| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandar Denic, John C Lieske, Harini A Chakkera, Emilio D Poggio, Mariam P Alexander, Prince Singh, Walter K Kremers, Lilach O Lerman, Andrew D Rul. The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging. Journal of the American Society of Nephrology : JASN. vol 28. issue 1. 2017-06-02. PMID:27401688. |
the incomplete representation of nephron loss with aging by either increased glomerulosclerosis or by cortical volume decline is consistent with atrophy and reabsorption of globally sclerotic glomeruli and hypertrophy of remaining nephrons. |
2017-06-02 |
2023-08-13 |
human |
| Kiyoshi Arai, Yuka Morikawa, Naoko Ubukata, Hiroyuki Tsuruoka, Tsuyoshi Homm. CS-3150, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, Shows Preventive and Therapeutic Effects On Renal Injury in Deoxycorticosterone Acetate/Salt-Induced Hypertensive Rats. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27384074. |
development of renal injury (proteinuria, renal hypertrophy, and histopathological changes in glomeruli and tubule) was also suppressed by cs-3150 with inhibition of mrna expression of fibrosis, inflammation, and oxidative stress markers. |
2017-05-26 |
2023-08-13 |
rat |
| Linhao Xu, Peiqiang Shen, Yanli Bi, Jian Chen, Zhangang Xiao, Xiaoming Zhang, Zheng Wan. Danshen injection ameliorates STZ-induced diabetic nephropathy in association with suppression of oxidative stress, pro-inflammatory factors and fibrosis. International immunopharmacology. vol 38. 2017-04-06. PMID:27355131. |
danshen injection was also found to ameliorate hypertrophy and dilatation of renal tubule and glomeruli possibly by decreasing the expression of collagen and fibronectin in association with suppression of tgf-β1/smad pathway. |
2017-04-06 |
2023-08-13 |
rat |
| Taras Kotyk, Nilanjan Dey, Amira S Ashour, Dana Balas-Timar, Sayan Chakraborty, Ahmed S Ashour, João Manuel R S Tavare. Measurement of glomerulus diameter and Bowman's space width of renal albino rats. Computer methods and programs in biomedicine. vol 126. 2016-12-27. PMID:26796351. |
as well as, the proposed solution has the ability to manage any input images assuring its robustness to the deformations of the glomeruli even with the glomerular hypertrophy cases. |
2016-12-27 |
2023-08-13 |
rat |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology. vol 767. 2016-10-05. PMID:26481166. |
recent studies have shown that calcineurin plays a central role in hypertrophy and extracellular matrix (ecm) accumulation in glomeruli at the early stages of diabetic nephropathy. |
2016-10-05 |
2023-08-13 |
rat |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology. vol 767. 2016-10-05. PMID:26481166. |
in parallel, the diabetic glomeruli became hypertrophic with an increase in kidney weight. |
2016-10-05 |
2023-08-13 |
rat |
| Anita Barzegar-Fallah, Houman Alimoradi, Ali Razmi, Ahmad Reza Dehpour, Mojgan Asgari, Massoumeh Shafie. Inhibition of calcineurin/NFAT pathway plays an essential role in renoprotective effect of tropisetron in early stage of diabetic nephropathy. European journal of pharmacology. vol 767. 2016-10-05. PMID:26481166. |
tropisetron, as potent as cyclosporine a, significantly ameliorated the early nephropathy symptoms, potentially through suppression of calcineurin expression, nuclear localization of nfatc1 and accumulation of fibronectin, and thereby reduced hypertrophy in glomeruli of diabetic rats. |
2016-10-05 |
2023-08-13 |
rat |
| Aleksandar Denic, Richard J Glassock, Andrew D Rul. Structural and Functional Changes With the Aging Kidney. Advances in chronic kidney disease. vol 23. issue 1. 2016-09-22. PMID:26709059. |
the microanatomical structural changes of the kidney with older age include a decreased number of functional glomeruli from an increased prevalence of nephrosclerosis (arteriosclerosis, glomerulosclerosis, and tubular atrophy with interstitial fibrosis), and to some extent, compensatory hypertrophy of remaining nephrons. |
2016-09-22 |
2023-08-13 |
Not clear |
| Miguel Eduardo Sogbe-Díaz, Emilia Elena Díaz-Lópe. [Adrenomedullin in the kidney: physiology and pathophysiology]. Investigacion clinica. vol 57. issue 1. 2016-09-15. PMID:27382803. |
this disease presents compensatory hypertrophy of the glomeruli and mesangial proliferation, administration of am reduces the levels of proteinuria, suggesting that am has an important modulator role in blood pressure and could be a therapeutic option for chronic renal failure. |
2016-09-15 |
2023-08-13 |
Not clear |
| Shuko Ueda, Shota Ozawa, Kiyoshi Mori, Katsuhiko Asanuma, Motoko Yanagita, Shunya Uchida, Takahiko Nakagaw. ENOS deficiency causes podocyte injury with mitochondrial abnormality. Free radical biology & medicine. vol 87. 2016-08-01. PMID:26119782. |
while many glomeruli did not have such advanced lesions, ultrastructural analysis showed cellular hypertrophy, vacuolization, lysosomal enlargement, and microvillus formation in podocytes of enos knockout (ko) mice. |
