All Relations between microtubule-associated protein tau and mesencephalon

Publication Sentence Publish Date Extraction Date Species
Jiaying Lu, Jingjie Ge, Hai Yu, Guixian Zhao, Xiangjun Che. Colocalization of Increased Midbrain Signals in Neuroinflammation and Tau PET Imaging Suggests the Diagnosis of Progressive Supranuclear Palsy. Clinical nuclear medicine. 2024-01-26. PMID:38271226. colocalization of increased midbrain signals in neuroinflammation and tau pet imaging suggests the diagnosis of progressive supranuclear palsy. 2024-01-26 2024-01-28 Not clear
Jiaying Lu, Jingjie Ge, Hai Yu, Guixian Zhao, Xiangjun Che. Colocalization of Increased Midbrain Signals in Neuroinflammation and Tau PET Imaging Suggests the Diagnosis of Progressive Supranuclear Palsy. Clinical nuclear medicine. 2024-01-26. PMID:38271226. subsequently, colocalization of increased midbrain signals was observed in neuroinflammation pet using [ 18 f]dpa-714 and in tau pet using [ 18 f]florzolotau, suggesting the diagnosis of progressive supranuclear palsy. 2024-01-26 2024-01-28 Not clear
Ryota Satoh, Farwa Ali, Hugo Botha, Val L Lowe, Keith A Josephs, Jennifer L Whitwel. Direct Comparison between NeuroImage. 2024-01-06. PMID:38184157. direct comparison between the pattern of flortaucipir tau pet uptake is topographically similar to the pattern of magnetic susceptibility in progressive supranuclear palsy (psp); both with increased signal in subcortical structures such as the basal ganglia and midbrain, suggesting that they may be closely related. 2024-01-06 2024-01-09 Not clear
Lingchao Li, Bin Ji, Min Zhao, Lin Bai, Bin Che. Nonfluent Variant Primary Progressive Aphasia on FDG, 11C-PIB, and 18F-APN-1607 PET Imaging. Clinical nuclear medicine. 2023-09-27. PMID:37756439. the 11c-pib pet showed no amyloid accumulation; the 18f-fdg pet showed hypometabolism in the bilateral frontal lobe, temporal lobe, and midbrain; and the 18f-apn-1607 pet showed tau accumulation in the brainstem, basal ganglia, and left inferior frontal gyrus. 2023-09-27 2023-10-07 Not clear
Valeria Parrales-Macias, Patrick P Michel, Aurore Tourville, Rita Raisman-Vozari, Stéphane Haïk, Stéphane Hunot, Nicolas Bizat, Annie Lannuze. The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and Cells. vol 12. issue 9. 2023-05-14. PMID:37174736. the pesticide chlordecone promotes parkinsonism-like neurodegeneration with tau lesions in midbrain cultures and chlordecone (cld) is an organochlorine pesticide (ocp) that is currently banned but still contaminates ecosystems in the french caribbean. 2023-05-14 2023-08-14 mouse
Aisan Farhadi, Mehdi Totonchi, Seyed Masood Nabavi, Hossein Baharvand, Hossein Pakdaman, Ensiyeh Hajizadeh-Saffar, Seyed Ahmad Mousavi, Fatemeh Hadi, Hamed Al-Sinawi, Quan Li, Jin-San Zhang, Yaser Tahamtani, Koorosh Shahpasan. P38 Initiates Degeneration of midbrain GABAergic and Glutamatergic Neurons in Diabetes Models. The European journal of neuroscience. 2022-05-05. PMID:35513862. we observed that oxidative stress activated p38, which directly and indirectly drove tau pathology in the gabaergic and glutamatergic neurons of the midbrain of the diabetic mice after 96 hours, which accumulated in the other neighboring brain areas after two months. 2022-05-05 2023-08-13 mouse
Aisan Farhadi, Mehdi Totonchi, Seyed Masood Nabavi, Hossein Baharvand, Hossein Pakdaman, Ensiyeh Hajizadeh-Saffar, Seyed Ahmad Mousavi, Fatemeh Hadi, Hamed Al-Sinawi, Quan Li, Jin-San Zhang, Yaser Tahamtani, Koorosh Shahpasan. P38 Initiates Degeneration of midbrain GABAergic and Glutamatergic Neurons in Diabetes Models. The European journal of neuroscience. 2022-05-05. PMID:35513862. we showed that diabetes-related stresses and glucose metabolism deficiency could induce cis p-tau (an early driver of the tau pathology) accumulation in the midbrain and corpus callosum of the diabetic mice models and cells treated with 2-deoxy-d-glucose, respectively. 2022-05-05 2023-08-13 mouse
