| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneu. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 34. issue 4. 2020-01-06. PMID:29931336. |
diabetes elevates nox4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation. |
2020-01-06 |
2023-08-13 |
mouse |
| Daisuke Maeda, Tateki Kubo, Koichiro Kiya, Kenichiro Kawai, Shinsuke Matsuzaki, Daichi Kobayashi, Toshihiro Fujiwara, Taiichi Katayama, Ko Hosokaw. Periostin is induced by IL-4/IL-13 in dermal fibroblasts and promotes RhoA/ROCK pathway-mediated TGF-β1 secretion in abnormal scar formation. Journal of plastic surgery and hand surgery. vol 53. issue 5. 2019-12-31. PMID:31066603. |
excess scar formation can occur after skin injurふy and lead to abnormal scar formation, such as keloids and hypertrophic scars, which are characterised by substantial deposition of extracellular matrix in the dermis. |
2019-12-31 |
2023-08-13 |
human |
| Huan Zhou, Bin Wang, Ying-Xi Yang, Qiu-Jin Jia, Ao Zhang, Zhong-Wen Qi, Jun-Ping Zhan. Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature. BioMed research international. vol 2019. 2019-12-30. PMID:31355277. |
in addition, neat1, ak139328, apf, caif, ak088388, carl, malat1, hotair, xist, and nrf are involved in postischemia myocardial remodeling, while mhrt, chast, chrf, ror, h19, plscr4, and miat are involved in myocardial hypertrophy, and malat1, wisper, meg3, and h19 are involved in extracellular matrix (ecm) reconstitution. |
2019-12-30 |
2023-08-13 |
Not clear |
| Gabor A Fulop, Francisco I Ramirez-Perez, Tamas Kiss, Stefano Tarantini, Marta Noa Valcarcel Ares, Peter Toth, Andriy Yabluchanskiy, Shannon M Conley, Praveen Ballabh, Luis A Martinez-Lemus, Zoltan Ungvari, Anna Csisza. IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 4. 2019-12-26. PMID:29931048. |
mcas of control mice exhibited structural adaptation to hypertension, manifested as a significant increase in wall thickness, vascular smooth muscle cell (vsmc) hypertrophy, decreased internal diameter and up-regulation of extracellular matrix (ecm)-related genes. |
2019-12-26 |
2023-08-13 |
mouse |
| Marijn Rutgers, Frances Bach, Luciënne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one. vol 14. issue 4. 2019-12-19. PMID:30947269. |
extracellular matrix production, (pre)hypertrophy and pth signaling were assessed by rt-qpcr and/or immunohistochemistry for collagen type i, ii, x, runx2, mmp13, pthr1 and ihh and by determining glycosaminoglycan production and dna content. |
2019-12-19 |
2023-08-13 |
human |
| Marijn Rutgers, Frances Bach, Luciënne Vonk, Mattie van Rijen, Vanessa Akrum, Antonette van Boxtel, Wouter Dhert, Laura Creemer. PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation. PloS one. vol 14. issue 4. 2019-12-19. PMID:30947269. |
in conclusion, pth supplementation to healthy human articular chondrocytes did not affect hypertrophic differentiation, but negatively influenced cartilage quality, the tissues' extracellular matrix and cell content. |
2019-12-19 |
2023-08-13 |
human |
| Rodolphe Rakic, Bastien Bourdon, Magali Demoor, Stéphane Maddens, Nathalie Saulnier, Philippe Galér. Differences in the intrinsic chondrogenic potential of equine umbilical cord matrix and cord blood mesenchymal stromal/stem cells for cartilage regeneration. Scientific reports. vol 8. issue 1. 2019-12-06. PMID:30217993. |
we carried out an exhaustive characterization of the extracellular matrix generated by both these two types of mscs after the induction of chondrogenesis through evaluation of hyaline cartilage, hypertrophic and osteogenic markers (mrna, protein and histology levels). |
2019-12-06 |
2023-08-13 |
Not clear |
| De Luca F, Baro. Control of Bone Growth by Fibroblast Growth Factors. Trends in endocrinology and metabolism: TEM. vol 10. issue 2. 2019-11-20. PMID:10322396. |
in organ culture, fgf-2 inhibits growth by decreasing growth plate chondrocyte proliferation, hypertrophy and cartilage matrix synthesis. |
2019-11-20 |
2023-08-12 |
mouse |
| Cintia do Carmo E Silva, Jônathas Fernandes Queiroz de Almeida, Larissa Matuda Macedo, Marcos Barrouin Melo, Gustavo Rodrigues Pedrino, Fernanda Cristina Alcantara Dos Santos, Manoel Francisco Biancardi, Robson Augusto Souza Dos Santos, Adryano Augustto Valladão de Carvalho, Elizabeth Pereira Mendes, Diego Basile Colugnati, Renata Mazaro-Costa, Carlos Henrique de Castr. Mas receptor contributes to pregnancy-induced cardiac remodelling. Clinical science (London, England : 1979). vol 130. issue 24. 2019-11-20. PMID:27624141. |
in conclusion, these data show that although mas receptor blockade or deletion decreases physiological hypertrophy of pregnancy, it is associated with more extracellular matrix deposition. |
2019-11-20 |
2023-08-13 |
mouse |
| Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y C Lai, Christopher L O'Connor, YiFan Wu, Jeffrey B Hodgin, Robert G Nelson, Markus Bitzer, Rama Nataraja. An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy. Nature communications. vol 7. 2019-11-20. PMID:27686049. |
targeting early features of dn, including renal extracellular matrix accumulation (ecm) and glomerular hypertrophy, can prevent disease progression. |
