| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mirthe Erkens, Keiko Tanaka-Yamamoto, Guy Cheron, Javier Márquez-Ruiz, Cynthia Prigogine, Jan Tg Schepens, Nael Nadif Kasri, George J Augustine, Wiljan Jaj Hendrik. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Molecular brain. vol 8. 2016-01-19. PMID:25571783. |
in the cerebellum, a key centre for motor coordination, a positive feedback loop that includes mitogen-activated protein kinases (mapks) is required for proper temporal control of ltd at cerebellar purkinje cell synapses. |
2016-01-19 |
2023-08-13 |
Not clear |
| John E Greenlee, Susan A Clawson, Kenneth E Hill, Blair Wood, Stacey L Clardy, Ikuo Tsunoda, Noel G Carlso. Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PloS one. vol 10. issue 4. 2016-01-18. PMID:25885452. |
anti-yo antibody uptake and interaction with its intracellular target antigen causes purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. |
2016-01-18 |
2023-08-13 |
rat |
| John E Greenlee, Susan A Clawson, Kenneth E Hill, Blair Wood, Stacey L Clardy, Ikuo Tsunoda, Noel G Carlso. Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PloS one. vol 10. issue 4. 2016-01-18. PMID:25885452. |
we have previously demonstrated that incubation of rat cerebellar slice cultures with patient sera and cerebrospinal fluid containing anti-yo antibodies resulted in purkinje cell death. |
2016-01-18 |
2023-08-13 |
rat |
| Mieke Verslegers, Inge Van Hove, Eline Dekeyster, Ilse Gantois, Tjing-Tjing Hu, Rudi D'Hooge, Lutgarde Arckens, Lieve Moon. MMP-2 mediates Purkinje cell morphogenesis and spine development in the mouse cerebellum. Brain structure & function. vol 220. issue 3. 2016-01-15. PMID:24652381. |
mmp-2 mediates purkinje cell morphogenesis and spine development in the mouse cerebellum. |
2016-01-15 |
2023-08-12 |
mouse |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
differential purkinje cell simple spike activity and pausing behavior related to cerebellar modules. |
2016-01-01 |
2023-08-13 |
mouse |
| Haibo Zhou, Kai Voges, Zhanmin Lin, Chiheng Ju, Martijn Schonewill. Differential Purkinje cell simple spike activity and pausing behavior related to cerebellar modules. Journal of neurophysiology. vol 113. issue 7. 2016-01-01. PMID:25717166. |
this implies that pauses in purkinje cell simple spike activity are potentially instrumental in cerebellar information processing, but their occurrence and extent are still heavily debated. |
2016-01-01 |
2023-08-13 |
mouse |
| Tao Tao, Chen Chen, Jie Sun, YaJing Peng, MinSheng Zh. A bacterial artificial chromosome transgenic mouse model for visualization of neurite growth. Science China. Life sciences. vol 58. issue 4. 2015-12-31. PMID:25862661. |
the fusion protein labels purkinje cell dendrites during cerebellar circuit formation. |
2015-12-31 |
2023-08-13 |
mouse |
| Florian Meier, Florian Giesert, Sabit Delic, Theresa Faus-Kessler, Friederike Matheus, Antonio Simeone, Sabine M Hölter, Ralf Kühn, Daniela M Vogt Weisenhorn, Wolfgang Wurst, Nilima Prakas. FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum. PloS one. vol 9. issue 7. 2015-12-03. PMID:24983448. |
in this context, fgfr2-mediated signaling is required for the proper generation of bergmann glia cells and the correct positioning of these cells within the purkinje cell layer, and for cell survival in the developing cerebellar primordium. |
2015-12-03 |
2023-08-13 |
mouse |
| Sven Jarius, Madeleine Scharf, Nora Begemann, Winfried Stöcker, Christian Probst, Irina I Serysheva, Sigrun Nagel, Francesc Graus, Dimitri Psimaras, Brigitte Wildemann, Lars Komorowsk. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of neuroinflammation. vol 11. 2015-11-20. PMID:25498830. |
immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) igg antibodies, mainly igg1, to the molecular layer, purkinje cell layer, and white matter on mouse, rat, porcine, and monkey cerebellum sections. |
2015-11-20 |
2023-08-13 |
mouse |
| Charles H Vite, Jessica H Bagel, Gary P Swain, Maria Prociuk, Tracey U Sikora, Veronika M Stein, Patricia O'Donnell, Therese Ruane, Sarah Ward, Alexandra Crooks, Su Li, Elizabeth Mauldin, Susan Stellar, Marc De Meulder, Mark L Kao, Daniel S Ory, Cristin Davidson, Marie T Vanier, Steven U Walkle. Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. Science translational medicine. vol 7. issue 276. 2015-11-16. PMID:25717099. |
intracisternal cyclodextrin prevents cerebellar dysfunction and purkinje cell death in feline niemann-pick type c1 disease. |
2015-11-16 |
2023-08-13 |
Not clear |
| Charles H Vite, Jessica H Bagel, Gary P Swain, Maria Prociuk, Tracey U Sikora, Veronika M Stein, Patricia O'Donnell, Therese Ruane, Sarah Ward, Alexandra Crooks, Su Li, Elizabeth Mauldin, Susan Stellar, Marc De Meulder, Mark L Kao, Daniel S Ory, Cristin Davidson, Marie T Vanier, Steven U Walkle. Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. Science translational medicine. vol 7. issue 276. 2015-11-16. PMID:25717099. |
however, direct administration of hpβcd into the cisterna magna of presymptomatic cats with npc disease prevented the onset of cerebellar dysfunction for greater than a year and resulted in a reduction in purkinje cell loss and near-normal concentrations of cholesterol and sphingolipids. |
2015-11-16 |
2023-08-13 |
Not clear |
| James M Dell'Orco, Aaron H Wasserman, Ravi Chopra, Melissa A C Ingram, Yuan-Shih Hu, Vikrant Singh, Heike Wulff, Puneet Opal, Harry T Orr, Vikram G Shakkotta. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269637. |
in acute cerebellar slices from sca1 mice, we find that purkinje neuron pacemaker firing is initially normal but, with the onset of motor dysfunction, becomes disrupted, accompanied by abnormal depolarization. |
2015-11-05 |
2023-08-13 |
mouse |
| James M Dell'Orco, Aaron H Wasserman, Ravi Chopra, Melissa A C Ingram, Yuan-Shih Hu, Vikrant Singh, Heike Wulff, Puneet Opal, Harry T Orr, Vikram G Shakkotta. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 32. 2015-11-05. PMID:26269637. |
cerebellar perfusion of flufenamic acid, an agent that restores the depolarized membrane potential of sca1 purkinje neurons by activating potassium channels, prevents purkinje neuron dendritic atrophy. |
2015-11-05 |
2023-08-13 |
mouse |
| Yusuke Seto, Tomoya Nakatani, Norihisa Masuyama, Shinichiro Taya, Minoru Kumai, Yasuko Minaki, Akiko Hamaguchi, Yukiko U Inoue, Takayoshi Inoue, Satoshi Miyashita, Tomoyuki Fujiyama, Mayumi Yamada, Heather Chapman, Kenneth Campbell, Mark A Magnuson, Christopher V Wright, Yoshiya Kawaguchi, Kazuhiro Ikenaka, Hirohide Takebayashi, Shin'ichi Ishiwata, Yuichi Ono, Mikio Hoshin. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nature communications. vol 5. 2015-11-02. PMID:24535035. |
temporal identity transition from purkinje cell progenitors to gabaergic interneuron progenitors in the cerebellum. |
2015-11-02 |
2023-08-12 |
Not clear |
| Anna Duarri, Meng-Chin A Lin, Michiel R Fokkens, Michel Meijer, Cleo J L M Smeets, Esther A R Nibbeling, Erik Boddeke, Richard J Sinke, Harm H Kampinga, Diane M Papazian, Dineke S Verbee. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. Cellular and molecular life sciences : CMLS. vol 72. issue 17. 2015-10-29. PMID:25854634. |
