All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Florence Clavaguera, Markus Tolnay, Michel Goeder. The Prion-Like Behavior of Assembled Tau in Transgenic Mice. Cold Spring Harbor perspectives in medicine. vol 7. issue 10. 2018-06-07. PMID:27940600. the pattern of tau deposition in alzheimer's disease follows a stereotypical progression, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. 2018-06-07 2023-08-13 mouse
Betty M Tijms, Mara Ten Kate, Alida A Gouw, Andreas Borta, Sander Verfaillie, Charlotte E Teunissen, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flie. Gray matter networks and clinical progression in subjects with predementia Alzheimer's disease. Neurobiology of aging. vol 61. 2018-06-04. PMID:29040871. results remained after correcting for tau, hippocampal volume, and mmse scores. 2018-06-04 2023-08-13 human
Di Xia, Julia M Gutmann, Jürgen Göt. Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau. Scientific reports. vol 6. 2018-05-25. PMID:27378256. to establish a framework for understanding this pathology, we used the genome-editing tool talen and generated tau-meos2 knock-in mice to determine the mobility and subcellular localization of endogenous tau in hippocampal cultures. 2018-05-25 2023-08-13 mouse
Ladislav Baciak, Zdenka Gasparova, Tibor Liptaj, Ivo Jurane. In vivo magnetic resonance approach to trimethyltin induced neurodegeneration in rats. Brain research. vol 1673. 2018-05-22. PMID:28736106. hippocampal levels of n-acetylaspartate (naa), glutamate (glu), total creatine (tcr) and taurine (tau) significantly decreased, while the levels of myo-inositol (mins) and glutamine (gln) significantly increased in tmt treated rats compared to controls. 2018-05-22 2023-08-13 mouse
b' Susana Garc\\xc3\\xada-Cerro, Noem\\xc3\\xad Rueda, Ver\\xc3\\xb3nica Vidal, Sara Lantigua, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer\'s disease phenotypes. Neurobiology of disease. vol 106. 2018-05-15. PMID:28647555.' normalizing the gene dosage of dyrk1a in the ts mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced app expression in the hippocampus, aβ load in the cortex and hippocampus, the expression of phosphorylated tau at the ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum. 2018-05-15 2023-08-13 mouse
Xiaolei Zhu, Sulei Wang, Linjie Yu, Jiali Jin, Xing Ye, Yi Liu, Yun X. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer's disease. Aging cell. vol 16. issue 5. 2018-05-15. PMID:28771976. lentivirus -mediated inhibition or overexpression of hdac3 was used in the hippocampus of app/ps1 mice to investigate the role of hdac3 in spatial memory, amyloid burden, dendritic spine density, glial activation and tau phosphorylation. 2018-05-15 2023-08-13 mouse
Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. in this study, six different kaixin san formulas were compared to investigate their effects on learning and memory decline, brain-derived neurotrophic factor (bdnf) in the hippocampus, tau protein, acetylcholinesterase (ache) and n-terminal pro-brain natriuretic peptide (nt-probnp). 2018-05-15 2023-08-13 mouse
Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. 2018-05-15 2023-08-13 mouse
Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. the results showed that, kaixin san of qianjin yaofang three dose recorded significantly improved learning and memory ability of mice; increased the content of bdnf and ach in the hippocampus; decreased the content of aβ, tau protein, p-tau protein in the hippocampus; high, middle dose significantly decreased the serum nt-probnp and ache in hippocampus, the effect is most significant. 2018-05-15 2023-08-13 mouse
Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. part dose of kaixin san of yixin fang, kaixin wan of yimen fang, dingzhi xiaowan of beji qianjin yaofang and dingzhi wan of guji luyan could improve the learning and memory ability evaluation indicators, significantly increased bdnf and ach in the hippocampus of ad model mice, reduced the aβ, tau protein, p-tau protein in hippocampus of ad model mice, decreased the nt-probnp and ache in serum of ad mice, the effect is more significant. 2018-05-15 2023-08-13 mouse
