| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhencheng Yu, Yun Li, Rao Fu, Yaxin Xue, Danyang Zhao, Dong Ha. Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Archives of dermatological research. 2022-12-16. PMID:36526799. |
abnormal fibroblast proliferation and excessive extracellular matrix (ecm) deposition lead to the formation of hypertrophic scars (hss). |
2022-12-16 |
2023-08-14 |
human |
| Ashley A Thurstin, Allison N Egeli, Edie C Goldsmith, Francis G Spinale, Holly A LaVoi. Tissue Inhibitor of Metalloproteinase 4 (Timp4) Deletion in Mice Impacts Maternal Cardiac Function during Pregnancy and Postpartum. American journal of physiology. Heart and circulatory physiology. 2022-12-02. PMID:36459450. |
reversible physiological cardiac hypertrophy of the maternal heart occurs during pregnancy and involves extracellular matrix (ecm) remodeling. |
2022-12-02 |
2023-08-14 |
mouse |
| Cassandra L Clift, Janet Saunders, Richard R Drake, Peggi M Ange. Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies. Frontiers in cardiovascular medicine. vol 9. 2022-11-28. PMID:36439995. |
this is especially true in cases of pediatric congenital aortic valve stenosis (pcavs), in which extracellular matrix (ecm) dysregulation is a hallmark of the disease, eventually leading to left ventricular hypertrophy and heart failure. |
2022-11-28 |
2023-08-14 |
Not clear |
| Yan Yang, Lutong Liu, Xiaojin Wu, Xue Wang, Qiang Lu, Zhen Zhan. CO Burns & trauma. vol 10. 2022-11-16. PMID:36380852. |
co hypertrophic scars are skin fibrotic diseases, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. |
2022-11-16 |
2023-08-14 |
Not clear |
| Farideh Amirrad, Gregory A Fishbein, Robert A Edwards, Surya M Naul. Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGF-β Cell and tissue research. 2022-11-15. PMID:36376769. |
our histopathology data of human pkd hearts showed an increased extracellular matrix associated with cardiac hypertrophy and fibrosis. |
2022-11-15 |
2023-08-14 |
human |
| Alice Ruth Lapthorn, Marcus Maximillian Ilg, Justine Victoria Sullivan, Peter Dziewulski, Selim Celle. Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars. European journal of pharmacology. 2022-11-07. PMID:36343693. |
hypertrophic scars are a result of dysregulated wound healing, characterised by persistent myofibroblast transformation and the excessive accumulation of extracellular matrix (ecm). |
2022-11-07 |
2023-08-14 |
human |
| Hongxin Chen, Kai Xu, Chao Sun, Si Gui, Juanjuan Wu, Song Wan. Inhibition of ANGPT2 activates autophagy during hypertrophic scar formation via PI3K/AKT/mTOR pathway. Anais brasileiros de dermatologia. 2022-10-22. PMID:36272879. |
hypertrophic scar (hs), a fibroproliferative disorder caused by aberrant wound healing following skin injuries such as burns, lacerations and surgery, is characterized by invasive proliferation of fibroblasts and excessive extracellular matrix (ecm) accumulation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Lishan Lin, Yaling Yu, Kangping Liu, Yixin Jiang, Zhenlei Zho. Downregulation of miR-30b-5p Facilitates Chondrocyte Hypertrophy and Apoptosis via Targeting Runx2 in Steroid-Induced Osteonecrosis of the Femoral Head. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232582. |
the nobly increased expression of matrix metallopeptidase 13 (mmp13) and type x collagen (col10a1) as runx2 downstream genes contributed to the hypertrophic differentiation of chondrocytes, and the efficiently upregulated level of matrix metallopeptidase 9 (mmp9) may trigger chondrocyte apoptosis with mps treatments. |
2022-10-14 |
2023-08-14 |
Not clear |
| Z H Chen, B Yu, Q F Ye, Y F Wan. [Research advances on interleukin-6 in hypertrophic scar formation]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 9. 2022-09-30. PMID:36177594. |
hypertrophic scar is a pathological repair result of excessive accumulation of extracellular matrix after skin damage, which affects the appearance and function of patients with varying degrees. |
2022-09-30 |
2023-08-14 |
Not clear |
| Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Sha. Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy Frontiers in pharmacology. vol 13. 2022-09-12. PMID:36091816. |
rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy the progression from compensatory hypertrophy to heart failure is difficult to reverse, in part due to extracellular matrix fibrosis and continuous activation of abnormal signaling pathways. |
2022-09-12 |
2023-08-14 |
Not clear |
| Brenda LaTowsky, David W Robertson, Christopher C Capell. Long-term improvement in the appearance of hypertrophic scars following a single treatment with acoustic subcision-A single center proof-of-concept study. Lasers in surgery and medicine. 2022-09-07. PMID:36069160. |
