-zinc levels, demonstrating that tangles were sequestering zinc. |
2019-07-15 |
2023-08-13 |
mouse |
| Catherine M Roe, Beau M Ances, Denise Head, Ganesh M Babulal, Sarah H Stout, Elizabeth A Grant, Jason Hassenstab, Chengjie Xiong, David M Holtzman, Tammie L S Benzinger, Suzanne E Schindler, Anne M Fagan, John C Morri. Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers. Brain : a journal of neurology. vol 141. issue 11. 2019-07-15. PMID:30304397. |
stepwise cox proportional hazards models tested associations of molecular (pittsburgh compound b; csf amyloid-β42, tau, ptau181, tau/amyloid-β42, ptau181/amyloid-β42), structural (normalized hippocampal volume, normalized whole brain volume), and cognitive (animal naming, trail making a, trail making b, selective reminding test - free recall) biomarkers with time to clinical dementia rating (cdr) > 0. |
2019-07-15 |
2023-08-13 |
human |
| Eric M Gold, Vitaly Vasilevko, Jonathan Hasselmann, Casey Tiefenthaler, Danny Hoa, Kasuni Ranawaka, David H Cribbs, Brian J Cumming. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits. ASN neuro. vol 10. 2019-07-11. PMID:29932344. |
in human tau transgenic mice, rmchi induced increases in hyperphosphorylated paired helical filament 1 tau in the hippocampus. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
in c57bl/6 mice, chronic midazolam administration immediately increased hippocampal tau phosphorylation, and this effect was more pronounced in older mice. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
interestingly, in young c57bl/6 mice, chronic midazolam administration induced hippocampal tau hyperphosphorylation, which persisted for 1 week. |
2019-07-11 |
2023-08-13 |
mouse |
| Robert A Whittington, László Virág, Maud Gratuze, Hilana Lewkowitz-Shpuntoff, Mehdi Cheheltanan, Franck Petry, Isabelle Poitras, Françoise Morin, Emmanuel Plane. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of aging. vol 75. 2019-07-11. PMID:30508732. |
in htau mice, chronic midazolam administration increased hippocampal tau phosphorylation and, although this was not associated with proaggregant changes, this correlated with a decreased capacity of tau to bind to preassembled microtubules. |
2019-07-11 |
2023-08-13 |
mouse |
| Caoyi Chen, Jianlan Gu, Gustavo Basurto-Islas, Nana Jin, Feng Wu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific reports. vol 7. issue 1. 2019-07-01. PMID:29044200. |
overexpression of ck1ε in the mouse hippocampus increased tau phosphorylation and impaired spontaneous alternation behavior. |
2019-07-01 |
2023-08-13 |
mouse |
| Hugo Botha, William G Mantyh, Melissa E Murray, David S Knopman, Scott A Przybelski, Heather J Wiste, Jonathan Graff-Radford, Keith A Josephs, Christopher G Schwarz, Walter K Kremers, Bradley F Boeve, Ronald C Petersen, Mary M Machulda, Joseph E Parisi, Dennis W Dickson, Val Lowe, Clifford R Jack, David T Jone. FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis. Brain : a journal of neurology. vol 141. issue 4. 2019-06-28. PMID:29538658. |
we evaluated the utility of 18f-fdg-pet to differentiate flortaucipir tau pet negative from flortaucipir positive amnestic mild cognitive impairment and dementia and used an autopsy confirmed cohort to test the hypothesis that hippocampal sclerosis might account for the observed pattern. |
2019-06-28 |
2023-08-13 |
human |
| Michaeline L Hebron, Monica Javidnia, Charbel E-H Mouss. Tau clearance improves astrocytic function and brain glutamate-glutamine cycle. Journal of the neurological sciences. vol 391. 2019-06-27. PMID:30103978. |
to obtain an animal model that expresses tau in the brainstem, we bred hemizygous mice that express p301l tau (taup301l) and detected hyper-phosphorylated tau (p-tau) predominantly in the hippocampus, cortex, brainstem and thalamus. |
2019-06-27 |
2023-08-13 |
mouse |
| Bension Shlomo Tilley, Colin Smith, Nicola Pavese, Johannes Attem. Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration. BMJ case reports. vol 12. issue 3. 2019-06-24. PMID:30850568. |
