| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ramón Perea, Marta Bolós, Jesús Avil. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. vol 10. issue 10. 2021-09-07. PMID:33066368. |
this pathology is characterized by the accumulation of amyloid-β peptide (aβ), which forms senile plaques in the neocortex, as well as by the aggregation of hyperphosphorylated tau protein, a process that leads to the development of neurofibrillary tangles (nfts). |
2021-09-07 |
2023-08-13 |
Not clear |
| Christina N Rogers Flattery, Rebecca F Rosen, Aaron S Farberg, Jeromy M Dooyema, Patrick R Hof, Chet C Sherwood, Lary C Walker, Todd M Preus. Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32909100. |
we also sought evidence of aβ deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. |
2021-08-11 |
2023-08-13 |
human |
| Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine. vol 52. issue 8. 2021-08-10. PMID:32859953. |
the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. |
2021-08-10 |
2023-08-13 |
Not clear |
| Kimberly L Fiock, Jodi D Smith, John F Crary, Marco M Heft. β-amyloid and tau pathology in the aging feline brain. The Journal of comparative neurology. vol 528. issue 1. 2021-07-01. PMID:31273784. |
in 75% of these cases (3/4), tau deposition was limited to entorhinal cortex, while one case showed diffuse positive staining throughout the hippocampal formation and neocortex. |
2021-07-01 |
2023-08-13 |
human |
| Vincent Doré, Natasha Krishnadas, Pierrick Bourgeat, Kun Huang, Shenpeng Li, Samantha Burnham, Colin L Masters, Jurgen Fripp, Victor L Villemagne, Christopher C Row. Relationship between amyloid and tau levels and its impact on tau spreading. European journal of nuclear medicine and molecular imaging. vol 48. issue 7. 2021-06-25. PMID:33495928. |
however, the aβ levels necessary for tau to spread in the neocortex is still unclear. |
2021-06-25 |
2023-08-13 |
Not clear |
| Saak V Ovsepian, Valerie B O'Leary, Cyril Hoschl, Laszlo Zaborszk. Integrated phylogeny of the human brain and pathobiology of Alzheimer's disease: A unifying hypothesis. Neuroscience letters. vol 755. 2021-06-08. PMID:33862141. |
given that acetylcholine (ach) regulates properties of the microtubule-associated protein (map) tau and promotes non-amyloidogenic processing of amyloid precursor protein (app), growing neocortex predicts higher demands for ach, while the emerging role of bf cholinergic projections in aβ clearance infers greater exposure of source neurons and their innervation fields to amyloid pathology. |
2021-06-08 |
2023-08-13 |
human |
| Florian Eckenweber, Jose Medina-Luque, Tanja Blume, Christian Sacher, Gloria Biechele, Karin Wind, Maximilian Deussing, Nils Briel, Simon Lindner, Guido Boening, Barbara von Ungern-Sternberg, Marcus Unterrainer, Nathalie L Albert, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Paul Cumming, Axel Rominger, Günter U Höglinger, Jochen Herms, Matthias Brende. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32660586. |
p301s tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. |
2021-05-24 |
2023-08-13 |
mouse |
| Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 2. 2021-03-25. PMID:33219003. |
studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of β-amyloid (aβ) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
these elements are the extent of involvement (spread) by cerebral aβ based on the progression model defined by the thal aβ phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. |
2021-03-09 |
2023-08-13 |
Not clear |
| Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049030. |
alzheimer's disease (ad) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. |
2021-03-08 |
2023-08-13 |
mouse |
| Renpei Sengok. Aging and Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 1. 2020-11-12. PMID:31863504. |
braak advocates the spread of tau deposits from the entorhinal to associative regions of the neocortex as the disease progresses. |
2020-11-12 |
2023-08-13 |
Not clear |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
the tau pathology starts from the entorhinal cortex (ec), spreads to the hippocampus and frontal and temporal cortices, and finally to all isocortex areas, but the cerebellum is spared from tau lesions. |
2020-10-01 |
2023-08-13 |
human |
| R A. Armstrong, P L. Lantos, N J. Cairn. The spatial patterns of pathological brain lesions in 12 patients with corticobasal degeneration. Pathophysiology : the official journal of the International Society for Pathophysiology. vol 8. issue 1. 2020-09-30. PMID:11476973. |
we studied the spatial patterns of the bn, tau positive neurons with inclusions (tau+ neurons), and tau positive plaques in the neocortex and hippocampus in 12 cases of cbd. |
2020-09-30 |
2023-08-12 |
Not clear |
| Camille Pernègre, Antoine Duquette, Nicole Lecler. Tau Secretion: Good and Bad for Neurons. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293374. |
in alzheimer's disease (ad), neurofibrillary tangles (nfts), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
agd has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. |
2020-09-28 |
2023-08-13 |
mouse |
| J Cummings, K Blennow, K Johnson, M Keeley, R J Bateman, J L Molinuevo, J Touchon, P Aisen, B Vella. Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force. The journal of prevention of Alzheimer's disease. vol 6. issue 3. 2020-07-30. PMID:31062825. |
both neuropathological and imaging studies indicate that tau first appears in the entorhinal cortex and then spreads to the neocortex. |
2020-07-30 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096045. |
top-down projections direct the gradual progression of alzheimer-related tau pathology throughout the neocortex. |
2020-04-08 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. Top-Down Projections Direct the Gradual Progression of Alzheimer-Related Tau Pathology Throughout the Neocortex. Advances in experimental medicine and biology. vol 1184. 2020-04-08. PMID:32096045. |
in sporadic alzheimer's disease (sad), tau pathology gradually but relentlessly progresses from the transentorhinal region of the temporal lobe into both the allocortex and temporal high order association areas of the neocortex. |
2020-04-08 |
2023-08-13 |
Not clear |
| Brendan P Lucey, Austin McCullough, Eric C Landsness, Cristina D Toedebusch, Jennifer S McLeland, Aiad M Zaza, Anne M Fagan, Lena McCue, Chengjie Xiong, John C Morris, Tammie L S Benzinger, David M Holtzma. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Science translational medicine. vol 11. issue 474. 2020-02-21. PMID:30626715. |
in alzheimer's disease (ad), deposition of insoluble amyloid-β (aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. |
2020-02-21 |
2023-08-13 |
human |
| Heiko Braak, Kelly Del Tredic. Spreading of Tau Pathology in Sporadic Alzheimer's Disease Along Cortico-cortical Top-Down Connections. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 9. 2019-11-13. PMID:29982389. |
we report the presence of abnormal tau changes within solitary pyramidal neurons in layers iii and v of the neocortex. |
2019-11-13 |
2023-08-13 |
Not clear |