| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ugo E Pazzaglia, Marcella Reguzzoni, Lavinia Casati, Valeria Sibilia, Guido Zarattini, Mario Raspant. New morphological evidence of the 'fate' of growth plate hypertrophic chondrocytes in the general context of endochondral ossification. Journal of anatomy. vol 236. issue 2. 2021-03-09. PMID:31820452. |
furthermore, the study provided evidence that the metaphyseal capillaries could advance inside the columns of stacked hypertrophic chondrocytes (delimited by the intercolumnar septa) without the need for calcified matrix resorption because the thin transverse septa between the stacked chondrocyte (below the mineral deposition line) were not calcified. |
2021-03-09 |
2023-08-13 |
Not clear |
| Xuanye Bi, Chengzhi Yang, Yunhu Song, Jiansong Yuan, Jingang Cui, Fenghuan Hu, Shubin Qia. Matrix Metalloproteinases Increase Because of Hypoperfusion in Obstructive Hypertrophic Cardiomyopathy. The Annals of thoracic surgery. vol 111. issue 3. 2021-03-09. PMID:32738221. |
matrix metalloproteinases increase because of hypoperfusion in obstructive hypertrophic cardiomyopathy. |
2021-03-09 |
2023-08-13 |
Not clear |
| Monika Szepes, Anna Melchert, Julia Dahlmann, Jan Hegermann, Christopher Werlein, Danny Jonigk, Axel Haverich, Ulrich Martin, Ruth Olmer, Ina Gru. Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33255686. |
myocardial interstitial fibrosis (mif) is characterized by excessive extracellular matrix (ecm) deposition, increased myocardial stiffness, functional weakening, and compensatory cardiomyocyte (cm) hypertrophy. |
2021-03-05 |
2023-08-13 |
human |
| Sara Al-Ghadban, India A Pursell, Zaidmara T Diaz, Karen L Herbst, Bruce A Bunnel. 3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro. International journal of molecular sciences. vol 21. issue 21. 2021-03-01. PMID:33171717. |
in lipedema, both inflammation and hypoxia influence the expansion and differentiation of ascs, resulting in hypertrophic adipocytes and deposition of collagen, a primary component of the extracellular matrix (ecm). |
2021-03-01 |
2023-08-13 |
human |
| Marlies Corvelyn, Nathalie De Beukelaer, Robin Duelen, Jorieke Deschrevel, Anja Van Campenhout, Sandra Prinsen, Ghislaine Gayan-Ramirez, Karen Maes, Guido Weide, Kaat Desloovere, Maurilio Sampaolesi, Domiziana Costamagn. Muscle Microbiopsy to Delineate Stem Cell Involvement in Young Patients: A Novel Approach for Children With Cerebral Palsy. Frontiers in physiology. vol 11. 2021-02-26. PMID:32848872. |
previous research reported altered muscle properties, such as reduced volume and satellite cell (sc) numbers and hypertrophic extracellular matrix compared to typically developing (td) children (>10 years). |
2021-02-26 |
2023-08-13 |
human |
| Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhur. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 295. issue 42. 2021-02-23. PMID:32732288. |
tgfβ acts through pdgfrβ to activate mtorc1 via the akt/pras40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. |
2021-02-23 |
2023-08-13 |
mouse |
| Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhur. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 295. issue 42. 2021-02-23. PMID:32732288. |
interaction of transforming growth factor-β (tgfβ)-induced canonical signaling with the noncanonical kinase cascades regulates glomerular hypertrophy and matrix protein deposition, which are early features of glomerulosclerosis. |
2021-02-23 |
2023-08-13 |
mouse |
| Soumya Maity, Falguni Das, Balakuntalam S Kasinath, Nandini Ghosh-Choudhury, Goutam Ghosh Choudhur. TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 295. issue 42. 2021-02-23. PMID:32732288. |
thus, pursuing tgfβ noncanonical signaling, we identified how tgfβ receptor i achieves mtorc1 activation through pdgfrβ-mediated akt/pras40 phosphorylation to spur mesangial cell hypertrophy and matrix protein accumulation. |
2021-02-23 |
2023-08-13 |
mouse |
| Nihui Zhang, Tao Gao, Yao Wang, Juan Liu, Junwei Zhang, Ruijuan Yao, Fang W. Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing. International journal of biological macromolecules. vol 154. 2021-02-19. PMID:32194120. |
an optimum window of chitosan cationicity (5% in our case) demonstrated potential to mitigate hypertrophic scar in wound healing by suppressing the expression of a-smooth muscle actin (a-sma) and promoting secretion of type i matrix metalloproteinases (mmp-1). |
2021-02-19 |
2023-08-13 |
Not clear |
| Reginald W Taylor, Georgia K Mitchell, Jon Lee Andrade, Kathy K Svobod. Expression of Collagen Types I, II, IX, and X in the Mineralizing Turkey Gastrocnemius Tendon. Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 6. 2021-02-16. PMID:30768858. |
type x collagen was in the pericellular matrix of hypertrophic chondrocytes and in some calcified matrix. |
2021-02-16 |
2023-08-13 |
Not clear |
