All Relations between microtubule-associated protein tau and mesencephalon

Publication Sentence Publish Date Extraction Date Species
Annachiara Cagnin, Sara Mariotto, Michele Fiorini, Marina Gaule, Nicola Bonetto, Matteo Tagliapietra, Emanuele Buratti, Gianluigi Zanusso, Sergio Ferrari, Salvatore Monac. Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy. Journal of Alzheimer's disease : JAD. vol 59. issue 1. 2018-04-06. PMID:28550263. postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal tdp-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain. 2018-04-06 2023-08-13 Not clear
Kateřina Storey, Silvie Johanidesová, Radoslav Matěj, Jiří Keller, Zdeněk Rohan, Robert Rusin. FTLD-TDP and progressive supranuclear palsy in comorbidity-a report of two cases with different clinical presentations. Neurocase. vol 23. issue 1. 2018-02-20. PMID:27915581. neuropathological examination revealed neuronal and glial tau pathology together with ubiquitin, and phospho-tdp-43-immunoreactivities in the hippocampus, striatum, mesencephalon, and frontal and temporal cortices. 2018-02-20 2023-08-13 Not clear
Sara Garcia-Ratés, Paul Morrill, Henry Tu, Gwenael Pottiez, Antoine-Scott Badin, Cristina Tormo-Garcia, Catherine Heffner, Clive W Coen, Susan A Greenfiel. (I) Pharmacological profiling of a novel modulator of the α7 nicotinic receptor: Blockade of a toxic acetylcholinesterase-derived peptide increased in Alzheimer brains. Neuropharmacology. vol 105. 2017-06-21. PMID:26867503. here we show for the first time that (1) a peptide derived from acetylcholinesterase, with independent trophic functions that turn toxic in maturity, is significantly raised in the alzheimer midbrain and cerebrospinal fluid; (2) a synthetic version of this peptide enhances calcium influx and eventual production of amyloid beta and tau phosphorylation via an allosteric site on the α7 nicotinic receptor; (3) a synthetic cyclic version of this peptide is neuroprotective against the toxicity not only of its linear counterpart but also of amyloid beta, thereby opening up the prospect of a novel therapeutic approach. 2017-06-21 2023-08-13 Not clear
Allan K Hansen, Karoline Knudsen, Thea P Lillethorup, Anne M Landau, Peter Parbo, Tatyana Fedorova, Hélène Audrain, Dirk Bender, Karen Østergaard, David J Brooks, Per Borghamme. In vivo imaging of neuromelanin in Parkinson's disease using 18F-AV-1451 PET. Brain : a journal of neurology. vol 139. issue Pt 7. 2017-05-10. PMID:27190023. the tau tangle ligand (18)f-av-1451 ((18)f-t807) binds to neuromelanin in the midbrain, and may therefore be a measure of the pigmented dopaminergic neuronal count in the substantia nigra. 2017-05-10 2023-08-13 human
Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. the hippocampus, midbrain, and cerebellum of aged (14 to 18 months old) non-transgenic (ntg) and transgenic mice overexpressing wild-type human tau (tg601 mice) were evaluated after a treatment with stz. 2016-12-29 2023-08-13 mouse
Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. tau hyperphosphorylation was also enhanced in the hippocampus, but not in the midbrain or cerebellum. 2016-12-29 2023-08-13 mouse
Akane Nogami, Mineo Yamazaki, Yuko Saito, Hiroyuki Hatsuta, Yoshio Sakiyama, Masaki Takao, Kazumi Kimura, Shigeo Murayam. Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. vol 82. issue 6. 2016-11-14. PMID:26823029. then, we used anti-phosphorylated tau antibody to immunostain sections from the basal ganglia, subthalamic nucleus, midbrain, pons, medulla, and cerebellum. 2016-11-14 2023-08-13 Not clear
Akane Nogami, Mineo Yamazaki, Yuko Saito, Hiroyuki Hatsuta, Yoshio Sakiyama, Masaki Takao, Kazumi Kimura, Shigeo Murayam. Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. vol 82. issue 6. 2016-11-14. PMID:26823029. paraffin sections of the midbrain were immunostained with anti 4-repeat tau antibodies (rd4). 2016-11-14 2023-08-13 Not clear
María Elena Erro Aguirre, María Victoria Zelaya, Javier Sánchez Ruiz de Gordoa, María Teresa Tuñón, José Luis Lancieg. Midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy. Frontiers in neuroanatomy. vol 9. 2015-03-27. PMID:25814937. midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy. 2015-03-27 2023-08-13 Not clear
Casper Jansen, Piero Parchi, Sabina Capellari, Rosaria Strammiello, Elise G P Dopper, John C van Swieten, Wouter Kamphorst, Annemieke J M Rozemulle. A second case of Gerstmann-Sträussler-Scheinker disease linked to the G131V mutation in the prion protein gene in a Dutch patient. Journal of neuropathology and experimental neurology. vol 70. issue 8. 2011-09-16. PMID:21760536. in addition, there were tau accumulations around numerous amyloid deposits in the cerebral cortex, striatum, hippocampal formation, and midbrain. 2011-09-16 2023-08-12 Not clear
