| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Shimizu, M Sakaguchi, M Inage, A Ichikawa, F Masaki, H Obi, Y Akie, M Nakazawa, R Ishihar. [Thirteen-week repeated dose toxicity by oral administration of trandolapril (RU44570) with 4-week recovery test in beagles]. The Journal of toxicological sciences. vol 18 Suppl 1. 1993-07-20. PMID:8515498. |
in addition, thickening of the afferent arteriolar wall of the glomeruli, a basophilic change of the renal tubular epithelial cells, and localized atrophy and hypertrophy of the renal tubules were observed in the 25 and 250 mg/kg groups, and increases in bun, alp and creatinine, and a slight dilation of the renal tubules were seen in the 250 mg/kg group. |
1993-07-20 |
2023-08-12 |
Not clear |
| Y Nagashima, F Hisaoka, M Ide, K Tamura, K Shimura, G Tanaka, H Tanak. [A 13-week percutaneous toxicity study of prednisolone farnesylate (PNF) gel in beagle dogs with a recovery period of 5 weeks]. The Journal of toxicological sciences. vol 17 Suppl 3. 1993-04-07. PMID:1293321. |
in the histological examinations, a decrease in the weight of the thymus and adrenal glands, vacuolation of hepatocytes in the middle zone of the liver, atrophy of zona fasciculata of the adrenal glands, hypertrophy of zona glomeruli, swelling of cortical cells of zona faciculate and atrophy of the thymus were observed in the pnf gel 0.8 mg/kg/day and above groups. |
1993-04-07 |
2023-08-11 |
dog |
| S M Austin, J S Lieberman, L D Newton, M Mejia, W A Peters, B D Myer. Slope of serial glomerular filtration rate and the progression of diabetic glomerular disease. Journal of the American Society of Nephrology : JASN. vol 3. issue 7. 1993-04-01. PMID:8439648. |
remaining open glomeruli exhibited hypertrophy, excessive extracellular matrix, and deformation of epithelial podocytes. |
1993-04-01 |
2023-08-12 |
Not clear |
| A Guasch, R K Sibley, P Huie, B D Myer. Extent and course of glomerular injury in human membranous glomerulopathy. The American journal of physiology. vol 263. issue 6 Pt 2. 1993-02-05. PMID:1282782. |
morphometric examination of glomeruli in a second group of 16 nephrotic patients with mg revealed a low prevalence of glomerulosclerosis (5 +/- 3%) and a twofold increase in filtration surface due to marked glomerular hypertrophy. |
1993-02-05 |
2023-08-11 |
human |
| S Ban, N Mori, K Saito, K Mizukami, T Suzuki, H Shiraish. An autopsy case of mitochondrial encephalomyopathy (MELAS) with special reference to extra-neuromuscular abnormalities. Acta pathologica japonica. vol 42. issue 11. 1993-01-28. PMID:1471529. |
in addition to severe atrophy and degeneration of the generalized striated muscles and many foci of laminar necrosis of the cerebral cortex, the following abnormalities were observed: 1) hypertrophy of the myocardium, 2) fatty change of the liver, 3) focal sclerosis of the glomeruli and dilatation of the tubules of the kidneys, 4) hyalinous degeneration of the langerhans' islands of the pancreas and 5) wavy change of the smooth muscle fibers of the muscularis propria of the gastrointestinal tract. |
1993-01-28 |
2023-08-11 |
Not clear |
| J E Scherberich, A Matthess, W Remelius, W Schoepp. Aminopeptidase A (= angiotensinase A) in human progressive renal disease. Mineral and electrolyte metabolism. vol 18. issue 2-5. 1993-01-21. PMID:1465088. |
irrespective of the progression of the disease, hypertrophic glomeruli of remnant nephrons exhibited a high and homogeneous expression of ata. |
1993-01-21 |
2023-08-11 |
human |
| N Marcussen, N O Jacobse. The progression of cisplatin-induced tubulointerstitial nephropathy in rats. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 100. issue 3. 1992-05-19. PMID:1562318. |
the findings suggest that a toxic destruction of most s3 segments leads to atrophy or disappearance of the corresponding nephrons with formation of atubular glomeruli, and that the remaining hypertrophic nephrons are connected to the few surviving or regenerated s3 segments. |
1992-05-19 |
2023-08-11 |
rat |
| S Mackensen-Haen, A Bohle, J Christensen, M Wehrmann, H Kendziorra, F Koko. The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases. Clinical nephrology. vol 37. issue 2. 1992-04-24. PMID:1551253. |
5) compensatory hypertrophy of individual nephrons, as proposed by bricker's hypothesis, was found only where more than 90% of the glomeruli were hyalinized. |
1992-04-24 |
2023-08-11 |
Not clear |
| L Paczek, M Teschner, R M Schaefer, J Kovar, W Romen, A Heidlan. Intraglomerular proteinase activity in adriamycin-induced nephropathy. Nephron. vol 60. issue 1. 1992-03-18. PMID:1738419. |
based on these data, we suggest that this relatively decreased proteinase activity in glomeruli exposed to adr might play a pathogenetic role in the development of glomerular hypertrophy, an important harbinger of glomerulosclerosis. |