2016-08-01 |
2023-08-13 |
mouse |
| Sun Ha Lee, Sung Jin Moon, Jisun Paeng, Hye-Young Kang, Bo Young Nam, Seonghun Kim, Chan Ho Kim, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kan. Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:25953318. |
podocyte hypertrophy and apoptosis are two hallmarks of diabetic glomeruli, but the sequence in which these processes occur remains a matter of debate. |
2016-01-04 |
2023-08-13 |
rat |
| Sun Ha Lee, Sung Jin Moon, Jisun Paeng, Hye-Young Kang, Bo Young Nam, Seonghun Kim, Chan Ho Kim, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kan. Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions. Apoptosis : an international journal on programmed cell death. vol 20. issue 8. 2016-01-04. PMID:25953318. |
here we investigated the effects of inhibiting hypertrophy on apoptosis, and vice versa, in both podocytes and glomeruli, under diabetic conditions. |
2016-01-04 |
2023-08-13 |
rat |
| Victor G Puelles, Rebecca N Douglas-Denton, Luise A Cullen-McEwen, Jinhua Li, Michael D Hughson, Wendy E Hoy, Peter G Kerr, John F Bertra. Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells. Journal of the American Society of Nephrology : JASN. vol 26. issue 9. 2015-11-24. PMID:25568174. |
this may render hypertrophic glomeruli susceptible to pathology. |
2015-11-24 |
2023-08-13 |
Not clear |
| Samy L Habi. Alterations in tubular epithelial cells in diabetic nephropathy. Journal of nephrology. vol 26. issue 5. 2015-06-04. PMID:24052469. |
the morphological changes in kidney sections of diabetic patients showed tubular thickening, glomerular and tubular hypertrophy, compared to normal structure of tubuli and glomeruli in kidney from healthy control subjects. |
2015-06-04 |
2023-08-12 |
human |
| Debra Fong, Kate M Denton, Karen M Moritz, Roger Evans, Reetu R Sing. Compensatory responses to nephron deficiency: adaptive or maladaptive? Nephrology (Carlton, Vic.). vol 19. issue 3. 2015-04-06. PMID:24533732. |
hypertrophy of tubules (predominantly the proximal tubule) and glomeruli is accompanied by increased single nephron glomerular filtration rate and tubular reabsorption of sodium. |
2015-04-06 |
2023-08-12 |
Not clear |
| D Lizicarova, B Krahulec, E Hirnerova, L Gaspar, Z Celecov. Risk factors in diabetic nephropathy progression at present. Bratislavske lekarske listy. vol 115. issue 8. 2014-12-01. PMID:25246291. |
the glomeruli of patients with diabetes are characterized by glomerular hypertrophy, widening of the glomerular basement membrane, mesangial expansion, podocytopenia leading to nodular (kimmelstiel-wilson) glomerulosclerosis. |
2014-12-01 |
2023-08-13 |
Not clear |
| Akira Yabuki, Shinichiro Yoneshige, Shin Tanaka, Masashi Tsujio, Sawane Mitani, Osamu Yamat. Age-related histological changes in kidneys of Brown Norway rat. The Journal of veterinary medical science. vol 76. issue 2. 2014-11-03. PMID:24107464. |
sclerotic and hypertrophic changes of the glomeruli were observed, and quantitative scores of these changes persistently increased with age. |
2014-11-03 |
2023-08-12 |
rat |
| P Anil Kumar, Gavin I Welsh, Moin A Saleem, Ram K Meno. Molecular and cellular events mediating glomerular podocyte dysfunction and depletion in diabetes mellitus. Frontiers in endocrinology. vol 5. 2014-10-13. PMID:25309512. |
histological alterations in dm include early hypertrophy of glomerular and tubular components, subsequent thickening of basement membrane in glomeruli and tubules, progressive accumulation of extracellular matrix proteins in the glomerular mesangium and loss of podocytes, together constituting a clinical condition referred to as diabetic nephropathy (dn). |
2014-10-13 |
2023-08-13 |
Not clear |
| Frithjof Lohmann, Marlies Sachs, Tobias N Meyer, Henning Sievert, Maja T Lindenmeyer, Thorsten Wiech, Clemens D Cohen, Stefan Balabanov, R A K Stahl, Catherine Meyer-Schwesinge. UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. Biochimica et biophysica acta. vol 1842. issue 7. 2014-07-24. PMID:24583340. |
functionally, inhibition of uch-l1 activity and knockdown or inhibition of uch-l1 attenuated podocyte hypertrophy by decreasing the total protein content in isolated glomeruli and in cultured podocytes. |
2014-07-24 |
2023-08-12 |
human |
| Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Jung Hoon Choi, Woosuk Kim, Hyo Young Jung, Moo-Ho Won, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoo. Effects of treadmill exercise on neural stem cells, cell proliferation, and neuroblast differentiation in the subgranular zone of the dentate gyrus in cyclooxygenase-2 knockout mice. Neurochemical research. vol 38. issue 12. 2014-07-21. PMID:24150751. |
loss of cox-2 expression in the knockout mice was confirmed with two measures: (1) cox immunolabeling in the hippocampus, and (2) the identification of abnormal kidney development using hematoxylin and eosin staining, including subcapsular glomerular hypoplasia and hypertrophy of the deeper cortical glomeruli. |
2014-07-21 |
2023-08-12 |
mouse |