All Relations between microtubule-associated protein tau and isocortex

Reference Sentence Publish Date Extraction Date Species
Isidro Ferrer, Pol Andr\\xc3\\xa9s-Benito, Karina Aus\\xc3\\xadn, Paz Cartas-Cejudo, Mercedes Lach\\xc3\\xa9n-Montes, Jos\\xc3\\xa9 Antonio Del Rio, Joaqu\\xc3\\xadn Fern\\xc3\\xa1ndez-Irigoyen, Enrique Santamar\\xc3\\xad. Dysregulated Protein Phosphorylation in a Mouse Model of FTLD-Tau. Journal of neuropathology and experimental neurology vol issue 2022 35848963 the neocortex of p301s mice, used as a model of fronto-temporal lobar degeneration linked to tau mutation (ftld-tau), and wild-type mice, both aged 9\xe2\x80\x89months, were analyzed with conventional label-free phosphoproteomics and swath-ms (sequential window acquisition of all theoretical fragment ion spectra mass spectrometry) to assess the (phospho)proteomes. 2022-07-18 2022-07-19 Not clear
Michael S Pollanen, Sylvester Onzivua, Paul M McKeever, Janice Robertson, Ian R Mackenzie, Gabor G Kovacs, Francis Olwa, David L Kitara, Amanda Fon. The spectrum of disease and tau pathology of nodding syndrome in Uganda. Brain : a journal of neurology vol issue 2022 35411378 all cases showed some degree of tau pathology in the neocortex and in the locus coeruleus with frequent involvement of the substantia nigra and tegmental nuclei and lesser involvement of other grey matter sites, but there was a lack of glial tau pathology. 2022-04-12 2022-04-14 Not clear
Michael S Pollanen, Sylvester Onzivua, Paul M McKeever, Janice Robertson, Ian R Mackenzie, Gabor G Kovacs, Francis Olwa, David L Kitara, Amanda Fon. The spectrum of disease and tau pathology of nodding syndrome in Uganda. Brain : a journal of neurology vol issue 2022 35411378 the tau pathology in the neocortex showed a multifocal superficial laminar pattern. 2022-04-12 2022-04-14 Not clear
Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne, Joseph Classen, Andrew W Stephens, Osama Sabri, Henryk Barthel, On Behalf Of The German Imaging Initiative For Tauopathies Gii . Multicenter Biomolecules vol 12 issue 3 2022 35327650 multicenter tau aggregates accumulate in the alzheimer's disease (ad) brain according to the established braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. 2022-03-25 2022-04-14 Not clear
Shinobu Kawakatsu, Ryota Kobayashi, Hiroshi Hayashi, Daichi Morioka, Aya Utsunomiya, Takanobu Kabasawa, Rintaro Ohe, Koichi Otan. Clinicopathological heterogeneity of Alzheimer's disease with pure Alzheimer's disease pathology: Cases associated with dementia with Lewy bodies, very early-onset dementia, and primary progressive aphasia. Neuropathology : official journal of the Japanese Society of Neuropathology vol issue 2021 34816507 tau deposits were also abundant in the cerebral neocortex, hippocampus, basal ganglia, and brain stem. 2021-11-24 2022-01-13 Not clear
Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances vol 6 issue 42 2021 33067235 tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. 2021-11-17 2022-01-13 Not clear
Alexander J Ehrenberg, Kun Leng, Kaitlyn N Letourneau, Israel Hernandez, Caroline Lew, William W Seeley, Salvatore Spina, Bruce Miller, Helmut Heinsen, Martin Kampmann, Kenneth S Kosik, Lea T Grinber. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta neuropathologica vol 141 issue 5 2021 33677647 we examined histological slides of allocortex and neocortex from multiple postmortem cases in five different tauopathies, ftld-tdp, and healthy controls using immunofluorescence for rhes, several tau post-translational modifications, and phospho-tdp-43. 2021-11-16 2022-01-13 Not clear
D Boche, J A R Nicol. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and applied neurobiology vol 46 issue 7 2021 32643143 therefore, a sequence of (i) neocortical a\xce\xb2 accumulation followed by (ii) a microglial inflammatory reaction to a\xce\xb2, causing neuritic dystrophy which promotes (iii) spread of tau from the limbic system to the neocortex with (iv) progressive tau accumulation and spread resulting in (v) neurodegeneration, explains the evidence. 2021-10-28 2022-01-13 Not clear
Tharick A Pascoal, Andrea L Benedet, Nicholas J Ashton, Min Su Kang, Joseph Therriault, Mira Chamoun, Melissa Savard, Firoza Z Lussier, C\\xc3\\xa9cile Tissot, Thomas K Karikari, Julie Ottoy, Sulantha Mathotaarachchi, Jenna Stevenson, Gassan Massarweh, Michael Sch\\xc3\\xb6ll, Mony J de Leon, Jean-Paul Soucy, Paul Edison, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Net. Microglial activation and tau propagate jointly across Braak stages. Nature medicine vol 27 issue 9 2021 34446931 compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in alzheimer's disease (ad). 2021-10-08 2022-01-13 Not clear
