| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuya Enishi, Kiminori Yukata, Mitsuhiko Takahashi, Ryosuke Sato, Koichi Sairyo, Natsuo Yasu. Hypertrophic chondrocytes in the rabbit growth plate can proliferate and differentiate into osteogenic cells when capillary invasion is interposed by a membrane filter. PloS one. vol 9. issue 8. 2015-04-17. PMID:25121501. |
at the terminal end of the growth plate, hypertrophic chondrocytes extruded from their territorial matrix into the open cavity on the surface of the membrane filter. |
2015-04-17 |
2023-08-13 |
rabbit |
| Guido Tarone, Jean-Luc Balligand, Johann Bauersachs, Angela Clerk, Leon De Windt, Stephane Heymans, Denise Hilfiker-Kleiner, Emilio Hirsch, Guido Iaccarino, Ralph Knöll, Adelino F Leite-Moreira, André P Lourenço, Manuel Mayr, Thomas Thum, Carlo G Tocchett. Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European journal of heart failure. vol 16. issue 5. 2015-04-10. PMID:24639064. |
these include potentiating cardiomyocyte contractility, increasing cardiomyocyte survival and adaptive hypertrophy, increasing oxygen and nutrition supply by sustaining vessel formation, and reducing ventricular stiffness by favourable extracellular matrix remodelling. |
2015-04-10 |
2023-08-12 |
Not clear |
| Chao Li, Hua-Yu Zhu, Wen-Dong Bai, Lin-Lin Su, Jia-Qi Liu, Wei-Xia Cai, Bin Zhao, Jian-Xin Gao, Shi-Chao Han, Jun Li, Da-Hai H. MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA. FEBS letters. vol 589. issue 3. 2015-04-10. PMID:25554417. |
urokinase type plasminogen activator (upa) and plasminogen activator inhibitor-1 (pai-1) have been proposed to play key roles in extracellular matrix (ecm) deposition in hypertrophic scars (hs). |
2015-04-10 |
2023-08-13 |
Not clear |
| Sebastian Winocour, Joshua Vorstenbosch, Alissa Trzeciak, Lucie Lessard, Anie Phili. CD109, a novel TGF-β antagonist, decreases fibrotic responses in a hypoxic wound model. Experimental dermatology. vol 23. issue 7. 2015-04-07. PMID:24815824. |
excessive extracellular matrix deposition that occurs in many fibrotic skin disorders such as hypertrophic scarring and scleroderma is often associated with hypoxia. |
2015-04-07 |
2023-08-13 |
mouse |
| M Mathieu, S Vigier, M N Labour, C Jorgensen, E Belamie, D Noë. Induction of mesenchymal stem cell differentiation and cartilage formation by cross-linker-free collagen microspheres. European cells & materials. vol 28. 2015-04-02. PMID:25179212. |
human msc rapidly adhered to tgf-β3-loaded microspheres and, after 21 d of culture, exhibited typical chondrocyte morphology and produced an uncalcified matrix made of the predominant cartilage components, aggrecan and type ii collagen, but devoid of the hypertrophic marker type x collagen. |
2015-04-02 |
2023-08-13 |
mouse |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
hypertrophic scarring is characterized by collagen overproduction and excessive deposition of extracellular matrix. |
2015-03-31 |
2023-08-13 |
Not clear |
| Maria Adele Alberelli, Erica De Candi. Functional role of protease activated receptors in vascular biology. Vascular pharmacology. vol 62. issue 2. 2015-03-31. PMID:24924409. |
however, in conditions associated with endothelial dysfunction, pars mediate contraction, proliferation, migration, hypertrophy of vsmcs and their production of extracellular matrix, thereby contributing to the pathophysiology of atherosclerosis and hypertension. |
2015-03-31 |
2023-08-13 |
Not clear |
| Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert T Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal. vol 4. issue 4. 2015-03-13. PMID:25767782. |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2015-03-13 |
2023-08-13 |
Not clear |
| Moses B Ekong, Mine D Peter, Aniekan I Peter, Mokutima A Eluwa, Idorenyin U Umoh, Anozeng O Igiri, Theresa B Ekane. Cerebellar neurohistology and behavioural effects of gongronema latifolium and Rauwolfia vomitoria in mice. Metabolic brain disease. vol 29. issue 2. 2015-03-05. PMID:24254993. |
neurohistology of the cerebellum showed slight hypertrophy of purkinje cells, with brain matrix loss in treatment groups 2 and 3, but group 4 showed no apparent histopathology. |
