| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary B Goldring, Miguel Otero, Darren A Plumb, Cecilia Dragomir, Marta Favero, Karim El Hachem, Ko Hashimoto, Helmtrud I Roach, Eleonora Olivotto, Rosa Maria Borzì, Kenneth B Marc. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. European cells & materials. vol 21. 2011-08-01. PMID:21351054. |
to identify and characterize effectors or regulators of cartilage remodeling in these processes, we are using culture models of primary human and mouse chondrocytes and cell lines and mouse genetic models to manipulate gene expression programs leading to matrix remodeling and subsequent chondrocyte hypertrophic differentiation, pivotal processes which both go astray in oa disease. |
2011-08-01 |
2023-08-12 |
mouse |
| Zhan-Feng Zhang, Yan-Gang Zhang, Da-Hai Hu, Ji-Hong Shi, Jia-Qi Liu, Zhou-Ting Zhao, Hong-Tao Wang, Xiao-Zhi Bai, Wei-Xia Cai, Hua-Yu Zhu, Chao-Wu Tan. Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars. Burns : journal of the International Society for Burn Injuries. vol 37. issue 4. 2011-07-22. PMID:21236582. |
keloids and hypertrophic scars are significant symptomatic clinical problems characterized by the excessive and abnormal deposition of collagen-based extracellular matrix (ecm) components. |
2011-07-22 |
2023-08-12 |
Not clear |
| Mark W M Schellings, Geert C van Almen, E Helene Sage, Stephane Heyman. Thrombospondins in the heart: potential functions in cardiac remodeling. Journal of cell communication and signaling. vol 3. issue 3-4. 2011-07-14. PMID:19798592. |
cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yun Hee Lee, Tae Yeon Kim, Young Mi Hon. Metalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adolescents. Korean circulation journal. vol 39. issue 8. 2011-07-14. PMID:19949639. |
hypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
cardiac hypertrophy was accompanied with increased interleukin-6 (il-6), transforming growth factor (tgf)-β, atrial natriuretic peptide (anp), collagen i and iii, and matrix metallopeptidase 2 (mmp-2). |
2011-07-14 |
2023-08-12 |
mouse |
| Michael R Zile, Stacia M Desantis, Catalin F Baicu, Robert E Stroud, Sheila B Thompson, Catherine D McClure, Shannon M Mehurg, Francis G Spinal. Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. Circulation. Heart failure. vol 4. issue 3. 2011-07-14. PMID:21350055. |
plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. |
2011-07-14 |
2023-08-12 |
Not clear |
| Takashi Nishida, Azusa Maeda, Satoshi Kubota, Masaharu Takigaw. Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. Biorheology. vol 45. issue 3-4. 2011-07-13. PMID:18836231. |
the aim of this study is to determine the influence of mechanical load magnitude and frequency on cartilage metabolism in terms of the expression of hypertrophic chondrocyte-specific gene product 24/connective tissue growth factor/ccn family 2 (hcs24/ctgf/ccn2), as an essential mediator of extracellular matrix (ecm) production. |
2011-07-13 |
2023-08-12 |
human |
| Keith A Hruska, Suresh Mathe. The roles of the skeleton and phosphorus in the CKD mineral bone disorder. Advances in chronic kidney disease. vol 18. issue 2. 2011-07-11. PMID:21406294. |
phosphorus stimulates fgf-23 secretion by osteocytes and expression of the osteoblastic transcriptome, thereby increasing extracellular matrix mineralization in atherosclerotic plaques, hypertrophic cartilage, and skeletal osteoblast surfaces. |
2011-07-11 |
2023-08-12 |
Not clear |
| Daisuke Saito, Yohei Maeshima, Tatsuyo Nasu, Hiroko Yamasaki, Katsuyuki Tanabe, Hitoshi Sugiyama, Hikaru Sonoda, Yasufumi Sato, Hirofumi Makin. Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis. American journal of physiology. Renal physiology. vol 300. issue 4. 2011-07-01. PMID:21228103. |
adhvash-1 treatment resulted in significant suppression of glomerular hypertrophy, glomerular hyperfiltration, albuminuria, increase in the cd31(+) glomerular endothelial area, f4/80(+) monocyte/macrophage infiltration, the accumulation of type iv collagen, and mesangial matrix. |
2011-07-01 |
2023-08-12 |
mouse |
| H Yamasaki, Y Maeshima, T Nasu, D Saito, K Tanabe, K Hirokoshi-Kawahara, H Sugiyama, Y Sakai, H Makin. Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model. Prostaglandins, leukotrienes, and essential fatty acids. vol 84. issue 3-4. 2011-06-28. PMID:21177088. |
