| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
type i diabetes was induced in wild-type and β(-/-) mice and then renal function, extracellular matrix expansion and hypertrophy were evaluated. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
in conclusion, loss of the β isoform of calcineurin is sufficient to reproduce beneficial aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
therefore, while multiple signals appear to regulate matrix, calcineurin β appears to be a central mechanism involved in organ hypertrophy. |
2012-04-16 |
2023-08-12 |
mouse |
| Maria C Guido, Carolina F Clemente, Ana I Moretti, Hermes V Barbeiro, Victor Debbas, Elia G Caldini, Kleber G Franchini, Francisco G Sorian. Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia. Shock (Augusta, Ga.). vol 37. issue 1. 2012-04-16. PMID:21921830. |
the hearts of lipopolysaccharide-injected rats showed collagen deposition, increased matrix metalloproteinase 2 activity, and myocyte hypertrophy, as well as reduced 24-h +dp/dt and -dp/dt, together with hypotension, increased left ventricular end-diastolic pressure, and elevated levels of fak (phosphorylated and unphosphorylated). |
2012-04-16 |
2023-08-12 |
rat |
| Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. The Journal of biological chemistry. vol 287. issue 7. 2012-04-16. PMID:22158625. |
high glucose stimulation of global protein synthesis, cellular hypertrophy, and matrix laminin and type iv collagen content was inhibited by sodium hydrosulfide (nahs), an h(2)s donor. |
2012-04-16 |
2023-08-12 |
mouse |
| Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. The Journal of biological chemistry. vol 287. issue 7. 2012-04-16. PMID:22158625. |
renal cortical content of cystathionine β-synthase and cystathionine γ-lyase, hydrogen sulfide-generating enzymes, was significantly reduced in mice with type 1 diabetes or type 2 diabetes, coinciding with renal hypertrophy and matrix accumulation. |
2012-04-16 |
2023-08-12 |
mouse |
| Carlos E de Andrea, Malgorzata I Wiweger, Judith V M G Bovée, Salvatore Romeo, Pancras C W Hogendoor. Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation. Virchows Archiv : an international journal of pathology. vol 460. issue 1. 2012-04-12. PMID:22116208. |
endochondral chondrocytes undergo sequences of cell division, matrix secretion, cell hypertrophy, apoptosis, and matrix calcification/mineralisation. |
2012-04-12 |
2023-08-12 |
Not clear |
| William M Yarbrough, Rupak Mukherjee, John S Ikonomidis, Michael R Zile, Francis G Spinal. Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications. The Journal of thoracic and cardiovascular surgery. vol 143. issue 3. 2012-04-04. PMID:21762938. |
aortic valve stenosis is a common cause of left ventricular pressure overload, a pathologic process that elicits myocyte hypertrophy and alterations in extracellular matrix composition, both of which contribute to increases in left ventricular stiffness. |
2012-04-04 |
2023-08-12 |
Not clear |
| Nikolaos Donos, Filippo Graziani, Nikos Mardas, Lambros Kostopoulo. The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. Clinical oral implants research. vol 22. issue 12. 2012-04-03. PMID:21382090. |
the use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. |
2012-04-03 |
2023-08-12 |
human |
| Nikolaos Donos, Filippo Graziani, Nikos Mardas, Lambros Kostopoulo. The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects. Clinical oral implants research. vol 22. issue 12. 2012-04-03. PMID:21382090. |
to evaluate the effect of immortalized hypertrophic chondrocytes extracellular matrix (hcm) with or without the use of guided bone regeneration (gbr) on the healing of critical-size calvarial defects. |
2012-04-03 |
2023-08-12 |
human |
| Zerina Johanson, Anton Kearsley, Jan den Blaauwen, Michael Newman, Moya Meredith Smit. Ontogenetic development of an exceptionally preserved Devonian cartilaginous skeleton. Journal of experimental zoology. Part B, Molecular and developmental evolution. vol 318. issue 1. 2012-03-28. PMID:21954147. |
in large specimens of palaeospondylus, enlarged, hypertrophic cell spaces (lacunae) are dominant in the cartilage matrix, each defined by thin mineralized matrix, where phosphorus and calcium co-occur. |
2012-03-28 |
2023-08-12 |
Not clear |
