| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng-Hsuan Tsai, Chien-Ting Pan, Yi-Yao Chang, Zheng-Wei Chen, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Li. Left ventricular remodeling and dysfunction in primary aldosteronism. Journal of human hypertension. vol 35. issue 2. 2021-08-26. PMID:33067554. |
several mechanisms may explain the process of aldosterone-induced lv remodeling, including directly profibrotic and hypertrophic effects of aldosterone on myocardium, increased reactive oxygen species and profibrotic molecules, dysregulation of extracellular matrix metabolism, endothelium dysfunction and circulatory macrophages activation. |
2021-08-26 |
2023-08-13 |
Not clear |
| Rajiv S Raktoe, Ludo van Haasterecht, Nelda Antonovaite, Luca Bartolini, Remco van Doorn, Paul P M van Zuijlen, Marie Louise Groot, Abdoelwaheb El Ghalbzour. The effect of TGFβRI inhibition on extracellular matrix structure and stiffness in hypertrophic scar-specific fibroblast-derived matrix models. Biochemical and biophysical research communications. vol 559. 2021-08-25. PMID:33964734. |
the effect of tgfβri inhibition on extracellular matrix structure and stiffness in hypertrophic scar-specific fibroblast-derived matrix models. |
2021-08-25 |
2023-08-13 |
Not clear |
| Alexandra M Garvin, Bilal S Khokhar, Michael P Czubryt, Taben M Hal. RAS inhibition in resident fibroblast biology. Cellular signalling. vol 80. 2021-08-23. PMID:33370581. |
ang ii-mediated cardiomyocyte hypertrophy in combination with cardiac fibroblast proliferation, activation, and extracellular matrix production compromise cardiac function and increase mortality in humans. |
2021-08-23 |
2023-08-13 |
Not clear |
| Ichiro Kurokawa, Alison M Layton, Rei Ogaw. Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis. Dermatology and therapy. vol 11. issue 4. 2021-08-20. PMID:34115308. |
transforming growth factor-β (tgfβ), il-6, matrix metalloproteinase (mmp), igf-1, and b cells are found in keloid or hypertrophic scar tissues. |
2021-08-20 |
2023-08-13 |
Not clear |
| Claudia Kusmic, Alessio Vizzoca, Monia Taranta, Lorena Tedeschi, Lisa Gherardini, Gualtiero Pelosi, Ambra Giannetti, Sara Tombelli, Settimio Grimaldi, Francesco Baldini, Claudio Domenici, Maria Giovanna Trivella, Caterina Cint. Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy. Journal of cardiovascular translational research. 2021-08-19. PMID:34409583. |
myocardial hypertrophy, in the presence of different degree of myocardial fibrosis, is paralleled by significant molecular, cellular, and histological changes inducing alteration of cardiac extracellular matrix composition as well as sarcomeres and cytoskeleton remodeling. |
2021-08-19 |
2023-08-13 |
mouse |
| Navya Gupta, Anuradha Bishnoi, Don Mathew, Amanjot Arora, Sanjeev Handa, Jyotdeep Kaur, Dipankar De, Arnab Pa. Hypertrophic post-acne scarring is associated with a single nucleotide polymorphism (rs243865) in the matrix metalloproteinase-2 gene. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. vol 18. issue 12. 2021-08-18. PMID:33373134. |
hypertrophic post-acne scarring is associated with a single nucleotide polymorphism (rs243865) in the matrix metalloproteinase-2 gene. |
2021-08-18 |
2023-08-13 |
Not clear |
| Shuchen Gu, Xin Huang, Xiangwen Xu, Yunhan Liu, Yimin Khoong, Zewei Zhang, Haizhou Li, Yashan Gao, Tao Za. Inhibition of CUB and sushi multiple domains 1 (CSMD1) expression by miRNA-190a-3p enhances hypertrophic scar-derived fibroblast migration in vitro. BMC genomics. vol 22. issue 1. 2021-08-16. PMID:34384362. |
hypertrophic scar (hts) is a fibroproliferative skin disorder characterized by excessive cell proliferation, migration, and extracellular matrix (ecm) deposition. |
