All Relations between α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Alzheimer Disease

Reference Sentence Publish Date Extraction Date Species
Parvin Babae. NMDA and AMPA receptors dysregulation in Alzheimer's disease. European journal of pharmacology vol 908 issue 2022 34265291 NMDA and AMPA receptors dysregulation in Alzheimer's disease. 2022-01-06 2022-01-09 Not clear
K Wakabayashi, M Narisawa-Saito, Y Iwakura, T Arai, K Ikeda, H Takahashi, H Naw. Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease. Neurobiology of aging vol 20 issue 3 2000 10588576 We have quantitated the protein levels of alpha-amino-isoxazolepropionic acid (AMPA)-type (GluR1) and N-methyl-D-aspartate-type (NMDAR1) glutamate receptors in postmortem brain tissues of patients with Alzheimer's disease and age-matched controls using western blotting. 2000-01-03 2022-01-08 Not clear
K Wakabayashi, M Narisawa-Saito, Y Iwakura, T Arai, K Ikeda, H Takahashi, H Naw. Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease. Neurobiology of aging vol 20 issue 3 2000 10588576 These findings indicate that abnormal expressions of the AMPA receptor and its interacting PSD molecule are associated with Alzheimer's disease and implicated in pathophysiology of this disease. 2000-01-03 2022-01-08 Not clear
S L Chan, W S Griffin, M P Mattso. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease. Journal of neuroscience research vol 57 issue 3 1999 10412022 Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease. 1999-09-08 2022-01-08 Not clear
K A Yamad. Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease? Neurobiology of disease vol 5 issue 2 1998 9746904 Thus, AMPA modulators might ameliorate memory deficits that occur in dementia, such as Alzheimer's disease. 1998-12-07 2022-01-08 Not clear
W Sihver, P G\\xc3\\xbcnther, R Schliebs, V Big. Repeated administration of tacrine to normal rats: effects on cholinergic, glutamatergic, and GABAergic receptor subtypes in rat brain using receptor autoradiography. Neurochemistry international vol 31 issue 5 1997 9364455 Tacrine administration alters cortical AMPA receptor binding in the opposite direction to that observed in patients with Alzheimer's disease, suggesting that tacrine may exert a reversal in up/down-regulation of cortical glutamate receptor subtypes in Alzheimer patients. 1997-12-22 2022-01-08 rat
D M Armstrong, M D Ikonomovi. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal dentate gyrus of patients with Alzheimer disease. Evidence for hippocampal plasticity. Molecular and chemical neuropathology vol 28 issue 1-3 1997 8871942 Immunocytochemical techniques were employed in order to examine the distribution and relative intensity of immunolabeling of the alpha-amino-3-hydroxy-5-methyl-4-isoaxolepropionate (AMPA) receptor subunits GluR1 and GluR2/3 within the hippocampal formation of patients with Alzheimer disease (AD). 1997-01-23 2022-01-07 Not clear
T P Hicks, F Cont. Amino acids as the source of considerable excitation in cerebral cortex. Canadian journal of physiology and pharmacology vol 74 issue 4 1996 8828881 In addition to the recent growing realisation by clinicians that the excitatory amino acids are linked critically to a number of neurological conditions, including neurodegenerative syndromes such as Alzheimer's disease, cortical damage due to stroke and cerebral ischemia, epilepsy, amyotropic lateral sclerosis, and schizophrenia, the recent cloning and membrane reconstitution of specific receptors known as AMPA, NMDA, kainate, and metabotropic receptors and their known subunits have prompted a surge of renewed interest in this important family of synaptic transmitter molecules. 1996-12-18 2022-01-07 Not clear
M D Ikonomovic, R Sheffield, D M Armstron. AMPA-selective glutamate receptor subtype immunoreactivity in the hippocampal formation of patients with Alzheimer's disease. Hippocampus vol 5 issue 5 1996 8773259 Immunocytochemical techniques were employed in order to examine the distribution and relative intensity of the AMPA receptor subunits GluR1 and GluR2/3 within the hippocampal formation of normal controls and Alzheimer's disease (AD) cases. 1996-09-27 2022-01-07 Not clear
S Akbarian, M A Smith, E G Jone. Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. Brain research vol 699 issue 2 1996 8616634 Editing for an AMPA receptor subunit RNA in prefrontal cortex and striatum in Alzheimer's disease, Huntington's disease and schizophrenia. 1996-06-12 2022-01-07 Not clear
