| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Donegan, J A Tyson, S Y Branch, M J Beckstead, S A Anderson, D J Lodg. Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Molecular psychiatry. vol 22. issue 10. 2018-01-19. PMID:27480492. |
thus, we posit that stem cell-derived interneuron transplants may be an effective therapeutic strategy to reduce hippocampal hyperactivity and attenuate behavioral deficits in schizophrenia. |
2018-01-19 |
2023-08-13 |
Not clear |
| J J Donegan, J A Tyson, S Y Branch, M J Beckstead, S A Anderson, D J Lodg. Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Molecular psychiatry. vol 22. issue 10. 2018-01-19. PMID:27480492. |
these interneuron transplants integrate within the existing circuitry, reduce hippocampal hyperactivity and normalize aberrant dopamine neuron activity. |
2018-01-19 |
2023-08-13 |
Not clear |
| Fang-Fang Liu, Lin-Dong Yang, Xiao-Ru Sun, Hui Zhang, Wei Pan, Xing-Ming Wang, Jian-Jun Yang, Mu-Huo Ji, Hong-Mei Yua. NOX2 Mediated-Parvalbumin Interneuron Loss Might Contribute to Anxiety-Like and Enhanced Fear Learning Behavior in a Rat Model of Post-Traumatic Stress Disorder. Molecular neurobiology. vol 53. issue 10. 2017-12-29. PMID:26650043. |
in conclusion, our results provided evidence that nox2 activation in the hippocampus, at least in part, contributes to oxidative stress and neuroinflammation, which further results in pv interneuron loss and consequent ptsd symptoms in a rat model of ptsd induced by sps. |
2017-12-29 |
2023-08-13 |
rat |
| Alicia Flores-Cuadrado, Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos de la Rosa-Prieto, Alino Martinez-Marco. Hippocampal α-synuclein and interneurons in Parkinson's disease: Data from human and mouse models. Movement disorders : official journal of the Movement Disorder Society. vol 31. issue 7. 2017-12-29. PMID:26991075. |
differential α-synuclein involvement in hippocampal interneuron populations remains unknown. |
2017-12-29 |
2023-08-13 |
mouse |
| Chenjuan Tao, Weiwei Yan, Yuan Li, Xiaodong L. Effect of antidepressants on spatial memory deficit induced by dizocilpine. Psychiatry research. vol 244. 2017-11-22. PMID:27512913. |
additionally, the data of the present study suggested that fluvoxamine and escitalopram remitted hippocampal pv interneuron reduction induced by dizocilpine. |
2017-11-22 |
2023-08-13 |
rat |
| R Chittajallu, J C Wester, M T Craig, E Barksdale, X Q Yuan, G Akgül, C Fang, D Collins, S Hunt, K A Pelkey, C J McBai. Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. Nature communications. vol 8. issue 1. 2017-11-21. PMID:28751664. |
these afferent specific deficits potentially impact neurogliaform cell mediated inhibition within the hippocampus and our findings reveal circuit loci implicating this relatively understudied interneuron subtype in the etiology of neurodevelopmental disorders characterized by nmda receptor-hypofunction.proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. |
2017-11-21 |
2023-08-13 |
mouse |
| Andrew S Lapato, Jenny I Szu, Jonathan P C Hasselmann, Anna J Khalaj, Devin K Binder, Seema K Tiwari-Woodruf. Chronic demyelination-induced seizures. Neuroscience. vol 346. 2017-11-20. PMID:28153692. |
gray matter atrophy, hippocampal lesions, interneuron loss, and elevated juxtacortical lesion burden have been identified in ms patients with seizures; however, translational studies aimed at elucidating the pathophysiological processes underlying ms epileptogenesis are limited. |
2017-11-20 |
2023-08-13 |
mouse |
| Kenneth A Pelkey, Ramesh Chittajallu, Michael T Craig, Ludovic Tricoire, Jason C Wester, Chris J McBai. Hippocampal GABAergic Inhibitory Interneurons. Physiological reviews. vol 97. issue 4. 2017-10-10. PMID:28954853. |
here we provide an overview of the current state of the field of interneuron research, focusing largely on the hippocampus. |
2017-10-10 |
2023-08-13 |
Not clear |
| J J Botterill, N Nogovitsyn, H J Caruncho, L E Kalynchu. Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions. The Journal of comparative neurology. vol 525. issue 2. 2017-09-29. PMID:27362579. |
selective plasticity of hippocampal gabaergic interneuron populations following kindling of different brain regions. |
2017-09-29 |
2023-08-13 |
rat |
| J J Botterill, N Nogovitsyn, H J Caruncho, L E Kalynchu. Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions. The Journal of comparative neurology. vol 525. issue 2. 2017-09-29. PMID:27362579. |
