| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas G von Lueder, Jørgen Gravning, Ole-Jakob How, Leif E Vinge, Mohammed Shakil Ahmed, Kurt A Krobert, Finn Olav Levy, Terje S Larsen, Otto A Smiseth, Ellen Aasum, Håvard Attramada. Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload. American journal of physiology. Heart and circulatory physiology. vol 303. issue 1. 2012-09-04. PMID:22542621. |
increased cardiac mass and myocardial mrna expression of β-myosin heavy chain confirmed the similar induction of cardiac hypertrophy in both ab groups, but only nlc-ab hearts displayed significantly elevated mrna levels of brain natriuretic peptide and myocardial collagen contents as well as reduced β(1)-adrenergic receptor responsiveness to isoproterenol, indicating increased lv wall stress and the transition to hf. |
2012-09-04 |
2023-08-12 |
mouse |
| Feng Yin, Yun Zhu, Ping Li, Qi-De Han, You-Yi Zhan. [Isoproterenol-induced activation of MAPK, NFkappaB and JAK/STAT pathway in mouse myocardium]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 4. 2012-08-16. PMID:12937826. |
this study was aimed to determine the in vivo signal transduction pathway responsible for isoproterenol (iso)-induced cardiac hypertrophy or remodeling. |
2012-08-16 |
2023-08-12 |
mouse |
| Melissa F Jackson, Dung Luong, Dor Dor Vang, Dilip K Garikipati, James B Stanton, O Lynne Nelson, Buel D Rodger. The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism. The Journal of endocrinology. vol 213. issue 3. 2012-08-09. PMID:22431133. |
however, mstn-/- mice responded better to isoproterenol stress tests with greater increases in fractional shortening and ejection fraction-differences that were again more apparent in females and which are consistent with physiological cardiac hypertrophy. |
2012-08-09 |
2023-08-12 |
mouse |
| b' Bo Lu, Hongjuan Yu, Maarten Zwartbol, Willem P Ruifrok, Wiek H van Gilst, Rudolf A de Boer, Herman H W Sillj\\xc3\\xa. Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models. Physiological genomics. vol 44. issue 8. 2012-08-02. PMID:22353257.' |
hypertensive ren2 rats and animals with postmyocardial infarction (post-mi) hf were used as in vivo hf models, and neonatal rat cardiomyocytes treated with hypertrophy inducing hormones phenylephrine, endothelin-1, and isoproterenol were used as in vitro models. |
2012-08-02 |
2023-08-12 |
rat |
| Emanuele Giordano, Rebecca A Hillary, Thomas C Vary, Anthony E Pegg, Andrew D Sumner, Claudio M Caldarera, Xue-Qian Zhang, Jianliang Song, JuFang Wang, Joseph Y Cheung, Lisa M Shant. Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21814794. |
transgenic mice overexpressing odc in the heart (mhc-odc mice) experience a much more dramatic left ventricular hypertrophy in response to β-adrenergic stimulation with isoproterenol (iso) compared to wild-type (wt) controls. |
2012-05-31 |
2023-08-12 |
mouse |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
the function of calcineurin and erk1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. |
2012-05-08 |
2023-08-12 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
we determined the effects of trans-(+/-)-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid methanesulfonate salt (u50,488h), a selective kappa-opioid receptor agonist, on the enhancement of spontaneous ca2+ transients and the induction of hypertrophy by isoprenaline, a beta-adrenoceptor agonist, in cultured neonatal ventricular myocytes. |
2012-05-08 |
2023-08-12 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie. vol 67. issue 2. 2012-05-08. PMID:22512090. |
isoprenaline (10 micromol x l(-1)) increased all the three indices of hypertrophy, ca2+ transients, calcineurin activity and the level of phospho-erk1/2. |
2012-05-08 |
2023-08-12 |
Not clear |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 42. issue 4. 2012-05-03. PMID:21866628. |
[the antagonistic effect of pi3k-gamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. |
2012-05-03 |
2023-08-12 |
rat |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 42. issue 4. 2012-05-03. PMID:21866628. |
to investigate the therapeutic effect of pi3kgamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats. |
2012-05-03 |
2023-08-12 |
rat |
| David R Murray, Srinivas Mummidi, Anthony J Valente, Tadashi Yoshida, Naveen K Somanna, Patrice Delafontaine, Charles A Dinarello, Bysani Chandraseka. β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. Journal of molecular and cellular cardiology. vol 52. issue 1. 2012-04-24. PMID:22004899. |
