| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angélica Maria Sabogal-Guáqueta, Luis Carrillo-Hormaza, Edison Osorio, Gloria Patricia Cardona-Góme. Effects of biflavonoids from Garcinia madruno on a triple transgenic mouse model of Alzheimer's disease. Pharmacological research. vol 129. 2019-01-04. PMID:29229355. |
the bf treatment reduced βa deposition in different regions of the brain (the hippocampus, entorhinal cortex and amygdala), reduced βa1-40 and βa1-42 levels, bace1-mediated cleavage of app (ctfβ), tau pathology, astrogliosis and microgliosis in the brains of aged 3xtg-ad mice. |
2019-01-04 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of alzheimer's disease. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
the purpose of our study was to understand the toxic effects of hippocampal phosphorylated tau in tau mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
mwm and rotarod tests revealed that hippocampal learning and memory and motor learning and coordination were impaired in tau mice relative to wild-type (wt) mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
these findings suggest that hippocampal accumulation of phosphorylated tau is responsible for abnormal mitochondrial dynamics and reducing dendritic protein map2 and dendritic spines and hippocampal based learning and memory impairments, and mitochondrial structural and functional changes in tau mice. |
2019-01-02 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Xiangling Yin, Rui Wang, P Hemachandra Redd. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29040533. |
based on these observations, we propose that reduced hippocampal phosphorylated tau is an important therapeutic strategy for ad and other tauopathies. |
2019-01-02 |
2023-08-13 |
mouse |
| An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md Shariful Islam, Bernard L Schneider, Darren J Moor. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29088368. |
p301s-tau expression induces hippocampal tau pathology and marked degeneration of ca1 pyramidal neurons in mice, however, this occurs independently of endogenous or pathogenic lrrk2 expression. |
2019-01-02 |
2023-08-13 |
mouse |
| An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md Shariful Islam, Bernard L Schneider, Darren J Moor. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain. Human molecular genetics. vol 27. issue 1. 2019-01-02. PMID:29088368. |
we further developed new aav2/6 vectors co-expressing human wt-tau and gfp to monitor the neuron-to-neuron transmission of tau within defined hippocampal neuronal circuits. |
2019-01-02 |
2023-08-13 |
mouse |
| Nan Zhang, Marc L Gordo. Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients. Clinical interventions in aging. vol 13. 2018-12-20. PMID:30349215. |
based on these studies, donepezil has been shown to be effective and safe in chinese ad patients and may impact ad biomarkers, such as hippocampal atrophy, aβ, and tau. |
2018-12-20 |
2023-08-13 |
human |
| Caterina Scuderi, Maria Rosanna Bronzuoli, Roberta Facchinetti, Lorenzo Pace, Luca Ferraro, Kevin Donald Broad, Gaetano Serviddio, Francesco Bellanti, Gianmauro Palombelli, Giulia Carpinelli, Rossella Canese, Silvana Gaetani, Luca Steardo, Luca Steardo, Tommaso Cassan. Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects. Translational psychiatry. vol 8. issue 1. 2018-12-12. PMID:29382825. |
moreover, it reduces aβ formation, the phosphorylation of tau proteins, and promotes neuronal survival in the ca1 subregion of the hippocampus. |
2018-12-12 |
2023-08-13 |
mouse |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
forskolin induces hyperphosphorylation of tau accompanied by cell cycle reactivation in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
the aim of the present study was to investigate cell cycle reactivation during tau hyperphosphorylation in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
we used forskolin, a specific activator of pka, to induce tau hyperphosphorylation in cultured primary hippocampal neurons, and then measured levels of cyclin d1 and cyclin b1. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hai-Hong Wang, Yan Li, Ang Li, Fang Yan, Zhen-Lin Li, Zhong-Ying Liu, Lei Zhang, Jian Zhang, Wei-Ren Dong, Lin Zhan. Forskolin Induces Hyperphosphorylation of Tau Accompanied by Cell Cycle Reactivation in Primary Hippocampal Neurons. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27995573. |
the tau hyperphosphorylation was accompanied by increases in cyclin d1 and cyclin b1 levels; immunostaining showed overlapping distribution of hyperphosphorylated tau and cyclin d1 and cyclin b1 in primary hippocampal neurons. |
2018-12-11 |
2023-08-13 |
Not clear |
| Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tia. Gender-Related Hippocampal Proteomics Study from Young Rats After Chronic Unpredicted Mild Stress Exposure. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:28064424. |
further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by western blotting. |
2018-12-11 |
2023-08-13 |
rat |
| Christine L Tardif, Gabriel A Devenyi, Robert S C Amaral, Sandra Pelleieux, Judes Poirier, Pedro Rosa-Neto, John Breitner, M Mallar Chakravart. Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease. Human brain mapping. vol 39. issue 2. 2018-12-11. PMID:29164798. |
however, there has been limited investigation of the structural integrity of the components of the hippocampal circuit, including subfields and extra-hippocampal white matter structure, in relation to the progression of well-accepted cerebrospinal fluid (csf) biomarkers of ad, amyloid-β 1-42 (aβ) and total-tau (tau). |
2018-12-11 |
2023-08-13 |
human |
| Patrick H Lim, Stephanie L Wert, Elif Tunc-Ozcan, Robert Marr, Adriana Ferreira, Eva E Rede. Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behavioural brain research. vol 353. 2018-11-26. PMID:29490235. |
hippocampal expression of ad-related genes, such as amyloid precursor protein, amyloid beta 42, beta secretase, synucleins, total and dephosphorylated tau, and synaptophysin, did not differ between wlis and wmis in either age group. |
2018-11-26 |
2023-08-13 |
rat |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2018-11-16 |
2023-08-13 |
Not clear |
| Claudia Jara, Alejandra Aránguiz, Waldo Cerpa, Cheril Tapia-Rojas, Rodrigo A Quintanill. Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. Redox biology. vol 18. 2018-11-05. PMID:30077079. |
genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. |
2018-11-05 |
2023-08-13 |
mouse |
| Claudia Jara, Alejandra Aránguiz, Waldo Cerpa, Cheril Tapia-Rojas, Rodrigo A Quintanill. Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. Redox biology. vol 18. 2018-11-05. PMID:30077079. |
our results showed that tau deletion had positive effects on hippocampal cells by decreasing oxidative damage, favoring a mitochondrial pro-fusion state, and inhibiting mitochondrial permeability transition pore (mptp) formation by reducing cyclophilin d (cyp-d) protein. |
2018-11-05 |
2023-08-13 |
mouse |