| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fang Du, Qing Yu, Russell H Swerdlow, Clarissa L Waite. Glucocorticoid-driven mitochondrial damage stimulates Tau pathology. Brain : a journal of neurology. 2023-04-18. PMID:37070763. |
using cultured murine hippocampal neurons and 4-5-month-old mice treated with the synthetic glucocorticoid dexamethasone, we investigate the mechanisms underlying glucocorticoid-induced mitochondrial damage and tau pathology. |
2023-04-18 |
2023-08-14 |
mouse |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
of all the significant wm tracts, the uncinate fasciculus ([formula: see text]-0.274 for braak i, -0.311 for braak iii/iv, and -0.292 for braak v/vi, [formula: see text] 0.05) and cingulum adjoining hippocampus ([formula: see text] -0.274, -0.288, -0.233, [formula: see text] 0.05), both tracts anatomically connected to areas of early tau deposition, were consistently found to be within the top five distinguishing wm tracts associated with flortaucipir suvrs. |
2023-04-17 |
2023-08-14 |
human |
| Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Romain Perbet, Bradley T Hyma. Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034629. |
injection of sonicated fibrils or native hmw tau reveals similar local uptake into hippocampal neurons in ps19 tau transgenic mice. |
2023-04-10 |
2023-08-14 |
mouse |
| Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiav. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon : official journal of the International Society on Toxinology. 2023-04-10. PMID:37037273. |
botulinum neurotoxin a modulates the axonal release of pathological tau in hippocampal neurons. |
2023-04-10 |
2023-08-14 |
mouse |
| Chiara Panzi, Sunaina Surana, Samantha De La-Rocque, Edoardo Moretto, Oscar Marcelo Lazo, Giampietro Schiav. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon : official journal of the International Society on Toxinology. 2023-04-10. PMID:37037273. |
hippocampal neurons were grown in microfluidic chambers and transduced with lentiviruses expressing human tau (htau). |
2023-04-10 |
2023-08-14 |
mouse |
| Michael Malek-Ahmadi, Yi Su, Valentina Ghisays, Ji Luo, Vivek Devadas, Yinghua Chen, Wendy Lee, Hillary Protas, Kewei Chen, Henrik Zetterberg, Kaj Blennow, Richard J Caselli, Eric M Reima. Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults. Alzheimer's research & therapy. vol 15. issue 1. 2023-04-10. PMID:37038190. |
we then assessed plasma nfl associations with brain imaging measurements of ad-related neurodegeneration (hippocampal atrophy and a hypometabolic convergence index [hci]), brain imaging measurements of amyloid-β plaque burden, tau tangle burden and white matter hyperintensity volume (wmhv), and delayed and total recall memory scores. |
2023-04-10 |
2023-08-14 |
Not clear |
| Mingqi Liu, Jinhao Huang, Tao Liu, Jiangyuan Yuan, Chuanxiang Lv, Zhuang Sha, Chenrui Wu, Weiwei Jiang, Xuanhui Liu, Meng Nie, Yupeng Chen, Shiying Dong, Yu Qian, Chuang Gao, Yibing Fan, Di Wu, Rongcai Jian. Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice. Acta neuropathologica communications. vol 11. issue 1. 2023-04-06. PMID:37024941. |
we verified that exogenous il-33 could improve the motor and memory skills of tbi mice and demonstrated that in the acute phase, it increased the exchange of cerebrospinal and interstitial fluid, reversed the dysregulation and depolarization of aquaporin-4 in the cortex and hippocampus, improved the drainage of mlvs to deep cervical lymph nodes, and reduced tau accumulation and glial activation. |
2023-04-06 |
2023-08-14 |
mouse |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
here, we used quantitative immunohistochemistry to determine the density of posttranslational oligomeric (toc1 and tnt1), phosphorylated (at8), and late truncated (tauc3) tau epitopes within the mtl subfields including entorhinal cortex (ec) layer ii, subiculum, cornu ammonis (ca) subfields, and dentate gyrus (dg) in subjects who died with a clinical diagnosis of no cognitive impairment (nci), mild cognitive impairment (mci), and ad. |
2023-03-29 |
2023-08-14 |
human |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
decreased nuclear srsf2 in the presence of cytoplasmic phosphorylated tau suggests a dual-hit process in nft formation within the entorhinal hippocampal connectome during the onset of ad. |
2023-03-29 |
2023-08-14 |
human |
| Kangshuai Du, Yunxiao Dou, Kui Chen, Yanxin Zha. Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation. Experimental neurology. 2023-03-29. PMID:36990137. |
our data indicated that trpv4 activation increased tau phosphorylation in the cortex and hippocampus of p301s tauopathy mouse model and aggravated its cognitive decline. |
2023-03-29 |
2023-08-14 |
mouse |
| Ferre. The unique neuropathological vulnerability of the human brain to aging. Ageing research reviews. 2023-03-29. PMID:36990284. |