2021-08-16 |
2023-08-13 |
Not clear |
| Veronique J Mouli. Three-Dimensional Model of Hypertrophic Scar Using a Tissue-Engineering Approach. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028758. |
sometime, this scar can become pathologic, called hypertrophic scar, with a high amount of extracellular matrix, capillaries, and myofibroblast persistence. |
2021-08-10 |
2023-08-13 |
human |
| Veronique J Mouli. Three-Dimensional Model of Hypertrophic Scar Using a Tissue-Engineering Approach. Methods in molecular biology (Clifton, N.J.). vol 2299. 2021-08-10. PMID:34028758. |
as in tissue, cells are most often imbedded in extracellular matrix, we have developed, using a tissue engineering method, new in vitro models to study human fibrotic skin pathologies as hypertrophic scars. |
2021-08-10 |
2023-08-13 |
human |
| Yuxiang Ge, Yixuan Li, Zixu Wang, Lan Li, Huajian Teng, Qing Jian. Effects of Mechanical Compression on Chondrogenesis of Human Synovium-Derived Mesenchymal Stem Cells in Agarose Hydrogel. Frontiers in bioengineering and biotechnology. vol 9. 2021-08-06. PMID:34350163. |
on the contrary, dynamic compression applied at late time-point not only enhanced the levels of cartilage matrix gene expression, but also suppressed the hypertrophic development of smscs compared with unloaded controls. |
2021-08-06 |
2023-08-13 |
human |
| Zhengmeng Yang, Lu Feng, Jianping Huang, Xiaoting Zhang, Weiping Lin, Bin Wang, Liao Cui, Sien Lin, Gang L. Asiatic acid protects articular cartilage through promoting chondrogenesis and inhibiting inflammation and hypertrophy in osteoarthritis. European journal of pharmacology. vol 907. 2021-08-03. PMID:34174266. |
the mrna expression level of inflammatory markers nitric oxide synthase (inos) and cyclooxygenase 2 (cox2), as well as chondrogenic or hypertrophic markers including sry-box transcription factor 9 (sox9), aggrecan, collagen 2a1 (col ii), and matrix metalloproteinase-13 (mmp13) were measured by using real-time pcr analysis. |
2021-08-03 |
2023-08-13 |
Not clear |
| Inge Everaert, Thibaux Van der Stede, Jan Stautemas, Maxime Hanssens, Cleo van Aanhold, Hans Baelde, Lynn Vanhaecke, Wim Derav. Oral anserine supplementation does not attenuate type-2 diabetes or diabetic nephropathy in BTBR ob/ob mice. Amino acids. vol 53. issue 8. 2021-08-02. PMID:34264387. |
the albumin/creatine ratio, glomerular hypertrophy, and mesangial matrix expansion were aggravated in ob/ob vs. wt mice, but not alleviated by supplementation. |
2021-08-02 |
2023-08-13 |
mouse |
| Nivedhitha Velayutham, Christina M Alfieri, Emma J Agnew, Kyle W Riggs, R Scott Baker, Sithara Raju Ponny, Farhan Zafar, Katherine E Yutze. Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine. Journal of molecular and cellular cardiology. vol 146. 2021-07-28. PMID:32710980. |
here, we provide a comprehensive analysis of postnatal cardiac maturation in swine, including cm cell cycling, multinucleation and hypertrophic growth, as well as non-cm cardiac factors such as extracellular matrix (ecm), immune cells, capillaries, and neurons. |
2021-07-28 |
2023-08-13 |
Not clear |
| Cristina Cavinato, Sae-Il Murtada, Alexia Rojas, Jay D Humphre. Evolving structure-function relations during aortic maturation and aging revealed by multiphoton microscopy. Mechanisms of ageing and development. vol 196. 2021-07-27. PMID:33741396. |
the media similarly showed a progressive decrease in smooth muscle cell density and alignment though with inter-lamellar widening from intermediate to older ages, suggesting cell hypertrophy, matrix accumulation, or both. |
2021-07-27 |