1992-03-18 |
2023-08-11 |
Not clear |
| F Ishitobi, A Sagiya, K Oka, Y Ueda, T Takimoto, Y Ono, H Kanaya, T Yaguchi, K Iidaka, K Tauch. Focal segmental glomerular hyalinosis and/or sclerosis in rats with congenital unilateral hydronephrosis. Acta pathologica japonica. vol 41. issue 9. 1992-03-03. PMID:1776465. |
on the other hand, glomerular hypertrophy was observed in non-sclerotic glomeruli of cuh rats (superficial glomeruli; 12,477-16,123 microns2, juxtamedullary glomeruli; 14,635-18,418 microns2). |
1992-03-03 |
2023-08-11 |
human |
| B D Myers, L Newto. Cyclosporine-induced chronic nephropathy: an obliterative microvascular renal injury. Journal of the American Society of Nephrology : JASN. vol 2. issue 2 Suppl 1. 1991-12-17. PMID:1932643. |
remnant (spared) glomeruli exhibited hypertrophy; presumably elevated single nephron glomerular filtration rate maintained two-kidney glomerular filtration rate constant despite the declining fraction of functional glomeruli. |
1991-12-17 |
2023-08-11 |
Not clear |
| N Marcussen, S Christensen, J S Petersen, M Shalm. Atubular glomeruli, renal function and hypertrophic response in rats with chronic lithium nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 419. issue 4. 1991-12-13. PMID:1949611. |
atubular glomeruli, renal function and hypertrophic response in rats with chronic lithium nephropathy. |
1991-12-13 |
2023-08-11 |
rat |
| N Marcussen, S Christensen, J S Petersen, M Shalm. Atubular glomeruli, renal function and hypertrophic response in rats with chronic lithium nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 419. issue 4. 1991-12-13. PMID:1949611. |
only glomeruli connected to proximal tubules had a potential for hypertrophy. |
1991-12-13 |
2023-08-11 |
rat |
| A M el Nahas, A H Bassett, G H Cope, J E Le Carpentie. Role of growth hormone in the development of experimental renal scarring. Kidney international. vol 40. issue 1. 1991-11-01. PMID:1921152. |
the significantly smaller glomeruli and limited kidney hypertrophy over 120 days observed in dwarf rats may account for some of the protection against glomerular sclerosis and tubulointerstitial scarring observed in that strain. |
1991-11-01 |
2023-08-11 |
rat |
| A Guasch, H Hashimoto, R K Sibley, W M Deen, B D Myer. Glomerular dysfunction in nephrotic humans with minimal changes or focal glomerulosclerosis. The American journal of physiology. vol 260. issue 5 Pt 2. 1991-06-21. PMID:1709791. |
despite offsetting hypertrophy of remnant glomeruli in fsgs, a loss of filtration surface due to sclerosis likely contributed to the more marked reductions in pore number and gfr observed in this disorder than in mcn. |
1991-06-21 |
2023-08-11 |
Not clear |
| N Marcusse. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. An experimental stereological investigation. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. vol 98. issue 12. 1991-03-18. PMID:2282204. |
the presence of atubular glomeruli and the absence of compensatory hypertrophy of the remaining nephrons might be responsible for the reduction in kidney function in several chronic interstitial renal diseases. |
1991-03-18 |
2023-08-11 |
rat |
| N Marcussen, P D Ottosen, S Christense. Ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 417. issue 6. 1991-02-15. PMID:2125390. |
ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy. |
1991-02-15 |
2023-08-11 |
rat |
| N Marcussen, P D Ottosen, S Christense. Ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 417. issue 6. 1991-02-15. PMID:2125390. |
after 8 weeks of lithium treatment followed by 8 weeks without lithium the hypertrophic glomeruli showed no changes in their relative ultrastructural composition, including normal mesangium, basement membrane-like material and peripheral basement membrane. |
1991-02-15 |
2023-08-11 |
rat |
| N Marcussen, P D Ottosen, S Christense. Ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 417. issue 6. 1991-02-15. PMID:2125390. |
the thickness of the basement membrane was within normal limits in the group of hypertrophic glomeruli but increased by 31% above controls in the group of atubular glomeruli. |
1991-02-15 |
2023-08-11 |
rat |
| N Marcussen, P D Ottosen, S Christense. Ultrastructural quantitation of atubular and hypertrophic glomeruli in rats with lithium-induced chronic nephropathy. Virchows Archiv. A, Pathological anatomy and histopathology. vol 417. issue 6. 1991-02-15. PMID:2125390. |
the atubular glomeruli showed a disproportionate large decrease in peripheral filtration surface and capillary length, compared with the reduction in glomerular volume, whereas the hypertrophic glomeruli showed changes in proportion with the increased volume. |
1991-02-15 |
2023-08-11 |
rat |