| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lamia Bouslama-Oueghlani, Rosine Wehrlé, Constantino Sotelo, Isabelle Dusar. The developmental loss of the ability of Purkinje cells to regenerate their axons occurs in the absence of myelin: an in vitro model to prevent myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 23. 2003-10-08. PMID:12967994. |
by applying a high dose of bromodeoxyuridine in the culture medium of newborn cerebellar slices during the first 3 d in vitro, we have succeeded in obtaining cultures with oligodendrocyte depletion, together with a lack of ameboid microglia and enhancement of purkinje cell survival. |
2003-10-08 |
2023-08-12 |
Not clear |
| Friedrich Metzger, Josef P Kapfhamme. Protein kinase C: its role in activity-dependent Purkinje cell dendritic development and plasticity. Cerebellum (London, England). vol 2. issue 3. 2003-10-03. PMID:14509570. |
thereby, the ca(2+)-dependent pkc subtypes, activated by synaptic inputs through metabotropic glutamate receptors, trigger functional changes as well as long-term anatomical maturation of the purkinje cell dendritic tree during cerebellar development at different time levels. |
2003-10-03 |
2023-08-12 |
Not clear |
| Kazuyoshi Tsutsui, Hirotaka Sakamoto, Kazuyoshi Uken. A novel aspect of the cerebellum: biosynthesis of neurosteroids in the Purkinje cell. Cerebellum (London, England). vol 2. issue 3. 2003-10-03. PMID:14509571. |
a novel aspect of the cerebellum: biosynthesis of neurosteroids in the purkinje cell. |
2003-10-03 |
2023-08-12 |
Not clear |
| Kazuyoshi Tsutsui, Hirotaka Sakamoto, Kazuyoshi Uken. A novel aspect of the cerebellum: biosynthesis of neurosteroids in the Purkinje cell. Cerebellum (London, England). vol 2. issue 3. 2003-10-03. PMID:14509571. |
we have demonstrated that the purkinje cell, a typical cerebellar neuron, is a major site for neurosteroid formation in the brain. |
2003-10-03 |
2023-08-12 |
Not clear |
| Yu Dong Zhou, Timothy J Turner, Kathleen Dunla. Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering. The Journal of physiology. vol 547. issue Pt 2. 2003-09-23. PMID:12562906. |
we propose that this enhanced modulation shifts the balance of synaptic input to purkinje cells in favour of inhibition, reducing purkinje cell output from the cerebellum, and may contribute to the aberrant motor phenotype that is characteristic of this mutant animal. |
2003-09-23 |
2023-08-12 |
mouse |
| F J Sei. TrkB receptor signaling and activity-dependent inhibitory synaptogenesis. Histology and histopathology. vol 18. issue 2. 2003-09-22. PMID:12647813. |
when mouse organotypic cerebellar cultures were exposed to anti-gaba agents that increased neuronal activity early in development, there was a doubling of the ratio of inhibitory axosomatic synapse profiles to purkinje cell somatic profiles after two weeks in vitro, which correlated with a decrease in spontaneous cortical discharges. |
2003-09-22 |
2023-08-12 |
mouse |
| F J Sei. TrkB receptor signaling and activity-dependent inhibitory synaptogenesis. Histology and histopathology. vol 18. issue 2. 2003-09-22. PMID:12647813. |
when cerebellar cultures were simultaneously exposed to activity blocking agents and to neurotrophins bdnf or nt-4, both of which bound to the trkb receptor, the numbers of inhibitory purkinje cell axosomatic synapses were similar to those of untreated control cultures, and control rates of spontaneous cortical discharges were recorded. |
2003-09-22 |
2023-08-12 |
mouse |
| F J Sei. TrkB receptor signaling and activity-dependent inhibitory synaptogenesis. Histology and histopathology. vol 18. issue 2. 2003-09-22. PMID:12647813. |
subsequent exposure of cerebellar cultures to antibody to the extracellular domain of trkb induced an increased development of purkinje cell axosomatic synapses, while similar antibody activation of trkc had no effect on inhibitory synaptogenesis. |
2003-09-22 |
2023-08-12 |
mouse |
| Silvia Marino, Dennis Hoogervoorst, Sebastian Brandner, Anton Bern. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development (Cambridge, England). vol 130. issue 15. 2003-09-03. PMID:12810584. |
rb and p107 are required for normal cerebellar development and granule cell survival but not for purkinje cell persistence. |
2003-09-03 |
2023-08-12 |
mouse |
| Roy V Sillitoe, Matthew A Benson, Derek J Blake, Richard Hawke. Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 16. 2003-09-03. PMID:12878699. |
