| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weipang Chang, Andrea Pedroni, Victoria Hohendorf, Stefania Giacomello, Masahiko Hibi, Reinhard W Köster, Konstantinos Ampatzi. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 29. 2020-09-14. PMID:32632015. |
dual patch-clamp recordings showed that the cerebellar circuit contains all purkinje cell types that cross-communicate extensively using chemical and electrical synapses. |
2020-09-14 |
2023-08-13 |
zebrafish |
| Weipang Chang, Andrea Pedroni, Victoria Hohendorf, Stefania Giacomello, Masahiko Hibi, Reinhard W Köster, Konstantinos Ampatzi. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 29. 2020-09-14. PMID:32632015. |
thus, we show intricately organized purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions. |
2020-09-14 |
2023-08-13 |
zebrafish |
| Wolfgang Wagner, Kristina Lippmann, Frank F Heisler, Kira V Gromova, Franco L Lombino, Mona K Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R Schwarz, Jens Eilers, Matthias Kneusse. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell reports. vol 28. issue 1. 2020-08-27. PMID:31269433. |
we find that myosin vi localizes at cerebellar parallel fiber to purkinje cell synapses and that the myosin is indispensable for long-term depression of ampa-receptor-mediated synaptic signal transmission at this synapse. |
2020-08-27 |
2023-08-13 |
Not clear |
| Vanessa Hull, Yan Wang, Travis Burns, Sheng Zhang, Sarah Sternbach, Jennifer McDonough, Fuzheng Guo, David Pleasur. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Annals of neurology. vol 87. issue 3. 2020-08-03. PMID:31925837. |
we now demonstrate that inhibiting naa synthesis by intracisternal administration of a locked nucleic acid antisense oligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and diminishes cerebellar and thalamic vacuolation and purkinje cell dendritic atrophy. |
2020-08-03 |
2023-08-13 |
mouse |
| Zhi Zhang, Shilpa Narayan, Lilly Su, Hanaa Al-Alawyat, Jinhuan Liu, Sujatha Kanna. Cerebellar injury and impaired function in a rabbit model of maternal inflammation induced neonatal brain injury. Neurobiology of learning and memory. vol 165. 2020-07-30. PMID:30016703. |
the findings of altered purkinje cell morphology were consistent with impaired cerebellar function as tested by eye-blink conditioning at 1 month of age. |
2020-07-30 |
2023-08-13 |
rabbit |
| Andrea Cabrera-Pastor, Marta Llansola, Carmina Montoliu, Michele Malaguarnera, Tiziano Balzano, Lucas Taoro-Gonzalez, Raquel García-García, Alba Mangas-Losada, Paula Izquierdo-Altarejos, Yaiza M Arenas, Paola Leone, Vicente Felip. Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications. Acta physiologica (Oxford, England). vol 226. issue 2. 2020-07-21. PMID:30830722. |
we summarize studies showing that mhe in cirrhotic patients is associated with alterations in the immune system and that patients died with he show neuroinflammation in cerebellum, with microglial and astrocytic activation and purkinje cell loss. |
2020-07-21 |
2023-08-13 |
rat |
| Samuel S McAfee, Yu Liu, Roy V Sillitoe, Detlef H Hec. Cerebellar Lobulus Simplex and Crus I Differentially Represent Phase and Phase Difference of Prefrontal Cortical and Hippocampal Oscillations. Cell reports. vol 27. issue 8. 2020-07-16. PMID:31116979. |
we simultaneously recorded purkinje cell (pc) single-unit spike activity in cerebellar lobulus simplex (ls) and crus i and local field potential (lfp) activity in the medial prefrontal cortex (mpfc) and dorsal hippocampus ca1 region (dca1). |
2020-07-16 |
2023-08-13 |
Not clear |
| David Díaz, Carlos Del Pilar, José Carretero, José Ramón Alonso, Eduardo Weruag. Daily bone marrow cell transplantations for the management of fast neurodegenerative processes. Journal of tissue engineering and regenerative medicine. vol 13. issue 9. 2020-07-08. PMID:31272136. |
here we have employed a model of aggressive cerebellar neurodegeneration, the purkinje cell degeneration mouse, to optimize a cell therapy based on bone marrow-derived cell and cell fusion. |
2020-07-08 |
2023-08-13 |
mouse |
| Jennifer Rakotomamonjy, Alicia Guemez-Gambo. Purkinje Cell Survival in Organotypic Cerebellar Slice Cultures. Journal of visualized experiments : JoVE. issue 154. 2020-07-08. PMID:31904025. |
purkinje cell survival in organotypic cerebellar slice cultures. |
2020-07-08 |
2023-08-13 |
mouse |
| Shijia Ren, Meifang Chen, Lanying Yang, Zaiqun Li. 5-Hydroxytryptamine and Dopamine Neurons in the Cerebellum of the New-Hatching Yangtze Alligator Alligator sinensis. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 6. 2020-07-06. PMID:30315688. |
the results of cerebellar histological structure showed that there was a ventriculus cerebelli in the cerebellum of the new-hatching yangtze alligator, the surface of the cerebellar cortex was not very smooth, the cerebellar cortex could be divided into four layers, which include external granular layer, molecular layer, purkinje cell layer and granular layer, purkinje cell layer could be characterized specially by multilayer, two cerebellar nuclei termed as the nucleus cerebelli lateralis and the nucleus cerebelli medialis were found in the cerebellar medulla. |