β2 adrenergic activation induces the expression of il-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. |
2012-04-24 |
2023-08-12 |
mouse |
| Nada Choucair-Jaafar, Nadine Beetz, Ralf Gilsbach, Ipek Yalcin, Elisabeth Waltisperger, Marie-José Freund-Mercier, Laurent Monassier, Lutz Hein, Michel Barro. Cardiovascular effects of chronic treatment with a β2-adrenoceptor agonist relieving neuropathic pain in mice. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21352833. |
our data show that a chronic treatment with the β(2)-ar agonist terbutaline at low antiallodynic dose does not affect cardiovascular parameters, whereas the mixed β(1)/β(2)-ar agonist isoproterenol induces cardiac hypertrophy. |
2012-04-17 |
2023-08-12 |
mouse |
| Ning Liu, Kai-zheng Gong, Yuan-bin Cai, Zijian L. Identification of proteins responding to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches. Biochemistry. Biokhimiia. vol 76. issue 10. 2012-03-19. PMID:22098239. |
we present the first proteomics study identifying proteins that are related to ar subtype-specific hypertrophy in cardiomyocytes by comparing the two-dimensional electrophoresis patterns between neonatal rat cardiomyocytes treated by phenylepinephrin (pe) and by isoproterenol (iso). |
2012-03-19 |
2023-08-12 |
rat |
| Sanjeewa A Goonasekera, Karin Hammer, Mannix Auger-Messier, Ilona Bodi, Xiongwen Chen, Hongyu Zhang, Steven Reiken, John W Elrod, Robert N Correll, Allen J York, Michelle A Sargent, Franz Hofmann, Sven Moosmang, Andrew R Marks, Steven R Houser, Donald M Bers, Jeffery D Molkenti. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation. vol 122. issue 1. 2012-03-06. PMID:22133878. |
however, α1c⁻/⁺ mice subjected to pressure overload stimulation, isoproterenol infusion, and swimming showed greater cardiac hypertrophy, greater reductions in ventricular performance, and greater ventricular dilation than α1c⁺/⁺ controls. |
2012-03-06 |
2023-08-12 |
mouse |
| Alex P Carll, Najwa Haykal-Coates, Darrell W Winsett, Mehdi S Hazari, Abraham Nyska, Judy H Richards, Monte S Willis, Daniel L Costa, Aimen K Farra. Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. Toxicologic pathology. vol 39. issue 6. 2012-02-13. PMID:21878552. |
isoproterenol (iso) infusion can accelerate cardiomyopathy in young shhfs, while dietary salt loading in hypertensive rats induces cardiac fibrosis, hypertrophy, and--in a minority-congestive hf. |
2012-02-13 |
2023-08-12 |
rat |
| Changlin Li, Jing Li, Xiangyu Cai, Haili Sun, Jinjin Jiao, Ting Bai, Xing Wang Zhou, Xiongwen Chen, Donald L Gill, Xiang D Tan. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. The Journal of biological chemistry. vol 286. issue 47. 2012-01-16. PMID:21971046. |
in both in vitro and in vivo cardiac hypertrophic models, the normally undetectable pkd3 was profoundly up-regulated by isoproterenol followed by overt expression of cardiac tfs including nfatc4, nk family of transcription factor 2.5 (nkx2.5), gata4 and myocyte enhancer factor 2 (mef2). |
2012-01-16 |
2023-08-12 |
Not clear |
| Tzu-Chieh Wei, Hui-Yu Lin, Cheng-Chieh Lu, Chun-Ming Chen, Li-Ru Yo. Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene expression patterns : GEP. vol 11. issue 7. 2011-12-27. PMID:21601656. |
nonetheless, experimental studies revealed that the expression level of crip2 is not altered in the isoproterenol (iso) induced hypertrophic heart. |
2011-12-27 |
2023-08-12 |
mouse |
| John T Liles, Kevin K Ida, Kristin M Joly, Joseph Chapo, Craig F Plat. Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 2. 2011-10-18. PMID:21593430. |
contractile reserve decreases with advancing age and chronic isoproterenol (iso) administration is a well-characterized model of cardiac hypertrophy known to impair cardiovascular function. |
2011-10-18 |
2023-08-12 |
rat |
| FuKun W Hoffmann, Ann S Hashimoto, Byung Cheon Lee, Aaron H Rose, Ralph V Shohet, Peter R Hoffman. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Archives of biochemistry and biophysics. vol 512. issue 1. 2011-09-12. PMID:21621505. |
to determine how the selenoproteome responds to myocardial hypertrophy, two mouse models were employed: triidothyronine (t3)- or isoproterenol (iso)-treatment. |
2011-09-12 |
2023-08-12 |
mouse |
| Lianghui Zhang, Sundeep Malik, Grant G Kelley, Michael S Kapiloff, Alan V Smrck. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21550986. |
nrvms with plcε depletion were stimulated with endothelin (et-1), norepinephrine, insulin-like growth factor-1 (igf-1), or isoproterenol and assessed for development of hypertrophy. |
2011-09-09 |
2023-08-12 |
rat |