| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurentiu S Popa, Martha L Streng, Timothy J Ebne. Purkinje Cell Representations of Behavior: Diary of a Busy Neuron. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 25. issue 3. 2019-06-27. PMID:29985093. |
fundamental for understanding cerebellar function is determining the representations in purkinje cell activity, the sole output of the cerebellar cortex. |
2019-06-27 |
2023-08-13 |
Not clear |
| Vien Nguyen, Khalida Sabeur, Emin Maltepe, Kurosh Ameri, Omer Bayraktar, David H Rowitc. Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury. Cerebellum (London, England). vol 17. issue 2. 2019-06-26. PMID:29134361. |
in the setting of hypoxia and prednisolone, administration of a small molecule smoothened-hedgehog agonist (sag) preserved cerebellar volume and protected against purkinje cell death. |
2019-06-26 |
2023-08-13 |
mouse |
| Richard Hawke. The Ferdinando Rossi Memorial Lecture: Zones and Stripes-Pattern Formation in the Cerebellum. Cerebellum (London, England). vol 17. issue 1. 2019-06-14. PMID:28965328. |
cerebellar architecture is organized around the purkinje cell. |
2019-06-14 |
2023-08-13 |
mouse |
| Ryosuke Tsumagari, Yasuhito Shira. [Importance of diacylglycerol signaling in cerebellar motor coordination]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 2. 2019-05-30. PMID:30101866. |
the only output neuron in cerebellum, purkinje cell, regulates long term depression (ltd). |
2019-05-30 |
2023-08-13 |
mouse |
| Maryam Rahimi-Balaei, Xiaodan Jiao, Shahin Shabanipour, Rajiv Dixit, Carol Schuurmans, Hassan Marzba. Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum of Neurogenin 2 Null Mice. Cerebellum (London, England). vol 18. issue 1. 2019-05-20. PMID:29909450. |
zebrin ii/aldolase c expression in the normal cerebellum is restricted to a purkinje cell subset and is the canonical marker for stripes and zones. |
2019-05-20 |
2023-08-13 |
mouse |
| Cullen B Owens, Casper de Boer, Giulia Gennari, Robin Broersen, Johan J Pel, Brian Miller, Wesley Clapp, Ysbrand D van der Werf, Chris I De Zeeu. Early Trajectory Prediction in Elite Athletes. Cerebellum (London, England). vol 17. issue 6. 2019-05-13. PMID:30218394. |
while purkinje cell activity of the oculomotor vermis predicts eye movement speed and direction, more lateral areas of the cerebellum may play a role in more complex tasks, including decision-making. |
2019-05-13 |
2023-08-13 |
Not clear |
| Trace L Stay, Jean Laurens, Roy V Sillitoe, Dora E Angelak. Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 8. 2019-05-01. PMID:30723151. |
altogether, these data argue that purkinje neuron feedback regulates gain control within the cerebellar circuit. |
2019-05-01 |
2023-08-13 |
mouse |
| Vincenzo Romano, Licia De Propris, Laurens Wj Bosman, Pascal Warnaar, Michiel M Ten Brinke, Sander Lindeman, Chiheng Ju, Arthiha Velauthapillai, Jochen K Spanke, Emily Middendorp Guerra, Tycho M Hoogland, Mario Negrello, Egidio D'Angelo, Chris I De Zeeu. Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity. eLife. vol 7. 2019-04-29. PMID:30561331. |
thus, potentiation at parallel fiber to purkinje cell synapses may contribute to reflex adaptation and enable expression of cerebellar learning through increases in simple spike activity. |
2019-04-29 |
2023-08-13 |
mouse |
| Niceto R Luque, Francisco Naveros, Richard R Carrillo, Eduardo Ros, Angelo Arle. Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS computational biology. vol 15. issue 3. 2019-04-29. PMID:30860991. |
here, a spiking cerebellar model assesses the role of purkinje cell firing patterns in vestibular ocular reflex (vor) adaptation. |
2019-04-29 |
2023-08-13 |
Not clear |
| Niceto R Luque, Francisco Naveros, Richard R Carrillo, Eduardo Ros, Angelo Arle. Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS computational biology. vol 15. issue 3. 2019-04-29. PMID:30860991. |
a detailed purkinje cell model reproduces the three spike-firing patterns that are shown to regulate the cerebellar output. |
2019-04-29 |
2023-08-13 |
Not clear |
| Jakub Trzesniewski, Sandrine Altmann, Levy Jäger, Josef P Kapfhamme. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Experimental neurology. vol 311. 2019-04-10. PMID:30312605. |
we have now done a more extensive study of cerebellar morphology in these mice and show by rapid golgi staining that there is a marked reduction of purkinje cell dendritic tree size throughout the cerebellum. |
2019-04-10 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
an expandable embryonic stem cell-derived purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
many forms of ataxia result from degeneration of cerebellar purkinje cells, but thus far it has not been possible to efficiently generate purkinje neuron (pn) progenitors from human or mouse pluripotent stem cells, let alone to develop a methodology for in vivo transplantation in the adult cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Fengjun Ma, Zhiqiang Dong, Michael A Berberogl. Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain. Gene expression patterns : GEP. vol 31. 2019-03-21. PMID:30634066. |
in the cerebellum, rbfox1l and rbfox2 are expressed in the purkinje cell layer, reminiscent of rbfox1 and rbfox2 expression in the mammalian cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Hirokazu Hirai, Masanobu Kan. Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29525719. |
since the signaling pathway triggered by mglur1 activation in purkinje cell plays a pivotal role in coordinated movements and motor learning, pharmacological repair of aberrant mglur1 signaling in purkinje cell is critical for mitigation of cerebellar symptoms. |
2019-03-14 |
2023-08-13 |
Not clear |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
in order to investigate whether peroxisomal β-oxidation is essential within purkinje cells, the sole output neurons of the cerebellum, we generated and characterized a mouse model with purkinje cell selective deletion of the mfp2 gene. |
2019-03-05 |
2023-08-13 |
mouse |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
we show that selective loss of mfp2 from mature cerebellar purkinje neurons causes a late-onset motor phenotype and progressive purkinje cell degeneration, thereby mimicking ataxia and cerebellar deterioration in patients with mild hsd17b4 mutations. |
2019-03-05 |
2023-08-13 |
mouse |
| Sébastien Roux, Yannick Bailly, Jean L Boss. Regional and sex-dependent alterations in Purkinje cell density in the valproate mouse model of autism. Neuroreport. vol 30. issue 2. 2019-02-25. PMID:30461560. |
neuropathological and neuroimaging studies indicate a decrease in purkinje cell (pc) density in the cerebellum of autistic patients and rodent models of autism. |
2019-02-25 |
2023-08-13 |
mouse |
| Sara M Schaefer, Ana Vives Rodriguez, Elan D Loui. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert review of neurotherapeutics. vol 18. issue 2. 2019-02-19. PMID:29206482. |
two disease models for et have been proposed: 1) the olivary model, which attributes et to a pathological pacemaker in the inferior olivary nucleus, and 2) the cerebellar degeneration model, which postulates that et originates in the cerebellum and could be related to deficient or abnormal purkinje cell (pc) output. |
2019-02-19 |
2023-08-13 |
human |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
the genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive purkinje cell degeneration. |
2019-02-18 |
2023-08-13 |
Not clear |