| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
biochemical methods were used to evaluate self-associated tau, insoluble tau aggregates, total tau, and phosphorylated tau in the hindbrain, cortex, and hippocampus. |
2023-08-09 |
2023-08-16 |
mouse |
| Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Paha. Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. The Journal of clinical investigation. 2023-08-08. PMID:37552543. |
nasal administration of wttidm in p301s tau-expressing ps19 mice was found to inhibit gliosis and inflammatory markers, along with reduction of pathogenic tau in the hippocampus, resulting in improved cognitive behavior in ps19 mice. |
2023-08-08 |
2023-08-16 |
mouse |
| Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. |
two hallmark proteins in ad, amyloid-beta plaques and tau neurofibrillary tangles, accumulate in regions of the brain critical for learning and memory, including the hippocampus. |
2023-08-05 |
2023-08-14 |
mouse |
| Stephen Lippi, Rachel Barkey, Mya Rodrigue. The cognitive and noncognitive behavioral effects of a high-fat diet in the rTg4510 tau mouse model. Physiology & behavior. 2023-08-05. PMID:37543107. |
in the brain, tau mice had greater levels of glial fibrillary acidic protein (gfap) (p < 0.05) and significantly less hippocampal cell density than wt mice (p < 0.001). |
2023-08-05 |
2023-08-14 |
mouse |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 68-year-old presymptomatic l315r carrier (ftld-cdr = 0) had limited tau burden morphologically similar to l315r end-stage carriers in middle frontal, antero-inferior temporal, amygdala, (para-)hippocampus and striatum, along with age-related alzheimer's disease neuropathological change. |
2023-08-02 |
2023-08-14 |
Not clear |
| Asmaa Gaber, Osama M Ahmed, Yasser A Khadrawy, Khairy M A Zoheir, Rasha E Abo-ELeneen, Mohamed A Alblihed, Ahlam M Elbakr. Mesenchymal Stem Cells and Begacestat Mitigate Amyloid-β 25-35-Induced Cognitive Decline in Rat Dams and Hippocampal Deteriorations in Offspring. Biology. vol 12. issue 7. 2023-07-29. PMID:37508337. |
additionally, bm-msc or gsi-953 therapy reduced aβ 25-35-induced increases in tau phosphorylation and amyloid precursor protein levels in the neonates' hippocampus and elevated the lower levels of glycogen synthase kinase-3 and brain-derived neurotrophic factor; moreover, reversed aβ 25-35-induced alterations in gene expression in the neonatal hippocampus. |
2023-07-29 |
2023-08-14 |
rat |
| Pingting Liu, Md Razaul Karim, Ana Covelo, Yuan Yue, Michael K Lee, Wensheng Li. The UPR Maintains Proteostasis and the Viability and Function of Hippocampal Neurons in Adult Mice. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511300. |
these results suggest that the upr is required for maintaining neuronal proteostasis (particularly tau and aβ homeostasis) and the viability and function of neurons in the hippocampus of adult mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
additionally, fgf10 treatment reduced tau hyperphosphorylation and neuronal apoptosis, thereby mitigating neuronal cell damage and synaptic deficits in the cortex and hippocampus of 3xtg-ad mice, as well as appswe-transfected ht22 cells. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
similarly, endogenous fgf10 overexpression ameliorated tau hyperphosphorylation and neuronal apoptosis in the cortex and hippocampus of 3xtg-ad mice. |
2023-07-28 |
2023-08-14 |
mouse |
| Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Róisín Winters, Michael S Perkinton, Andrew Billinton, Jack A Prenderville, Dominic M Walsh, Michael J Rowa. Tau and Aß in patient-derived aqueous brain extracts act concomitantly to disrupt LTP The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-25. PMID:37491315. |
here, we explore how intracerebral injection of aß and tau present in such aqueous extracts of patient brain contribute to disruption of synaptic plasticity in the ca1 area of the male rat hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Wilber Romero-Fernandez, Cristian Carvajal-Tapia, Alex Prusky, Ketaki A Katdare, Emmeline Wang, Alena Shostak, Lissa Ventura-Antunes, Hannah J Harmsen, Ethan S Lippmann, Kjell Fuxe, Jason A MacGurn, Dasiel O Borroto-Escuela, Matthew S Schra. Detection, visualization and quantification of protein complexes in human Alzheimer's disease brains using proximity ligation assay. Scientific reports. vol 13. issue 1. 2023-07-24. PMID:37488165. |
