All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an aβ-dependent manner. 2023-09-25 2023-10-07 human
Suzanne D Lanooij, W H I M Drinkenburg, U L M Eisel, E A van der Zee, Martien J H Ka. The effects of social environment on AD-related pathology in hAPP-J20 mice and tau-P301L mice. Neurobiology of disease. 2023-09-25. PMID:37748620. in 12-week-old p301l mice, tau pathology was induced through seeding by injecting k18 into the dorsal hippocampus (p301l 2023-09-25 2023-10-07 mouse
Lovedeep Singh, Harpreet Kaur, Girish Chandra Arya, Rajbir Bhatt. Neuroprotective potential of formononetin, a naturally occurring isoflavone phytoestrogen. Chemical biology & drug design. 2023-09-18. PMID:37722967. furthermore, formononetin also increases the expression of adam-10, which affects the pathology of neurodegenerative disease by lowering tau phosphorylation, maintaining synaptic plasticity, and boosting hippocampus neurogenesis. 2023-09-18 2023-10-07 Not clear
Khadga Raj Aran, G D Gupta, Shamsher Sing. Cladribine Induces Apoptosis, Neuroinflammation, Mitochondrial Oxidative Stress, Tau Phosphorylation and Aβ (1-42) Pathway in the Hippocampus: An In vivo Approach. Journal of chemical neuroanatomy. 2023-09-14. PMID:37708945. cladribine induces apoptosis, neuroinflammation, mitochondrial oxidative stress, tau phosphorylation and aβ (1-42) pathway in the hippocampus: an in vivo approach. 2023-09-14 2023-10-07 rat
Christopher G Schwarz, Walter K Kremers, Stephen D Weigand, Carl M Prakaashana, Matthew L Senjem, Scott A Przybelski, Val J Lowe, Jeffrey L Gunter, Kejal Kantarci, Prashanthi Vemuri, Jonathan Graff-Radford, Ronald C Petersen, David S Knopman, Clifford R Jac. Effects of de-facing software mri_reface on utility of imaging biomarkers used in Alzheimer's disease research. NeuroImage. Clinical. vol 40. 2023-09-13. PMID:37703605. we created a retrospective sample of participants from three age- and sex-matched clinical groups (cognitively unimpaired, mild cognitive impairment, and ad dementia, and we performed region- and voxel-wise analyses of: hippocampal volume (n), white matter hyperintensity volume (v), amyloid pet (a), and tau pet (t) measures, each from multiple software pipelines, on their ability to separate cognitively defined groups and their degrees of correlation with age and clinical dementia rating (cdr)-sum of boxes (cdr-sb). 2023-09-13 2023-10-07 human
Li Gao, Dongqing Wang, Jia Ren, Xue Tan, Jiayuan Chen, Zheng Kong, Yunan Nie, Ming Ya. Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation. Phytotherapy research : PTR. 2023-09-04. PMID:37661763. we evaluated the levels of aβ40 and aβ42 in serum, cortex, and hippocampus, and aβ-related scavenging enzymes, phosphorylated gsk3β and hyperphosphorylated tau in the cortex and hippocampus of app/ps1 mice by western blotting. 2023-09-04 2023-09-07 mouse
Giulia Arenare, Riccardo Manca, Paolo Caffarra, Annalena Venneri, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Associations between Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers in People with Mild Cognitive Impairment. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626552. this study aimed to investigate the association between nps severity and alzheimer's disease (ad) biomarkers, i.e., amyloid-β (aβ), phosphorylated tau protein (p-tau) and hippocampal volume ratio (hr), to characterise in more detail mci patients with a poor prognosis. 2023-08-26 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. 2023-08-23 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. high pathologic tau stage (braak stage) or a high burden of hippocampal tau pathology has been associated with cognitive impairment in part. 2023-08-23 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. in this study, the hippocampal ca2 region showed loss of synaptophysin puncta and intensity in cases of part with either a high stage (braak iv) or a high burden of neuritic tau pathology. 2023-08-23 2023-09-07 Not clear
Meaghan Morris, Gabrielle I Coste, Javier Redding-Ochoa, Haidan Guo, Austin R Graves, Juan C Troncoso, Richard L Hugani. Hippocampal synaptic alterations associated with tau pathology in primary age-related tauopathy. Journal of neuropathology and experimental neurology. 2023-08-23. PMID:37595576. these novel findings suggest the presence of synaptic loss associated with either a high hippocampal tau burden or a braak stage iv in part. 2023-08-23 2023-09-07 Not clear
Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. while in animals moderate-intensity exercise restores hippocampal and amygdala memory through increased levels of p-akt, p-trkb, and p-pkc and decreased levels of aβ, tau phosphorylation, and amyloid precursor proteins (app) in ad. 2023-08-21 2023-09-07 human
Grace Minogue, Allegra Kawles, Antonia Zouridakis, Rachel Keszycki, Alyssa Macomber, Vivienne Lubbat, Nathan Gill, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefe. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of neurology. 2023-08-18. PMID:37592884. here, we investigated neuronal integrity and pathologic burden of tdp-43 and tau along the well-charted trisynaptic hippocampal circuit [dentate gyrus (dg), ca3, and ca1] in participants with amnestic dementia due to ad/tdp, amnestic dementia due to ad alone, or non-amnestic dementia due to tdp-43 proteinopathy associated with frontotemporal lobar degeneration (ftld-tdp). 2023-08-18 2023-09-07 human
Rebecca L Noel, Samantha L Gorman, Alec J Batts, Elisa E Konofago. Getting ahead of Alzheimer's disease: early intervention with focused ultrasound. Frontiers in neuroscience. vol 17. 2023-08-14. PMID:37575309. finally, fus-bbbo reduced hippocampal accumulation of aβ40, aβ42, and total tau in females by 12.54, 13.05, and 3.57%, respectively, and reduced total tau in males by 18.98%. 2023-08-14 2023-08-16 mouse
Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. biochemical methods were used to evaluate self-associated tau, insoluble tau aggregates, total tau, and phosphorylated tau in the hindbrain, cortex, and hippocampus. 2023-08-09 2023-08-16 mouse
Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. nasal administration of wttidm in p301s tau-expressing ps19 mice was found to inhibit gliosis and inflammatory markers, along with reduction of pathogenic tau in the hippocampus, resulting in improved cognitive behavior in ps19 mice. 2023-08-08 2023-08-16 mouse
Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. two hallmark proteins in ad, amyloid-beta plaques and tau neurofibrillary tangles, accumulate in regions of the brain critical for learning and memory, including the hippocampus. 2023-08-05 2023-08-14 mouse
Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. in the brain, tau mice had greater levels of glial fibrillary acidic protein (gfap) (p < 0.05) and significantly less hippocampal cell density than wt mice (p < 0.001). 2023-08-05 2023-08-14 mouse
Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. 2023-08-02 2023-08-14 Not clear
Asmaa Gaber, Osama M Ahmed, Yasser A Khadrawy, Khairy M A Zoheir, Rasha E Abo-ELeneen, Mohamed A Alblihed, Ahlam M Elbakr. Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-β 25-35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring. Biology. vol 12. issue 7. 2023-07-29. PMID:37508337. additionally, bm-msc or gsi-953 therapy reduced aβ 25-35-induced increases in tau phosphorylation and amyloid precursor protein levels in the neonates' hippocampus and elevated the lower levels of glycogen synthase kinase-3 and brain-derived neurotrophic factor; moreover, reversed aβ 25-35-induced alterations in gene expression in the neonatal hippocampus. 2023-07-29 2023-08-14 rat