| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stanislav Sutovsky, Tomas Smolek, Peter Turcani, Robert Petrovic, Petra Brandoburova, Santosh Jadhav, Petr Novak, Johannes Attems, Norbert Zilk. Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 6. 2019-11-12. PMID:29404783. |
in the neocortex, tau pathology, especially neuropil threads, was more abundant in the frontal and occipital cortex and in the hippocampus. |
2019-11-12 |
2023-08-13 |
human |
| Yvonne S Davidson, Andrew Robinson, Vee P Prasher, David M A Man. The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29973279. |
later, tau pathology spread throughout the neocortex reaching occipital lobes in most instances by mid-50 years of age. |
2019-06-04 |
2023-08-13 |
Not clear |
| Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V Kamath, George A Carlson, Israel Nelken, Bradley T Hyma. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559471. |
the coexistence of amyloid-β (aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in alzheimer's disease. |
2019-05-21 |
2023-08-13 |
Not clear |
| Andrew Arner, Edward Rockenstein, Michael Mante, Jazmin Florio, Deborah Masliah, Bahar Salehi, Anthony Adame, Cassia Overk, Eliezer Masliah, Robert A Rissma. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 3. 2019-01-17. PMID:29332037. |
we found that even in young animals we found that the presence of app/aβ increased the accumulation of 3r tau in the neocortex and hippocampus. |
2019-01-17 |
2023-08-13 |
mouse |
| Florence Clavaguera, Markus Tolnay, Michel Goeder. The Prion-Like Behavior of Assembled Tau in Transgenic Mice. Cold Spring Harbor perspectives in medicine. vol 7. issue 10. 2018-06-07. PMID:27940600. |
the pattern of tau deposition in alzheimer's disease follows a stereotypical progression, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2018-06-07 |
2023-08-13 |
mouse |
| Jesus Mendiola-Precoma, Karla Padilla, Alfredo Rodríguez-Cruz, Laura C Berumen, Ricardo Miledi, Guadalupe García-Alcoce. Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27792010. |
dementia caused by alzheimer's disease (ad) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus. |
2018-02-20 |
2023-08-13 |
rat |
| Tiina Laiterä, Jussi Paananen, Seppo Helisalmi, Timo Sarajärvi, Joel Huovinen, Marjo Laitinen, Tuomas Rauramaa, Irina Alafuzoff, Anne M Remes, Hilkka Soininen, Annakaisa Haapasalo, Juha E Jääskeläinen, Ville Leinonen, Mikko Hiltune. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-β Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2018-02-20. PMID:27802227. |
in alzheimer's disease (ad) patients, diffuse aggregates of amyloid-β (aβ) and neurofibrillary hyperphosphorylated tau are detected in the neocortex of the brain, while similar accumulation of aβ is also detected in inph. |
2018-02-20 |
2023-08-13 |
Not clear |
| Ana Laura Calderon-Garcidueñas, Charles Duyckaert. Alzheimer disease. Handbook of clinical neurology. vol 145. 2018-01-29. PMID:28987180. |
tau pathology affects in a stereotyped order some specific nuclei of the brainstem, the entorhinal area, the hippocampus, and the neocortex - first the associative areas and secondarily the primary cortices (braak stages). |
2018-01-29 |
2023-08-13 |
Not clear |
| Zhuang Song, Ian M McDonough, Peiying Liu, Hanzhang Lu, Denise C Par. Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults. NeuroImage. Clinical. vol 12. 2017-11-17. PMID:27408792. |
tau tangles, however, do often aggregate in the medial temporal lobe in parallel with amyloid deposition in the neocortex in ad. |
2017-11-17 |
2023-08-13 |
human |
| Toshiki Uchihara, Kentaro Endo, Hiromi Kondo, Sachi Okabayashi, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Eijiro Adachi, Nobuyuki Kimur. Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. Acta neuropathologica communications. vol 4. issue 1. 2017-10-24. PMID:27842611. |
we found, 1) extensive deposition of aβ in brains of cynomolgus monkeys over 25 years of age, 2) selective deposition of 4-repeat tau as pretangles in neurons, and as coiled body-like structures in oligodendroglia-like cells and astrocytes, 3) preferential distribution of tau in the basal ganglia and neocortex rather than the hippocampus, and 4) age-associated increases in 30-34 kda at8- and rd4-positive tau fragments in sarkosyl-insoluble fractions. |
2017-10-24 |
2023-08-13 |
human |
| Rachel E Bennett, Sarah L DeVos, Simon Dujardin, Bianca Corjuc, Rucha Gor, Jose Gonzalez, Allyson D Roe, Matthew P Frosch, Rose Pitstick, George A Carlson, Bradley T Hyma. Enhanced Tau Aggregation in the Presence of Amyloid β. The American journal of pathology. vol 187. issue 7. 2017-10-13. PMID:28500862. |