we confirmed that phosphorylated microtubule-associated protein tau (serine202, threonine205) aggregates were modified by ubiquitin and that phospho-tau-ubiquitin complexes were increased in hippocampal and frontal cortex regions in ad compared to non-ad brains. |
2023-07-24 |
2023-08-14 |
human |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
central administration of the tau protein did not affect the expression of the ntrk2, ngfr, mapt, bax and bcl-2 genes in the frontal cortex and hippocampus. |
2023-07-19 |
2023-08-14 |
mouse |
| Guang Yang, Yuting Tong, Xingyu Wang, Chenyi Zhao, Zongtao Ba, Reaila Ahelijiang, Xinjuan Liu, Waimao Gao, Yan Zhao, Yining Gu, Jianmei Yang, Ying X. Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice. Frontiers in immunology. vol 14. 2023-07-19. PMID:37465679. |
in addition, gzfl could inverse the tau hyperphosphorylation and the lessened expression of synaptic proteins in hippocampus of ps cdko mice. |
2023-07-19 |
2023-08-14 |
mouse |
| Shunsuke Koga, Aya Murakami, Alexandra I Soto-Beasley, Ronald L Walton, Matthew C Baker, Monica Castanedes-Casey, Keith A Josephs, Owen A Ross, Dennis W Dickso. Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies. Acta neuropathologica communications. vol 11. issue 1. 2023-07-06. PMID:37415197. |
tau immunohistochemistry showed numerous argyrophilic grains, pretangles, thorn-shaped astrocytes, and ballooned neurons in the amygdala, hippocampus, parahippocampal gyrus, anteromedial thalamus, insular cortex, superior temporal gyrus and cingulate gyrus, consistent with diffuse argyrophilic grain disease (agd). |
2023-07-06 |
2023-08-14 |
Not clear |
| Minli Qu, Linhui Zuo, Mengru Zhang, Peng Cheng, Zhanjun Guo, Junya Yang, Changjun Li, Jing W. High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m Cell death & disease. vol 14. issue 6. 2023-06-29. PMID:37385994. |
high glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of alkbh5-mediated dgkh m tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. |
2023-06-29 |
2023-08-14 |
Not clear |
| Carlos M Hernandez, Rachel E Barkey, Kristen M Craven, Karin A Pedemonte, Bernadette Alisantosa, Jonathan O Sanchez, Jane M Flin. Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371321. |
we found that tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and ca1 region of the hippocampus and smaller tau tangles in the cortex, when compared to tau mice injected with saline. |
2023-06-28 |
2023-08-14 |
mouse |
| Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping H. The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics. vol 15. issue 6. 2023-06-28. PMID:37376018. |
the results in murine hippocampal cells (ht22) revealed that co-treatment with mgf significantly decreased fa-induced cytotoxicity and inhibited tau hyperphosphorylation in a dose-dependent manner. |
2023-06-28 |
2023-08-14 |
Not clear |
| Maryam Hossein Rezaei, Elham Madadizadeh, Mohsen Aminaei, Mehdi Abbaspoor, Janis Schierbauer, Othmar Moser, Kayvan Khoramipour, Karim Chamar. Leptin Signaling Could Mediate Hippocampal Decumulation of Beta-Amyloid and Tau Induced by High-Intensity Interval Training in Rats with Type 2 Diabetes. Cellular and molecular neurobiology. 2023-06-28. PMID:37378849. |
leptin signaling could mediate hippocampal decumulation of beta-amyloid and tau induced by high-intensity interval training in rats with type 2 diabetes. |
2023-06-28 |
2023-08-14 |
rat |
| Lan Xiao, Xuyu Yang, Vinay Kumar Sharma, Daniel Abebe, Y Peng Lo. Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. Molecular psychiatry. 2023-06-27. PMID:37369719. |
here we report that viral-(aav) delivery of neurotrophic factor-α1/carboxypeptidase e (nf-α1/cpe) gene in hippocampus at an early age prevented later development of cognitive deficits as assessed by morris water maze and novel object recognition assays, neurodegeneration, and tau hyperphosphorylation in male 3xtg-ad mice. |
2023-06-27 |
2023-08-14 |
mouse |
| Ron Balczon, Chung-Sik Choi, Althea deWeever, Chun Zhou, Meredith S Gwin, Claire Kolb, C Michael Francis, Mike T Lin, Troy Steven. Infection promotes Ser-214 phosphorylation important for generation of cytotoxic tau variants. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 7. 2023-06-26. PMID:37358817. |
however, in the brain, both the ser-214 phosphorylated tau and the mutant ser-214-ala tau, which cannot be phosphorylated, disrupted hippocampal long-term potentiation suggesting that inhibition of long-term potentiation was relatively insensitive to the phosphorylation status of ser-214. |
2023-06-26 |
2023-08-14 |
Not clear |