Juan Ram\\xc3\\xb3n Perea, Marta Bol\\xc3\\xb3s, Jes\\xc3\\xbas Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules vol 10 issue 10 2021 33066368 this pathology is characterized by the accumulation of amyloid-\xce\xb2 peptide (a\xce\xb2), which forms senile plaques in the neocortex, as well as by the aggregation of hyperphosphorylated tau protein, a process that leads to the development of neurofibrillary tangles (nfts). 2021-09-07 2022-01-13 Not clear
Christina N Rogers Flattery, Rebecca F Rosen, Aaron S Farberg, Jeromy M Dooyema, Patrick R Hof, Chet C Sherwood, Lary C Walker, Todd M Preus. Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans. Brain structure & function vol 225 issue 8 2021 32909100 we also sought evidence of\xc2\xa0a\xce\xb2\xc2\xa0deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. 2021-08-11 2022-01-13 Not clear
Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine vol 52 issue 8 2021 32859953 the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. 2021-08-10 2022-01-13 Not clear
Kimberly L Fiock, Jodi D Smith, John F Crary, Marco M Heft. \\xce\\xb2-amyloid and tau pathology in the aging feline brain. The Journal of comparative neurology vol 528 issue 1 2021 31273784 in 75% of these cases (3/4), tau deposition was limited to entorhinal cortex, while one case showed diffuse positive staining throughout the hippocampal formation and neocortex. 2021-07-01 2022-01-13 Not clear
Vincent Dor\\xc3\\xa9, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Shenpeng Li, Samantha Burnham, Colin L Masters, Jurgen Fripp, Victor L Villemagne, Christopher C Row. Relationship between amyloid and tau levels and its impact on tau spreading. European journal of nuclear medicine and molecular imaging vol 48 issue 7 2021 33495928 however, the a\xce\xb2 levels necessary for tau to spread in the neocortex is still unclear. 2021-06-25 2022-01-13 Not clear
Saak V Ovsepian, Valerie B O'Leary, Cyril Hoschl, Laszlo Zaborszk. Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: A unifying hypothesis. Neuroscience letters vol 755 issue 2021 33862141 given that acetylcholine (ach) regulates properties of the microtubule-associated protein (map) tau and promotes non-amyloidogenic processing of amyloid precursor protein (app), growing neocortex predicts higher demands for ach, while the emerging role of bf cholinergic projections in a\xce\xb2 clearance infers greater exposure of source neurons and their innervation fields to amyloid pathology. 2021-06-08 2022-01-13 Not clear
Florian Eckenweber, Jose Medina-Luque, Tanja Blume, Christian Sacher, Gloria Biechele, Karin Wind, Maximilian Deussing, Nils Briel, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Marcus Unterrainer, Nathalie L Albert, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Paul Cumming, Axel Rominger, G\\xc3\\xbcnter U H\\xc3\\xb6glinger, Jochen Herms, Matthias Brende. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning. Journal of neuroinflammation vol 17 issue 1 2021 32660586 p301s tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. 2021-05-24 2022-01-13 Not clear
Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 41 issue 2 2021 33219003 studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of \xce\xb2-amyloid (a\xce\xb2) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). 2021-03-25 2022-01-13 Not clear
Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine vol 61 issue 10 2021 32764121 these elements are the extent of involvement (spread) by cerebral a\xce\xb2 based on the progression model defined by the thal a\xce\xb2 phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. 2021-03-09 2022-01-13 Not clear
Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports vol 30 issue 6 2021 32049030 alzheimer's disease (ad) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of \xce\xb2-amyloid in the neocortex. 2021-03-08 2022-01-13 Not clear
Renpei Sengok. Aging and Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology vol 40 issue 1 2020 31863504 braak advocates the spread of tau deposits from the entorhinal to associative regions of the neocortex as the disease progresses. 2020-11-12 2022-01-13 Not clear
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