| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K G Baker, A J Harding, G M Halliday, J J Kril, C G Harpe. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366000. |
there was a significant decrease in purkinje cell density (reduced on average by 43%) and molecular layer volume (reduced by 32%) in the cerebellar vermis in all thiamine-deficient chronic alcoholics. |
1999-08-02 |
2023-08-12 |
human |
| D Jaeger, J M Bowe. Synaptic control of spiking in cerebellar Purkinje cells: dynamic current clamp based on model conductances. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 14. 1999-08-02. PMID:10407045. |
we conclude that purkinje cell responses to synaptic input are strongly dependent on active somatic and dendritic properties and that theories of cerebellar function likely need to incorporate single-cell dynamics to a greater degree than is customary. |
1999-08-02 |
2023-08-12 |
Not clear |
| A Ishikawa, K Oyanagi, K Tanaka, S Igarashi, T Sato, S Tsuj. A non-familial Huntington's disease patient with grumose degeneration in the dentate nucleus. Acta neurologica Scandinavica. vol 99. issue 5. 1999-07-23. PMID:10348164. |
we report a non-familial huntington's disease (hd) patient presenting with increased levels of protein and igg in his cerebrospinal fluid (csf), antineuronal antibody in his serum and csf, purkinje cell and granule cell degeneration in the cerebellum, and grumose degeneration in the dentate nucleus, in addition to typical hd findings. |
1999-07-23 |
2023-08-12 |
Not clear |
| T Miki, S Harris, P Wilce, Y Takeuchi, K S Bed. The effect of the timing of ethanol exposure during early postnatal life on total number of Purkinje cells in rat cerebellum. Journal of anatomy. vol 194 ( Pt 3). 1999-07-19. PMID:10386779. |
we have previously shown that exposing rats to a high dose of ethanol on postnatal d 5 can affect purkinje cell numbers in the cerebellum whilst similar exposure on d 10 had no such effect. |
1999-07-19 |
2023-08-12 |
rat |
| J Townsend, E Courchesne, J Covington, M Westerfield, N S Harris, P Lyden, T P Lowry, G A Pres. Spatial attention deficits in patients with acquired or developmental cerebellar abnormality. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 13. 1999-07-15. PMID:10377369. |
we present evidence of slowed covert orienting of visuospatial attention in patients with developmental cerebellar abnormality (patients with autism, a disorder in which at least 90% of all postmortem cases reported to date have purkinje neuron loss), and in patients with cerebellar damage acquired from tumor or stroke. |
1999-07-15 |
2023-08-12 |
human |
| A A Nisim, C M Hernandez, R W Cohe. The neuroprotective effects of non-NMDA antagonists in the cerebellum of the spastic Han Wistar mutant. Developmental neuroscience. vol 21. issue 1. 1999-07-14. PMID:10077705. |
finally, cerebellar histological evaluations of mutants treated with both 50 and 500 microm cnqx showed dose-dependent higher cerebellar purkinje cell counts. |
1999-07-14 |
2023-08-12 |
rat |
| S C Martin, S J Russek, D H Far. Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Molecular and cellular neurosciences. vol 13. issue 3. 1999-07-12. PMID:10328880. |
gababr2 and gababr1 mrnas are also coexpressed in various brain regions such as the purkinje cell layer of the cerebellum. |
1999-07-12 |
2023-08-12 |
human |
| Y Skoglösa, C Patrone, D Lindhol. Pituitary adenylate cyclase activating polypepetide is expressed by developing rat Purkinje cells and decreases the number of cerebellar gamma-amino butyric acid positive neurons in culture. Neuroscience letters. vol 265. issue 3. 1999-07-01. PMID:10327167. |
during prenatal cerebellar development, pacap mrna was present in developing purkinje cells and some deep cerebellar nuclei, whilst pri mrna was expressed by adjacent cells in the purkinje cell layer (pcl). |
1999-07-01 |
2023-08-12 |
rat |
| J E Greenlee, J Dalmau, T Lyons, S Clawson, R H Smith, H R Pirc. Association of anti-Yo (type I) antibody with paraneoplastic cerebellar degeneration in the setting of transitional cell carcinoma of the bladder: detection of Yo antigen in tumor tissue and fall in antibody titers following tumor removal. Annals of neurology. vol 45. issue 6. 1999-06-24. PMID:10360776. |
anti-yo (type i) autoantibodies reactive with purkinje cell cytoplasmic antigens of 34 and 62 kd are found in the serum and cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration associated with cancer of the ovary, uterus, adnexa, or breast. |
1999-06-24 |
2023-08-12 |
Not clear |
| A Billinton, N Upton, N G Bower. GABA(B) receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum. British journal of pharmacology. vol 126. issue 6. 1999-06-22. PMID:10217533. |
