| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Austin Ferro, Anosha Arshad, Leah Boyd, Tess Stanley, Adrian Berisha, Uma Vrudhula, Adrian M Gomez, Jeremy C Borniger, Lucas Cheadl. The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617238. |
at the cellular level, microglia contacted fewer, but larger, excitatory synapses in ca1 in the absence of fn14, suggesting that these brain-resident immune cells may dampen neuronal activity by modifying synaptic inputs onto pyr neurons. |
2024-04-15 |
2024-04-17 |
mouse |
| Assunta Virtuoso, Christos Galanis, Maximilian Lenz, Michele Papa, Andreas Vlacho. Regional Microglial Response in Entorhino-Hippocampal Slice Cultures to Schaffer Collateral Lesion and Metalloproteinases Modulation. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38397023. |
in the present study, we mechanically induced a schaffer collateral lesion (scl) in mouse entorhino-hippocampal slice cultures to investigate glial behavior, i.e., microglia and astrocytes, under metalloproteinases (mmps) modulation in the lesioned area, ca3, and the denervated region, ca1. |
2024-02-24 |
2024-02-26 |
mouse |
| Shiva Zeini, Nahid Davoodian, Seyed Abdollah Mousav. Gamma-oryzanol attenuates lipopolysaccharide-induced cognitive impairment by modulation of hippocampal inflammatory response and glial activation in mice. Journal of neuroimmunology. vol 387. 2024-01-26. PMID:38278081. |
also, neuronal loss, microglia, and astrocyte densities were evaluated in the ca1 and ca3 hippocampus. |
2024-01-26 |
2024-01-29 |
mouse |
| Shiva Zeini, Nahid Davoodian, Seyed Abdollah Mousav. Gamma-oryzanol attenuates lipopolysaccharide-induced cognitive impairment by modulation of hippocampal inflammatory response and glial activation in mice. Journal of neuroimmunology. vol 387. 2024-01-26. PMID:38278081. |
this behavioral improvement was accompanied by a significant reduction in the number of microglia and astrocytes in the ca1 and ca3 hippocampus. |
2024-01-26 |
2024-01-29 |
mouse |
| Changran Niu, Xinpei Yue, Juan Ji An, Robert Bass, Haifei Xu, Baoji X. Genetic Dissection of BDNF and TrkB Expression in Glial Cells. Biomolecules. vol 14. issue 1. 2024-01-23. PMID:38254691. |
surprisingly, we found no bdnf- or trkb-expressing microglia in examined cns regions, including the somatomotor cortex, hippocampal ca1, and spinal cord. |
2024-01-23 |
2024-01-25 |
mouse |
| Xue-Jing Lv, Su-Su Lv, Guo-Hong Wang, Yue Chang, Ya-Qi Cai, Hui-Zhu Liu, Guang-Zhou Xu, Wen-Dong Xu, Yu-Qiu Zhan. Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia. Brain, behavior, and immunity. 2024-01-20. PMID:38244946. |
we found that rtn resulted in robust activation of astrocytes and microglia in the ca1 area of the vhpc (vca1). |
2024-01-20 |
2024-01-23 |
mouse |
| K Oberman, B L van Leeuwen, M Nabben, J E Villafranca, R G Schoemake. J147 affects cognition and anxiety after surgery in Zucker rats. Physiology & behavior. vol 273. 2023-11-26. PMID:37989448. |
surgery in zucker rats reduced exploration and increased anxiety in the open field test, impaired short-term spatial memory, induced a shift in circadian rhythm and increased plasma neutrophil gelatinase-associated lipocalin (ngal), microglia activity in the ca1 and blood brain barrier leakage. |
2023-11-26 |
2023-11-28 |
rat |
| Zhen Li, Meng-Xing Li, Yun-Peng Qin, Wei Tan. Electroacupuncture improves cognitive dysfunction in rats with Alzheimer's disease by regulating microglial cells. Zhen ci yan jiu = Acupuncture research. vol 48. issue 11. 2023-11-24. PMID:37984903. |
to observe the effect of electroacupuncture (ea) on microglia (mg), janus kinase-2 (jak2) and signal transducer and activator of transcription-3 (stat3) in hippocampal ca1 region of alzheimer's di-sease (ad) rats, so as to explore its mechanisms in the treatment of ad. |
2023-11-24 |
2023-11-28 |
rat |
| Juan Chen, Tao Wang, Yuting Zhou, Yiming Hong, Shiyong Zhang, Zhongtao Zhou, Ao Jiang, Danyang Li. Microglia trigger the structural plasticity of GABAergic neurons in the hippocampal CA1 region of a lipopolysaccharide-induced neuroinflammation model. Experimental neurology. 2023-10-08. PMID:37806513. |