2023-08-13 |
mouse |
| Karol Alí Apaza Alccayhuaman, Stefan Tangl, Stéphane Blouin, Markus A Hartmann, Patrick Heimel, Ulrike Kuchler, Jung-Seok Lee, Reinhard Grube. Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study. Biomedicines. vol 9. issue 7. 2021-07-27. PMID:34202317. |
histology revealed, apart from the characteristic woven bone formation, areas of round-shaped hypertrophic chondrocyte-like cells surrounded by a mineralized extracellular matrix. |
2021-07-27 |
2023-08-13 |
rat |
| Guo Chen, Xi Jin, Xiaoshuai Gao, Jianzhong Ai, Deyi Luo, Liang Zhou, Kaiwen Xiao, Zirui Li, Hong Li, Kunjie Wan. Monocyte Chemotactic Protein-1 Regulates Proliferation and Contractility of Human Bladder Smooth Muscle Cells Under Hydrostatic Pressure. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 40. issue 5. 2021-07-19. PMID:32091964. |
bladder growth and development require continuous mechanical stimuli; however, abnormal mechanical conditions caused by partial bladder outlet obstruction (pboo) result in detrusor smooth muscle hypertrophy and extracellular matrix accumulation. |
2021-07-19 |
2023-08-13 |
human |
| Susan J Wilson, Jonathan A Ward, Helen M Pickett, Simonetta Baldi, Ana R Sousa, Peter J Sterk, Kian Fan Chung, Ratko Djukanovic, Barbro Dahlen, Bo Billing, Dominick Shaw, Norbert Krug, Thomas Sandstrӧm, Christopher Brightling, Peter H Howart. Airway Elastin is increased in severe asthma and relates to proximal wall area: histological and computed tomography findings from the U-BIOPRED severe asthma study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 51. issue 2. 2021-07-19. PMID:33342006. |
airway remodelling, which may include goblet cell hyperplasia / hypertrophy, changes in epithelial integrity, accumulation of extracellular matrix components, smooth muscle hypertrophy and thickening of the lamina reticularis, is a feature of severe asthma and contributes to the clinical phenotype. |
2021-07-19 |
2023-08-13 |
Not clear |
| Gerhild Euler, Fabian Locquet, Joanna Kociszewska, Yvonne Osygus, Jacqueline Heger, Rolf Schreckenberg, Klaus-Dieter Schlüter, Éva Kenyeres, Tamara Szabados, Péter Bencsik, Péter Ferdinandy, Rainer Schul. Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes. Cardiovascular drugs and therapy. vol 35. issue 2. 2021-07-15. PMID:33400052. |
matrix metalloproteinases repress hypertrophic growth in cardiac myocytes. |
2021-07-15 |
2023-08-13 |
rat |
| Changxu Deng, Jin Yang, Hongtao He, Zhenjiang Ma, Wenhao Wang, Yuxin Zhang, Tao Li, Chuanglong He, Jinwu Wan. 3D bio-printed biphasic scaffolds with dual modification of silk fibroin for the integrated repair of osteochondral defects. Biomaterials science. vol 9. issue 14. 2021-07-15. PMID:34047307. |
in vitro results indicated that the gm + sf-ma bio-ink had good mechanical properties, while the gm + sf-pth bio-ink inhibited the hypertrophy of chondrocytes and was beneficial for the production of hyaline cartilage extracellular matrix. |
2021-07-15 |
2023-08-13 |
rabbit |
| Timothy D Smith, Rebecca L Reynolds, Nanami Mano, Brody J Wood, Lanre Oladipupo, Gabriel K Hughes, Hayley M Corbin, Jane Taylor, Alexander Ufelle, Anne M Burrows, Emily Durham, Christopher J Vinyard, James J Cray, Valerie B DeLeo. Cranial synchondroses of primates at birth. Anatomical record (Hoboken, N.J. : 2007). vol 304. issue 5. 2021-07-13. PMID:33015949. |
each synchondrosis was examined for characteristics of active growth centers, including a zonal distribution of proliferating and hypertrophic chondrocytes, as well as corresponding changes in matrix characteristics (i.e., density and organization of type ii collagen). |
2021-07-13 |
2023-08-13 |
monkey |