| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joaquín Martí, M C Santa-Cruz, Roger Serra, José P Hervá. Hydroxyurea Treatment and Development of the Rat Cerebellum: Effects on the Neurogenetic Profiles and Settled Patterns of Purkinje Cells and Deep Cerebellar Nuclei Neurons. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27401826. |
these parameters included area of the cerebellum, cerebellar cortex length, molecular layer area, purkinje cell number, granule cell counts, internal granular layer, white matter and cerebellar nuclei areas, and number of deep cerebellar nuclei neurons. |
2017-07-18 |
2023-08-13 |
rat |
| Selma Dadak, Nathalie Bouquier, Elise Goyet, Laurent Fagni, Carole Levenes, Julie Perro. mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor. Neuropharmacology. vol 115. 2017-07-07. PMID:27276689. |
these results were further confirmed on endogenous receptors at the parallel fiber - purkinje cell cerebellar synapse, indicating that the opening of the glud2 channel by mglu1 receptor mobilizes the canonical gq-plc-pkc pathway. |
2017-07-07 |
2023-08-13 |
Not clear |
| Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. |
purkinje cell pathology is a common finding in a range of inherited and acquired cerebellar disorders, with the degree of purkinje cell injury dependent on the underlying aetiology. |
2017-06-21 |
2023-08-13 |
Not clear |
| Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. |
analysing post-mortem cerebellum tissue from patients who had friedreich's ataxia, we provide evidence of significant injury to the purkinje cell axonal compartment with relative preservation of both the perikaryon and its extensive dendritic arborisation. |
2017-06-21 |
2023-08-13 |
Not clear |
| Kevin C Kemp, Amelia J Cook, Juliana Redondo, Kathreena M Kurian, Neil J Scolding, Alastair Wilkin. Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta neuropathologica communications. vol 4. issue 1. 2017-06-21. PMID:27215193. |
for the first time in a genetic condition, we have also shown a disease-related increase in the frequency of purkinje cell fusion and heterokaryon formation in friedreich's ataxia cases; with evidence that underlying levels of cerebellar inflammation influence heterokaryon formation. |
2017-06-21 |
2023-08-13 |
Not clear |
| Archana Sharma, Kavindra K Kesari, Virender K Saxena, Rashmi Sisodi. The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain. General physiology and biophysics. vol 36. issue 1. 2017-06-16. PMID:27787231. |
moreover, changes in cytoarchitechure of hippocampus and cerebellum of the brain and reduction in purkinje cell number were observed statistically significant after microwave exposure from both 0.25 and 11.25 days of gestation. |
2017-06-16 |
2023-08-13 |
mouse |
| Joke Delbaere, Pieter Vancamp, Stijn L J Van Herck, Nele M A Bourgeois, Mary J Green, Richard J T Wingate, Veerle M Darra. MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development. The Journal of endocrinology. vol 232. issue 2. 2017-06-14. PMID:27879339. |
electroporation of an mct8-rnai vector into the cerebellar anlage of a 3-day-old embryo allowed knockdown of mct8 in purkinje cell precursors. |
2017-06-14 |
2023-08-13 |
human |
| Melanie D Mark, Jan Claudius Schwitalla, Michelle Groemmke, Stefan Herlitz. Keeping Our Calcium in Balance to Maintain Our Balance. Biochemical and biophysical research communications. vol 483. issue 4. 2017-06-06. PMID:27392710. |
the gene mutations responsible for half of the ea members and over 35 of the sca subtypes have been identified, and several have been found to be responsible for cerebellar atrophy, abnormal intracellular calcium levels, dysregulation of purkinje cell pacemaking, altered cerebellar synaptic transmission and/or ataxia in mouse models. |
2017-06-06 |
2023-08-13 |
mouse |
| Barry E Kennedy, Amos S Hundert, Donna Goguen, Ian C G Weaver, Barbara Karte. Presymptomatic Alterations in Amino Acid Metabolism and DNA Methylation in the Cerebellum of a Murine Model of Niemann-Pick Type C Disease. The American journal of pathology. vol 186. issue 6. 2017-05-12. PMID:27083515. |
alterations in dna methylation were apparent in decreased expression of dna methyltransferase 3a and methyl-5'-cytosine-phosphodiester-guanine-domain binding proteins, reduced 5-methylcytosine immunoreactivity in the molecular and purkinje cell layers, demethylation of genome-wide repetitive line-1 elements, and hypermethylation in specific promoter regions of single-copy genes in npc1-deficient cerebellum at early stages of the disease. |
2017-05-12 |
2023-08-13 |
mouse |