microglia trigger the structural plasticity of gabaergic neurons in the hippocampal ca1 region of a lipopolysaccharide-induced neuroinflammation model. |
2023-10-08 |
2023-10-15 |
mouse |
| Shuo Zhao, Jinpeng Zhang, Yufeng Chen, Xinyuan Cui, Haiqing Liu, Ying Yan, Yuexiang Sun, Yongxiu Qi, Yuanyuan Li. The comprehensive mechanism underlying Schisandra polysaccharide in AD-like symptoms of Aβ25-35-induced rats based on hippocampal metabolomics and serum lipidomics techniques. Journal of pharmaceutical and biomedical analysis. vol 236. 2023-09-16. PMID:37716276. |
the pharmacodynamic results revealed that scp significantly improved the spatial learning and long-term memory function and the morphology of neurons in the hippocampal ca1 region, alleviated inflammatory damage and oxidative stress, inhibited the activation of microglia and astrocytes, and increased the proportion of mature neurons of ad-like symptoms of aβ25-35-induced rats. |
2023-09-16 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
we found that hpc decreased nlrp3 inflammasome in microglia and inhibited m1 polarization of microglia in ca1 after tgci. |
2023-09-08 |
2023-10-07 |
rat |
| Xiaomei Lu, Lixuan Zhan, Guorong Chai, Meiyan Chen, Weiwen Sun, En X. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology. 2023-09-08. PMID:37682454. |
additionally, the knockdown of p-mlkl by short hairpin rna (shrna) administration inhibited the activation of the nf-κb signaling pathway and reduced the formation of nlrp3 inflammasome, thus attenuating m1 polarization of microglia and decreasing the release of interleukin 1 beta (il-1β) and necrosis factor alpha (tnf-α) in ca1 post ischemia. |
2023-09-08 |
2023-10-07 |
rat |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |
| Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhan. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochemical research. 2023-07-25. PMID:37490197. |
ds also remarkably inhibited lps-induced neuroinflammation by suppressing microglia overactivation, pro-inflammatory cytok ine release (tnf-α and il-1β) and reducing neuronal loss in the ca1 and dg regions of the hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Gumaro Galindo-Paredes, Gonzalo Flores, Julio César Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. |
in the bla, cea and ca1, obx caused significant changes in glial cells, such as hypertrophy and hypotrophy in gfap-positive astrocytes and iba1-positive microglia, respectively. |
2023-06-30 |
2023-08-14 |
rat |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
in contrast to the hilus, microglia in the ca1 region had an increase in rod-like cells. |
2023-05-14 |
2023-08-14 |
rat |
| Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Syogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, Riho Kitazato, Shotaro Otsuka, Seiya Takada, Megumi Sumizono, Harutoshi Sakakim. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023-05-14. PMID:37182575. |
however, the 2m-detraining group showed increased bdnf positive area in the ca1 region and the enhancement of anti-inflammatory m2 phenotype microglia. |
2023-05-14 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
sexually differentiated microglia and ca1 hippocampal synaptic connectivity. |
2023-05-12 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
in this study, we tested whether sexual differentiation of microglia results in sex-dependent postnatal reorganization of ca1 synaptic connectivity in the hippocampus. |
2023-05-12 |
2023-08-14 |
mouse |
| Si-Jie Dai, Yu-Ying Shao, Yang Zheng, Jin-Yi Sun, Zhi-Sheng Li, Jia-Ying Shi, Meng-Qi Yan, Xiao-Yun Qiu, Ceng-Lin Xu, Wan-Sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Che. Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation. Acta pharmacologica Sinica. 2023-04-19. PMID:37076634. |
notably, in ca1 region, the seizure focus, icm pretreatment mainly inhibited hmgb1 translocation in microglia. |
2023-04-19 |
2023-08-14 |
mouse |