for example, amyloid deposition in the neocortex precedes the spread of tau neurofibrillary tangles from the limbic areas to the cortex. |
2017-10-13 |
2023-08-13 |
mouse |
| Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duf. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. PloS one. vol 11. issue 7. 2017-07-18. PMID:27466814. |
tau pathology was compared at four timepoints, up to 34 months as it spread through the hippocampal formation and out into the neocortex along an anatomically connected route. |
2017-07-18 |
2023-08-13 |
mouse |
| Hongjun Fu, S Abid Hussaini, Susanne Wegmann, Caterina Profaci, Jacob D Daniels, Mathieu Herman, Sheina Emrani, Helen Y Figueroa, Bradley T Hyman, Peter Davies, Karen E Duf. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. PloS one. vol 11. issue 7. 2017-07-18. PMID:27466814. |
as in human ad, mature tau pathology in the ec and the presence of tau pathology in the neocortex correlated with cognitive impairment. |
2017-07-18 |
2023-08-13 |
mouse |
| Brian Spencer, Paula A Desplats, Cassia R Overk, Elvira Valera-Martin, Robert A Rissman, Chengbiao Wu, Michael Mante, Anthony Adame, Jazmin Florio, Edward Rockenstein, Eliezer Maslia. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466341. |
alzheimer's disease (ad) is characterized by the progressive accumulation of amyloid β (aβ) and microtubule associate protein tau, leading to the selective degeneration of neurons in the neocortex, limbic system, and nucleus basalis, among others. |
2017-07-10 |
2023-08-13 |
mouse |
| David R Howlett, David Whitfield, Mary Johnson, Johannes Attems, John T O'Brien, Dag Aarsland, Mitchell K P Lai, Jasinda H Lee, Christopher Chen, Clive Ballard, Tibor Hortobágyi, Paul T Franci. Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. Brain pathology (Zurich, Switzerland). vol 25. issue 4. 2016-03-15. PMID:25103200. |
cortical α-synuclein, phosphorylated tau (phosphotau) and aβ plaque pathology in 34 pdd and 55 dlb patients was assessed semi-quantitatively in four regions of the neocortex. |
2016-03-15 |
2023-08-13 |
Not clear |
| Edward Rockenstein, Cassia R Overk, Kiren Ubhi, Michael Mante, Christina Patrick, Anthony Adame, Alejandro Bisquert, Margarita Trejo-Morales, Brian Spencer, Eliezer Maslia. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PloS one. vol 10. issue 3. 2016-02-22. PMID:25803611. |
by immunocytochemistry, mice from line 13 displayed extensive accumulation of 3r tau in neuronal cells bodies in the pyramidal neurons of the neocortex, ca1-3 regions, and dentate gyrus of the hippocampus. |
2016-02-22 |
2023-08-13 |
mouse |
| Tadashi Adachi, Michio Kitayama, Toshiya Nakano, Yoshiki Adachi, Shinsuke Kato, Kenji Nakashim. Autopsy case of spinocerebellar ataxia type 31 with severe dementia at the terminal stage. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 35. issue 3. 2016-02-19. PMID:25495291. |
our findings suggest that in sca31, accelerated tau and amyloid pathology in the neocortex might induce dementia at the terminal stage. |
2016-02-19 |
2023-08-13 |
Not clear |
| Daizo Kondo, Hiroaki Hino, Katsuhiko Shibuya, Koshiro Fujisawa, Kenji Kosaka, Yoshio Hirayasu, Ryoko Yamamoto, Koji Kasanuki, Michiko Minegishi, Kiyoshi Sato, Masato Hosokawa, Tetsuaki Arai, Heii Arai, Eizo Isek. An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 35. issue 3. 2016-02-19. PMID:25516199. |
tau isoform-specific immunostaining revealed that most tau-immunoreactive structures were positive for 4-repeat (4r) tau, but some of the nfts were positive for 3-repeat (3r) tau in the cerebral neocortex. |
2016-02-19 |
2023-08-13 |
Not clear |
| Leyan Xu, Jiwon Ryu, Judy V Nguyen, John Arena, Elizabeth Rha, Pamela Vranis, Devon Hitt, Nicholas Marsh-Armstrong, Vassilis E Koliatso. Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury. Experimental neurology. vol 273. 2016-02-18. PMID:26311071. |
we explored the progression of tauopathy in the retina and neocortex based on density of neuronal profiles loaded with tau ps422, a marker of advanced tau hyperphosphorylation. |
2016-02-18 |
2023-08-13 |
mouse |
| F Clavaguera, J Hench, M Goedert, M Tolna. Invited review: Prion-like transmission and spreading of tau pathology. Neuropathology and applied neurobiology. vol 41. issue 1. 2015-09-15. PMID:25399729. |
in the most prevalent tauopathy, alzheimer's disease, tau pathology progresses in a stereotypical manner with the first lesions appearing in the locus coeruleus and the entorhinal cortex from where they appear to spread to the hippocampus and neocortex. |
2015-09-15 |
2023-08-13 |
Not clear |