| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noel J Leigh, Michelle K Page, Denisha L Robinson, Scott D Heldwein, Richard J O'Connor, Maciej L Goniewic. Nicotine, Humectants, and Tobacco-Specific Nitrosamines (TSNAs) in IQOS Heated Tobacco Products (HTPs): A Cross-Country Study. Toxics. vol 12. issue 3. 2024-03-27. PMID:38535913. |
this cross-sectional study examined the content of nicotine, two humectants (propylene glycol (pg) and vegetable glycerin (vg)), and four tobacco-specific nitrosamines (tsnas: nnn, nnk, nat, and nab) in the tobacco filler of a popular htp brand (iqos). |
2024-03-27 |
2024-03-29 |
human |
| Jie Zhang, Xingyu Liu, Bing Shi, Zhendong Yang, Yanbo Luo, Tongguang Xu, Deshui Liu, Chengyong Jiang, Guorong Du, Nan Lu, Chen Zhang, Yanjun Ma, Ruoshi Bai, Jun Zho. Investigation of exposure biomarkers in human plasma following differing levels of tobacco-specific N-nitrosamines and nicotine in cigarette smoke. Environmental research. 2022-07-14. PMID:35835167. |
the main objective of this study was to investigate the effects of cigarette smoke with different yields of tsnas (nnk, nnn, nat, nab) and nicotine on the levels of biomarkers of exposure in smokers' plasma. |
2022-07-14 |
2023-08-14 |
human |
| Jie Zhang, Xingyu Liu, Bing Shi, Zhendong Yang, Yanbo Luo, Tongguang Xu, Deshui Liu, Chengyong Jiang, Guorong Du, Nan Lu, Chen Zhang, Yanjun Ma, Ruoshi Bai, Jun Zho. Investigation of exposure biomarkers in human plasma following differing levels of tobacco-specific N-nitrosamines and nicotine in cigarette smoke. Environmental research. 2022-07-14. PMID:35835167. |
these findings suggested that the total nnal, nnn, nat, nab and cotinine in plasma were valid and reliable biomarkers for human exposure to tsnas and nicotine. |
2022-07-14 |
2023-08-14 |
human |
| Jie Zhang, Xingyu Liu, Bing Shi, Zhendong Yang, Yanbo Luo, Tongguang Xu, Deshui Liu, Chengyong Jiang, Guorong Du, Nan Lu, Chen Zhang, Yanjun Ma, Ruoshi Bai, Jun Zho. Investigation of exposure biomarkers in human plasma following differing levels of tobacco-specific N-nitrosamines and nicotine in cigarette smoke. Environmental research. 2022-07-14. PMID:35835167. |
the results showed that nnal, nat, nnn, nab and cotinine in the plasma of smokers smoking cigarette with low tsnas and nicotine were lower than that with high tsnas and nicotine. |
2022-07-14 |
2023-08-14 |
human |
| Xingyu Liu, Jie Zhang, Chen Zhang, Bicheng Yang, Limeng Wang, Jun Zho. The inhibition of cytochrome P450 2A13-catalyzed NNK metabolism by NAT, NAB and nicotine. Toxicology research. vol 5. issue 4. 2020-09-30. PMID:30090417. |
the inhibition of cytochrome p450 2a13-catalyzed nnk metabolism by nat, nab and nicotine. |
2020-09-30 |
2023-08-13 |
Not clear |
| M R Castino, D Baker-Andresen, V S Ratnu, G Shevchenko, K V Morris, T W Bredy, N A Youngson, K J Clemen. Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857504. |
quantitative pcr-identified changes in several genes associated with nab treatment that were independent of nicotine exposure; however, an interaction of nicotine history and nab treatment was detected only in the expression of bdnf iv and bdnf ix. |
2018-08-30 |
2023-08-13 |
rat |
| M R Castino, D Baker-Andresen, V S Ratnu, G Shevchenko, K V Morris, T W Bredy, N A Youngson, K J Clemen. Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857504. |
rats received intravenous nicotine or saline self-administration, followed by 6 days of extinction training, with each extinction session followed immediately by treatment with nab or vehicle. |
2018-08-30 |
2023-08-13 |
rat |
| M R Castino, D Baker-Andresen, V S Ratnu, G Shevchenko, K V Morris, T W Bredy, N A Youngson, K J Clemen. Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857504. |
a history of nicotine exposure significantly decreased h3k14 acetylation at the brain-derived neurotrophic factor (bdnf) exon iv promoter, and this effect was abolished with nab treatment. |
2018-08-30 |
2023-08-13 |
rat |
| M R Castino, D Baker-Andresen, V S Ratnu, G Shevchenko, K V Morris, T W Bredy, N A Youngson, K J Clemen. Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, brain, and behavior. vol 17. issue 2. 2018-08-30. PMID:28857504. |
together these results suggest that nicotine self-administration leads to a number of epigenetic changes at both the bdnf and cdk-5 promoters, and that these changes may contribute to the enhanced extinction of nicotine-seeking by nab. |