alzheimer's disease (ad)-related neurofibrillary tangles (nft), argyrophilic grain disease (agd), aging-related tau astrogliopathy (artag), limbic predominant tdp-43 proteinopathy (late), and amygdala-predominant lewy body disease (lbd) are proteinopathies that, together with hippocampal sclerosis, progressively appear in the elderly affecting from 50% to 99% of individuals aged 80 years, depending on the disease. |
2023-03-29 |
2023-08-14 |
human |
| Yusong Wu, Xiaohui Niu, Peifan Li, Tong Tong, Qinger Wang, Michael Zhang, Yongli Li, Jia Liu, Zuming L. Lactobacillaceae improve cognitive dysfunction via regulating gut microbiota and suppressing Aβ deposits and neuroinflammation in APP/PS1 mice. Archives of microbiology. vol 205. issue 4. 2023-03-17. PMID:36928985. |
furthermore, the expression of aβ plaques, tau phosphorylation and neuroinflammation were markedly reduced in the hippocampus. |
2023-03-17 |
2023-08-14 |
mouse |
| Benjamin B Tournier, Christophe Snoeijs, Stergios Tsartsalis, Quentin Amossé, Ramzi Farchoukh, Eniko Kövari, Kelly Ceyzériat, Philippe Mille. The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects. Aging brain. vol 2. 2023-03-13. PMID:36908874. |
to determine if tspo is associated with the presence of amyloid β plaques and/or phosphorylated tau accumulation, we analyzed hippocampal sections using immunohistochemistry of 14 non-demented subjects with positive staining for aβ and/or phosphorylated tau. |
2023-03-13 |
2023-08-14 |
human |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
we included 78 cognitively unimpaired identical twins with [18f]flutemetamol (amyloid-β)-pet, [18f]flortaucipir (tau)-pet, mri (hippocampal volume), and cognitive data (composite memory). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
within-pair differences in amyloid-β were strongly associated with within-pair differences in tau (β=0.68, p < 0.001), and moderately associated with within-pair differences in hippocampal volume (β=-0.37, p = 0.03) and memory functioning (β=-0.57, p < 0.001). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
within-pair differences in tau were moderately associated with within-pair differences in hippocampal volume (β=-0.53, p < 0.001) and strongly associated with within-pair differences in memory functioning (β=-0.68, p < 0.001). |
2023-03-09 |
2023-08-14 |
Not clear |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M Tijms, Luigi Lorenzini, Mara Ten Kate, Lyduine E Collij, Fiona Heeman, Roos M Rikken, Sophie M van der Landen, Marijke E den Hollander, Sandeep S V Golla, Maqsood Yaqub, Albert D Windhorst, Frederik Barkhof, Philip Scheltens, Eco J C de Geus, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twin-pair difference models support the amyloid cascade hypothesis. Brain : a journal of neurology. 2023-03-09. PMID:36892415. |
mediation analyses showed that of the total twin-difference effect of amyloid-β on memory functioning, the proportion mediated through pathways including tau and hippocampal volume was 69.9%, which was largely attributable to the pathway leading from amyloid-β to tau to memory functioning (proportion mediated: 51.6%). |
2023-03-09 |
2023-08-14 |
Not clear |
| Kayvan Khoramipour, Mohammad Abbas Bejeshk, Mohammad Amin Rajizadeh, Hamid Najafipour, Padideh Dehghan, Fattaneh Farahman. High-Intensity Interval Training Ameliorates Molecular Changes in the Hippocampus of Male Rats with the Diabetic Brain: the Role of Adiponectin. Molecular neurobiology. 2023-03-06. PMID:36877358. |
this study investigated the impact of high-intensity interval training (hiit) on diabetes-induced disturbances in ad-related factors (including amp-activated protein kinase (ampk), glycogen synthase kinase-3β (gsk3β), and tau protein) in the hippocampus, with the main focus on adiponectin signaling.in total, 28 male wistar rats at the age of 8 weeks were randomly assigned to four groups (n = 7 in each group): control (con), type 2 diabetes (t2d), hiit (ex), and type 2 diabetes + hiit (t2d + ex). |
2023-03-06 |
2023-08-14 |
rat |
| Marco Antônio De Bastiani, Bruna Bellaver, Wagner S Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimme. Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies. Brain, behavior, and immunity. 2023-03-06. PMID:36878332. |
hippocampal gfap-positive astrocyte responses to amyloid and tau pathologies. |
2023-03-06 |
2023-08-14 |
mouse |
| Marco Antônio De Bastiani, Bruna Bellaver, Wagner S Brum, Debora G Souza, Pamela C L Ferreira, Andreia S Rocha, Guilherme Povala, João Pedro Ferrari-Souza, Andrea L Benedet, Nicholas J Ashton, Thomas K Karikari, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto, Tharick A Pascoal, Eduardo R Zimme. Hippocampal GFAP-positive astrocyte responses to amyloid and tau pathologies. Brain, behavior, and immunity. 2023-03-06. PMID:36878332. |
here we investigated biomarker and transcriptomic associations of hippocampal gfap-positive astrocytes with aβ and tau pathologies in humans and mouse models. |
2023-03-06 |
2023-08-14 |
mouse |