| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming Wang, Dan-Qian Chen, Min-Chang Wang, Hua Chen, Lin Chen, Dan Liu, Hui Zhao, Ying-Yong Zha. Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 36. 2018-05-15. PMID:29157821. |
the pathogenesis of tubulo-interstitial fibrosis and glomerulosclerosisis was characterized by cellular hypertrophy, extracellular matrix accumulation and podocyte detachment. |
2018-05-15 |
2023-08-13 |
Not clear |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. |
2018-05-11 |
2023-08-13 |
human |
| Zhe Wang, Qibin Song, Hongqiu L. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849177. |
a hypertrophic scar is characterized by fibroblast proliferation and excessive extracellular matrix deposition. |
2018-05-11 |
2023-08-13 |
human |
| Tangni Gómez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre, David Ollitrault, Claire de Vienne, Michel Herlicoviez, Philippe Galéra, Magali Demoo. Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges. International journal of molecular sciences. vol 18. issue 9. 2018-05-03. PMID:28885597. |
however, hypoxia exerted more benefit by decreasing collagen x and matrix metalloproteinase-13 (mmp13) expression, two chondrocyte hypertrophy markers. |
2018-05-03 |
2023-08-13 |
human |
| Xiaoxia Wang, E Shen, Yanzhe Wang, Junhui Li, Dongsheng Cheng, Yuqiang Chen, Dingkun Gui, Niansong Wan. Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions. Scientific reports. vol 6. 2018-05-02. PMID:27549568. |
this study aimed to investigate the therapeutic role of mirna in diabetic glomerular mcs hypertrophy and synthesis of extracellular matrix (ecm). |
2018-05-02 |
2023-08-13 |
mouse |
| Verena Dexheimer, Jessica Gabler, Katharina Bomans, Tanja Sims, Georg Omlor, Wiltrud Richte. Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation. Scientific reports. vol 6. 2018-05-02. PMID:27848974. |
conclusively, alk1,2,3,6-signalling was essential for msc-chondrogenesis and its prochondrogenic rather than prohypertrophic role may explain why inhibition of canonical bmp-signalling could not uncouple cartilage matrix production from hypertrophy as this was achieved with pulsed pthrp-application. |
2018-05-02 |
2023-08-13 |
Not clear |
| Katherine Marie Huber, Alicia Rose Billington, Loryn J Taylor, Kimberly Brown Maynell, C Wayne Crus. Nonoperative Treatment of a Tracheocutaneous Fistula in a Burn Patient. Journal of burn care & research : official publication of the American Burn Association. vol 38. issue 4. 2018-04-30. PMID:27893570. |
she subsequently underwent excision of hypertrophic burn scar contractures of the neck with placement of bilayer wound matrix followed by split-thickness skin grafting. |
2018-04-30 |
2023-08-13 |
Not clear |
| Zhen Cao, Yun Bai, Chuan Liu, Ce Dou, Jianmei Li, Junyu Xiang, Chunrong Zhao, Zhao Xie, Qiang Xiang, Shiwu Don. Hypertrophic differentiation of mesenchymal stem cells is suppressed by xanthotoxin via the p38‑MAPK/HDAC4 pathway. Molecular medicine reports. vol 16. issue 3. 2018-04-30. PMID:28677757. |
the results revealed that xat inhibited the expression of various chondrocyte hypertrophic markers, including runt related transcription factor 2 (runx2), matrix metalloproteinase 13 and collagen type x α1 chain. |
2018-04-30 |
2023-08-13 |
Not clear |
| Koichiro Kiya, Tateki Kubo, Kenichiro Kawai, Shinsuke Matsuzaki, Daisuke Maeda, Toshihiro Fujiwara, Akimitsu Nishibayashi, Shigeyuki Kanazawa, Kenji Yano, Genki Amano, Taiichi Katayama, Ko Hosokaw. Endothelial cell-derived endothelin-1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho-kinase pathway. Experimental dermatology. vol 26. issue 8. 2018-04-24. PMID:27892645. |
hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. |
2018-04-24 |
2023-08-13 |
human |
| Leonardo Schirone, Maurizio Forte, Silvia Palmerio, Derek Yee, Cristina Nocella, Francesco Angelini, Francesca Pagano, Sonia Schiavon, Antonella Bordin, Albino Carrizzo, Carmine Vecchione, Valentina Valenti, Isotta Chimenti, Elena De Falco, Sebastiano Sciarretta, Giacomo Frat. A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. Oxidative medicine and cellular longevity. vol 2017. 2018-04-17. PMID:28751931. |
among the complex signaling network that characterizes myocardial remodeling, the distinct processes are myocyte loss, cardiac hypertrophy, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy, metabolic abnormalities, and mitochondrial dysfunction. |
2018-04-17 |
2023-08-13 |
Not clear |