Li-Na Lu, Zhong-Ming Qian, Ka-Chun Wu, Wing-Ho Yung, Ya K. Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27578012. we also found an age-dependent increase in hyperphosphorylated tau, total beta-amyloid, and neurotoxic oligomeric aggregates in the cortex and hippocampus as well as an increase in α-synuclein and a decrease in tyrosine hydroxylase positive neurons in the substantia nigra. 2018-05-10 2023-08-13 rat
Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. 2018-05-07 2023-08-13 mouse
Tetsuya Kimura, Mamiko Suzuki, Takumi Akag. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28874186. analysis of the lc3 ratio, an indicator of autophagosome formation, showed that lfs increased cleaved lc3 (type ii) in the aged hippocampus relative to type i lc3, suggesting potentiation of the alp accompanied by ltd. pharmacological inhibition of autophagosome formation depressed lfs-induced oligomerization of tau. 2018-05-07 2023-08-13 mouse
Jonas Elias Schweig, Hailan Yao, David Beaulieu-Abdelahad, Ghania Ait-Ghezala, Benoit Mouzon, Fiona Crawford, Michael Mullan, Daniel Pari. Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. Acta neuropathologica communications. vol 5. issue 1. 2018-05-07. PMID:28877763. in tg tau p301s mice, a pure model of tauopathy, activated syk occurs in neurons that show an accumulation of misfolded and hyperphosphorylated tau in the cortex and hippocampus. 2018-05-07 2023-08-13 mouse
Koichi Okamoto, Masakuni Amari, Toshio Fukuda, Keiji Suzuki, Masamitsu Takatam. Comparison of AT8 immunoreactivity in the locus ceruleus and hippocampus of 154 brains from routine autopsies. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28168741. we compared semiquantitatively at8 immunoreactivity in the locus ceruleus (lc) and hippocampus of 154 brains from routine autopsies to investigate the initial sites of phosphorylated tau (phospho-tau) development. 2018-05-03 2023-08-13 Not clear
Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama, Ryoya Takahashi, Keiko Unno, Keiichi Higuchi, Masanori Hosokaw. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28261874. as for the hallmarks of alzheimer brains, tau morphology has not yet been confirmed regardless of the age-related increase in phosphorylated tau in samp8 mice brains, but early age-related aβ deposition in the hippocampus has recently been published. 2018-05-03 2023-08-13 mouse
Yaling Yin, Yali Wang, Di Gao, Jinwang Ye, Xin Wang, Lin Fang, Dongqin Wu, Guilin Pi, Chengbiao Lu, Xin-Wen Zhou, Ying Yang, Jian-Zhi Wan. Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2. Scientific reports. vol 6. 2018-04-25. PMID:27277673. here, we found that overexpression of human wild-type full-length tau (termed htau) induced a significant reduction of α4 subunit of nicotinic acetylcholine receptors (nachrs) with an increased cleavage of the receptor producing a ~55kda fragment in primary hippocampal neurons and in the rat brains, meanwhile, the α4 nachr currents decreased. 2018-04-25 2023-08-13 human
Jing Wu, Shan-Lei Zhou, Lin-Hua Pi, Xia-Jie Shi, Ling-Ran Ma, Zi Chen, Min-Li Qu, Xin Li, Sheng-Dan Nie, Duan-Fang Liao, Jin-Jing Pei, Shan Wan. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget. vol 8. issue 25. 2018-04-25. PMID:28489581. we found: 1) that a chronic hgc directly decreases cav-1 expression, increases tau phosphorylation and activates mtor/s6k signalling in the brain neurons of diabetic rats, 2) that overexpression of cav-1 attenuates tau hyperphosphorylation induced by chronic hgc in primary hippocampal neurons, whereas down-regulation of cav-1 using cav-1 sirna dramatically worsens tau hyperphosphorylation via mtor/s6k signalling pathway, and 3) that the down-regulation of cav-1 induced by hgc is independent of mtor signalling. 2018-04-25 2023-08-13 rat
Andrew Kneynsberg, Nicholas M Kanaa. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro. vol 4. issue 4. 2018-04-25. PMID:28785724. aging does not affect axon initial segment structure and somatic localization of tau protein in hippocampal neurons of fischer 344 rats. 2018-04-25 2023-08-13 rat
Andrew Kneynsberg, Nicholas M Kanaa. Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats. eNeuro. vol 4. issue 4. 2018-04-25. PMID:28785724. none of the outcome measurements assessed, including ais structure, ais protein levels, the distribution of tau in neurons of the hippocampus (hp), and total tau or phospho-tau protein levels were different in young, middle-, and old-age fischer 344 rats. 2018-04-25 2023-08-13 rat