the dominantly inherited cerebellar ataxias are a heterogeneous group of neurodegenerative disorders caused by purkinje cell loss in the cerebellum. |
2015-10-29 |
2023-08-13 |
Not clear |
| Laetitia Wioland, Jean-Luc Dupont, Frédéric Doussau, Stéphane Gaillard, Flavia Heid, Philippe Isope, Serge Pauillac, Michel R Popoff, Jean-Louis Bossu, Bernard Poulai. Epsilon toxin from Clostridium perfringens acts on oligodendrocytes without forming pores, and causes demyelination. Cellular microbiology. vol 17. issue 3. 2015-10-28. PMID:25287162. |
using organotypic cultures of cerebellar slices, we found that et induced the demyelination of purkinje cell axons within 24 h. as this effect was suppressed by antagonizing mglur1 and nmda-r, demyelination is therefore caused by the initial et-induced rise in extracellular glutamate concentration. |
2015-10-28 |
2023-08-13 |
Not clear |
| Georgia Mandolesi, Antonietta Gentile, Alessandra Musella, Diego Centonz. IL-1β dependent cerebellar synaptopathy in a mouse mode of multiple sclerosis. Cerebellum (London, England). vol 14. issue 1. 2015-10-23. PMID:25326653. |
we recently demonstrated that the cerebellum is also targeted in experimental autoimmune encephalomyelitis (eae), the most widely used animal model of ms. electrophysiological studies, supported by immunofluorescence and biochemical analysis, revealed an imbalance between the spontaneous excitatory and inhibitory synaptic transmission at purkinje cell synapses. |
2015-10-23 |
2023-08-13 |
mouse |
| Naofumi Uesaka, Motokazu Uchigashima, Takayasu Mikuni, Hirokazu Hirai, Masahiko Watanabe, Masanobu Kan. Retrograde signaling for climbing fiber synapse elimination. Cerebellum (London, England). vol 14. issue 1. 2015-10-23. PMID:25338972. |
here, we show that semaphorin3a (sema3a) and semaphorin7a (sema7a) mediate retrograde signals for elimination of redundant climbing fiber (cf) to purkinje cell (pc) synapses in the developing cerebellum, a representative model of synapse elimination in the central nervous system. |
2015-10-23 |
2023-08-13 |
Not clear |
| Robert N Jinks, Erik G Puffenberger, Emma Baple, Brian Harding, Peter Crino, Agnes B Fogo, Olivia Wenger, Baozhong Xin, Alanna E Koehler, Madeleine H McGlincy, Margaret M Provencher, Jeffrey D Smith, Linh Tran, Saeed Al Turki, Barry A Chioza, Harold Cross, Gaurav V Harlalka, Matthew E Hurles, Reza Maroofian, Adam D Heaps, Mary C Morton, Lisa Stempak, Friedhelm Hildebrandt, Carolin E Sadowski, Joshua Zaritsky, Kenneth Campellone, D Holmes Morton, Heng Wang, Andrew Crosby, Kevin A Straus. Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. Brain : a journal of neurology. vol 138. issue Pt 8. 2015-10-13. PMID:26070982. |
post-mortem studies revealed (i) micrencephaly without polymicrogyria or heterotopia; (ii) atrophic cerebellar hemispheres with stunted folia, profound granule cell depletion, bergmann gliosis, and signs of purkinje cell deafferentation; (iii) selective striatal cholinergic interneuron loss; and (iv) optic atrophy with delamination of the lateral geniculate nuclei. |
2015-10-13 |
2023-08-13 |
human |
| Yannick J R Bailly, Francis Castet. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. Cerebellum (London, England). vol 6. issue 4. 2015-10-02. PMID:17853115. |
this review focuses on immuno-cytochemical studies showing the strict localization of phocein in purkinje cell dendritic spines involved in excitatory transmission in the cerebellum of postnatal and adult rodents. |
2015-10-02 |
2023-08-12 |
Not clear |