2015-03-05 |
2023-08-12 |
mouse |
| Peihua Zhang, Jin Li, Xudong Tang, Junlei Zhang, Jie Liang, Guofang Zen. Dracorhodin perchlorate induces apoptosis in primary fibroblasts from human skin hypertrophic scars via participation of caspase-3. European journal of pharmacology. vol 728. 2015-03-02. PMID:24525335. |
hypertrophic scar (hs) is an abnormally proliferative disorder characterized by excessive proliferation of fibroblasts and redundant deposition of extracellular matrix. |
2015-03-02 |
2023-08-12 |
human |
| M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie. vol 73. issue 5. 2015-02-23. PMID:24924727. |
in the process of endochondral ossification, the link between hypertrophy and matrix mineralization is particularly well described. |
2015-02-23 |
2023-08-13 |
Not clear |
| M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie. vol 73. issue 5. 2015-02-23. PMID:24924727. |
hypertrophic chondrocytes in oa cartilage and at the growth line share certain features, not only hypertrophy but also a capability to mineralize the matrix. |
2015-02-23 |
2023-08-13 |
Not clear |
| Waldemar Hoffmann, Sandra Feliciano, Ivan Martin, Michael de Wild, David Wend. Novel Perfused Compression Bioreactor System as an in vitro Model to Investigate Fracture Healing. Frontiers in bioengineering and biotechnology. vol 3. 2015-02-20. PMID:25699254. |
our findings provide a proof-of-principle that dynamic mechanical loading applied by the pcb can enhance the maturation process of mesenchymal stromal cells toward late hypertrophic chondrocytes and the mineralization of the deposited extracellular matrix. |
2015-02-20 |
2023-08-13 |
human |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose forces a positive feedback loop connecting akt kinase and foxo1 transcription factor to activate mtorc1 kinase for mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
high glucose-induced akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. |
2015-02-12 |
2023-08-13 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry. vol 289. issue 47. 2015-02-12. PMID:25288788. |
together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of akt involving inactivated foxo1 and a decrease in catalase expression, leading to increased ros and mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-08-13 |
mouse |
| Xu Yang, Samir K Trehan, Yingjie Guan, Changqi Sun, Douglas C Moore, Chathuraka T Jayasuriya, Qian Che. Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. The Journal of biological chemistry. vol 289. issue 50. 2015-02-12. PMID:25331953. |
hence, as a novel bmp-2-binding protein and antagonist in the cartilage extracellular matrix, matn3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing bmp-2/smad1 activity. |
2015-02-12 |
2023-08-13 |
mouse |
| Kristen L Lauing, Mauricio Cortes, Miriam S Domowicz, Judith G Henry, Alexis T Baria, Nancy B Schwart. Aggrecan is required for growth plate cytoarchitecture and differentiation. Developmental biology. vol 396. issue 2. 2015-02-05. PMID:25446537. |
aggrecan-null growth plates were devoid of matrix and lacked chondrocyte organization and differentiation, while those of the rescue embryos exhibited matrix production concomitant with partial zonation of chondrocytes having proliferative and hypertrophic morphologies. |
2015-02-05 |
2023-08-13 |
mouse |
| Katsuhiko Amano, Michael Densmore, Riko Nishimura, Beate Lansk. Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25028519. |
independent of this function, we and others recently reported independent ihh functions to promote chondrocyte hypertrophy and matrix mineralization in vivo and in vitro. |
2015-01-28 |
2023-08-13 |
Not clear |
| Tarek Hamdy Abd-Elhamid, Marianne L Conway, Allan R Sinnin. The hLAMP-1-positive particulate matrix involved in cardiac mesenchyme formation in the chick does not include BMP-2. Cells, tissues, organs. vol 198. issue 5. 2015-01-22. PMID:24503594. |
the particulate matrix causes a subset of endocardial cells to hypertrophy, lose their cell-cell contacts, form migratory processes, transform into mesenchymal cells, and migrate into the underlying endocardial cushions. |
2015-01-22 |
2023-08-12 |
chicken |