in the rodent cerebellum gaba(b) receptors are localized to a greater extent in the molecular layer, and are reported to exist on granule cell parallel fibre terminals and purkinje cell (pc) dendrites, which may represent pre- and post-synaptic receptors. |
1999-06-22 |
2023-08-12 |
human |
| Y Ishiduka, R Mochizuki, K Yanai, M Takatsuka, T Nonomura, S Niida, H Horiguchi, N Maeda, A Fukamiz. Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin. Biochimica et biophysica acta. vol 1450. issue 1. 1999-06-10. PMID:10231559. |
expression of the gene was localized to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and purkinje cell layer of cerebellum in the brain. |
1999-06-10 |
2023-08-12 |
mouse |
| P Krémarik, C Strazielle, R Lalond. Regional brain variations of cytochrome oxidase activity and motor coordination in hot-foot mutant mice. The European journal of neuroscience. vol 10. issue 9. 1999-06-07. PMID:9758150. |
these results indicate regionally selective abnormalities of metabolic activity in a cerebellar mutant with defective dendritic arborization of the purkinje cell. |
1999-06-07 |
2023-08-12 |
mouse |
| R Ashery-Padan, G Alvarez-Bolado, B Klamt, M Gessler, P Grus. Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. Mechanisms of development. vol 80. issue 2. 1999-06-07. PMID:10072791. |
(3) in the adult, fjx1 is expressed by neurones evenly distributed in the telencephalon (isocortex, striatum, hippocampus, olfactory bulb, piriform cortex), in the purkinje cell layer of the cerebellum, and numerous medullary nuclei. |
1999-06-07 |
2023-08-12 |
mouse |
| R Nakamura, K Kurita, T Kawanami, T Kat. An immunohistochemical study of Purkinje cells in a case of hereditary cerebellar cortical atrophy. Acta neuropathologica. vol 97. issue 2. 1999-05-18. PMID:9928832. |
we report an immunohistochemical study of purkinje cells located in the molecular layer (ectopic purkinje cells) and in the purkinje cell layer (orthotopic purkinje cells) of a patient who died young and had been diagnosed with hereditary cerebellar cortical atrophy from both clinical and neuropathological findings. |
1999-05-18 |
2023-08-12 |
Not clear |
| M A Xu-Friedman, W G Regeh. Presynaptic strontium dynamics and synaptic transmission. Biophysical journal. vol 76. issue 4. 1999-05-07. PMID:10096899. |
here we study the action of strontium at the granule cell to purkinje cell synapse in mouse cerebellar slices. |
1999-05-07 |
2023-08-12 |
mouse |
| M L Doughty, A Lohof, F Selimi, N Delhaye-Bouchaud, J Marian. Afferent-target cell interactions in the cerebellum: negative effect of granule cells on Purkinje cell development in lurcher mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 9. 1999-05-07. PMID:10212305. |
afferent-target cell interactions in the cerebellum: negative effect of granule cells on purkinje cell development in lurcher mice. |
1999-05-07 |
2023-08-12 |
mouse |
| M L Doughty, A Lohof, F Selimi, N Delhaye-Bouchaud, J Marian. Afferent-target cell interactions in the cerebellum: negative effect of granule cells on Purkinje cell development in lurcher mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 9. 1999-05-07. PMID:10212305. |
thus, the normal trophic effects of granule cell interaction on purkinje cell development are absent in the +/lc cerebellum, suggesting that granule cells are powerful regulators of purkinje cell differentiation. |
1999-05-07 |
2023-08-12 |
mouse |
| A Molinero, J Carrasco, J Hernandez, J Hidalg. Effect of nitric oxide synthesis inhibition on mouse liver and brain metallothionein expression. Neurochemistry international. vol 33. issue 6. 1999-05-06. PMID:10098726. |
in agreement with the liver results, in situ hybridization analysis demonstrated a significant upregulation of the brain mt-i isoform in areas such as the cerebrum cortex, neuronal ca1-ca3 layers and dentate gyrus of the hippocampus, and purkinje cell layer of the cerebellum, in 7-ni treated mice. |
1999-05-06 |
2023-08-12 |
mouse |
| G Y Ching, C L Chien, R Flores, R K Lie. Overexpression of alpha-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 8. 1999-04-27. PMID:10191315. |
these torpedoes are abnormal swellings of purkinje cell axons that are usually seen in neurodegenerative diseases involving the cerebellum. |
1999-04-27 |
2023-08-12 |
mouse |
| T E Nelson, I L Campbell, D L Gruo. Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6. Neuroscience. vol 89. issue 1. 1999-04-26. PMID:10051222. |
interleukin-6 induced alterations of purkinje neuron physiology would ultimately affect the flow of information out of the cerebellum, and could thus contribute to the motor deficits observed in the transgenic mice. |
1999-04-26 |
2023-08-12 |
mouse |