| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangjun Li, Chaoyuan Li, Xiaoxia Li, Peihe Cui, Qifeng Li, Qiaoyan Guo, Hongbo Han, Shujun Liu, Guangdong Su. Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions. Journal of diabetes research. vol 2016. 2017-06-09. PMID:27652271. |
diabetic nephropathy (dn), a common complication associated with type 1 and type 2 diabetes mellitus (dm), characterized by glomerular mesangial expansion, inflammation, accumulation of extracellular matrix (ecm) protein, and hypertrophy, is the major cause of end-stage renal disease (esrd). |
2017-06-09 |
2023-08-13 |
rat |
| Vincenzo Grimaldi, Maria Rosaria De Pascale, Alberto Zullo, Andrea Soricelli, Teresa Infante, Francesco Paolo Mancini, Claudio Napol. Evidence of epigenetic tags in cardiac fibrosis. Journal of cardiology. vol 69. issue 2. 2017-06-09. PMID:27863907. |
activated fibroblasts are principal determinants of cardiac fibrosis by producing excessive fibrotic extracellular matrix and causing hypertrophy of cardiomyocytes. |
2017-06-09 |
2023-08-13 |
Not clear |
| Bijaya K Nayak, Karthigayan Shanmugasundaram, William E Friedrichs, Rita C Cavaglierii, Mandakini Patel, Jeffrey Barnes, Karen Bloc. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice. Diabetes. vol 65. issue 5. 2017-06-06. PMID:26908870. |
yc-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an hif-1 inhibitor, reduced whole kidney glomerular hypertrophy, mesangial matrix expansion, extracellular matrix accumulation, and urinary albumin excretion as well as nox4 protein expression and nadph-dependent reactive oxygen species production, while blood glucose levels remained unchanged. |
2017-06-06 |
2023-08-13 |
mouse |
| Hua Wang, Haiyan Zhang, Qiuyi Sun, Yun Wang, Jun Yang, Jincheng Yang, Tao Zhang, Shenqiu Luo, Liping Wang, Yu Jiang, Chun Zeng, Daozhang Cai, Xiaochun Ba. Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 3. 2017-06-06. PMID:28139355. |
furthermore, our results revealed mir-483-5p directly targeted to the cartilage matrix protein matrilin 3 (matn3) and tissue inhibitor of metalloproteinase 2 (timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of oa. |
2017-06-06 |
2023-08-13 |
mouse |
| Atanas Todorov, Matthias Kreutz, Alexander Haumer, Celeste Scotti, Andrea Barbero, Paul E Bourgine, Arnaud Scherberich, Claude Jaquiery, Ivan Marti. Fat-Derived Stromal Vascular Fraction Cells Enhance the Bone-Forming Capacity of Devitalized Engineered Hypertrophic Cartilage Matrix. Stem cells translational medicine. vol 5. issue 12. 2017-06-01. PMID:27460849. |
fat-derived stromal vascular fraction cells enhance the bone-forming capacity of devitalized engineered hypertrophic cartilage matrix. |
2017-06-01 |
2023-08-13 |
mouse |
| Peter A McCullough, Christopher T Chan, Eric D Weinhandl, John M Burkart, George L Bakri. Intensive Hemodialysis, Left Ventricular Hypertrophy, and Cardiovascular Disease. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 68. issue 5S1. 2017-06-01. PMID:27772643. |
lvh is an adaptive response to increased cardiac work, typically caused by combined pressure and volume overload, resulting in cardiomyocyte hypertrophy and increased intercellular matrix. |
2017-06-01 |
2023-08-13 |
Not clear |
| Alan J Mouton, Van K Ninh, Elia C El Hajj, Milad C El Hajj, Nicholas W Gilpin, Jason D Gardne. Exposure to chronic alcohol accelerates development of wall stress and eccentric remodeling in rats with volume overload. Journal of molecular and cellular cardiology. vol 97. 2017-05-31. PMID:27107489. |
our data indicate that these effects may be due to disruptions in compensatory hypertrophy and extracellular matrix remodeling in response to volume overload. |
2017-05-31 |
2023-08-13 |
rat |
| Masatoshi Kubota, Reiko Watanabe, Miki Yamaguchi, Michihiro Hosojima, Akihiko Saito, Mikio Fujii, Shinobu Fujimura, Motoni Kadowak. Rice endosperm protein slows progression of fatty liver and diabetic nephropathy in Zucker diabetic fatty rats. The British journal of nutrition. vol 116. issue 8. 2017-05-19. PMID:27724997. |
in addition, there was a distinct suppression of mesangial matrix expansion and glomerular hypertrophy in response to rep (p<0·01). |
2017-05-19 |
2023-08-13 |
rat |
| N Zhao, B L Foster, L F Bonewal. The Cementocyte-An Osteocyte Relative? Journal of dental research. vol 95. issue 7. 2017-05-15. PMID:27029548. |
as apparently terminally differentiated cells embedded in a mineralized extracellular matrix, cementocytes are part of a select group of specialized cells, also including osteocytes, hypertrophic chondrocytes, and odontoblasts. |
2017-05-15 |
2023-08-13 |
Not clear |
| Guangzao Li, Renpeng Zhou, Qi Zhang, Banghong Jiang, Qingkai Wu, Chen Wan. Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts. Experimental cell research. vol 345. issue 1. 2017-05-15. PMID:27207585. |