hyperphosphorylated tau was only found in the entorhinal cortex and hippocampus. |
2019-06-24 |
2023-08-13 |
Not clear |
| Catia M Teixeira, Noemí Pallas-Bazarra, Marta Bolós, Julia Terreros-Roncal, Jesús Ávila, María Llorens-Martí. Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29562522. |
importantly, it has been revealed that gsk-3β and tau proteins, which are two of the main players driving ad pathology, are cornerstones of adult hippocampal neurogenesis regulation. |
2019-06-11 |
2023-08-13 |
Not clear |
| Tomas Smolek, Santosh Jadhav, Veronika Brezovakova, Veronika Cubinkova, Bernadeta Valachova, Petr Novak, Norbert Zilk. First-in-Rat Study of Human Alzheimer's Disease Tau Propagation. Molecular neurobiology. vol 56. issue 1. 2019-06-11. PMID:29770957. |
by using specific monoclonal antibodies, we were able to monitor the spreading of tau isolated from human brain directly in the rat hippocampus. |
2019-06-11 |
2023-08-13 |
mouse |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29973279. |
tau pathology usually commenced after 35 years of age, initially involving not only entorhinal areas and hippocampus but also subcortical regions such as locus caeruleus (lc) and dorsal raphe nucleus (drn). |
2019-06-04 |
2023-08-13 |
Not clear |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29973279. |
we found no evidence that tau pathology might commence within the brain in ds before amyloid deposition had occurred, but there was limited data that suggests tau pathology in lc or drn might predate that in entorhinal areas and hippocampus or at least be coincident. |
2019-06-04 |
2023-08-13 |
Not clear |
| Carl Julien, Colson Tomberlin, Christine M Roberts, Aumbreen Akram, Gretchen H Stein, Michael A Silverman, Christopher D Lin. In vivo induction of membrane damage by β-amyloid peptide oligomers. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30497524. |
this repair response does not occur when c. elegans is exposed to an aβ gly37leu variant, which we have previously shown to be incapable of inducing tau phosphorylation in hippocampal neurons. |
2019-06-03 |
2023-08-13 |
human |
| Carl Julien, Colson Tomberlin, Christine M Roberts, Aumbreen Akram, Gretchen H Stein, Michael A Silverman, Christopher D Lin. In vivo induction of membrane damage by β-amyloid peptide oligomers. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30497524. |
to investigate the role of membrane repair on tau phosphorylation directly, we exposed hippocampal neurons to streptolysin o (slo), a pore-forming toxin that induces a well-characterized membrane repair response. |
2019-06-03 |
2023-08-13 |
human |
| Iván Méndez-López, Idoia Blanco-Luquin, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, Blanca Acha, Carmen Echavarri, Victoria Zelaya, Ivonne Jericó, Maite Mendioro. Hippocampal International journal of molecular sciences. vol 20. issue 4. 2019-05-31. PMID:30781626. |
here, we examined a-type and b-type lamin expression levels by rt-qpcr in alzheimer's disease (ad) patients and controls in the hippocampus, the core of tau pathology in the brain. |
2019-05-31 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Meritxell Aguiló García, Irene López González, Daniela Diaz Lucena, Aina Roig Villalonga, Margarita Carmona Tech, Franc Llorens, Paula Garcia-Esparcia, Alejandra Martinez-Maldonado, Margalida Frau Mendez, Benjamín Torrejón Escribano, Joan Josep Bech-Serra, Eduard Sabido, Carolina de la Torre Gómez, José Antonio Del Ri. Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes. Brain pathology (Zurich, Switzerland). vol 28. issue 6. 2019-05-28. PMID:29396893. |
finally, present results show for the first time that tau seeding is produced in neurons of the hippocampal complex, astrocytes, oligodendroglia and along fibers of the corpus callosum, fimbria and fornix following inoculation into the hippocampus of wild type mice of sarkosyl-insoluble fractions enriched in hyper-phosphorylated tau from selected artag cases. |
2019-05-28 |
2023-08-13 |
mouse |