2019-11-20 |
2023-08-13 |
mouse |
| N V Medvedev, N K Gorshunov. [Apoptosis and interstitial fibrosis in development of myocardial remodelling in elderly patients with arterial hypertension]. Advances in gerontology = Uspekhi gerontologii. vol 26. issue 2. 2019-11-20. PMID:28976159. |
structural reorganization of a myocardium from concentric to eccentric hypertrophy and concentric remodelling of left ventricle was characterized by strengthening of cellular apoptosis and interstitial myocardial fibrosis in extracellular matrix expressiveness, prevalence of collagen synthesis over collagen degradation, progressing of myocardium dysfunction. |
2019-11-20 |
2023-08-13 |
Not clear |
| Qian Tang, Gang Zheng, Zhenhua Feng, Minji Tong, Jianxiang Xu, Zhiyan Hu, Ping Shang, Yu Chen, Chenggui Wang, Yiting Lou, Deheng Chen, Di Zhang, Majid Nisar, Xiaolei Zhang, Huazi Xu, Haixiao Li. Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis. Oncotarget. vol 8. issue 37. 2019-11-20. PMID:28977876. |
the inflammatory environment is correlated with extracellular matrix (ecm) degradation and chondrocyte hypertrophy in the development of osteoarthritis (oa). |
2019-11-20 |
2023-08-13 |
mouse |
| Jihong Shi, Shan Shi, Bin Wu, Jian Zhang, Yan Li, Xue Wu, Julei Zhang, Kejia Wang, Bin Zhao, Weixia Cai, Xiaozhi Bai, Dahai Hu, Hao Gua. Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts. Oncotarget. vol 8. issue 55. 2019-11-20. PMID:29212187. |
hypertrophic scar (hs) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ecm) component deposition. |
2019-11-20 |
2023-08-13 |
rabbit |
| Chunpeng Zou, Weixin Li, Yong Pan, Zia A Khan, Jieli Li, Xixi Wu, Yi Wang, Liancheng Deng, Guang Liang, Yunjie Zha. 11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity. Oncotarget. vol 8. issue 56. 2019-11-20. PMID:29221204. |
we also show that high levels of glucose caused cardiomyocyte hypertrophy and increased matrix protein deposition in culture. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, Jirong Wang, Meiping Lu, Wei Shi, Liu Mei, Chengyun Xu, Xueying Fan, Musaddique Hussain, Jingyu Du, Junsong Wu, Ximei W. Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 33. issue 5. 2019-10-23. PMID:29314205. |
specifically, genetic disruption of cdc42, knockdown of cdc42 expression, or inhibition of cdc42 activity robustly attenuates the dmm-induced destruction, hypertrophy, high expression of matrix metallopeptidase-13 and collagen x, and activation of stat3 in articular cartilages. |
2019-10-23 |
2023-08-13 |
mouse |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30559344. |
an increase in csi-mg10 content is desirable for promoting the hypertrophy and mineralization of chondrocytes, as well as cell proliferation and matrix deposition. |
2019-10-18 |
2023-08-13 |
human |
| Xinning Yu, Tengfei Zhao, Yiying Qi, Jianyang Luo, Jinghua Fang, Xianyan Yang, Xiaonan Liu, Tengjing Xu, Quanming Yang, Zhongru Gou, Xuesong Da. In vitro Chondrocyte Responses in Mg-doped Wollastonite/Hydrogel Composite Scaffolds for Osteochondral Interface Regeneration. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30559344. |
it is noteworthy that the hdzcs in the 6% csi-mg10 scaffolds maintained a higher expression of the calcified cartilage zone specific extracellular matrix marker and hypertrophic marker, collagen type x. immunohistochemical and alizarin red staining reconfirmed these findings. |
2019-10-18 |
2023-08-13 |
human |
| Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibb. Endothelial cells enhance adipose mesenchymal stromal cell-mediated matrix contraction via ALK receptors and reduced follistatin: Potential role of endothelial cells in skin fibrosis. Journal of cellular physiology. vol 233. issue 10. 2019-10-03. PMID:29345319. |
in conclusion, our study shows that ec may play a critical role in fibrotic events, as seen in hypertrophic scars, by stimulating asc-mediated matrix contraction via regulation of fibrosis-related proteins. |
2019-10-03 |
2023-08-13 |
Not clear |
| Aaron J Rogers, Ramaswamy Kannappan, Hadil Abukhalifeh, Mohammed Ghazal, Jessica M Miller, Ayman El-Baz, Vladimir G Fast, Palaniappan Seth. Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells, tissues, organs. vol 206. issue 1-2. 2019-09-19. PMID:30840966. |
following 7 days of gradually increasing stimulation, we show that hemodynamic loading results in (a) enhanced alignment of the cells and extracellular matrix, (b) significant increases in genes associated with physiological hypertrophy, (c) noticeable changes in sarcomeric organization and potential changes to cellular metabolism, and (d) a significant increase in fractional shortening, suggestive of a positive force frequency response. |
2019-09-19 |
2023-08-13 |
human |
| Marcela M Blascke de Mello, Juliana M Parente, Richard Schulz, Michele M Castr. Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. Vascular pharmacology. vol 116. 2019-09-03. PMID:30339939. |
matrix metalloproteinase (mmp)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension. |
2019-09-03 |
2023-08-13 |
rat |