| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michalis Panteli, James S H Vun, Ippokratis Pountos, Anthony J Howard, Elena Jones, Peter V Giannoudi. Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights. Journal of cellular and molecular medicine. 2022-01-05. PMID:34984803. |
there was a lower bmp expression in non-union site and absent in the extracellular matrix, with no difference observed between atrophic and hypertrophic non-unions. |
2022-01-05 |
2023-08-13 |
human |
| Maria Marketou, Joanna Kontaraki, Spyros Maragkoudakis, Christos Danelatos, Sofia Papadaki, Stelios Zervakis, Anthoula Plevritaki, Panos Vardas, Fragiskos Parthenakis, George Kochiadaki. Effects of sodium-glucose cotransporter-2 inhibitors on cardiac structural and electrical remodeling: from myocardial cytology to cardiodiabetology. Current vascular pharmacology. 2021-12-28. PMID:34961447. |
sglt2i ameliorate myocardial extracellular matrix remodeling, cardiomyocyte stiffness and concentric hypertrophy, achieving beneficial remodeling of the left ventricle with significant implications for the pathogenesis and outcome of heart failure. |
2021-12-28 |
2023-08-13 |
Not clear |
| Ming-Xiao Zhang, Qing-Xin Tian, Jian-Long Li. [The myocardial protective effect of propofol on rats with experimental myocardial infarction and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 6. 2021-12-28. PMID:34961861. |
furthermore, after myocardial infarction, the administration of propofol significantly improved the diastolic strain rate, down-regulated the mrna expression levels of myocardial hypertrophy markers, atrial natriuretic peptide and β-myosin heavy chain, and reversed the up-regulation of matrix metalloproteinase 2 (mmp2), mmp9 and tissue inhibitor of metalloproteinase-2 (timp-2) induced by myocardial infarction. |
2021-12-28 |
2023-08-13 |
rat |
| Hongpeng Zhang, Hao Wang, Cuibao Jiang, Hongwei Wang, Yong Xia, Danpeng Shen, Fan Xie, Nianmin Qi, Kaiyang L. Fractional laser-assisted administration of human umbilical cord mesenchymal stem cells to reduce hypertrophic scars in rabbit ears. Lasers in surgery and medicine. 2021-12-28. PMID:34962300. |
the formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. |
2021-12-28 |
2023-08-13 |
human |
| Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Gu. The immune microenvironment in cartilage injury and repair. Acta biomaterialia. 2021-12-13. PMID:34896634. |
the inflammatory milieu created by cartilage damage is critical for chondrocyte death and hypertrophy, extracellular matrix breakdown, ectopic bone formation, and progression of cartilage injury to osteoarthritis. |
2021-12-13 |
2023-08-13 |
Not clear |
| b' Jos\\xc3\\xa9 Vald\\xc3\\xa9s-Fern\\xc3\\xa1ndez, Tania L\\xc3\\xb3pez-Mart\\xc3\\xadnez, Purificaci\\xc3\\xb3n Ripalda-Cembor\\xc3\\xa1in, Isabel A Calvo, Borja S\\xc3\\xa1ez, Juan Antonio Romero-Torrecilla, Javier Aldazabal, Emma Mui\\xc3\\xb1os-L\\xc3\\xb3pez, Ver\\xc3\\xb3nica Montiel, Josune Orbe, Jos\\xc3\\xa9 Antonio Rodr\\xc3\\xadguez, Jos\\xc3\\xa9 Antonio P\\xc3\\xa1ramo, Felipe Pr\\xc3\\xb3sper, Froil\\xc3\\xa1n Granero-Molt\\xc3\\xb. Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 36. issue 11. 2021-12-10. PMID:34173256.' |
during secondary fracture healing, vascular invasion and bone growth requires the removal of the cartilage intermediate and the coordinate action of the collagenase matrix metalloproteinase (mmp)-13, produced by hypertrophic chondrocytes, and the gelatinase mmp-9, produced by cells of hematopoietic lineage. |
2021-12-10 |
2023-08-13 |
mouse |
| Harunur Rashid, Haiyan Chen, Amjad Jave. Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. Matrix biology plus. vol 12. 2021-12-07. PMID:34805821. |
runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification. |
2021-12-07 |
2023-08-13 |
Not clear |
| Megumi Nakamura, Mu-Chen Yang, Keijyu Ashida, Miyuki Mayanagi, Yasuyuki Sasan. Calcification and resorption of mouse Meckel's cartilage analyzed by von Kossa and tartrate-resistant acid phosphatase histochemistry and scanning electron microscopy/energy-dispersive X-ray spectrometry. Anatomical science international. 2021-12-03. PMID:34859366. |
the results demonstrated that the intermediate portion of meckel's cartilage is resorbed by chondroclasts after chondrocyte hypertrophy and cartilage matrix calcification and that the mineral concentration of calcified meckel's cartilage is comparable to that of the surrounding bone. |
2021-12-03 |
2023-08-13 |
mouse |
| Dylan O'Toole, Ali Abdullah I Zaeri, Stuart A Nicklin, Anne T French, Christopher M Loughrey, Tamara P Marti. Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular signalling. vol 76. 2021-11-29. PMID:32891693. |
cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ecm), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yao Wang, Xiaojing Sun, Xianglan Su. The Functions of LncRNA H19 in the Heart. Heart, lung & circulation. 2021-11-29. PMID:34840062. |
