| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siyuan Wu, Lihui Lu, Mingyue Zhao, Wenchao Wu, Hua Fu, Xiajing Li. [Study on Potential Role of Calreticulin in Pressure Overload Induced Cardiac Hypertrophy]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 3. 2018-05-24. PMID:29709152. |
this study aims to investigate the role of calreticulin in(crt)pressure overload induced cardiac hypertrophy.in our study,cardiac hypertrophy was induced by left ventricular pressure overload in male sd rats subjected to transverse aortic constriction(tac)operation.expression of gene and protein of calreticulin,markers of cardiac hypertrophy and endoplasmic reticulum stress(ers)were measured with real-time qpcr and western blot respectively.meanwhile,atorvastatin(a known ers inhibitor)and calreticulin-specific small interference ribonucleic acid(sirna)were used to inhibit the expression of ers and calreticulin respectively.the experimental data demonstrated that the gene and protein levels of calreticulin,hypertrophic and ers markers were increased significantly in the heart tissues of tac rat models after 4weeks.moreover,atorvastatin administration improved the cardiac function and reduced the expression of calreticulin and ers markers in tac rats.in addition,cultured primary neonatal rat cardiomyocytes(ncms)were treated with norepinephrine(ne),angiotensionⅡ(angⅡ)or isoprenaline(iso)to induce hypertrophic phenotype and ers.the expression of hypertrophic markers was reduced in ncms transfected with calreticulin-sirna.the results suggested that calreticulin might be a promising target for the treatment of cardiac hypertrophy. |
2018-05-24 |
2023-08-13 |
rat |
| Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J Reiter, Weixun Duan, Shiqiang Y. Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. Journal of pineal research. vol 63. issue 3. 2018-05-18. PMID:28708271. |
melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. |
2018-05-18 |
2023-08-13 |
mouse |
| Hao Su, Marco Pistolozzi, Xingjuan Shi, Xiaoou Sun, Wen Ta. Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036266. |
here we investigated the development of isoproterenol (iso)-induced cardiac hypertrophy in an in vitro experimental model. |
2018-05-18 |
2023-08-13 |
Not clear |
| Xin Li, Zhou-Long Zhang, Hui-Fen Wan. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-23. PMID:28624424. |
isoproterenol (isp) was used to induce cardiac fibrosis and hypertrophy in vitro and in vivo. |
2018-04-23 |
2023-08-13 |
mouse |
| Ilona Schirmer, Tippaporn Bualeong, Heidi Budde, Diana Cimiotti, Avinash Appukuttan, Nicole Klein, Philip Steinwascher, Peter Reusch, Andreas Mügge, Rainer Meyer, Yury Ladilov, Kornelia Jaque. Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. PloS one. vol 13. issue 2. 2018-04-09. PMID:29466442. |
soluble adenylyl cyclase: a novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. |
2018-04-09 |
2023-08-13 |
Not clear |
| Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wrigh. Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28059795. |
tau ko mice showed an increased systolic blood pressure and cardiac hypertrophy at 13 months, which was accompanied by a significantly lower right atrial rate and a subtle decrease in the maximum contractility to calcium, isoprenaline, and electrical sympathetic nerve stimulation. |
2018-02-23 |
2023-08-13 |
mouse |
| Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wrigh. Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28059795. |
aging tau ko mice to 23 months resulted in cardiac hypertrophy with significantly attenuated left atrial contractility, increased blood pressure, and sensitivity of isolated mesenteric arteries to angiotensin ii contraction and isoprenaline relaxation compared to their younger counterparts. |
2018-02-23 |
2023-08-13 |
mouse |
| Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang, Si-Chi Xu, Sha-Sha Wang, Qi-Zhu Tan. Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways. EBioMedicine. vol 18. 2018-01-17. PMID:28330809. |
here, we show that piperine-treated mice had similar hypertrophic responses as mice treated with vehicle but exhibited significantly attenuated cardiac fibrosis after pressure overload or isoprenaline (iso) injection. |
2018-01-17 |
2023-08-13 |
mouse |
| Chunmei Li, Dan Huang, Jing Tang, Mengqing Chen, Qun Lu, He Li, Mengzhen Zhang, Bin Xu, Jianwen Ma. ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy. Gene. vol 642. 2017-12-26. PMID:29158167. |
isoprenaline, an activator of β-adrenergic receptor, has been found to induce cardiac hypertrophy in vivo and in vitro, but the exact mechanism is still unclear. |
2017-12-26 |
2023-08-13 |
mouse |
| Yuhua Fan, Li Liu, Kun Fang, Tao Huang, Lin Wan, Youbin Liu, Sen Zhang, Dongxia Yan, Guangnan Li, Yanhui Gao, Yanjie Lv, Yanjun Chen, Yingfeng T. Resveratrol Ameliorates Cardiac Hypertrophy by Down-regulation of miR-155 Through Activation of Breast Cancer Type 1 Susceptibility Protein. Journal of the American Heart Association. vol 5. issue 4. 2017-11-02. PMID:27107135. |
the polyphenol resveratrol (rev) has been reported to exhibit cardioprotective effects, such as inhibition of tac (transverse aortic constriction) or isoprenaline (iso)-induced hypertrophy. |