2020-07-06 |
2023-08-13 |
Not clear |
| Julia Saifetiarova, Manzoor A Bha. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30447021. |
using 4.1b and whrn single and double mutant animals, we show that both proteins are expressed in common cellular compartments of the cerebellum and play cooperative roles in preservation of the integrity of purkinje neuron myelinated axons. |
2020-07-01 |
2023-08-13 |
Not clear |
| Lidia Yshii, Béatrice Pignolet, Emilie Mauré, Mandy Pierau, Monika Brunner-Weinzierl, Oliver Hartley, Jan Bauer, Roland Libla. IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration. JCI insight. vol 4. issue 7. 2020-06-29. PMID:30944244. |
in an animal model, in which a neo-self-antigen was expressed in both purkinje neurons and implanted breast tumor cells, immune checkpoint blockade led to complete tumor control at the expense of cerebellum infiltration by t cells and purkinje neuron loss, thereby mimicking pcd. |
2020-06-29 |
2023-08-13 |
mouse |
| Ruth Sheffer, Michal Gur, Rebecca Brooks, Somaya Salah, Muhannad Daana, Nitay Fraenkel, Eli Eisenstein, Malcolm Rabie, Yoram Nevo, Chaim Jalas, Orly Elpeleg, Shimon Edvardson, Tamar Hare. Biallelic variants in AGTPBP1, involved in tubulin deglutamylation, are associated with cerebellar degeneration and motor neuropathy. European journal of human genetics : EJHG. vol 27. issue 9. 2020-06-12. PMID:30976113. |
in the mutant mice, cerebellar atrophy due to purkinje cell degeneration is observed, likely due to increased tubulin polyglutamylation in affected brain areas. |
2020-06-12 |
2023-08-13 |
mouse |
| Weisong Duan, Moran Guo, Le Yi, Jie Zhang, Yue Bi, Yakun Liu, Yuanyuan Li, Zhongyao Li, Yanqin Ma, Guisen Zhang, Yaling Liu, Xueqing Song, Chunyan L. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging. vol 11. issue 8. 2020-05-21. PMID:31039129. |
the purkinje cell layer of the cerebellum presented dendritic swelling, abnormally shaped astrocytes, and p62- and ubiquitin-positive aggregates, suggesting impaired autophagy. |
2020-05-21 |
2023-08-13 |
mouse |
| Tianyu Tang, Timothy A Blenkinsop, Eric J Lan. Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity. eLife. vol 8. 2020-05-18. PMID:30624204. |
the rules governing cerebellar output are not fully understood, but must involve purkinje cell (pc) activity, as pcs are the major input to deep cerebellar nuclear (dcn) cells (which form the majority of cerebellar output). |
2020-05-18 |
2023-08-13 |
rat |
| Qiong Liu, Shanshan Huang, Peng Yin, Su Yang, Jennifer Zhang, Liang Jing, Siying Cheng, Beisha Tang, Xiao-Jiang Li, Yongcheng Pan, Shihua L. Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17. Nature communications. vol 11. issue 1. 2020-05-05. PMID:32107387. |
crispr/cas9-mediated deletion of inpp5a in the cerebellum of wild-type mice leads to purkinje cell degeneration, and inpp5a overexpression decreases inositol 1,4,5-trisphosphate (ip |
2020-05-05 |
2023-08-13 |
mouse |
| Aurora Badaloni, Filippo Casoni, Laura Croci, Francesca Chiara, Antonella Bizzoca, Gianfranco Gennarini, Ottavio Cremona, Richard Hawkes, G Giacomo Consale. Dynamic Expression and New Functions of Early B Cell Factor 2 in Cerebellar Development. Cerebellum (London, England). vol 18. issue 6. 2020-04-10. PMID:31273610. |
the early b cell factor 2 (ebf2) gene plays an important role in the establishment of cerebellar cortical topography and in purkinje cell (pc) subtype specification. |
2020-04-10 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsu. Kobayashi award: Discovery of cerebellar and pineal neurosteroids and their biological actions on the growth and survival of Purkinje cells during development (review). General and comparative endocrinology. vol 284. 2020-02-25. PMID:30339808. |
in the mid 1990s, the purkinje cell, an important cerebellar neuron, was discovered as a major cell producing neurosteroids in the brain of vertebrates. |
2020-02-25 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsu. Kobayashi award: Discovery of cerebellar and pineal neurosteroids and their biological actions on the growth and survival of Purkinje cells during development (review). General and comparative endocrinology. vol 284. 2020-02-25. PMID:30339808. |
progesterone and estradiol, which are known as sex steroid hormones, are actively synthesized de novo from cholesterol in the purkinje cell during development, when cerebellar neuronal circuit formation occurs. |
2020-02-25 |
2023-08-13 |
Not clear |
| Hassan Marzban, Maryam Rahimi-Balaei, Richard Hawke. Early trigeminal ganglion afferents enter the cerebellum before the Purkinje cells are born and target the nuclear transitory zone. Brain structure & function. vol 224. issue 7. 2020-02-18. PMID:31256239. |
in the standard model for the development of climbing and mossy fiber afferent pathways to the cerebellum, the ingrowing axons target the embryonic purkinje cell somata (around embryonic ages (e13-e16 in mice). |
2020-02-18 |
2023-08-13 |
mouse |