| Chan Chung, Matthew J Elrick, James M Dell'Orco, Zhaohui S Qin, Shanker Kalyana-Sundaram, Arul M Chinnaiyan, Vikram G Shakkottai, Andrew P Lieberma. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease. PLoS genetics. vol 12. issue 5. 2017-05-12. PMID:27152617. |
many forms of cerebellar degeneration exhibit an anterior-to-posterior gradient of purkinje cell loss including niemann-pick type c1 (npc) disease, a lysosomal storage disorder characterized by progressive neurological deficits that often begin in childhood. |
2017-05-12 |
2023-08-13 |
mouse |
| J W Finnie, P C Blumbergs, J Manavi. Temporal Sequence of Autolysis in the Cerebellar Cortex of the Mouse. Journal of comparative pathology. vol 154. issue 4. 2017-04-14. PMID:27156898. |
this study examined the temporal sequence of post-mortem changes in the cerebellar cortical granular and purkinje cell layers of mice kept at a constant ambient temperature for up to 4 weeks. |
2017-04-14 |
2023-08-13 |
mouse |
| Elan D Loui. Linking Essential Tremor to the Cerebellum: Neuropathological Evidence. Cerebellum (London, England). vol 15. issue 3. 2017-03-06. PMID:26129713. |
these studies have systematically identified a broad range of structural, degenerative changes in the et cerebellum, spanning across all purkinje cell compartments. |
2017-03-06 |
2023-08-13 |
Not clear |
| Nartnutda Morakotsriwan, Jintanaporn Wattanathorn, Woranan Kirisattayakul, Kowit Chaisiwamongko. Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034733. |
the improvement of oxidative stress and purkinje cell loss was also observed in the cerebellum of vpa-treated rats. |
2017-03-03 |
2023-08-13 |
rat |
| Chiara Di Pietro, Daniela Marazziti, Gina La Sala, Zeinab Abbaszadeh, Elisabetta Golini, Rafaele Matteoni, Glauco P Tocchini-Valentin. Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma. Cellular and molecular neurobiology. vol 37. issue 1. 2017-02-13. PMID:26935062. |
the mammalian g-protein-coupled receptor 37-like 1 is specifically expressed in cerebellar bergmann glia astrocytes and participates in regulating postnatal cerebellar granule neuron proliferation/differentiation and bergmann glia and purkinje neuron maturation. |
2017-02-13 |
2023-08-13 |
mouse |
| Dario Cupolillo, Eriola Hoxha, Alessio Faralli, Annarita De Luca, Ferdinando Rossi, Filippo Tempia, Daniela Carull. Autistic-Like Traits and Cerebellar Dysfunction in Purkinje Cell PTEN Knock-Out Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 6. 2017-01-05. PMID:26538449. |
autistic-like traits and cerebellar dysfunction in purkinje cell pten knock-out mice. |
2017-01-05 |
2023-08-13 |
mouse |
| Heather K Titley, Christian Hanse. Asymmetries in Cerebellar Plasticity and Motor Learning. Cerebellum (London, England). vol 15. issue 2. 2016-12-13. PMID:25578035. |
synaptic plasticity at the parallel fiber to purkinje cell synapse has long been considered a cellular correlate for cerebellar motor learning. |
2016-12-13 |
2023-08-13 |
Not clear |
| G Cheron, J Márquez-Ruiz, B Da. Oscillations, Timing, Plasticity, and Learning in the Cerebellum. Cerebellum (London, England). vol 15. issue 2. 2016-12-13. PMID:25808751. |
according to llinás's theory, the cerebellum acts as a control machine that uses the rhythmic activity of the inferior olive to synchronize purkinje cell populations for fine-tuning of coordination. |
2016-12-13 |
2023-08-13 |
Not clear |
| G Cheron, J Márquez-Ruiz, B Da. Oscillations, Timing, Plasticity, and Learning in the Cerebellum. Cerebellum (London, England). vol 15. issue 2. 2016-12-13. PMID:25808751. |
in contrast, the ito-marr-albus theory views the cerebellum as a motor learning machine that heuristically refines synaptic weights of the purkinje cell based on error signals coming from the inferior olive. |
2016-12-13 |
2023-08-13 |
Not clear |
| Elan D Loui. Essential Tremor: A Common Disorder of Purkinje Neurons? The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 22. issue 2. 2016-12-13. PMID:26044399. |
this new formulation centers on the notion that et might be a disease of the cerebellum and, more specifically, the purkinje cell (pc) population. |
2016-12-13 |
2023-08-13 |
Not clear |
| Andrei Khilkevich, Hunter E Halverson, Jose Ernesto Canton-Josh, Michael D Mau. Links Between Single-Trial Changes and Learning Rate in Eyelid Conditioning. Cerebellum (London, England). vol 15. issue 2. 2016-12-13. PMID:26112423. |
the discovery of single-trial learning effects, where the presence or absence (or the number) of climbing fiber inputs produces measureable changes in purkinje cell response and in behavior, represents a major breakthrough in cerebellar learning. |
2016-12-13 |
2023-08-13 |
Not clear |