2017-11-02 |
2023-08-13 |
Not clear |
| Rongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, Zijian Li, Lixiang Xu. Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy. PloS one. vol 12. issue 8. 2017-10-06. PMID:28783759. |
to verify this hypothesis and examine whether cardiac senescence is a novel mechanism of hypertrophy induced by isoproterenol, 2-month-old male sprague dawley rats were subjected to isoproterenol infusion (0.25mg/kg/day) for 7 days by subcutaneous injection). |
2017-10-06 |
2023-08-13 |
rat |
| Rongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, Zijian Li, Lixiang Xu. Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy. PloS one. vol 12. issue 8. 2017-10-06. PMID:28783759. |
our results showed for the first time that cardiac senescence is involved in the process of pathological cardiac hypertrophy induced by isoproterenol. |
2017-10-06 |
2023-08-13 |
rat |
| Ying Feng, Jun Cheng, Baozhu Wei, Yanggan Wan. CaMKII inhibition reduces isoproterenol-induced ischemia and arrhythmias in hypertrophic mice. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:28177919. |
here, we investigated the effect of camkii inhibition in isoproterenol (iso)-induced arrhythmias in hypertrophic mice. |
2017-09-20 |
2023-08-13 |
mouse |
| W Xu, Y Wang, J Zhou, X Zhu, S Zhang, W Yuan, X Liu, Y Shi, L Cao, Q Zeng, Z Jiang, X Ye, Y Wan, X Peng, Y Deng, F Chen, X Wang, G Dai, S Luo, X Fan, X Mo, X Wu, Y L. Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling. Current molecular medicine. vol 16. issue 5. 2017-09-15. PMID:27211802. |
in a cardiac specific transgenic mouse model, it was observed that overexpression of hhole specifically in heart attenuated cardiac hypertrophy and fibrosis induced by isoproterenol (iso), with blunted transcriptions of erk1/2, total erk1/2 proteins and phosphorylated erk1/2 (p-erk1/2) levels. |
2017-09-15 |
2023-08-13 |
mouse |
| Anne Järve, Silke Mühlstedt, Fatimunnisa Qadri, Bernadette Nickl, Herbert Schulz, Norbert Hübner, Cemil Özcelik, Michael Bade. Adverse left ventricular remodeling by glycoprotein nonmetastatic melanoma protein B in myocardial infarction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 2. 2017-09-01. PMID:28148779. |
moreover, gpnmb deficiency attenuated the dilated cardiomyopathy in muscle lim protein knockout mice but could not prevent cardiac hypertrophy induced by isoprenaline infusion. |
2017-09-01 |
2023-08-13 |
mouse |
| Jie Lou, Dan Zhao, Ling-Ling Zhang, Shu-Ying Song, Yan-Chao Li, Fei Sun, Xiao-Qing Ding, Chang-Jiang Yu, Yuan-Yuan Li, Mei-Tong Liu, Chang-Jiang Dong, Yong Ji, Hongliang Li, Wenfeng Chu, Zhi-Ren Zhan. Type III Transforming Growth Factor-β Receptor Drives Cardiac Hypertrophy Through β-Arrestin2-Dependent Activation of Calmodulin-Dependent Protein Kinase II. Hypertension (Dallas, Tex. : 1979). vol 68. issue 3. 2017-08-07. PMID:27432858. |
cardiac-specific transgenic expression of tβriii independently led to cardiac hypertrophy in mice, which was further aggravated by isoproterenol and tac treatment. |
2017-08-07 |
2023-08-13 |
mouse |
| Jamaira A Victorio, Stefano P Clerici, Roberto Palacios, María J Alonso, Dalton V Vassallo, Iris Z Jaffe, Luciana V Rossoni, Ana P Dave. Spironolactone Prevents Endothelial Nitric Oxide Synthase Uncoupling and Vascular Dysfunction Induced by β-Adrenergic Overstimulation: Role of Perivascular Adipose Tissue. Hypertension (Dallas, Tex. : 1979). vol 68. issue 3. 2017-08-07. PMID:27432866. |
β-ar overstimulation with associated cardiac hypertrophy and increased vasoconstrictor response to phenylephrine in aorta were modeled in rats by 7-day isoproterenol treatment. |
2017-08-07 |
2023-08-13 |
rat |
| Lung-Shuo Wang, Chun-Ting Lee, Wei-Lieh Su, Shih-Che Huang, Shu-Chi Wan. Delonix regia Leaf Extract (DRLE): A Potential Therapeutic Agent for Cardioprotection. PloS one. vol 11. issue 12. 2017-07-10. PMID:27936072. |
in this study, we found that the delonix regia leaf extract (drle) (400 mg/kg/d) can reduce the mortality rate in an isoproterenol (iso)-induced heart injury and hypertrophy mouse model. |
2017-07-10 |
2023-08-13 |
mouse |
| Jing Lu, Duanping Sun, Zhiping Liu, Min Li, Huiqi Hong, Cui Liu, Si Gao, Hong Li, Yi Cai, Shaorui Chen, Zhuoming Li, Jiantao Ye, Peiqing Li. SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy. Translational research : the journal of laboratory and clinical medicine. vol 172. 2017-06-26. PMID:27016702. |
primary neonatal rat cardiomyocytes (nrcms) or sprague-dawley (sd) rats were submitted to isoproterenol (iso) treatment, and then the hypertrophic responses and changes in autophagy activity were measured. |
2017-06-26 |
2023-08-13 |
rat |
| Quanlu Duan, Li Ni, Peihua Wang, Chen Chen, Lei Yang, Ben Ma, Wei Gong, Zhejun Cai, Ming-Hui Zou, Dao Wen Wan. Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo. Aging cell. vol 15. issue 4. 2017-06-05. PMID:27133203. |
western blots showed that myocardial xbp1s protein was significantly increased in both isoproterenol (iso)-induced and pressure-overload-induced hypertrophic and failing heart compared to normal control. |
2017-06-05 |
2023-08-13 |
human |