| Yu Gao, Changhong Ren, Xiaohua Li, Wantong Yu, Sijie Li, Haiyan Li, Yan Wang, Dong Li, Ming Ren, Xunming J. Ischemic Conditioning Ameliorated Hypertension and Vascular Remodeling of Spontaneously Hypertensive Rat via Inflammatory Regulation. Aging and disease. vol 12. issue 1. 2021-02-06. PMID:33532132. |
lric ameliorated vascular remodeling by decreasing cross-sectional area, suppressing deposition of the extracellular matrix, and hypertrophy of smooth muscle cell in conduit artery and small resistance artery (n = 7). |
2021-02-06 |
2023-08-13 |
rat |
| Serdar Korpayev, Özge Toprak, Gülşah Kaygusuz, Murat Şen, Kaan Orhan, Ayşe Karakeçil. Regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix. Colloids and surfaces. B, Biointerfaces. vol 193. 2021-02-03. PMID:32531647. |
regulation of chondrocyte hypertrophy in an osteochondral interface mimicking gel matrix. |
2021-02-03 |
2023-08-13 |
Not clear |
| Mário Morais Silva, Fernando Pedro de Souza-Neto, Itamar Couto Guedes de Jesus, Gleisy Kelly Gonçalves, Melissa de Carvalho Santuchi, Bruno de Lima Sanches, Thaís Cristina de Alcântara-Leonídio, Marcos Barrouin Melo, Maria Aparecida Ribeiro Vieira, Silvia Guatimosim, Robson Augusto Souza Santos, Rafaela Fernandes da Silv. Alamandine improves cardiac remodeling induced by transverse aortic constriction in mice. American journal of physiology. Heart and circulatory physiology. vol 320. issue 1. 2021-02-01. PMID:33124885. |
tac induced myocyte hypertrophy, collagen deposition, and the expression of matrix metalloproteinase (mmp)-2 and transforming growth factor (tgf)-β in the left ventricle. |
2021-02-01 |
2023-08-13 |
mouse |
| Wen-Feng Xiao, Yu-Sheng Li, Ang Deng, Yun-Tao Yang, Miao H. Functional role of hedgehog pathway in osteoarthritis. Cell biochemistry and function. vol 38. issue 2. 2021-01-29. PMID:31833076. |
usually in oa, activation of hedgehog induces up-regulation of the expression of hypertrophic markers, including type x collagen, increases production of nitric oxide and prostaglandin e2, several matrix-degrading enzymes including matrix metalloproteinase and a disintegrin and metalloproteinase with thrombospondin motifs in human knee joint cartilage leading to cartilage degeneration, and thus contributes in oa. |
2021-01-29 |
2023-08-13 |
human |
| Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumot. Bioinspired Mineralization Using Chondrocyte Membrane Nanofragments. ACS biomaterials science & engineering. vol 4. issue 2. 2021-01-11. PMID:33418750. |
instead, chondrocyte membrane nanofragments were found in the fibrous matrix surrounding the hypertrophic chondrocytes. |
2021-01-11 |
2023-08-13 |
mouse |
| Jianlin Feng, Maria K Armillei, Albert S Yu, Bruce T Liang, Loren W Runnels, Lixia Yu. Ca Journal of cardiovascular development and disease. vol 6. issue 4. 2021-01-10. PMID:31547577. |
ca cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most heart diseases, including arrhythmia, hypertrophy, and heart failure. |
2021-01-10 |
2023-08-13 |
Not clear |
| Behzad Javaheri, Soraia P Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A Pitsillide. The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? Frontiers in bioengineering and biotechnology. vol 6. 2021-01-09. PMID:29619368. |
endochondral ossification (eo), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix synthesis, calcification, and angiogenesis, followed by osteoblast-mediated ossification. |
2021-01-09 |
2023-08-13 |
Not clear |
| Bishara S Atiye. Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods. Aesthetic plastic surgery. vol 44. issue 4. 2021-01-06. PMID:32766921. |
hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. |
2021-01-06 |
2023-08-13 |
Not clear |
| Mazaher Gholipourmalekabadi, Sadjad Khosravimelal, Zeinab Nokhbedehghan, Marzieh Sameni, Vahid Jajarmi, Aleksandra M Urbanska, Hadi Mirzaei, Maryam Salimi, Narendra Pal Singh Chauhan, Mohammadmahdi Mobaraki, Rui L Reis, Ali Samadikuchaksaraei, Subhas C Kund. Modulation of Hypertrophic Scar Formation Using Amniotic Membrane/Electrospun Silk Fibroin Bilayer Membrane in a Rabbit Ear Model. ACS biomaterials science & engineering. vol 5. issue 3. 2021-01-06. PMID:33405623. |
hypertrophic scarring is a dermal disorder resulting from collagen and other extra cellular matrix protein depositions following the deep trauma, severe burn injury, and surgery incisions. |
2021-01-06 |
2023-08-13 |
human |
| Heather Fairfield, Samantha Costa, Victoria DeMambro, Celine Schott, Janaina Da Silva Martins, Mathieu Ferron, Calvin Vary, Michaela R Reaga. Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. JBMR plus. vol 4. issue 11. 2020-11-21. PMID:33210065. |
in endochondral ossification, chondroblasts become embedded in their matrix and become chondrocytes, which are mature cells that continue to proliferate, eventually becoming hypertrophic. |
2020-11-21 |
2023-08-13 |
mouse |