in this experiment, we used the electrical kindling model of epilepsy to determine whether seizures that originate in different brain regions have differential effects on hippocampal interneuron subpopulations. |
2017-09-29 |
2023-08-13 |
rat |
| J J Botterill, N Nogovitsyn, H J Caruncho, L E Kalynchu. Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions. The Journal of comparative neurology. vol 525. issue 2. 2017-09-29. PMID:27362579. |
we analyzed markers of dendritic (somatostatin), perisomatic (parvalbumin), and interneuron-selective (calretinin) inhibition, as well as an overall indicator (gad67) of interneuron distribution across all major hippocampal subfields. |
2017-09-29 |
2023-08-13 |
rat |
| Stephen Keeley, André A Fenton, John Rinze. Modeling fast and slow gamma oscillations with interneurons of different subtype. Journal of neurophysiology. vol 117. issue 3. 2017-09-13. PMID:27927782. |
moreover, in ca1 of the hippocampus, experimental evidence indicates the presence of multiple gamma oscillators, two of which may be coordinated by differing interneuron populations. |
2017-09-13 |
2023-08-13 |
Not clear |
| Jennifer J Donegan, Daniel J Lodg. Cell-based therapies for the treatment of schizophrenia. Brain research. vol 1655. 2017-08-08. PMID:27544423. |
therefore, it has been hypothesized that restoring interneuron function in the hippocampus and/or prefrontal cortex may be an effective treatment strategy for schizophrenia. |
2017-08-08 |
2023-08-13 |
Not clear |
| Riley E Perszyk, John O DiRaddo, Katie L Strong, Chian-Ming Low, Kevin K Ogden, Alpa Khatri, Geoffrey A Vargish, Kenneth A Pelkey, Ludovic Tricoire, Dennis C Liotta, Yoland Smith, Chris J McBain, Stephen F Trayneli. GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity. Molecular pharmacology. vol 90. issue 6. 2017-05-09. PMID:27625038. |
glun2d-containing n-methyl-d-aspartate receptors mediate synaptic transmission in hippocampal interneurons and regulate interneuron activity. |
2017-05-09 |
2023-08-13 |
mouse |
| Riley E Perszyk, John O DiRaddo, Katie L Strong, Chian-Ming Low, Kevin K Ogden, Alpa Khatri, Geoffrey A Vargish, Kenneth A Pelkey, Ludovic Tricoire, Dennis C Liotta, Yoland Smith, Chris J McBain, Stephen F Trayneli. GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity. Molecular pharmacology. vol 90. issue 6. 2017-05-09. PMID:27625038. |
glun2d mrna was detected by single-cell pcr and in situ hybridization in diverse interneuron subtypes in the ca1 region of the hippocampus. |
2017-05-09 |
2023-08-13 |
mouse |
| Andreas Bjorefeldt, Pontus Wasling, Henrik Zetterberg, Eric Hans. Neuromodulation of fast-spiking and non-fast-spiking hippocampal CA1 interneurons by human cerebrospinal fluid. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634295. |
this issue is examined in the hippocampal brain slice by comparing gabaergic interneuron activity in human versus artificial cerebrospinal fluid. |
2016-11-04 |
2023-08-13 |
human |
| Stephan Heckers, Christine Konrad. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25449711. |
the initial evidence for gabaergic abnormalities of the hippocampus in schizophrenia came from post-mortem studies of interneuron number, protein expression, and gene expression. |
2016-06-27 |
2023-08-13 |
Not clear |
| Klaus Oliver Schubert, Melanie Föcking, David R Cotte. Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: potential roles in GABAergic interneuron pathology. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25728835. |
proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: potential roles in gabaergic interneuron pathology. |
2016-06-27 |
2023-08-13 |
human |
| Klaus Oliver Schubert, Melanie Föcking, David R Cotte. Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: potential roles in GABAergic interneuron pathology. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25728835. |
these findings are interpreted with a focus on gabaergic interneuron pathology in the hippocampus. |
2016-06-27 |
2023-08-13 |
human |
| Min Jee Jang, Woon Ryoung Kim, Sunghoon Joo, Jae Ryun Ryu, Eunsoo Lee, Yoonkey Nam, Woong Su. Cell-Type Dependent Effect of Surface-Patterned Microdot Arrays on Neuronal Growth. Frontiers in neuroscience. vol 10. 2016-05-31. PMID:27242421. |
in this study, we used surface-printed microdot arrays to investigate the effect of the same micropatterns on the growth of mouse spinal interneuron, mouse hippocampal neurons, and rat hippocampal neurons. |
2016-05-31 |
2023-08-13 |
mouse |