| Li Zhang, Qianmei Zhang, Shuangxin Liu, Yuanhan Chen, Ruizhao Li, Ting Lin, Chunping Yu, Hong Zhang, Zhongshun Huang, Xinchen Zhao, Xiaofan Tan, Zhuo Li, Zhiming Ye, Jianchao Ma, Bin Zhang, Wenjian Wang, Wei Shi, Xinling Lian. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney international. vol 92. issue 1. 2018-04-03. PMID:28318634. |
this was accompanied by alleviation of glomerular hypertrophy, mesangial matrix expansion, and podocyte injury. |
2018-04-03 |
2023-08-13 |
mouse |
| Peter O Kwan, Edward E Tredge. Biological Principles of Scar and Contracture. Hand clinics. vol 33. issue 2. 2018-03-21. PMID:28363295. |
these cells also both modify and interact with extracellular matrix of the wound, ultimately forming hypertrophic scar. |
2018-03-21 |
2023-08-13 |
Not clear |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one. vol 13. issue 2. 2018-03-13. PMID:29389945. |
measurements of glomerular hypertrophy and mesangial matrix expansion were made in periodic acid-schiff stained kidney sections, while glomerular transforming growth factor-β1 (tgf-β1), connective tissue growth factor (ctgf) and vascular endothelial growth factor-a (vegf-a) proteins were semi-quantified by immunohistochemistry. |
2018-03-13 |
2023-08-13 |
mouse |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one. vol 13. issue 2. 2018-03-13. PMID:29389945. |
we conclude that ih causes kidney injury that is accompanied by glomerular hypertrophy, mesangial matrix expansion, increased expression of glomerular growth factors and an increased cellular apoptosis. |
2018-03-13 |
2023-08-13 |
mouse |
| Shun Wang, Mian Cheng, Zhengqing Hu, Shan Hu, Qiang Zou, Xin Lai, Beilei Liu, Hong Jiang, Congxin Huang, Gang W. Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 6. 2018-03-12. PMID:29262413. |
angiotensin ii facilitates matrix metalloproteinase-9-mediated myosin light chain kinase degradation in pressure overload-induced cardiac hypertrophy. |
2018-03-12 |
2023-08-13 |
Not clear |
| Umadevi Subramanian, Prerna Kumar, Indra Mani, David Chen, Isaac Kessler, Ramu Periyasamy, Giri Raghavaraju, Kailash N Pande. Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice. Physiological genomics. vol 48. issue 7. 2018-01-25. PMID:27199456. |
the objective of the present study was to examine the genetically determined differences in the natriuretic peptide receptor-a (npra) gene (npr1) copies affecting the expression of cardiac hypertrophic markers, proinflammatory mediators, and matrix metalloproteinases (mmps) in a gene-dose-dependent manner. |
2018-01-25 |
2023-08-13 |
mouse |
| Young Jun Oh, Vanessa C Pau, Jochen Steppan, Gautam Sikka, Valeriani R Bead, Daniel Nyhan, Benjamin D Levine, Dan E Berkowitz, Lakshmi Santhana. Role of tissue transglutaminase in age-associated ventricular stiffness. Amino acids. vol 49. issue 3. 2017-12-29. PMID:27438265. |
aging is associated with increased cardiomyocyte loss, left-ventricular hypertrophy, and the accumulation of extracellular matrix, which results in declining cardiac function. |
2017-12-29 |
2023-08-13 |
rat |
| Ana B García-Redondo, Andrea Aguado, Ana M Briones, Mercedes Salaice. NADPH oxidases and vascular remodeling in cardiovascular diseases. Pharmacological research. vol 114. 2017-12-26. PMID:27773825. |
a misbalance between the production and detoxification of ros increases oxidative stress that is involved in the vascular remodeling associated with cardiovascular diseases such as hypertension by affecting inflammation, hypertrophy, migration, growth/apoptosis and extracellular matrix protein turnover. |
2017-12-26 |
2023-08-13 |
Not clear |
| Sandeep C Chaudhary, Maria Kuzynski, Massimo Bottini, Elia Beniash, Terje Dokland, Callie G Mobley, Manisha C Yadav, Anne Poliard, Odile Kellermann, José Luis Millán, Dobrawa Napieral. Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro. Matrix biology : journal of the International Society for Matrix Biology. vol 52-54. 2017-12-20. PMID:26883946. |
in mineralizing tissues, such as dentin, bone and hypertrophic cartilage, this process is initiated by a specific population of extracellular vesicles (ev), called matrix vesicles (mv). |
2017-12-20 |
2023-08-13 |
Not clear |
| Teruyo Nakatani, Tiffany Chen, Nicola C Partridg. MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone. vol 90. 2017-12-18. PMID:27320207. |
previously, we reported that hdac4 is a repressor of matrix metalloproteinase-13 (mmp13) transcription, and the absence of hdac4 leads to increased expression of mmp-13 both in vitro (osteoblastic cells) and in vivo (hypertrophic chondrocytes and trabecular osteoblasts). |
2017-12-18 |
2023-08-13 |
mouse |