Kaidong Wang, Baofu Zhang, Tian Tian, Bingyang Zhang, Ge Shi, Chunhui Zhang, Guoliang Li, Min Huan. Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways. Amino acids. 2021-11-27. PMID:34837554. in conclusion, our results suggest that tau may regulate microglia-mediated inflammatory responses through inhibition of the pi3k/akt pathway in the midbrain of pd mice, thereby reducing dac neurons damage. 2021-11-27 2023-08-13 mouse
Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R Martin, Stacy R Loushin, Matthew L Senjem, Robert I Reid, Christopher G Schwarz, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell, Farwa Al. Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34655905. progressive supranuclear palsy is a neurodegenerative disorder characterized primarily by tau inclusions and neurodegeneration in the midbrain, basal ganglia, thalamus, premotor and frontal cortex. 2021-11-17 2023-08-13 Not clear
David Wallon, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, Antoine Bonnevalle, Marie Sarazin, Michel Bottlaender, Mathieu Mula, Serge Marty, Natsuko Nakamura, Catherine Schramm, François Sellal, Thérèse Jonveaux, Camille Heitz, Isabelle Le Ber, Stéphane Epelbaum, Eloi Magnin, Aline Zarea, Stéphane Rousseau, Olivier Quenez, Didier Hannequin, Florence Clavaguera, Dominique Campion, Charles Duyckaerts, Gaël Nicola. Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:34095977. distribution, aspect and 4r/3r tau aggregates composition suggested a spectrum from predominantly 3r, mainly cortical deposits well correlating with cognitive and behavioral changes, to predominantly 4r deposits, mainly in the basal ganglia and midbrain, in patients with prominent extrapyramidal syndrome. 2021-08-16 2023-08-13 human
Jordan Follett, Matthew J Farre. LRRK2; a dynamic regulator of cellular trafficking. Brain research. vol 1761. 2021-03-21. PMID:33662339. nevertheless, the age-associated midbrain pathology observed post-mortem in lrrk2-parkinsonism may involve the abnormal accumulation of either α-synuclein or tau, or just the loss of dopaminergic neurons and gliosis. 2021-03-21 2023-08-13 Not clear
Luyan Jiao, Meige Zheng, Jinhai Duan, Ting Wu, Zhao Li, Lin Liu, Xianhong Xiang, Xiaolu Tang, Jinyang He, Xingjian Li, Guofeng Zhang, Jinhui Ding, Huaibin Cai, Xian Li. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 9. 2021-03-16. PMID:33000527. to investigate how the expression of tau affects α-syn-induced neurodegeneration in vivo, we generated triple transgenic mice that overexpressed α-syn a53t mutation in the midbrain dopaminergic neurons (mdans) with different expression levels of tau. 2021-03-16 2023-08-13 mouse
Eun-Joo Kim, Ji-Hye L Hwang, Stephanie E Gaus, Alissa L Nana, Jersey Deng, Jesse A Brown, Salvatore Spina, Myung Jun Lee, Eliana Marisa Ramos, Lea T Grinberg, Joel H Kramer, Adam L Boxer, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William W Seele. Evidence of corticofugal tau spreading in patients with frontotemporal dementia. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31542807. within each clinical syndrome, there were predicted relationships between cortical atrophy patterns and axonal tau deposition in midbrain cerebral peduncle and pontine base. 2021-01-19 2023-08-13 human
Onder Albayram, Bryce MacIver, John Mathai, Anne Verstegen, Sean Baxley, Chenxi Qiu, Carter Bell, Barbara J Caldarone, Xiao Zhen Zhou, Kun Ping Lu, Mark Zeide. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific reports. vol 9. issue 1. 2020-10-15. PMID:31201348. hyperphosphorylated tau deposition and neural tangle-like pathology occurred in cortical and hippocampal regions only of igg control mice accompanied with post-traumatic neuroinflammation and was not seen in midbrain and hindbrain regions associated with bladder filling and voiding reflex arcs. 2020-10-15 2023-08-13 mouse