sr-ono significantly suppressed albuminuria, glomerular hypertrophy, mesangial matrix accumulation, glomerular accumulation of monocyte/macrophage, increase in glomerular levels of pro-fibrotic factor transforming growth factor (tgf)-beta1 and the number of glomerular alpha-smooth muscle actin (sma)(+) cells in diabetic animals. |
2011-06-28 |
2023-08-12 |
rat |
| Sara Hinds, Weining Bian, Robert G Dennis, Nenad Bursa. The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials. vol 32. issue 14. 2011-06-22. PMID:21324402. |
optimized matrix composition yielded significant cellular hypertrophy (protein/dna ratio = 11.4 ± 4.1 vs. 6.5 ± 1.9 μg/μg in control) and a prolonged ca(2+) transient half-width (ca(50) = 232.8 ± 33.3 vs. 101.7 ± 19.8 ms). |
2011-06-22 |
2023-08-12 |
rat |
| Anne Marie Rauten, Petra Surlin, B Oprea, Izabela Siloşi, Mihaela Moisa, D Caramizaru, Mihaela Văt. Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 1 Suppl. 2011-06-09. PMID:21424088. |
matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. |
2011-06-09 |
2023-08-12 |
Not clear |
| Mahipal Singh, Cerrone R Foster, Suman Dalal, Krishna Sing. Role of osteopontin in heart failure associated with aging. Heart failure reviews. vol 15. issue 5. 2011-06-02. PMID:20127409. |
the post-mi infarct healing process involves temporarily overlapping phases that include the following--(1) inflammation with migration and adhesion of neutrophils and macrophages, phagocytosis and inflammatory gene expression; (2) tissue repair with fibroblast adhesion and proliferation, myofibroblast differentiation, extracellular matrix deposition and scar formation; and (3) structural and functional remodeling of infarcted and non-infarcted myocardium through cardiac myocyte apoptosis, hypertrophy and myocardial angiogenesis. |
2011-06-02 |
2023-08-12 |
mouse |
| Sunila Mahavadi, Robert S Flynn, John R Grider, Li-Ya Qiao, Karnam S Murthy, Krystina B Hazelgrove, John F Kuemmerl. Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice. Inflammatory bowel diseases. vol 17. issue 3. 2011-05-31. PMID:20722057. |
strictures occur in ≈ 30% of patients with crohn's disease (cd) and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. |
2011-05-31 |
2023-08-12 |
mouse |
| Chetan P Hans, Yumei Feng, Amarjit S Naura, Dana Troxclair, Mourad Zerfaoui, Danish Siddiqui, Ju Jihang, Hogyoung Kim, Alan D Kaye, Khalid Matrougui, Eric Lazartigues, A Hamid Boulare. Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 20. issue 2. 2011-05-26. PMID:20434371. |
given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (mmps) and timps, we hypothesized that parp-1 gene deletion may protect against hf-induced cardiac hypertrophy and dilatations by altering timp-2/mmps balance in favor of a maintenance of tissue homeostasis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Motofumi Sasaki, Kenichi Shikata, Shinichi Okada, Satoshi Miyamoto, Shingo Nishishita, Hitomi Usui Kataoka, Chikage Sato, Jun Wada, Daisuke Ogawa, Hirofumi Makin. The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration. Acta medica Okayama. vol 65. issue 2. 2011-05-19. PMID:21519365. |
the 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. |
2011-05-19 |
2023-08-12 |
mouse |
| Robert S Flynn, Sunila Mahavadi, Karnam S Murthy, John R Grider, John M Kellum, Homayoon Akbari, John F Kuemmerl. Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures. Inflammatory bowel diseases. vol 17. issue 1. 2011-05-12. PMID:20848532. |
strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, including collagen. |
2011-05-12 |
2023-08-12 |
human |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine. vol 50. issue 1. 2011-05-09. PMID:21047552. |
inhibition of nuclear factor κb regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. |
2011-05-09 |
2023-08-12 |
mouse |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine. vol 50. issue 1. 2011-05-09. PMID:21047552. |
increased production of ros and nuclear factor κb (nf-κb) activation provide a strong link between oxidative stress and extracellular matrix (ecm) remodeling in cardiac hypertrophy. |
2011-05-09 |
2023-08-12 |
mouse |
| Francis I Achike, Nim-Hin Peter To, Huidi Wang, Chiu-Yin Kwa. Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clinical and experimental pharmacology & physiology. vol 38. issue 1. 2011-05-04. PMID:21083697. |
excess fat deposition requires space, created by adipocyte (hypertrophy and hyperplasia) and extracellular matrix (ecm) remodelling. |
2011-05-04 |
2023-08-12 |
Not clear |