U Madsen, B Ebert, P Krogsgaard-Larse. Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 48 issue 7 1995 7858161 Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease. 1995-03-22 2022-01-07 Not clear
J L Muir, K J Page, D J Sirinathsinghji, T W Robbins, B J Everit. Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behavioural brain research vol 57 issue 2 1994 7509608 However, recently, with the availability of more potent cholinergic excitotoxins such as AMPA, it has become apparent that nbM lesions do not provide a simple animal model of the cognitive deficits in ageing and Alzheimer's disease. 1994-04-06 2022-01-07 Not clear
M D Carlson, J B Penney, A B Youn. NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiology of aging vol 14 issue 4 1993 7690114 NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. 1993-10-04 2022-01-07 Not clear
M D Carlson, J B Penney, A B Youn. NMDA, AMPA, and benzodiazepine binding site changes in Alzheimer's disease visual cortex. Neurobiology of aging vol 14 issue 4 1993 7690114 Quantitative receptor autoradiography was used to measure the laminar distribution of [3H]glycine and [3H]glutamate binding to the N-methyl-D-aspartate (NMDA) receptor complex, [3H]D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) binding to the AMPA receptor, and [3H]flunitrazepam binding to the benzodiazepine (BDZ) receptor in three areas of visual cortex in control and Alzheimer's disease (AD) postmortem human brains (primary or striate visual cortex, visual association cortex, and higher-order visual association cortex, corresponding to Brodmann Areas 17, 18, and 21, respectively). 1993-10-04 2022-01-07 Not clear
J W Geddes, J U\\xc5\\x82as, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience vol 50 issue 1 1992 1328933 In both control and Alzheimer's disease individuals, [3H]kainic acid and [3H]AMPA binding densities were similar at anterior and posterior levels of the hippocampal formation. 1992-11-23 2022-01-07 rat
J W Geddes, J U\\xc5\\x82as, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience vol 50 issue 1 1992 1328933 The results suggest that several factors including cortical and subcortical pathology and seizure activity may contribute to the alterations in [3H]kainic acid and [3H]AMPA binding observed in the hippocampal formation in Alzheimer's disease. 1992-11-23 2022-01-07 rat
J W Geddes, J U\\xc5\\x82as, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience vol 50 issue 1 1992 1328933 Quantitative receptor autoradiography was used to examine the density and distribution of [3H]kainic acid and [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) binding sites in the hippocampal formation and parahippocampal gyrus obtained at autopsy from 10 Alzheimer's disease and eight normal control individuals. 1992-11-23 2022-01-07 rat
J W Geddes, J U\\xc5\\x82as, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience vol 50 issue 1 1992 1328933 In Alzheimer's disease patients, there was a significant increase in [3H]AMPA binding in the infragranular layer. 1992-11-23 2022-01-07 rat
D Dewar, D T Chalmers, D I Graham, J McCulloc. Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain research vol 553 issue 1 1991 1933277 Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. 1991-12-24 2022-01-07 human
D Dewar, D T Chalmers, D I Graham, J McCulloc. Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain research vol 553 issue 1 1991 1933277 Glutamate metabotropic binding and AMPA binding were reduced significantly in CA1 in subjects with Alzheimer's disease whereas kainate binding was minimally altered in this region. 1991-12-24 2022-01-07 human
D Dewar, D T Chalmers, D I Graham, J McCulloc. Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus. Brain research vol 553 issue 1 1991 1933277 Kainate and AMPA binding were reduced significantly in the parahippocampal gyrus in Alzheimer's disease while glutamate metabotropic binding was not. 1991-12-24 2022-01-07 human
D Dewar, D T Chalmers, A Shand, D I Graham, J McCulloc. Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum. Annals of neurology vol 28 issue 6 1991 1980999 Quisqualate (AMPA) receptor binding was markedly reduced in the molecular layer of the cerebellum from patients with Alzheimer's disease (167 +/- 13 pmoles/gm) compared with control patients (280 +/- 13 pmoles/gm). 1991-03-18 2022-01-07 Not clear
D Dewar, D T Chalmers, A Shand, D I Graham, J McCulloc. Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum. Annals of neurology vol 28 issue 6 1991 1980999 Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum. 1991-03-18 2022-01-07 Not clear
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