for example, lncrna h19 (h19), also known as a fetal gene abundant in adult heart and skeletal muscles and evolutionarily conserved in humans and mice, has a regulatory role in aortic aneurysm, myocardial hypertrophy, extracellular matrix reconstitution, and coronary artery diseases. |
2021-11-29 |
2023-08-13 |
mouse |
| Weipeng Ge, Cuiliu Hou, Wei Zhang, Xiaoxiao Guo, Pan Gao, Xiaomin Song, Ran Gao, Ying Liu, Wenjun Guo, Bolun Li, Hongmei Zhao, Jing Wan. Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation. Journal of molecular and cellular cardiology. vol 152. 2021-11-23. PMID:33301800. |
pathological cardiac remodeling, characterized by excessive deposition of extracellular matrix proteins and cardiac hypertrophy, leads to the development of heart failure. |
2021-11-23 |
2023-08-13 |
Not clear |
| Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamur. Biglycan expression and its function in human ligamentum flavum. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33649499. |
to investigate the involvement of bgn in the pathomechanism of human ligamentum hypertrophy, first we confirmed increased expression of bgn by immunohistochemistry in the extracellular matrix of hypertrophied lf of lss patients compared to lf without hypertrophy. |
2021-11-22 |
2023-08-13 |
human |
| Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang, Birong Don. Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33977869. |
silencing of long noncoding inhba antisense rna1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microrna-141-3p/myeloid cell leukemia 1 axis. |
2021-11-10 |
2023-08-13 |
human |
| Xiaodong Li, Zeliang He, Julei Zhang, Yan Ha. Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. FEBS open bio. vol 11. issue 6. 2021-11-08. PMID:33932142. |
hypertrophic scarring (hs) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. |
2021-11-08 |
2023-08-13 |
human |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology. 2021-11-03. PMID:34137454. |
hypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (vegf), receptor activator of nuclear factor kappa-b ligand (rankl) and matrix metallopeptidases-9/13 (mmp-9/13). |
2021-11-03 |
2023-08-13 |
Not clear |
| Shawn A Hallett, Wanida Ono, Noriaki On. The hypertrophic chondrocyte: To be or not to be. Histology and histopathology. 2021-11-03. PMID:34137454. |
hypertrophic chondrocytes also indirectly regulate resorption of the cartilaginous extracellular matrix, by controlling formation of a special subtype of osteoclasts termed "chondroclasts". |
2021-11-03 |
2023-08-13 |
Not clear |
| Sijia Xu, Wenxin Dong, Yu Sh. LncRNA PICSAR binds to miR-485-5p and activates TGF-β1/Smad to promote abnormal proliferation of hypertrophic scar fibroblasts (HSFs) and excessive deposition of extracellular matrix (ECM). Medical molecular morphology. vol 54. issue 4. 2021-11-01. PMID:34255190. |
lncrna picsar binds to mir-485-5p and activates tgf-β1/smad to promote abnormal proliferation of hypertrophic scar fibroblasts (hsfs) and excessive deposition of extracellular matrix (ecm). |
2021-11-01 |
2023-08-13 |
Not clear |
| Jan M Leerink, Mabel van de Ruit, Elizabeth A M Feijen, Leontien C M Kremer, Annelies M C Mavinkurve-Groothuis, Yigal M Pinto, Esther E Creemers, Wouter E M Ko. Extracellular matrix remodeling in animal models of anthracycline-induced cardiomyopathy: a meta-analysis. Journal of molecular medicine (Berlin, Germany). vol 99. issue 9. 2021-10-29. PMID:34052857. |
collagens, matrix metalloproteinases (mmps), inflammation markers, transforming growth factor ß signaling markers, and markers for cardiac hypertrophy were upregulated, whereas the protein kinase b (akt) pro-survival pathway was downregulated. |
2021-10-29 |
2023-08-13 |
mouse |
| Alan Christhian Bahr, Julia Paim DA Luz, Rayane Brinck Teixeira, Patrick Türck, Alexsandra Zimmer, Alexandre Luz DE Castro, Eduardo Echer Dos Reis, Fernanda Visioli, Adriane Belló-Klein, Alex Sander DA Rosa Araujo, Paulo Cavalheiro Schenke. The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction. Anais da Academia Brasileira de Ciencias. vol 93. issue suppl 4. 2021-10-29. PMID:34706009. |
methylprednisolone acetate attenuated matrix metalloproteinase-2 activity, cardiac dilatation, and prevented the onset of pulmonary congestion, as well as avoided cardiac hypertrophy. |
2021-10-29 |
2023-08-13 |
rat |
| Keshvad Hedayatyanfard, Nazgol-Sadat Haddadi, Seyed Ali Ziai, Hossein Karim, Feizollah Niazi, Ulrike Muscha Steckelings, Behnam Habibi, Ali Modarressi, Ahmad-Reza Dehpou. The renin-angiotensin system in cutaneous hypertrophic scar and keloid formation. Experimental dermatology. vol 29. issue 9. 2021-10-28. PMID:32678966. |
hypertrophic scar and keloid are two types of fibroproliferative conditions that result from excessive extracellular matrix production. |
2021-10-28 |
2023-08-13 |
Not clear |