Adnan A Hirad, Jeffrey J Bazarian, Kian Merchant-Borna, Frank E Garcea, Sarah Heilbronner, David Paul, Eric B Hintz, Edwin van Wijngaarden, Giovanni Schifitto, David W Wright, Tamara R Espinoza, Bradford Z Maho. A common neural signature of brain injury in concussion and subconcussion. Science advances. vol 5. issue 8. 2020-05-05. PMID:31457074. we then replicate the observation of reduced midbrain white matter integrity in a retrospective cohort of individuals with frank concussion, and further show that variance in white matter integrity is correlated with levels of serum-based tau, a marker of blood-brain barrier disruption. 2020-05-05 2023-08-13 Not clear
Bennet Omalu, Gary W Small, Julian Bailes, Linda M Ercoli, David A Merrill, Koon-Pong Wong, Sung-Cheng Huang, Nagichettiar Satyamurthy, Jennifer L Hammers, John Lee, Robert P Fitzsimmons, Jorge R Barri. Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy. Neurosurgery. vol 82. issue 2. 2019-09-04. PMID:29136240. [f-18]fddnp-pet signals may be consistent with neuropathological patterns of tau deposition in cte, involving areas that receive the maximal shearing, angular-rotational acceleration-deceleration forces in american football players, consistent with distinctive and differential topographic vulnerability and selectivity of cte beyond brain cortices, also involving midbrain and limbic areas. 2019-09-04 2023-08-13 human
Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Krame. The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb. Pediatric research. vol 83. issue 6. 2019-08-12. PMID:29741516. the overall microglial response and tau phosphorylation were also measured in the sn, surrounding the midbrain gray matter structures and the hippocampal white matter.resultsthe isoflurane-treated uco group had fewer tyrosine hydroxylase-expressing neurons in the sn at 8 h after the insult than the propofol-treated uco or sham-operated groups (p<0.05). 2019-08-12 2023-08-13 Not clear
Thomas E Cope, Timothy Rittman, Robin J Borchert, P Simon Jones, Deniz Vatansever, Kieren Allinson, Luca Passamonti, Patricia Vazquez Rodriguez, W Richard Bevan-Jones, John T O'Brien, James B Row. Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy. Brain : a journal of neurology. vol 141. issue 2. 2019-05-30. PMID:29293892. further, we demonstrate that in psp increasing tau burden in midbrain and deep nuclei was associated with strengthened cortico-cortical functional connectivity. 2019-05-30 2023-08-13 Not clear
Xiaolu Tang, Luyan Jiao, Meige Zheng, Yan Yan, Qi Nie, Ting Wu, Xiaomei Wan, Guofeng Zhang, Yonglin Li, Song Wu, Bin Jiang, Huaibin Cai, Pingyi Xu, Jinhai Duan, Xian Li. Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice. Neuroscience. vol 373. 2018-11-26. PMID:29337233. in this study, we examined motor functions and analyzed several proteins implicated in the maintenance of midbrain dopaminergic (da) neurons (mdans) function of adult and aged tau 2018-11-26 2023-08-13 mouse
Marta Marquié, Eline E Verwer, Avery C Meltzer, Sally Ji Who Kim, Cinthya Agüero, Jose Gonzalez, Sara J Makaretz, Michael Siao Tick Chong, Prianca Ramanan, Ana C Amaral, Marc D Normandin, Charles R Vanderburg, Stephen N Gomperts, Keith A Johnson, Matthew P Frosch, Teresa Gómez-Isl. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta neuropathologica communications. vol 5. issue 1. 2018-06-13. PMID:29047416. in vivo uptake has also consistently been observed in midbrain, basal ganglia and choroid plexus in elderly individuals regardless of their clinical diagnosis, including clinically normal whose brains are not expected to harbor tau pathology in those areas. 2018-06-13 2023-08-13 human