David J Houghton, Irene Litva. Unraveling progressive supranuclear palsy: from the bedside back to the bench. Parkinsonism & related disorders. vol 13 Suppl 3. 2009-04-01. PMID:18267262. the pathological hallmark of psp is widespread neuronal cell loss with deposition of aggregated hyperphosphorylated tau, particularly within the midbrain. 2009-04-01 2023-08-12 Not clear
Jose A Rodríguez-Navarro, Ana Gómez, Izaskun Rodal, Juan Perucho, Armando Martinez, Vicente Furió, Israel Ampuero, María J Casarejos, Rosa M Solano, Justo García de Yébenes, Maria A Men. Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Human molecular genetics. vol 17. issue 20. 2008-11-12. PMID:18640988. pk(-/-)/tau(vlw) mice have abnormal behaviour and severe drop out of dopamine neurons in the ventral midbrain, up to 70%, at 12 months and abundant phosphorylated tau positive neuritic plaques, neuro-fibrillary tangles, astrogliosis, microgliosis and plaques of murine beta-amyloid in the hippocampus. 2008-11-12 2023-08-12 mouse
P L Edds-Walton, R R Fa. Directional selectivity and frequency tuning of midbrain cells in the oyster toadfish, Opsanus tau. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 189. issue 7. 2003-10-03. PMID:12827421. directional selectivity and frequency tuning of midbrain cells in the oyster toadfish, opsanus tau. 2003-10-03 2023-08-12 Not clear
Dominique Caparros-Lefebvre, Nicolas Sergeant, Andrew Lees, Agnes Camuzat, Susan Daniel, Annie Lannuzel, Alexis Brice, Eduardo Tolosa, Andre Delacourte, Charles Duyckaert. Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy. Brain : a journal of neurology. vol 125. issue Pt 4. 2002-05-10. PMID:11912113. neuropathological examination showed an accumulation of tau proteins, predominating in the midbrain. 2002-05-10 2023-08-12 Not clear
Tao Xie, Liqiong Tong, Tanya Barrett, Jie Yuan, George Hatzidimitriou, Una D McCann, Kevin G Becker, David M Donovan, George A Ricaurt. Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756511. this led to the identification of several genes in the ventral midbrain associated with the neurotoxic process, including genes for energy metabolism [cytochrome c oxidase subunit 1 (cox1), reduced nicotinamide adenine dinucleotide ubiquinone oxidoreductase chain 2, and phosphoglycerate mutase b], ion regulation (members of sodium/hydrogen exchanger and sodium/bile acid cotransporter family), signal transduction (adenylyl cyclase iii), and cell differentiation and degeneration (n-myc downstream-regulated gene 3 and tau protein). 2002-02-04 2023-08-12 Not clear
J Kulczycki, W Kura. [Progressive supranuclear palsy, diagnostic problems in the light of own case]. Neurologia i neurochirurgia polska. vol 32. issue 6. 1999-06-21. PMID:10358839. the main features of neuropathological changes are described fibrillary degeneration and atrophy of neurons in midbrain and pons, with accumulation of tau protein in the neurons and astrocytes in the areas involved by the process. 1999-06-21 2023-08-12 Not clear
K T Wong, I V Allen, S McQuaid, R McConnel. An immunohistochemical study of neurofibrillary tangle formation in post-encephalitic Parkinsonism. Clinical neuropathology. vol 15. issue 1. 1997-01-17. PMID:8998852. staining patterns for tau protein, ubiquitin and beta/a4 amyloid protein were studied in frontal lobe, hippocampus, and midbrain in 2 classical cases of pep, 2 cases of ad and 2 controls matched for age and sex. 1997-01-17 2023-08-12 Not clear
R Durán, M C Arufe, B Arias, M Alfons. Effect of domoic acid on brain amino acid levels. Revista espanola de fisiologia. vol 51. issue 1. 1995-11-06. PMID:7569276. dose induces changes in the levels of amino acids of neurochemical interest (asp, glu, gly, tau, ala, gaba) in different rat brain regions (hypothalamus, hippocampus, amygdala, striatum, cortex and midbrain). 1995-11-06 2023-08-12 rat
H Rösner, M Rebhan, G Vacun, E Vanmechele. Expression of a paired helical filament tau epitope in embryonic chicken central nervous system. Neuroreport. vol 5. issue 9. 1994-10-11. PMID:7521684. immunoblots from embryonic chicken optic lobes (midbrain) and spinal cord were found to contain different proteins with a molecular weight between 45 and 70 kda that are recognized by monoclonal antibodies (mabs) directed at human tau proteins. 1994-10-11 2023-08-12 human