| Zerina Johanson, Anton Kearsley, Jan den Blaauwen, Michael Newman, Moya Meredith Smit. Ontogenetic development of an exceptionally preserved Devonian cartilaginous skeleton. Journal of experimental zoology. Part B, Molecular and developmental evolution. vol 318. issue 1. 2012-03-28. PMID:21954147. |
this is comparable to living endochondral cartilage, where cell hypertrophy and matrix mineralization mark the end of an ontogenetic process of cell growth and division before bone formation. |
2012-03-28 |
2023-08-12 |
Not clear |
| Zerina Johanson, Anton Kearsley, Jan den Blaauwen, Michael Newman, Moya Meredith Smit. Ontogenetic development of an exceptionally preserved Devonian cartilaginous skeleton. Journal of experimental zoology. Part B, Molecular and developmental evolution. vol 318. issue 1. 2012-03-28. PMID:21954147. |
new information from small individuals of palaeospondylus demonstrates that the skeleton comprises mostly unmineralized organic matrix with fewer hypertrophic cell spaces, these occurring only in the central regions of each element. |
2012-03-28 |
2023-08-12 |
Not clear |
| Zerina Johanson, Anton Kearsley, Jan den Blaauwen, Michael Newman, Moya Meredith Smit. Ontogenetic development of an exceptionally preserved Devonian cartilaginous skeleton. Journal of experimental zoology. Part B, Molecular and developmental evolution. vol 318. issue 1. 2012-03-28. PMID:21954147. |
this reflects cellular control of mineralization in living tissues through phosphate accumulation around hypertrophic cells, with later increase in calcium in the cartilaginous matrix. |
2012-03-28 |
2023-08-12 |
Not clear |
| Shaina R Eckhouse, Francis G Spinal. Changes in the myocardial interstitium and contribution to the progression of heart failure. Heart failure clinics. vol 8. issue 1. 2012-03-27. PMID:22108723. |
these changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. |
2012-03-27 |
2023-08-12 |
Not clear |
| Duncan J Stewart, Shirley H J Me. Cell-based therapies for lung vascular diseases: lessons for the future. Proceedings of the American Thoracic Society. vol 8. issue 6. 2012-03-15. PMID:22052933. |
pulmonary arterial hypertension is a progressive and debilitating lung disorder, which is characterized by hallmark pathological features in the small peripheral pulmonary arteries, including intimal hyperplasia and fibrosis, medial hypertrophy, increased deposition of extracellular matrix, infiltration of inflammatory mediators, and in many instances of advanced disease, plexiform lesions. |
2012-03-15 |
2023-08-12 |
Not clear |
| Shiao-Ying Chang, Yun-Wen Chen, Isabelle Chenier, Stella Le Minh Tran, Shao-Ling Zhan. Angiotensin II type II receptor deficiency accelerates the development of nephropathy in type I diabetes via oxidative stress and ACE2. Experimental diabetes research. vol 2011. 2012-03-15. PMID:22110472. |
after 4 weeks of diabetes, compared to wt controls, at(2)rko mice clearly developed features of early diabetic nephropathy (dn), such as renal hypertrophy, tubular apoptosis, and progressive extracellular matrix (ecm) protein accumulation as well as increased gfr. |
2012-03-15 |
2023-08-12 |
mouse |
| Hyuk-Jae Kwon, Jeong-Oh Shin, Jong-Min Lee, Kyoung-Won Cho, Min-Jung Lee, Sung-Won Cho, Han-Sung Jun. Retinoic acid modulates chondrogenesis in the developing mouse cranial base. Journal of experimental zoology. Part B, Molecular and developmental evolution. vol 316. issue 8. 2012-03-07. PMID:21826789. |
in the ra study, the sphenooccipital synchondrosis showed reduced cartilage matrix and lower bmp4 expression while hypertrophic chondrocytes were replaced with proliferating chondrocytes. |
2012-03-07 |
2023-08-12 |
mouse |
| Martina Cebova, Frantisek Kriste. Age-dependent ultrastructural changes of coronary artery in spontaneously hypertensive rats. General physiology and biophysics. vol 30. issue 4. 2012-03-06. PMID:22131318. |
arterial wall hypertrophy was evoked by increase of csa of medial extracellular matrix and smooth muscle cells. |
2012-03-06 |
2023-08-12 |
rat |
| A S Patil, R B Sable, R M Kothar. Occurrence, biochemical profile of vascular endothelial growth factor (VEGF) isoforms and their functions in endochondral ossification. Journal of cellular physiology. vol 227. issue 4. 2012-03-05. PMID:21604271. |
thus, transformation of cartilage into bone involves proliferation of mesenchymal cells, hypertrophy in chondrocytes, capillary invasion, and calcification by extra cellular matrix (ecm). |
2012-03-05 |
2023-08-12 |
human |