2018-08-30 |
2023-08-13 |
rat |
| Michael Auer, Harald Hegen, Thomas Luft, Gabriel Bsteh, Anna Fogdell-Hahn, Amy Loercher, Florian Deisenhamme. Serum Cotinine Does Not Predict Neutralizing Antibodies Against Interferon Beta in an Austrian MS Cohort. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 36. issue 12. 2018-01-12. PMID:27918711. |
we measured cotinine levels in nab-positive and nab-negative patients to find a potential association of nicotine consumption and nab development. |
2018-01-12 |
2023-08-13 |
Not clear |
| Xingyu Liu, Jie Zhang, Limeng Wang, Bicheng Yang, Chen Zhang, Wei Liu, Jun Zho. In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27567546. |
these results implied that cyp2a13 is the most efficient enzyme to metabolize nnn in vitro and structurally similar tobacco constitutes including nicotine, nat and nab influence the metabolic activation of nnn, which may further interfere in its carcinogenicity. |
2017-01-31 |
2023-08-13 |
Not clear |
| Xingyu Liu, Jie Zhang, Limeng Wang, Bicheng Yang, Chen Zhang, Wei Liu, Jun Zho. In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27567546. |
addition of nicotine, n'-nitrosoanatabine (nat), n'-nitrosoanabasine (nab) resulted in a competitive inhibition for nnn metabolism. |
2017-01-31 |
2023-08-13 |
Not clear |
| Xingyu Liu, Jie Zhang, Limeng Wang, Bicheng Yang, Chen Zhang, Wei Liu, Jun Zho. In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine. Chemico-biological interactions. vol 260. 2017-01-31. PMID:27567546. |
the inhibition constant ki value was calculated as 0.98 μm (nicotine), 1.37 μm (nat), 0.71 μm (nab) for hpb formation, 1.35 μm (nicotine), 1.35 μm (nat), 1.01 μm (nab) for hydroxy acid formation and 8.40 μm (nicotine), 3.40 μm (nat), 3.04 μm (nab) for opb formation, respectively. |
2017-01-31 |
2023-08-13 |
Not clear |
| Hongbo Wang, Xiang Li, Junwei Guo, Bin Peng, Huapeng Cui, Kejian Liu, Sheng Wang, Yaqiong Qin, Peijian Sun, Le Zhao, Fuwei Xie, Huimin Li. Distribution of toxic chemicals in particles of various sizes from mainstream cigarette smoke. Inhalation toxicology. vol 28. issue 2. 2016-12-13. PMID:26865272. |
nicotine, tobacco-specific n-nitrosamines (tsnas, including nnn, nat, nab, and nnk), polycyclic aromatic hydrocarbons (pahs, including benzo(a)pyrene (bap), benzo(a)anthracene, and chrysene), and heavy metals (including cr, as, cd, and pb) present in the particles of different sizes were analyzed by gc, hplc-ms/ms, gc/ms, or icp-ms, respectively. |
2016-12-13 |
2023-08-13 |
Not clear |
| Matthew R Castino, Jennifer L Cornish, Kelly J Clemen. Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats. PloS one. vol 10. issue 4. 2016-04-19. PMID:25880762. |
in the first experiment, treatment with nab significantly attenuated nicotine and nicotine + cue reinstatement when administered immediately, but not six hours after each extinction session. |
2016-04-19 |
2023-08-13 |
rat |
| M F Borgerding, J A Bodnar, G M Curtin, J E Swauge. The chemical composition of smokeless tobacco: a survey of products sold in the United States in 2006 and 2007. Regulatory toxicology and pharmacology : RTP. vol 64. issue 3. 2013-05-17. PMID:23000415. |
chemical endpoints determined included benzo[a]pyrene (b[a]p), n'-nitrosonornicotine (nnn), n'-nitrosoanatabine (nat), n'-nitrosoanabasine (nab), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk), n-nitrosodimethylamine (ndma), nitrite, cadmium, lead, arsenic, nickel, chromium, chloride, water, ph and nicotine. |
2013-05-17 |
2023-08-12 |
Not clear |
| S G Carmella, A Borukhova, D Desai, S S Hech. Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis. vol 18. issue 3. 1997-04-14. PMID:9067560. |
nnn (0.53 x 10(-3)% of nicotine dose), nab (0.68%) and nat (2.1%) were detected in the urine of the rats treated with the (s)-nicotine and nano2. |
1997-04-14 |
2023-08-12 |
human |
| S Fischer, B Spiegelhalder, J Eisenbarth, R Preussman. Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis. vol 11. issue 5. 1990-06-12. PMID:2335004. |
addition of the nitrosamine precursors nitrate and nicotine to the tobacco prior to smoking did not change the mainstream smoke concentrations of n'-nitrosonornicotine (nnn) and 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (nnk), whereas the mainstream smoke concentration of n'-nitrosoanabasine (nab) and n'-nitrosoanatabine (nat) increased after spiking the cigarettes with nitrate. |
1990-06-12 |
2023-08-11 |
Not clear |