the acoustic subcision device uses rapid acoustic pulse technology to noninvasively improve the appearance of hypertrophic scars through both microdisruption of scar tissue matrix and downregulation of fibrotic fibroblasts leading to scar remodeling. |
2022-09-07 |
2023-08-14 |
human |
| Yan Chen, Junteng Zhou, Zisong Wei, Yue Cheng, Geer Tian, Yue Quan, Qihang Kong, Wenchao Wu, Xiaojing Li. Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis. Frontiers in pharmacology. vol 13. 2022-08-25. PMID:36003513. |
gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) pathway analyses identified several significant pathways, including hypertrophic cardiomyopathy, extracellular matrix (ecm)-receptor interaction and focal adhesion. |
2022-08-25 |
2023-08-14 |
Not clear |
| Teresa Grieco, Vito Gomes, Alfredo Rossi, Carmen Cantisani, Maria Elisabetta Greco, Giovanni Rossi, Alvise Sernicola, Giovanni Pellacan. The Pathological Culprit of Neuropathic Skin Pain in Long COVID-19 Patients: A Case Series. Journal of clinical medicine. vol 11. issue 15. 2022-08-12. PMID:35956094. |
the histology investigation showed hypertrophic glomus vascular bodies with hypertrophic s100+ perineural sheath cells and adjacent hypertrophy of the nerve branches associated with increased basophil polysaccharide matrix. |
2022-08-12 |
2023-08-14 |
Not clear |
| Alejandro Gugliucc. Biomarkers of dysfunctional visceral fat. Advances in clinical chemistry. vol 109. 2022-08-11. PMID:35953124. |
this leads to the ominous triad: inflammation, fibrosis (extracellular matrix hypertrophy) and impaired angiogenesis as well as consequent unresolved hypoxia. |
2022-08-11 |
2023-08-14 |
Not clear |
| Jessica M Overstreet, Cody C Gifford, Jiaqi Tang, Paul J Higgins, Rohan Samarakoo. Emerging role of tumor suppressor p53 in acute and chronic kidney diseases. Cellular and molecular life sciences : CMLS. vol 79. issue 9. 2022-08-08. PMID:35941392. |
tgf-β1-induced micro-rnas (such as mir-192) could facilitate p53 activation, leading to renal hypertrophy and matrix expansion in response to diabetic insults while aa-mediated mir-192 induction regulates p53 dependent epithelial g |
2022-08-08 |
2023-08-14 |
mouse |
| Xuechun Sun, Yu Yang, Xiaodan Sun, Huali Meng, Wenhao Hao, Jialin Yin, Fuzhe Ma, Xin Guo, Lei Du, Lei Sun, Hao W. Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy. Journal of agricultural and food chemistry. 2022-08-02. PMID:35916281. |
the diabetic mice developed albuminuria, mesangial matrix accumulation, glomerular hypertrophy, and fibrosis formation, with an increase in renal proinflammatory, oxidative and profibrotic gene expression. |
2022-08-02 |
2023-08-14 |
mouse |
| Camille R Brightwell, Christine M Latham, Nicholas T Thomas, Alexander R Keeble, Kevin A Murach, Christopher S Fr. A Glitch in the Matrix: The Pivotal Role for Extracellular Matrix Remodeling During Muscle Hypertrophy. American journal of physiology. Cell physiology. 2022-07-25. PMID:35876284. |
a glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy. |
2022-07-25 |
2023-08-14 |
Not clear |
| Yawei Bian, Chonglin Shi, Shan Song, Lin Mu, Ming Wu, Duojun Qiu, Jiajia Dong, Wei Zhang, Chen Yuan, Dongyun Wang, Zihui Zhou, Xuan Dong, Yonghong Sh. Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy. Cell and tissue research. 2022-07-13. PMID:35821438. |
sesn2 overexpression improved renal function and decreased glomerular hypertrophy, albuminuria, mesangial expansion, extracellular matrix accumulation, and tgf-β1 expression, as well as oxidative stress in diabetic mice. |
2022-07-13 |
2023-08-14 |
mouse |
| Ilaria Stadiotti, Rosaria Santoro, Alessandro Scopece, Sergio Pirola, Anna Guarino, Gianluca Polvani, Angela Serena Maione, Flora Ascione, Qingsen Li, Domenico Delia, Marco Foiani, Giulio Pompilio, Elena Sommariv. Pressure Overload Activates DNA-Damage Response in Cardiac Stromal Cells: A Novel Mechanism Behind Heart Failure With Preserved Ejection Fraction? Frontiers in cardiovascular medicine. vol 9. 2022-07-11. PMID:35811699. |
aortic valve stenosis can cause an hfpef-like syndrome by inducing sustained pressure overload (po) and cardiac remodeling, as cardiomyocyte (cm) hypertrophy and fibrotic matrix deposition. |
2022-07-11 |
2023-08-14 |
Not clear |
| Patsy Gomez-Picos, Katie Ovens, B Frank Eame. Limb Mesoderm and Head Ectomesenchyme Both Express a Core Transcriptional Program During Chondrocyte Differentiation. Frontiers in cell and developmental biology. vol 10. 2022-07-05. PMID:35784462. |
immature chondrocytes (imm) represent the early stages of cartilage differentiation, while mature chondrocytes (mat) undergo additional stages of differentiation, including hypertrophy and stimulating matrix mineralization and degradation. |
2022-07-05 |
2023-08-14 |
chicken |