| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Long Zhang, Shufen Hu, Shu-Ting Qu, Meng-Dan Lv, Jun-Jun Wang, Xin-Ting Liu, Jia-He Yao, Yi-Yan Ding, Guang-Yin X. Inhibition of NKCC1 Ameliorates Anxiety and Autistic Behaviors Induced by Maternal Immune Activation in Mice. Current issues in molecular biology. vol 46. issue 3. 2024-03-27. PMID:38534737. |
we further demonstrated that mia offspring showed significant microglia activation, excessive dendritic spines, and narrow postsynaptic density (psd) in their prefrontal cortex (pfc). |
2024-03-27 |
2024-03-29 |
mouse |
| Weizhuo Lu, Jiyue We. Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes. Aging and disease. 2024-02-29. PMID:38421829. |
importantly, astrocytes and microglia exert dual roles in the pathological process of psd due to the phenotypic transformation. |
2024-02-29 |
2024-03-03 |
Not clear |
| Weizhuo Lu, Jiyue We. Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes. Aging and disease. 2024-02-29. PMID:38421829. |
we summarize the latest evidence of neuroinflammation involving in psd in this review, focus on the phenotypic transformation of microglia and astrocytes following ischemic stroke and reveal the dual roles of both microglia and astrocytes in the psd via modulating the neuroinflammation. |
2024-02-29 |
2024-03-03 |
Not clear |
| Qiqi Fan, Yuanyue Liu, Lei Sheng, Shuang Lv, Li Yang, Zhaoming Zhang, Jiaping Guo, Yafei Fan, Dan H. Chaihu-Shugan-San inhibits neuroinflammation in the treatment of post-stroke depression through the JAK/STAT3-GSK3β/PTEN/Akt pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-12. PMID:36774722. |
the results showed that chaihu-shugan-san has a therapeutic effect on an in vivo model for psd and can regulate microglia polarization through the activation of the jak/stat3-gsk3β/pten/akt pathway, suggesting that it exerts its effect via the inhibition of neuroinflammation. |
2023-02-12 |
2023-08-14 |
human |
| Qiqi Fan, Yuanyue Liu, Lei Sheng, Shuang Lv, Li Yang, Zhaoming Zhang, Jiaping Guo, Yafei Fan, Dan H. Chaihu-Shugan-San inhibits neuroinflammation in the treatment of post-stroke depression through the JAK/STAT3-GSK3β/PTEN/Akt pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 160. 2023-02-12. PMID:36774722. |
flow cytometry showed microglia polarization towards the m1 phenotype in an in vitro psd model, which was reversed after treatment with a gsk3β overexpression virus, chaihu-shugan-san, or a jak-stat3 inhibitor. |
2023-02-12 |
2023-08-14 |
human |
| Yangming Zhang, Yuqiao Xie, Zishuo Cheng, Kaiwen Xi, Xin Huang, Fang Kuang, Wenting Wang, Tiaotiao Liu, Baolin Guo, Shengxi W. Quercetin ameliorates memory impairment by inhibiting abnormal microglial activation in a mouse model of paradoxical sleep deprivation. Biochemical and biophysical research communications. vol 632. 2022-10-03. PMID:36191372. |
morphological analysis showed that quercetin, by targeting the hippocampal ca1 region, strikingly ameliorated the overactivation of microglia induced by psd. |
2022-10-03 |
2023-08-14 |
mouse |
| Weili Xia, Yong Xu, Yuandong Gong, Xiaojing Cheng, Tiangui Yu, Gongchang Y. Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence. Oxidative medicine and cellular longevity. vol 2022. 2022-08-12. PMID:35958023. |
with research advancement, immunoactive cells in the central nervous system, particularly microglia, play a role in the occurrence and development of psd. |
2022-08-12 |
2023-08-14 |
Not clear |
| Weili Xia, Yong Xu, Yuandong Gong, Xiaojing Cheng, Tiangui Yu, Gongchang Y. Microglia Involves in the Immune Inflammatory Response of Poststroke Depression: A Review of Evidence. Oxidative medicine and cellular longevity. vol 2022. 2022-08-12. PMID:35958023. |