in the cerebellar vermis, dysbindin-immunoreactive glomeruli are restricted to an array of parasagittal stripes that bears a consistent relationship to purkinje cell parasagittal band boundaries as defined by the expression of the respiratory isoenzyme zebrin ii/aldolase c. in a mouse model of duchenne muscular dystrophy, the mdx mutant, in which dystrophin is not expressed, there is a dramatic increase in the number of dysbindin-immunoreactive glomeruli in the posterior cerebellar vermis. |
2003-09-03 |
2023-08-12 |
mouse |
| Hassan Marzban, Umme Khanzada, Saima Shabir, Richard Hawkes, Kristina Langnaese, Karl-Heinz Smalla, Tobias M Bockers, Eckart D Gundelfinger, Phillip R Gordon-Weeks, Philip W Beesle. Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes. The Journal of comparative neurology. vol 462. issue 3. 2003-08-29. PMID:12794733. |
first, neuroplastin is associated with purkinje cell dendrites in two mouse granuloprival cerebellar mutants, disabled and cerebellar deficient folia. |
2003-08-29 |
2023-08-12 |
mouse |
| Hassan Marzban, Umme Khanzada, Saima Shabir, Richard Hawkes, Kristina Langnaese, Karl-Heinz Smalla, Tobias M Bockers, Eckart D Gundelfinger, Phillip R Gordon-Weeks, Philip W Beesle. Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes. The Journal of comparative neurology. vol 462. issue 3. 2003-08-29. PMID:12794733. |
finally, primary cerebellar cultures show neuroplastin expression in purkinje cell dendrites and somata lacking normal histotypic organization and synaptic connections, and high-magnification views indicate a preferential association with dendritic spines. |
2003-08-29 |
2023-08-12 |
mouse |
| Wei-Jung A Chen, Russell B Edwards, Roland D Romero, Scott E Parnell, Rebecca J Mon. Long-term nicotine exposure reduces Purkinje cell number in the adult rat cerebellar vermis. Neurotoxicology and teratology. vol 25. issue 3. 2003-08-19. PMID:12757829. |
long-term nicotine exposure reduces purkinje cell number in the adult rat cerebellar vermis. |
2003-08-19 |
2023-08-12 |
rat |
| S Zheng, Z Zu. Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia. Neuroscience. vol 118. issue 1. 2003-08-13. PMID:12676141. |
isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia. |
2003-08-13 |
2023-08-12 |
rat |
| Chris Sekirnjak, Bryce Vissel, Jacob Bollinger, Michael Faulstich, Sascha du La. Purkinje cell synapses target physiologically unique brainstem neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867525. |
the cerebellum controls motor learning via purkinje cell synapses onto discrete populations of neurons in the deep cerebellar nuclei and brainstem vestibular nuclei. |
2003-08-13 |
2023-08-12 |
Not clear |
| T C Frank, M C Nunley, H D Sons, R Ramon, L C Abbot. Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710975. |
in addition, we showed that there is a significant difference in the amount of cerebellar purkinje cell death between rostral and caudal divisions of the leaner cerebellum, and that there is little to no purkinje cell death in the wild type cerebellum at the ages we examined. |
2003-08-08 |
2023-08-12 |
mouse |
| T C Frank, M C Nunley, H D Sons, R Ramon, L C Abbot. Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710975. |
this information can be used to gain insight into the dynamic mechanisms controlling purkinje cell death in the leaner cerebellum. |
2003-08-08 |
2023-08-12 |
mouse |
| Phyllis L Faus. Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency. The Journal of comparative neurology. vol 461. issue 3. 2003-07-31. PMID:12746876. |
defects in cerebellar growth and the rostro-caudal foliation pattern reflect a reduced granule neuron population and abnormal purkinje cell dendrite development. |
2003-07-31 |
2023-08-12 |
mouse |
| A M Ghoumari, I Dusart, M El-Etr, F Tronche, C Sotelo, M Schumacher, E-E Baulie. Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 13. 2003-07-31. PMID:12810951. |
indeed, this steroid is able to prevent purkinje cells from death in organotypic cultures of cerebellar slices from purkinje cell degeneration (pcd) mutant mice, a murine model of hereditary neurodegenerative ataxia. |
2003-07-31 |
2023-08-12 |
mouse |
| Hassan Marzban, Sepehr Zahedi, Miguel Sanchez, Richard Hawke. Antigenic compartmentation of the cerebellar cortex in the syrian hamster Mesocricetus auratus. Brain research. vol 974. issue 1-2. 2003-07-22. PMID:12742635. |
based on the distribution of these purkinje cell subsets the hamster cerebellar vermis was found to consist of four transverse zones-the anterior zone, central zone, posterior zone and nodular zone. |
2003-07-22 |
2023-08-12 |
Not clear |