hypertrophic scar (hs) is a fibroproliferative disorder caused by abnormal wound healing, which is characterized by excessive deposition of extracellular matrix (ecm) secreted by fibroblasts. |
2017-05-15 |
2023-08-13 |
mouse |
| Kristoffer B Sugg, Michael A Korn, Dylan C Sarver, James F Markworth, Christopher L Mendia. Inhibition of platelet-derived growth factor signaling prevents muscle fiber growth during skeletal muscle hypertrophy. FEBS letters. vol 591. issue 5. 2017-05-15. PMID:28129672. |
the results from this study indicate that pdgf signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth. |
2017-05-15 |
2023-08-13 |
mouse |
| Hemanth Akkiraju, Jeremy Bonor, Anja Noh. CK2.1, a novel peptide, induces articular cartilage formation in vivo. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 35. issue 4. 2017-05-09. PMID:27312334. |
however, it also induces chondrocyte hypertrophy and cartilage matrix degradation. |
2017-05-09 |
2023-08-13 |
mouse |
| Brett E Fenster, Luis Lasalvia, Joyce D Schroeder, Jamey Smyser, Lori J Silveira, J Kern Buckner, Kevin K Brow. Galectin-3 levels are associated with right ventricular functional and morphologic changes in pulmonary arterial hypertension. Heart and vessels. vol 31. issue 6. 2017-05-02. PMID:25976729. |
the response of the right ventricle (rv) to pulmonary arterial hypertension (pah) involves changes in contractile function, chamber size, hypertrophy, and extracellular matrix (ecm). |
2017-05-02 |
2023-08-13 |
human |
| Mark J Hackett, Graham N George, Ingrid J Pickering, B Frank Eame. Chemical Biology in the Embryo: In Situ Imaging of Sulfur Biochemistry in Normal and Proteoglycan-Deficient Cartilage Matrix. Biochemistry. vol 55. issue 17. 2017-05-02. PMID:26985789. |
levels of both sulfur and sulfate esters decrease as cartilage develops through late phase differentiation (maturation or hypertrophy), suggesting a functional link between cartilage matrix sulfur content and chondrocyte differentiation. |
2017-05-02 |
2023-08-13 |
zebrafish |
| Fengjun Fang, Ru-Lin Huang, Yongchao Zheng, Ming Liu, Ran Hu. Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling. Journal of dermatological science. vol 83. issue 2. 2017-05-02. PMID:27211019. |
hypertrophic scars and keloids, characterized by over-proliferation of fibroblasts and aberrant formation of the extracellular matrix (ecm), are considered fibrotic diseases. |
2017-05-02 |
2023-08-13 |
Not clear |
| Jennifer Fischer, Marlen Ortel, Sebastien Hagmann, Andreas Hoeflich, Wiltrud Richte. Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis. Journal of cellular physiology. vol 231. issue 12. 2017-05-01. PMID:27548511. |
generation of phenotypically stable, articular chondrocytes from mesenchymal stromal cells (mscs) is still an unaccomplished task, with formation of abundant, hyaline extracellular matrix, and avoidance of hypertrophy being prime challenges. |
2017-05-01 |
2023-08-13 |
human |
| Jennifer Fischer, Marlen Ortel, Sebastien Hagmann, Andreas Hoeflich, Wiltrud Richte. Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis. Journal of cellular physiology. vol 231. issue 12. 2017-05-01. PMID:27548511. |
we recently demonstrated that parathyroid hormone-related protein (pthrp) is a promising factor to direct chondrogenesis of mscs towards an articular phenotype, since intermittent pthrp application stimulated cartilage matrix production and reduced undesired hypertrophy. |
2017-05-01 |
2023-08-13 |
human |
| Weishen Chen, Puyi Sheng, Zhiyu Huang, Fangang Meng, Yan Kang, Guangxin Huang, Zhiqi Zhang, Weiming Liao, Ziji Zhan. MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. International journal of molecular sciences. vol 17. issue 9. 2017-05-01. PMID:27563877. |
chondrocyte hypertrophy, regulated by runt-related transcription factor 2 (runx2) and matrix metalloproteinase 13 (mmp13), is a crucial step in cartilage degeneration and osteoarthritis (oa) pathogenesis. |
2017-05-01 |
2023-08-13 |
mouse |
| Koh Terauchi, Hajime Kobayashi, Kanaka Yatabe, Naoko Yui, Hiroto Fujiya, Hisateru Niki, Haruki Musha, Kazuo Yudo. The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. International journal of molecular sciences. vol 17. issue 7. 2017-03-21. PMID:27367673. |
we postulated that sirt1 regulates a hypertrophic chondrocyte lineage and degeneration of articular cartilage through the activation of osteogenic transcriptional activator runx2 and matrix metalloproteinase (mmp)-13 in oa chondrocytes. |
2017-03-21 |
2023-08-13 |
mouse |
| Nadja Zöller, Anke König, Manuel Butting, Roland Kaufmann, August Bernd, Eva Valesky, Stefan Kippenberge. Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreskin fibroblasts. Journal of photochemistry and photobiology. B, Biology. vol 163. 2017-03-17. PMID:27588716. |
hypertrophic scar development is associated to impaired wound healing, imbalanced fibroblast proliferation and extracellular matrix synthesis. |
2017-03-17 |
2023-08-13 |
Not clear |