the research progress of microglia in psd has been summarized to review the evidence regarding the pathogenesis and treatment target of psd in the future. |
2022-08-12 |
2023-08-14 |
Not clear |
| Xiao Ke, Manfei Deng, Zhuoze Wu, Hongyan Yu, Dian Yu, Hao Li, Youming Lu, Kai Shu, Lei Pe. miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice. Neuroscience bulletin. 2022-07-08. PMID:35802246. |
furthermore, silencing eif4e inactivated microglia, inhibited neuroinflammation, and abolished the depression-like behaviors in psd mice. |
2022-07-08 |
2023-08-14 |
mouse |
| Xiao Ke, Manfei Deng, Zhuoze Wu, Hongyan Yu, Dian Yu, Hao Li, Youming Lu, Kai Shu, Lei Pe. miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice. Neuroscience bulletin. 2022-07-08. PMID:35802246. |
together, our data demonstrated that insufficient mir34b-3p after stroke cannot inhibit eif4e translation, which causes psd by the activation of microglia in the hippocampus. |
2022-07-08 |
2023-08-14 |
mouse |
| Yoshiki Hase, Kamar E Ameen-Ali, Rachel Waller, Julie E Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B Wharton, Raj N Kalari. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain pathology (Zurich, Switzerland). 2022-06-24. PMID:35748290. |
immunohistochemical and immunofluorescent methods were used to assess the distribution and quantification of total and perivascular microglial cell densities in 68 brains focusing on the frontal lobe wm and overlying neocortex in post-stroke dementia (psd), post-stroke non-dementia (psnd) and similar age control subjects. |
2022-06-24 |
2023-08-14 |
human |
| Lin Zhou, Tian Wang, Yawen Yu, Mingan Li, Xiaohui Sun, Wenhao Song, Yunjie Wang, Ce Zhang, Fenghua F. The etiology of poststroke-depression: a hypothesis involving HPA axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 151. 2022-06-01. PMID:35643064. |
the role of hyperactive of hpa axis in psd was discussed in detail, which includes the role of high level corticotropin-releasing hormone in psd, the effects of glucocorticoids on the alterations in specific brain structures, the expression of enzymes, excitotoxicity, the change in intestinal permeability, and the activation of microglia. |
2022-06-01 |
2023-08-13 |
Not clear |
| Li Wei, Jing Guo, Xiaopeng Yu, Hui Chen, Yupeng Du, Zhongkang Ji, Yirui Xie, Yunqing Qi. Role and characteristics of hippocampal region microglial activation in poststroke depression. Journal of affective disorders. vol 291. 2021-07-08. PMID:34058609. |
to study the role and characteristics of activated microglia in poststroke depression (psd) . |
2021-07-08 |
2023-08-13 |
Not clear |
| Hui Chen, Baoming Wang, Gerard Li, Joel R Steele, Sandy Stayte, Bryce Vissel, Yik Lung Chan, Chenju Yi, Sonia Saad, Rita Machaalani, Brian G Olive. Brain health is independently impaired by E-vaping and high-fat diet. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33221488. |
nicotine free e-vapour induced greater changes compared to the nicotine e-vapour and included, increased systemic cytokines, increased brain p-tau and decreased postsynaptic density protein (psd)-95 levels in chow-fed mice, and decreased astrogliosis marker, increased microglia and increased glycogen synthase kinase levels in hfd-fed mice. |
2021-05-27 |
2023-08-13 |
mouse |
| Han-Xiao Zhu, Li-Jing Cheng, Ri-Wei Ou Yang, Yang-Yang Li, Jian Liu, Dan Dai, Wei Wang, Ning Yang, Yun L. Reduced Amygdala Microglial Expression of Brain-Derived Neurotrophic Factor and Tyrosine Kinase Receptor B (TrkB) in a Rat Model of Poststroke Depression. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:33206632. |
conclusions these results suggest that decreased bdnf and trkb expression by amygdala microglia may contribute to psd pathogenesis and depression-like behaviors. |
2021-05-20 |
2023-08-13 |
rat |